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Conserved domains on  [gi|363744698|ref|XP_003643107|]
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solute carrier family 12 member 2 isoform X1 [Gallus gallus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Gene Ontology:  GO:0015377|GO:0016020|GO:0055085|GO:0022857
PubMed:  23506871|12739168|34849164

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 150-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1606.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   150 NTMDAVPRIDHYRHTAADLGEKLIRPSLAELHDELDKE-----PFEDGYANGEEGTP---AGDAAATYTPDSKGIVKFGW 221
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   222 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 301
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   302 IGLIFAFANAVAVAMYVVGFAETVVELLKENGT-LMIDEMNDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAI 380
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   381 GDFVIGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRKEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 459
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   460 ILITTLVYMGIAVSVGSCVVRDATGNVNNTIITeltNCTTAACklnydFSSCQTG-CHYGLMNNFQVMSMVSGFAPLISA 538
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNtCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   539 GIFSATLSSALASLVSAPKIFQALCKDNIYPGFQMFAKGYGKNNEPLRGYLLTFLIALGFILIAELNVIAPIISNFFLAS 618
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   619 YALINFSVFHASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 698
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   699 TYLNALQHSIRLSGVEDHVKNFRPQCLIMTGAPNARPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDLAKYQRW 778
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   779 LIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMRPNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEG 858
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   859 LDISHLQGQEELLssqekspcskdvivkVDYSKKAetdtsvafvpsssertsalhkEEDEDGKTPTQPLLKkdlkspssp 938
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS---------------------IELNDGKISTQPDMH--------- 747

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   939 lnltdqrlLDASSQFQKKQGKSNIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGG-KINRIDHDRRAMATLLSKF 1017
Cdd:TIGR00930  748 --------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKF 819

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  1018 RIDFSDIMVLGDINTKPKKENIAAFEEMIEPFRLHEDDKEQEVAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKE 1096
Cdd:TIGR00930  820 RIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....
gi 363744698  1097 HSSTANVIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1150
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 150-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1606.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   150 NTMDAVPRIDHYRHTAADLGEKLIRPSLAELHDELDKE-----PFEDGYANGEEGTP---AGDAAATYTPDSKGIVKFGW 221
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   222 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 301
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   302 IGLIFAFANAVAVAMYVVGFAETVVELLKENGT-LMIDEMNDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAI 380
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   381 GDFVIGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRKEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 459
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   460 ILITTLVYMGIAVSVGSCVVRDATGNVNNTIITeltNCTTAACklnydFSSCQTG-CHYGLMNNFQVMSMVSGFAPLISA 538
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNtCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   539 GIFSATLSSALASLVSAPKIFQALCKDNIYPGFQMFAKGYGKNNEPLRGYLLTFLIALGFILIAELNVIAPIISNFFLAS 618
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   619 YALINFSVFHASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 698
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   699 TYLNALQHSIRLSGVEDHVKNFRPQCLIMTGAPNARPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDLAKYQRW 778
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   779 LIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMRPNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEG 858
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   859 LDISHLQGQEELLssqekspcskdvivkVDYSKKAetdtsvafvpsssertsalhkEEDEDGKTPTQPLLKkdlkspssp 938
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS---------------------IELNDGKISTQPDMH--------- 747

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   939 lnltdqrlLDASSQFQKKQGKSNIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGG-KINRIDHDRRAMATLLSKF 1017
Cdd:TIGR00930  748 --------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKF 819

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  1018 RIDFSDIMVLGDINTKPKKENIAAFEEMIEPFRLHEDDKEQEVAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKE 1096
Cdd:TIGR00930  820 RIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....
gi 363744698  1097 HSSTANVIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1150
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
734-1150 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 658.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   734 RPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDlaKYQRWLIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMR 813
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSELQK--KAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   814 PNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEK-------------SPCS 880
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGdetnssyaeqsseEQST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   881 KDVIVKVDYSKKAETDTSVAFVPSSSertsalHKEEDEDGKTPTQPLLKKDLKSPSSPLNlTDQRLLDASSQFQKKQGKS 960
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS------TKNPSGKDSSKSDKLKKKSPSIILRTAS-NEKEILNNITQFQKKQKKG 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   961 NIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENI 1039
Cdd:pfam03522  232 TIDVWWLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETK 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  1040 AAFEEMIEPFRLHEDDKEQEVAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANVIVMSLPVARKGAVSSA 1119
Cdd:pfam03522  312 KFFDELIEPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAP 383

                          410       420       430
                   ....*....|....*....|....*....|.
gi 363744698  1120 LYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1150
Cdd:pfam03522  384 LYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
232-686 1.29e-48

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 179.71  E-value: 1.29e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  232 NIWGVMLFIRLSWIVGQAGiGLSVVVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 311
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  312 VAVAMYVVGFAETVVELLKENGTLmidemndirIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAIGDFVIGtfipl 391
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  392 dskkakGFFGYKAEIFmENFGPDFRKEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYMGIA 471
Cdd:COG0531   169 ------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  472 VSVGSCVVRDATGNVNNTIiteltncttaacklnydfsscqtgchyglmnnFQVMSMVSG--FAPLISAGIFSATLSSAL 549
Cdd:COG0531   242 LALTGVVPYDELAASGAPL--------------------------------ADAAEAVFGpwGAILIALGALLSLLGALN 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  550 ASLVSAPKIFQALCKDNIYPGFqmFAKGYGKNNEPLRGYLLTFLIALGFILI--AELNVIAPIISNFFLASYALINFSVF 627
Cdd:COG0531   290 ASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVI 367

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  628 hASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 686
Cdd:COG0531   368 -VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 249-678 6.85e-03

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 40.23  E-value: 6.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  249 AGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLIsrslgpeFGGAIGLIFafanavavamYVVGFAETVVEL 328
Cdd:cd10322    33 AGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYI-------LGAALGALL----------LALFLAPRLRRL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  329 LKENGTLMIDEMND---IRIIGAI-TVVILLGISVA--------------GMEWEAKAQIVLLVILILAIG--------D 382
Cdd:cd10322    96 GKTTIPETILERYYskgLRLLVAIiIIIALIPYLALqligggyilstllgIPYTVAVIIAAVIVILYTVFGgmravawtD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  383 FV----------IGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRKEETFFSVFAIFFPAATGILAGANISGDLA---DPQ 449
Cdd:cd10322   176 VIqgivmligvlVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILaakDEK 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  450 SAIpKGTLLAILITtLVYMGIAVSVGSCV-VRDATGNVNNTIITELTNcttaacklnydfsscqtgchyglmnnfqvMSM 528
Cdd:cd10322   256 TAR-RAFLLAGLLL-LLIGFLVALIGLAArALFPDLENPDLALPTLIN-----------------------------SLL 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  529 VSGFAPLISAGIFSATLSSALASLVSAPkifQALCKDnIYPGFqmFAKGYGKNNEPLRGYLLTFLIA-LGFILIAELNVI 607
Cdd:cd10322   305 PPGLAGLVLAGLLAAAMSTADSLLLAAS---TLFTRD-IYKPL--INPKASDKKLLRVSRIAVVVVGvLALLLALLPPSI 378

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 363744698  608 APIISNFFLASYALINFSVFHASLAKSPGWRPAFkyynmwISLVGAILCCIVMFVINWWAALLTYVIVLGL 678
Cdd:cd10322   379 LLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAI------AGIIVGLIVTLVWLLLPLASPLGIDPIIPAL 443
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
 150-1150 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1606.69  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   150 NTMDAVPRIDHYRHTAADLGEKLIRPSLAELHDELDKE-----PFEDGYANGEEGTP---AGDAAATYTPDSKGIVKFGW 221
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVvsllgPLADYTNNGQGMKEheeAEDAEGTKEKPPAGAVKFGW 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   222 IKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGA 301
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   302 IGLIFAFANAVAVAMYVVGFAETVVELLKENGT-LMIDEMNDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAI 380
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   381 GDFVIGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRKEET-FFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLA 459
Cdd:TIGR00930  241 LNIFVGTIIPAFDKPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   460 ILITTLVYMGIAVSVGSCVVRDATGNVNNTIITeltNCTTAACklnydFSSCQTG-CHYGLMNNFQVMSMVSGFAPLISA 538
Cdd:TIGR00930  321 ILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNtCSYGLMNNLQVMSLVSPFPPLITA 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   539 GIFSATLSSALASLVSAPKIFQALCKDNIYPGFQMFAKGYGKNNEPLRGYLLTFLIALGFILIAELNVIAPIISNFFLAS 618
Cdd:TIGR00930  393 GIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLAS 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   619 YALINFSVFHASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQAL 698
Cdd:TIGR00930  473 YALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQAL 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   699 TYLNALQHSIRLSGVEDHVKNFRPQCLIMTGAPNARPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDLAKYQRW 778
Cdd:TIGR00930  553 SYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTW 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   779 LIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMRPNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEG 858
Cdd:TIGR00930  633 LEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSEG 712

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   859 LDISHLQGQEELLssqekspcskdvivkVDYSKKAetdtsvafvpsssertsalhkEEDEDGKTPTQPLLKkdlkspssp 938
Cdd:TIGR00930  713 LPISVLQVQEELE---------------NDCSEDS---------------------IELNDGKISTQPDMH--------- 747

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   939 lnltdqrlLDASSQFQKKQGKSNIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGG-KINRIDHDRRAMATLLSKF 1017
Cdd:TIGR00930  748 --------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKF 819

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  1018 RIDFSDIMVLGDINTKPKKENIAAFEEMIEPFRLHEDDKEQEVAD-KMKEDEPWRITDNELELYKTKTYRQIRLNELLKE 1096
Cdd:TIGR00930  820 RIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLE 899

                          970       980       990      1000      1010
                   ....*....|....*....|....*....|....*....|....*....|....
gi 363744698  1097 HSSTANVIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1150
Cdd:TIGR00930  900 YSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
734-1150 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 658.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   734 RPALLHLVHAFTKNVGLMICGHVHMGPRRQAMKELSTDlaKYQRWLIKNKMKAFYAPVHAEDLRDGGQYLMQAAGLGRMR 813
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSELQK--KAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   814 PNTLVVGFKKNWRQSDMRDVETYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEK-------------SPCS 880
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEELGLGdetnssyaeqsseEQST 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   881 KDVIVKVDYSKKAETDTSVAFVPSSSertsalHKEEDEDGKTPTQPLLKKDLKSPSSPLNlTDQRLLDASSQFQKKQGKS 960
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS------TKNPSGKDSSKSDKLKKKSPSIILRTAS-NEKEILNNITQFQKKQKKG 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   961 NIDVWWLFDDGGLTLLIPYLITTKKKWKECKIRVFIGG-KINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENI 1039
Cdd:pfam03522  232 TIDVWWLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETK 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  1040 AAFEEMIEPFRLHEDDKEQEVAdkmkedepWRITDNELELYKTKTYRQIRLNELLKEHSSTANVIVMSLPVARKGAVSSA 1119
Cdd:pfam03522  312 KFFDELIEPFRLHEDDKEEESA--------EKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAP 383

                          410       420       430
                   ....*....|....*....|....*....|.
gi 363744698  1120 LYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1150
Cdd:pfam03522  384 LYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
224-725 2.96e-136

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 421.34  E-value: 2.96e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   224 GVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGAIG 303
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   304 L------IFAFANAVAVAMYVVGFAETVVELLKENGTlmidemndiriiGAITVVILLGISVAGMEWEAKAQIVLLVILI 377
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLWVW------------GAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   378 LAIGDFVIGTFIPL---DSKKAKGFFGYKAEIFMENFGPDFrkEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPK 454
Cdd:pfam00324  148 IAIIGFIIVGIILLsggNPNDGAIFRYLGDNGGKNNFPPGF--GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPK 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   455 GTLLAILITTLVYMGIAVSVGSCVVRDATGNVNNTIITeltncttaacklnydfsscqtgchYGLMNNFQVMSMVSGFAP 534
Cdd:pfam00324  226 AILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA------------------------ASPFVIFFKFLGISGLAP 281

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   535 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPgfqMFAKGYGKNNEPLRGYLLTFLIALGFILIAELNviAPIISNF 614
Cdd:pfam00324  282 LINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLN--PAIVFNF 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   615 FLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSS 694
Cdd:pfam00324  357 LLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAG 436

                          490       500       510
                   ....*....|....*....|....*....|.
gi 363744698   695 TQALTYLNALQHSIRLSGVEDHVKNFRPQCL 725
Cdd:pfam00324  437 SFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
232-686 1.29e-48

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 179.71  E-value: 1.29e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  232 NIWGVMLFIRLSWIVGQAGiGLSVVVIAMATVVTTITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGAIGLIFAFANA 311
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  312 VAVAMYVVGFAETVVELLKENGTLmidemndirIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAIGDFVIGtfipl 391
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLFPAGGSV---------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  392 dskkakGFFGYKAEIFmENFGPDFRKEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYMGIA 471
Cdd:COG0531   169 ------GLFAFDPANF-TPFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILVS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  472 VSVGSCVVRDATGNVNNTIiteltncttaacklnydfsscqtgchyglmnnFQVMSMVSG--FAPLISAGIFSATLSSAL 549
Cdd:COG0531   242 LALTGVVPYDELAASGAPL--------------------------------ADAAEAVFGpwGAILIALGALLSLLGALN 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  550 ASLVSAPKIFQALCKDNIYPGFqmFAKGYGKNNEPLRGYLLTFLIALGFILI--AELNVIAPIISNFFLASYALINFSVF 627
Cdd:COG0531   290 ASILGASRLLYAMARDGLLPKV--FAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVI 367

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  628 hASLAKSPGWRPAFKYYNMWISLVGAILCCIVMFVINWWAALLTYV-IVLGLYIYVTYKK 686
Cdd:COG0531   368 -VLRRRRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGALLIGLVlLAIGLLLYLLYRR 426
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
 136-198 8.62e-32

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 118.70  E-value: 8.62e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   136 DTHTNTYYLRTFGHNTMDAVPRIDHYRHTAADLGEKLIRPSLAELHDELDK-------EPFEDGYANGEE 198
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKnsalavaEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
249-675 3.41e-17

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 85.44  E-value: 3.41e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   249 AGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETvveL 328
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASY---L 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   329 LKENGTLMIDEMNDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILILAIGDFVIgtFIPLDSKKAKGFFGykAEIFM 408
Cdd:pfam13520  104 LSALGPDLVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILII--ILGLVTADGGGFNL--LSGEW 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   409 ENFGPDFrkEETFFSVFAIFFPAATGILAGANISGDlaDPQSAIPKGTLLAILITTLVYMGIAVSVGSCVVRDATGNVNN 488
Cdd:pfam13520  180 HTFFPDG--WPGVFAGFLGVLWSFTGFESAANVSEE--VKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALSSG 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   489 TIiteltncttaacklnydfsscqtgchyGLMNNFQVMSMVSGFAPLISAGIFSATLSSALASLVSAPKIFQALCKDNIY 568
Cdd:pfam13520  256 LG---------------------------QVAALLFQAVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALARDGVL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   569 PGFQMFAKgYGKNNEPLRGYLLTFLIALGFILIAelnVIAPIISNFFLASYALINFSVFHASLA-------KSPGWRPAF 641
Cdd:pfam13520  309 PFSRFFAK-VNKFGSPIRAIILTAILSLILLLLF---LLSPAAYNALLSLSAYGYLLSYLLPIIgllilrkKRPDLGRIP 384

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 363744698   642 KYYNM-WISLVGAILCCIVMFVI--------NWWAALLTYVIV 675
Cdd:pfam13520  385 GRWPVaIFGILFSLFLIVALFFPpvgpatgsSLNYAIILIVAF 427
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 242-676 5.09e-03

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 40.75  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   242 LSWIVGQAGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAY-Y--LISRSLGPEFGGAIGLIFAFANAVAVAMYV 318
Cdd:pfam01490   24 LPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRNKsYgdLGYRLLGPKGRLLILFAILLNLFGVCISYL 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   319 VGFAETVVELLKENGTlmiDEMNDIRIIGAITVVILLGISVAG-MEWEAKAQIV--LLVILILAIGDFVIGTFIPLDSKk 395
Cdd:pfam01490  104 IFAGDNLPAIFDSFFD---TCPISLVYFIIIFGLIFIPLSFIPnLSALSILSLLaaVSSLYYIVILVLSVAEGIVLTAQ- 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   396 akgffgykaEIFMENFGPDFRKEETFFSVFAIFFpAATGILAGANISGDLADPQS--AIPKGTLLAILITTLVYMGIAvs 473
Cdd:pfam01490  180 ---------GVGHLGSKTNIKLAGTFLAIGIIVF-AFEGHAVLLPIQNEMKNPSKfkAMTKILLTAIIIATVLYILIG-- 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   474 vgsCVVRDATGnvnNTIITELTncttaackLNYDFSScqtgchyglmnnfqvmsmvsgfaPLISAGIFSATLSSALASLV 553
Cdd:pfam01490  248 ---LVGYLAFG---DNVKGNIL--------LNLPKSA-----------------------WLIDIANLLLVLHVILSFPL 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698   554 SAPKIFQALckDNIYPGFQMFAKGYGKNNEP--LRGYLLTFLIALGFILIA----ELNVIAPIISNFFLASYALINFSVF 627
Cdd:pfam01490  291 QLFPIRQIV--ENLLFRKEAPFGASGKNNPKskLLRVVIRSGLVVITYLIAisvpFFGDLLSLVGATSCAPLSFILPPLF 368

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 363744698   628 HASLAKSPGWRpafkyYNMWISLVGAILCCIVMFVINWwaALLTYVIVL 676
Cdd:pfam01490  369 HLKLKKTKKKS-----QEKLWKPDILDVICIVIGLLLM--AYGVAGLIL 410
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 249-678 6.85e-03

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 40.23  E-value: 6.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  249 AGIGLSVVVIAMATVVTTITGLSTSAIATNGFVRGGGAYYLIsrslgpeFGGAIGLIFafanavavamYVVGFAETVVEL 328
Cdd:cd10322    33 AGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYI-------LGAALGALL----------LALFLAPRLRRL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  329 LKENGTLMIDEMND---IRIIGAI-TVVILLGISVA--------------GMEWEAKAQIVLLVILILAIG--------D 382
Cdd:cd10322    96 GKTTIPETILERYYskgLRLLVAIiIIIALIPYLALqligggyilstllgIPYTVAVIIAAVIVILYTVFGgmravawtD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  383 FV----------IGTFIPLDSKKAKGFFGYKAEIFMENFGPDFRKEETFFSVFAIFFPAATGILAGANISGDLA---DPQ 449
Cdd:cd10322   176 VIqgivmligvlVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILaakDEK 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  450 SAIpKGTLLAILITtLVYMGIAVSVGSCV-VRDATGNVNNTIITELTNcttaacklnydfsscqtgchyglmnnfqvMSM 528
Cdd:cd10322   256 TAR-RAFLLAGLLL-LLIGFLVALIGLAArALFPDLENPDLALPTLIN-----------------------------SLL 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363744698  529 VSGFAPLISAGIFSATLSSALASLVSAPkifQALCKDnIYPGFqmFAKGYGKNNEPLRGYLLTFLIA-LGFILIAELNVI 607
Cdd:cd10322   305 PPGLAGLVLAGLLAAAMSTADSLLLAAS---TLFTRD-IYKPL--INPKASDKKLLRVSRIAVVVVGvLALLLALLPPSI 378

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 363744698  608 APIISNFFLASYALINFSVFHASLAKSPGWRPAFkyynmwISLVGAILCCIVMFVINWWAALLTYVIVLGL 678
Cdd:cd10322   379 LLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAI------AGIIVGLIVTLVWLLLPLASPLGIDPIIPAL 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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