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Conserved domains on  [gi|354465042|ref|XP_003494989|]
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ankyrin repeat domain-containing protein 16 isoform X4 [Cricetulus griseus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-267 3.62e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 3.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  44 PAGDTLVHCAARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTR 123
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 124 KNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCFEAVQELLD 201
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 202 RCHyEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKAcSSAEDSLGAQALHRAAVTGQNEAIRFL 267
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALLLAAAAGAALIVKLL 271
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-267 3.62e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 3.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  44 PAGDTLVHCAARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTR 123
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 124 KNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCFEAVQELLD 201
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 202 RCHyEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKAcSSAEDSLGAQALHRAAVTGQNEAIRFL 267
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-236 1.22e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  150 FHIASREGDPVILRYLLTVCPDAWKTESNiRRTPLHTAAMHGCFEAVQELLDrcHYEPDCKDNcGVTPFMDAIQCGHVDI 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLE--HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*..
gi 354465042  230 AKLLLEK 236
Cdd:pfam12796  77 VKLLLEK 83
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 84-311 9.93e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 76.95  E-value: 9.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 164 YLL---TVCPDAWKTESNirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKAC 240
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 354465042 241 SSAEDSLGAQALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTQLTALHYAA---KPCIwpvqVSMWLAPGSSCS 311
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLLDS-GANIDYFGKNGCVAALCYAIennKIDI----VRLFIKRGADCN 229
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 83-107 2.14e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.14e-04
                           10        20
                   ....*....|....*....|....*
gi 354465042    83 PLHEAASMGHRDCVRYLLDRGAVVD 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 83-166 3.00e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  83 PLHEAASMGHRDCVRYLLDRGAVV---DSLKKadwTPLMMACTRKN-------LEVIQDLVEHGANP---LLKNKDGWNS 149
Cdd:cd22192  139 PLSFAACVGNEEIVRLLIEHGADIraqDSLGN---TVLHILVLQPNktfacqmYDLILSYDKEDDLQpldLVPNNQGLTP 215

                         90
                 ....*....|....*..
gi 354465042 150 FHIASREGDPVILRYLL 166
Cdd:cd22192  216 FKLAAKEGNIVMFQHLV 232
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-267 3.62e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.01  E-value: 3.62e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  44 PAGDTLVHCAARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTR 123
Cdd:COG0666   51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 124 KNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT--VCPDAwktESNIRRTPLHTAAMHGCFEAVQELLD 201
Cdd:COG0666  131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEagADVNA---RDNDGETPLHLAAENGHLEIVKLLLE 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 202 RCHyEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKAcSSAEDSLGAQALHRAAVTGQNEAIRFL 267
Cdd:COG0666  208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-292 6.71e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 6.71e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  53 AARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 133 VEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT--VCPDAWkteSNIRRTPLHTAAMHGCFEAVQELLDRcHYEPDCK 210
Cdd:COG0666  107 LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEagADVNAQ---DNDGNTPLHLAAANGNLEIVKLLLEA-GADVNAR 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 211 DNCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKTTQLTALHYA 290
Cdd:COG0666  183 DNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAA 260


                 ..
gi 354465042 291 AK 292
Cdd:COG0666  261 AA 262
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-239 9.66e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.76  E-value: 9.66e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKN 125
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 126 LEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGCFEAVQELLDRcHY 205
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA-GA 243

                        170       180       190
                 ....*....|....*....|....*....|....
gi 354465042 206 EPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKA 239
Cdd:COG0666  244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-292 2.17e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 2.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  71 MDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSF 150
Cdd:COG0666   12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 151 HIASREGDPVILRYLLtvcpdAWKTESNIR----RTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGH 226
Cdd:COG0666   92 HAAARNGDLEIVKLLL-----EAGADVNARdkdgETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGN 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 227 VDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKtTQLTALHYAAK 292
Cdd:COG0666  166 LEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDN-DGKTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-202 5.24e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.05  E-value: 5.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  42 QGPAGDTLVHCAARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMAC 121
Cdd:COG0666  116 RDKDGETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 122 TRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGCFEAVQELLD 201
Cdd:COG0666  195 ENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL-NAKDKDGLTALLLAAAAGAALIVKLLLL 273


                 .
gi 354465042 202 R 202
Cdd:COG0666  274 A 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-292 4.70e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 4.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  99 LLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVcPDAWKTESN 178
Cdd:COG0666    7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAA-GADINAKDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 179 IRRTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVT 258
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQDNDGNTPLHLAAAN 163

                        170       180       190
                 ....*....|....*....|....*....|....
gi 354465042 259 GQNEAIRFLVScLGVDIDVRAKTTQlTALHYAAK 292
Cdd:COG0666  164 GNLEIVKLLLE-AGADVNARDNDGE-TPLHLAAE 195
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-236 1.22e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  150 FHIASREGDPVILRYLLTVCPDAWKTESNiRRTPLHTAAMHGCFEAVQELLDrcHYEPDCKDNcGVTPFMDAIQCGHVDI 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLE--HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*..
gi 354465042  230 AKLLLEK 236
Cdd:pfam12796  77 VKLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
184-278 1.69e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 1.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  184 LHTAAMHGCFEAVQELLDrCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKhkaCSSAEDSLGAQALHRAAVTGQNEA 263
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 354465042  264 IRFLVSClGVDIDVR 278
Cdd:pfam12796  77 VKLLLEK-GADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-143 8.84e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 8.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042   51 HCAARHGRQDILAYLVETWSmDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVvdSLKKADWTPLMMACTRKNLEVIQ 130
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 354465042  131 DLVEHGANPLLKN 143
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 84-311 9.93e-16

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 76.95  E-value: 9.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 164 YLL---TVCPDAWKTESNirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKAC 240
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 354465042 241 SSAEDSLGAQALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTQLTALHYAA---KPCIwpvqVSMWLAPGSSCS 311
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLLDS-GANIDYFGKNGCVAALCYAIennKIDI----VRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-166 1.55e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042   84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGAnpLLKNKDGWNSFHIASREGDPVILR 163
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78


                  ...
gi 354465042  164 YLL 166
Cdd:pfam12796  79 LLL 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-108 6.72e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 6.72e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465042   36 EAARGCQGPAGDTLVHCAARHGRQDILAYLVETWSMDIEAANRDykrPLHEAASMGHRDCVRYLLDRGAVVDS 108
Cdd:pfam12796  20 GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-292 6.92e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 6.92e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354465042  218 FMDAIQCGHVDIAKLLLEKHKACSSaEDSLGAQALHRAAVTGQNEAIRFLVSClgvdIDVRAKTTQLTALHYAAK 292
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKDNGRTALHYAAR 70
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-241 1.64e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.55  E-value: 1.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  79 DYKRPLHEAASMGHRDCVRYLLDRGAVV-DSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREG 157
Cdd:PHA02875  67 DIESELHDAVEEGDVKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 158 DPVILRYLLT--VCPDawkTESNIRRTPLHTAAMHGCFEAVQELLDRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLE 235
Cdd:PHA02875 147 DIKGIELLIDhkACLD---IEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIK 223


                 ....*.
gi 354465042 236 KHKACS 241
Cdd:PHA02875 224 RGADCN 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-148 1.12e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  42 QGPAGDTLVHCAARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMAC 121
Cdd:COG0666  182 RDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260

                         90       100
                 ....*....|....*....|....*..
gi 354465042 122 TRKNLEVIQDLVEHGANPLLKNKDGWN 148
Cdd:COG0666  261 AAGAALIVKLLLLALLLLAAALLDLLT 287
Ank_4 pfam13637
Ankyrin repeats (many copies);
180-234 3.54e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 3.54e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 354465042  180 RRTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLL 234
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 83-281 5.42e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 5.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  83 PLHEAASMGHRDC---VRYLLDRGAVVDSLKKADWTPLMM-ACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHI------ 152
Cdd:PHA03095  50 PLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylsgfn 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 153 -------------------------------ASREGDPVILRYLLTVCPDAWkTESNIRRTPLHTaamHGCF----EAVQ 197
Cdd:PHA03095 130 inpkvirlllrkgadvnaldlygmtplavllKSRNANVELLRLLIDAGADVY-AVDDRFRSLLHH---HLQSfkprARIV 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 198 ELLDRCHYEPDCKDNCGVTPFMDAI---QCGHVDIAKLLLekHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVD 274
Cdd:PHA03095 206 RELIRAGCDPAATDMLGNTPLHSMAtgsSCKRSLVLPLLI--AGISINARNRYGQTPLHYAAVFNNPRACRRLIA-LGAD 282


                 ....*..
gi 354465042 275 IDVRAKT 281
Cdd:PHA03095 283 INAVSSD 289
Ank_4 pfam13637
Ankyrin repeats (many copies);
46-100 1.77e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.77e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 354465042   46 GDTLVHCAARHGRQDILAYLVETWsMDIEAANRDYKRPLHEAASMGHRDCVRYLL 100
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-293 2.28e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.97  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  53 AARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGavvdslkkADWTPLMMACTRKnlEVIQDL 132
Cdd:PHA02874  42 AIRSGDAKIVELFIKH-GADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG--------VDTSILPIPCIEK--DMIKTI 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 133 VEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTvcpdaWKTESNIRRT----PLHTAAMHGCFEAVQELLDRCHYePD 208
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFE-----YGADVNIEDDngcyPIHIAIKHNFFDIIKLLLEKGAY-AN 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 209 CKDNCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNeAIRFLVSCLGV-DIDVRAKttqlTAL 287
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYACIKLLID-HGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNASInDQDIDGS----TPL 258


                 ....*.
gi 354465042 288 HYAAKP 293
Cdd:PHA02874 259 HHAINP 264
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-166 3.10e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 3.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 354465042  114 WTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLL 166
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-276 3.23e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.65  E-value: 3.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHG-RQDILAYLVETwSMDIEAANRDYKRPLHE-AASMG-HRDCVRYLLDRGAVVDSLKKADWTPL--MMA 120
Cdd:PHA03095  83 GFTPLHLYLYNAtTLDVIKLLIKA-GADVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLavLLK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 121 CTRKNLEVIQDLVEHGANPLLKNKDGWNSFHI--ASREGDPVILRYLLTVCPDAWKTEsNIRRTPLHTAAMHGCFEA--V 196
Cdd:PHA03095 162 SRNANVELLRLLIDAGADVYAVDDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCKRslV 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 197 QELL-----------------------------DRC---HYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHkacSSAE 244
Cdd:PHA03095 241 LPLLiagisinarnrygqtplhyaavfnnpracRRLialGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKN---PSAE 317

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 354465042 245 dsLGAQALHRAAVTGQN-------EAIRFLVSCLGVDID 276
Cdd:PHA03095 318 --TVAATLNTASVAGGDipsdatrLCVAKVVLRGAFSLL 354
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-201 3.77e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 3.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMG-HRDCVRYLLDRGAVVDSLKKADWTPLMMACTRK 124
Cdd:PHA02876 307 GETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRN 386

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 354465042 125 NLEVIQDLVEHGAN-PLLKNKDGwNSFHIASREGDPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGC-FEAVQELLD 201
Cdd:PHA02876 387 NVVIINTLLDYGADiEALSQKIG-TALHFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCkLDVIEMLLD 464
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 127-255 4.44e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 4.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 127 EVIQDLVEHGANPLLKNKDGWNS-FHIASREGDPVILRYLLTvcpdaWKTESNI----RRTPLHTAAMHGCFEAVQELLD 201
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTaLHYATENKDQRLTELLLS-----YGANVNIpdktNNSPLHHAVKHYNKPIVHILLE 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 202 RCHYEpDCKDNCGVTPFMDAI-QCGHVDIAKLLLEkHKACSSAEDS-LGAQALHRA 255
Cdd:PHA02878 223 NGAST-DARDKCGNTPLHISVgYCKDYDILKLLLE-HGVDVNAKSYiLGLTALHSS 276
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 72-238 4.64e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 4.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  72 DIEAANRDY-KRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSF 150
Cdd:PHA02878 159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 151 HIA-SREGDPVILRYLLT--VCPDAwktESNIRR-TPLHTaAMHGcfEAVQELLDRCHYEPDCKDNCGVTPFMDA----- 221
Cdd:PHA02878 239 HISvGYCKDYDILKLLLEhgVDVNA---KSYILGlTALHS-SIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAvkqyl 312

                        170
                 ....*....|....*...
gi 354465042 222 -IQCGHVDIAKLLLEKHK 238
Cdd:PHA02878 313 cINIGRILISNICLLKRI 330
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-133 6.37e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 6.37e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 354465042   82 RPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLV 133
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-236 1.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  60 DILAYLVETWSMDIEAANRDYKR---PLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLM-----MACTRKNLEVIQD 131
Cdd:PHA03100  12 IIKVKNIKYIIMEDDLNDYSYKKpvlPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 132 LVEHGANPLLKNKDGWNSFHIASRE--GDPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGC--FEAVQELLDR----- 202
Cdd:PHA03100  92 LLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANV-NIKNSDGENLLHLYLESNKidLKILKLLIDKgvdin 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 354465042 203 ----------CHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEK 236
Cdd:PHA03100 171 aknrvnyllsYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDL 214
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 46-139 8.72e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHGRQDILAYLVEtWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKN 125
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIA-RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180

                         90
                 ....*....|....
gi 354465042 126 LEVIQDLVEHGANP 139
Cdd:PHA02875 181 IAICKMLLDSGANI 194
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-292 2.48e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.72  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  83 PLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHG-----ANPLLKNKDGWNSFHI----- 152
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSInkcsvFYTLVAIKDAFNNRNVeifki 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 153 -------ASREGDPV--------------ILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCFEaVQELLDRCHYEPDCKD 211
Cdd:PHA02878 120 iltnrykNIQTIDLVyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQR-LTELLLSYGANVNIPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 212 NCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVSCLGVDIDVRAKTTQLTALHYAA 291
Cdd:PHA02878 199 KTNNSPLHHAVKHYNKPIVHILLE-NGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSI 277


                 .
gi 354465042 292 K 292
Cdd:PHA02878 278 K 278
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 71-291 8.42e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.37  E-value: 8.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  71 MDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANpllKNKDGWNSF 150
Cdd:PHA02876 169 ADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN---INKNDLSLL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 151 H-IASREGDPVILRYlltvcpDAWKTESNI---RRTPLHTAAMHGCFEA-VQELLDRcHYEPDCKDNCGVTPFMDAIQCG 225
Cdd:PHA02876 246 KaIRNEDLETSLLLY------DAGFSVNSIddcKNTPLHHASQAPSLSRlVPKLLER-GADVNAKNIKGETPLYLMAKNG 318

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042 226 HVDIAKLLLEKHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVSCLGVDIDVRAKTTQlTALHYAA 291
Cdd:PHA02876 319 YDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAA 383
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 84-178 9.71e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 9.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*
gi 354465042 164 YLLTVCPDAWKTESN 178
Cdd:PTZ00322 166 LLSRHSQCHFELGAN 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-180 1.12e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  71 MDIEAANRDYKRPLHEAASMGHRDC------------------VRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:PHA03100 132 ANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYL 211

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 354465042 133 VEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAWKTESNIR 180
Cdd:PHA03100 212 LDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLL 259
Ank_5 pfam13857
Ankyrin repeats (many copies);
99-153 1.85e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 1.85e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042   99 LLDRGAV-VDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIA 153
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 115-290 2.13e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 115 TPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLL------TVCP------DAWKT------E 176
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdngvdtSILPipciekDMIKTildcgiD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 177 SNIR----RTPLHTAAMHGCFEAVQELLDrchYEPDC--KDNCGVTPFMDAIQCGHVDIAKLLLEKhKACSSAEDSLGAQ 250
Cdd:PHA02874 117 VNIKdaelKTFLHYAIKKGDLESIKMLFE---YGADVniEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGES 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 354465042 251 ALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTqLTALHYA 290
Cdd:PHA02874 193 PLHNAAEYGDYACIKLLIDH-GNHIMNKCKNG-FTPLHNA 230
Ank_5 pfam13857
Ankyrin repeats (many copies);
199-255 7.40e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 7.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 354465042  199 LLDRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKACsSAEDSLGAQALHRA 255
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 78-135 1.86e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 1.86e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  78 RDY--KRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEH 135
Cdd:PTZ00322 111 RDYdgRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 83-107 2.14e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 2.14e-04
                           10        20
                   ....*....|....*....|....*
gi 354465042    83 PLHEAASMGHRDCVRYLLDRGAVVD 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 114-144 3.01e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 3.01e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 354465042  114 WTPLMMACTR-KNLEVIQDLVEHGANPLLKNK 144
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 46-153 8.29e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 8.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHGRQDILAYLVETWSMdIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRkN 125
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-N 234

                         90       100
                 ....*....|....*....|....*...
gi 354465042 126 LEVIQDLVEHgANPLLKNKDGWNSFHIA 153
Cdd:PHA02874 235 RSAIELLINN-ASINDQDIDGSTPLHHA 261
Ank_5 pfam13857
Ankyrin repeats (many copies);
65-120 9.38e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 9.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 354465042   65 LVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMA 120
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 113-139 9.70e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 9.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 354465042   113 DWTPLMMACTRKNLEVIQDLVEHGANP 139
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 46-167 1.20e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  46 GDTLVHCAARHGRQD-ILAYLVETWSMDIEAANRDykRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWtpLMMACTRK 124
Cdd:PLN03192 558 GRTPLHIAASKGYEDcVLVLLKHACNVHIRDANGN--TALWNAISAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRN 633

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 354465042 125 NLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT 167
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIM 676
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 78-166 2.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  78 RDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREG 157
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179


                 ....*....
gi 354465042 158 DPVILRYLL 166
Cdd:PHA02875 180 DIAICKMLL 188
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 83-107 2.83e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 354465042   83 PLHEAA-SMGHRDCVRYLLDRGAVVD 107
Cdd:pfam00023   5 PLHLAAgRRGNLEIVKLLLSKGADVN 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 83-166 3.00e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  83 PLHEAASMGHRDCVRYLLDRGAVV---DSLKKadwTPLMMACTRKN-------LEVIQDLVEHGANP---LLKNKDGWNS 149
Cdd:cd22192  139 PLSFAACVGNEEIVRLLIEHGADIraqDSLGN---TVLHILVLQPNktfacqmYDLILSYDKEDDLQpldLVPNNQGLTP 215

                         90
                 ....*....|....*..
gi 354465042 150 FHIASREGDPVILRYLL 166
Cdd:cd22192  216 FKLAAKEGNIVMFQHLV 232
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 81-234 5.02e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 38.70  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042  81 KRPLHEAASMGHRDCVRYLLdrgavvdslkkadwtplmmactrknleviqdlvEHGANPLLKNKDG----WNSfhIASre 156
Cdd:PLN03192 559 RTPLHIAASKGYEDCVLVLL---------------------------------KHACNVHIRDANGntalWNA--ISA-- 601

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 354465042 157 GDPVILRYLLTVcpdAWKTESNIRRTPLHTAAMHGCFEAVQELLdRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLL 234
Cdd:PLN03192 602 KHHKIFRILYHF---ASISDPHAAGDLLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 182-253 6.12e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.07  E-value: 6.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465042 182 TPLHTAAMHGCFEAVQELLDR-------------CHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHkACSSAEDSLG 248
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARgadvvspratgtfFRPGPKNLIYYGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLG 169


                 ....*
gi 354465042 249 AQALH 253
Cdd:cd22192  170 NTVLH 174
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 181-202 8.21e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|..
gi 354465042  181 RTPLHTAAMHGCFEAVQELLDR 202
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLEN 24
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 114-139 8.29e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.38  E-value: 8.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 354465042  114 WTPLMMACTRKNLEVIQDLVEHGANP 139
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADI 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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