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Conserved domains on  [gi|354465040|ref|XP_003494988|]
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ankyrin repeat domain-containing protein 16 isoform X2 [Cricetulus griseus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-346 1.63e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.93  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  53 AARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 133 VEHGANPLLKNKDGWnsfhiasregdpvilrylltvcpdawktesnirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDN 212
Cdd:COG0666  107 LEAGADVNARDKDGE----------------------------------TPLHLAAYNGNLEIVKLLLEA-GADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 213 CGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKtTQLTALHYAAK 292
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDN-DGKTALDLAAE 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354465040 293 EGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSGLKDSEDL 346
Cdd:COG0666  229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-346 1.63e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.93  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  53 AARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 133 VEHGANPLLKNKDGWnsfhiasregdpvilrylltvcpdawktesnirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDN 212
Cdd:COG0666  107 LEAGADVNARDKDGE----------------------------------TPLHLAAYNGNLEIVKLLLEA-GADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 213 CGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKtTQLTALHYAAK 292
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDN-DGKTALDLAAE 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354465040 293 EGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSGLKDSEDL 346
Cdd:COG0666  229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-313 8.14e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 8.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  218 FMDAIQCGHVDIAKLLLEKHKACSSaEDSLGAQALHRAAVTGQNEAIRFLVSClgvdIDVRAKTTQLTALHYAAKEGQTS 297
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 354465040  298 TVQTLLSLGANINSKD 313
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 84-310 2.14e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 82.73  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 164 YLL---TVCPDAWKTESNirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKAC 240
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 241 SSAEDSLGAQALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTQLTALHYAAKEGQTSTVQTLLSLGANIN 310
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLLDS-GANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 182-304 2.69e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 182 TPLHTAAMHGCFEAVQELLDR-------------CHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHkACSSAEDSLG 248
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARgadvvspratgtfFRPGPKNLIYYGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLG 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354465040 249 AQALHrAAVTGQN-----EAIRFLVSCLGVDIDVRAKTTQ----LTALHYAAKEGQTSTVQTLLS 304
Cdd:cd22192  170 NTVLH-ILVLQPNktfacQMYDLILSYDKEDDLQPLDLVPnnqgLTPFKLAAKEGNIVMFQHLVQ 233
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 83-107 4.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.03e-04
                           10        20
                   ....*....|....*....|....*
gi 354465040    83 PLHEAASMGHRDCVRYLLDRGAVVD 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-346 1.63e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.93  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  53 AARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 133 VEHGANPLLKNKDGWnsfhiasregdpvilrylltvcpdawktesnirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDN 212
Cdd:COG0666  107 LEAGADVNARDKDGE----------------------------------TPLHLAAYNGNLEIVKLLLEA-GADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 213 CGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKtTQLTALHYAAK 292
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLE-AGADVNAKDN-DGKTALDLAAE 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 354465040 293 EGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSGLKDSEDL 346
Cdd:COG0666  229 NGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-239 3.44e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 3.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKN 125
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 126 LEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGCFEAVQELLDRcHY 205
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEA-GA 243

                        170       180       190
                 ....*....|....*....|....*....|....
gi 354465040 206 EPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKA 239
Cdd:COG0666  244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
42-202 9.21e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 9.21e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  42 QGPAGDTLVHCAARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMAC 121
Cdd:COG0666  116 RDKDGETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAA 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 122 TRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAwKTESNIRRTPLHTAAMHGCFEAVQELLD 201
Cdd:COG0666  195 ENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL-NAKDKDGLTALLLAAAAGAALIVKLLLL 273


                 .
gi 354465040 202 R 202
Cdd:COG0666  274 A 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
129-347 1.73e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 1.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 129 IQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGcFEAVQELLDRCHYEPD 208
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAG-DLLVALLLLAAGADIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 209 CKDNCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVScLGVDIDVRAKTTQlTALH 288
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQDNDGN-TPLH 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465040 289 YAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSG----LKDSEDLT 347
Cdd:COG0666  159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGadvnAKDNDGKT 221
Ank_2 pfam12796
Ankyrin repeats (3 copies);
218-313 8.14e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.46  E-value: 8.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  218 FMDAIQCGHVDIAKLLLEKHKACSSaEDSLGAQALHRAAVTGQNEAIRFLVSClgvdIDVRAKTTQLTALHYAAKEGQTS 297
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 354465040  298 TVQTLLSLGANINSKD 313
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 84-310 2.14e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 82.73  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 164 YLL---TVCPDAWKTESNirrTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKAC 240
Cdd:PHA02875  86 ELLdlgKFADDVFYKDGM---TPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLI-DHKAC 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 241 SSAEDSLGAQALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTQLTALHYAAKEGQTSTVQTLLSLGANIN 310
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMAKGDIAICKMLLDS-GANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-236 9.31e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 9.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  150 FHIASREGDPVILRYLLTVCPDAWKTESNiRRTPLHTAAMHGCFEAVQELLDrcHYEPDCKDNcGVTPFMDAIQCGHVDI 229
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLE--HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*..
gi 354465040  230 AKLLLEK 236
Cdd:pfam12796  77 VKLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-143 5.07e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 5.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040   51 HCAARHGRQDILAYLVETWSmDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVvdSLKKADWTPLMMACTRKNLEVIQ 130
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 354465040  131 DLVEHGANPLLKN 143
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
252-339 2.43e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.14  E-value: 2.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  252 LHRAAVTGQNEAIRFLVSClGVDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSlGANINSKDErNRSALHLACAGQHVAC 331
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGR-TALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEI 76


                  ....*...
gi 354465040  332 TRFLLQSG 339
Cdd:pfam12796  77 VKLLLEKG 84
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-166 6.98e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 6.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040   84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGAnpLLKNKDGWNSFHIASREGDPVILR 163
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78


                  ...
gi 354465040  164 YLL 166
Cdd:pfam12796  79 LLL 81
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 96-370 2.64e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.38  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  96 VRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREG-----DPVILRYLLTVCP 170
Cdd:PHA03100  18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKynltdVKEIVKLLLEYGA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 171 DAWKTESNIRrTPLHTAAMH--GCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVD--IAKLLLeKHKACSSAEDS 246
Cdd:PHA03100  98 NVNAPDNNGI-TPLLYAISKksNSYSIVEYLLDN-GANVNIKNSDGENLLHLYLESNKIDlkILKLLI-DKGVDINAKNR 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 247 lgaqalhraavtgqneaIRFLVScLGVDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAG 326
Cdd:PHA03100 175 -----------------VNYLLS-YGVPINIKDVYGF-TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 354465040 327 QHVACTRFLLQSGlKDSEDLTGTLAQQLTKCIDILQDFDHTMKS 370
Cdd:PHA03100 236 NNKEIFKLLLNNG-PSIKTIIETLLYFKDKDLNTITKIKMLKKS 278
PHA03095 PHA03095
ankyrin-like protein; Provisional
 83-336 6.57e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 6.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  83 PLHEAASMGHRDC---VRYLLDRGAVVDSLKKADWTPLMM-ACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHI--ASRE 156
Cdd:PHA03095  50 PLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 157 GDPVILRYLLTVCPDAWKTEsNIRRTPLHtAAM--HGCFEAVQELLDRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLL 234
Cdd:PHA03095 130 INPKVIRLLLRKGADVNALD-LYGMTPLA-VLLksRNANVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRARIVRE 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 235 EKHKACS-SAEDSLGAQALHRAAVTGQNEAIR---FLVSclGVDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSLGANIN 310
Cdd:PHA03095 208 LIRAGCDpAATDMLGNTPLHSMATGSSCKRSLvlpLLIA--GISINARNRYGQ-TPLHYAAVFNNPRACRRLIALGADIN 284

                        250       260
                 ....*....|....*....|....*.
gi 354465040 311 SKDERNRSALHLACAGQHVACTRFLL 336
Cdd:PHA03095 285 AVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 71-326 3.14e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.70  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  71 MDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANpllKNKDGWNSF 150
Cdd:PHA02876 169 ADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN---INKNDLSLL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 151 H-IASREGDPVILRYlltvcpDAWKTESNI---RRTPLHTAAMHGCFEA-VQELLDRcHYEPDCKDNCGVTPFMDAIQCG 225
Cdd:PHA02876 246 KaIRNEDLETSLLLY------DAGFSVNSIddcKNTPLHHASQAPSLSRlVPKLLER-GADVNAKNIKGETPLYLMAKNG 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 226 HVDIAKLLLEKHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVSCLGVDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSL 305
Cdd:PHA02876 319 YDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDK-TPIHYAAVRNNVVIINTLLDY 397

                        250       260
                 ....*....|....*....|.
gi 354465040 306 GANINSKDERNRSALHLACAG 326
Cdd:PHA02876 398 GADIEALSQKIGTALHFALCG 418
Ank_2 pfam12796
Ankyrin repeats (3 copies);
287-349 4.46e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 4.46e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465040  287 LHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSGLKDSEDLTGT 349
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT 63
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-108 2.31e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 2.31e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465040   36 EAARGCQGPAGDTLVHCAARHGRQDILAYLVETWSMDIEAANRDykrPLHEAASMGHRDCVRYLLDRGAVVDS 108
Cdd:pfam12796  20 GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-323 6.42e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.36  E-value: 6.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  53 AARHGRQDILAYLVETwSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGavvdslkkADWTPLMMACTRKnlEVIQDL 132
Cdd:PHA02874  42 AIRSGDAKIVELFIKH-GADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG--------VDTSILPIPCIEK--DMIKTI 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 133 VEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTvcpdaWKTESNIRRT----PLHTAAMHGCFEAVQELLDRCHYePD 208
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFE-----YGADVNIEDDngcyPIHIAIKHNFFDIIKLLLEKGAY-AN 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 209 CKDNCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNeAIRFLVSCLGV-DIDVRAKttqlTAL 287
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYACIKLLID-HGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNASInDQDIDGS----TPL 258

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 354465040 288 HYAAK-EGQTSTVQTLLSLGANINSKDERNRSALHLA 323
Cdd:PHA02874 259 HHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 186-339 7.09e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 60.65  E-value: 7.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 186 TAAMHGCFEAVQELLdRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKACSSAEDSLGAQALHRAAVTGQNEAIR 265
Cdd:PLN03192 531 TVASTGNAALLEELL-KAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 354465040 266 FLVSClgvdidVRAKTTQLTA--LHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSG 339
Cdd:PLN03192 609 ILYHF------ASISDPHAAGdlLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNG 678
Ank_4 pfam13637
Ankyrin repeats (many copies);
283-336 8.03e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 8.03e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 354465040  283 QLTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLL 336
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 116-360 6.37e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.20  E-value: 6.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 116 PLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVcpdawKTESNIrrtplhtaamhgcFEA 195
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRS-----INKCSV-------------FYT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 196 VQELLDRCHYEpdckdncgvtpfmdaiqcgHVDIAK-LLLEKHKACSSAEDSLGAQALHRAAVtgQNEAIRFLVScLGVD 274
Cdd:PHA02878 102 LVAIKDAFNNR-------------------NVEIFKiILTNRYKNIQTIDLVYIDKKSKDDII--EAEITKLLLS-YGAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 275 IDVRAKTTQLTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSGLK-DSEDLTGT--LA 351
Cdd:PHA02878 160 INMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAStDARDKCGNtpLH 239


                 ....*....
gi 354465040 352 QQLTKCIDI 360
Cdd:PHA02878 240 ISVGYCKDY 248
Ank_4 pfam13637
Ankyrin repeats (many copies);
180-234 6.68e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 6.68e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 354465040  180 RRTPLHTAAMHGCFEAVQELLDRcHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLL 234
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-313 1.37e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  83 PLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHG-----ANPLLKNKDGWNSFHI----- 152
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSInkcsvFYTLVAIKDAFNNRNVeifki 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 153 -------ASREGDPV--------------ILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCFEaVQELLDRCHYEPDCKD 211
Cdd:PHA02878 120 iltnrykNIQTIDLVyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQR-LTELLLSYGANVNIPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 212 NCGVTPFMDAIQCGHVDIAKLLLEkHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVSCLGVDIDVRAKTTQLTALHYAA 291
Cdd:PHA02878 199 KTNNSPLHHAVKHYNKPIVHILLE-NGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYILGLTALHSSI 277

                        250       260
                 ....*....|....*....|..
gi 354465040 292 KEGQtsTVQTLLSLGANINSKD 313
Cdd:PHA02878 278 KSER--KLKLLLEYGADINSLN 297
Ank_4 pfam13637
Ankyrin repeats (many copies);
46-100 2.99e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 2.99e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 354465040   46 GDTLVHCAARHGRQDILAYLVETWsMDIEAANRDYKRPLHEAASMGHRDCVRYLL 100
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
114-166 5.18e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 5.18e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 354465040  114 WTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLL 166
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 215-339 5.42e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 5.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 215 VTPFMDAIQCGHVDIAKLLLeKHKACSSAEDSLGAQALHRAAVTGQNEAIRFL-----------VSCL-----------G 272
Cdd:PHA02874  36 TTPLIDAIRSGDAKIVELFI-KHGADINHINTKIPHPLLTAIKIGAHDIIKLLidngvdtsilpIPCIekdmiktildcG 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 354465040 273 VDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSG 339
Cdd:PHA02874 115 IDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 99-350 6.48e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 6.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  99 LLDRGAVVDSLKKADWTPLMMACTRKNL-EVIQDLVEHGANPLLKNKDGWNSFHIASREG-DPVILRYLLTVCPDAWKTE 176
Cdd:PHA02876 259 LYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAAD 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 177 SnIRRTPLHTAAMHGCFEAVQELLDRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKACSSAEDSLGAqALHrAA 256
Cdd:PHA02876 339 R-LYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGT-ALH-FA 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 257 VTGQNE--AIRFLVScLGVDIDVRAKTTQlTALHYAAKEG-QTSTVQTLLSLGANINSKDERNRSALHLACaGQHvACTR 333
Cdd:PHA02876 416 LCGTNPymSVKTLID-RGANVNSKNKDLS-TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL-EYH-GIVN 491

                        250
                 ....*....|....*....
gi 354465040 334 FLLQSG--LKDSEDLTGTL 350
Cdd:PHA02876 492 ILLHYGaeLRDSRVLHKSL 510
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 72-238 6.95e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 6.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  72 DIEAANRDY-KRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSF 150
Cdd:PHA02878 159 DINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 151 HIA-SREGDPVILRYLLT--VCPDAwktESNIRR-TPLHTaAMHGcfEAVQELLDRCHYEPDCKDNCGVTPFMDA----- 221
Cdd:PHA02878 239 HISvGYCKDYDILKLLLEhgVDVNA---KSYILGlTALHS-SIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAvkqyl 312

                        170
                 ....*....|....*...
gi 354465040 222 -IQCGHVDIAKLLLEKHK 238
Cdd:PHA02878 313 cINIGRILISNICLLKRI 330
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-276 8.98e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 8.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHG-RQDILAYLVETwSMDIEAANRDYKRPLHE-AASMG-HRDCVRYLLDRGAVVDSLKKADWTPL--MMA 120
Cdd:PHA03095  83 GFTPLHLYLYNAtTLDVIKLLIKA-GADVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLavLLK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 121 CTRKNLEVIQDLVEHGANPLLKNKDGWNSFHI--ASREGDPVILRYLLTVCPDAWKTEsNIRRTPLHTAAMHGCFEA--V 196
Cdd:PHA03095 162 SRNANVELLRLLIDAGADVYAVDDRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATD-MLGNTPLHSMATGSSCKRslV 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 197 QELL-----------------------------DRC---HYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHkacSSAE 244
Cdd:PHA03095 241 LPLLiagisinarnrygqtplhyaavfnnpracRRLialGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKN---PSAE 317

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 354465040 245 dsLGAQALHRAAVTGQN-------EAIRFLVSCLGVDID 276
Cdd:PHA03095 318 --TVAATLNTASVAGGDipsdatrLCVAKVVLRGAFSLL 354
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-133 1.11e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 1.11e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 354465040   82 RPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLV 133
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 115-323 7.50e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.73  E-value: 7.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 115 TPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLL------TVCP------DAWKT------E 176
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdngvdtSILPipciekDMIKTildcgiD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 177 SNIR----RTPLHTAAMHGCFEAVQELLDrchYEPDC--KDNCGVTPFMDAIQCGHVDIAKLLLEKhKACSSAEDSLGAQ 250
Cdd:PHA02874 117 VNIKdaelKTFLHYAIKKGDLESIKMLFE---YGADVniEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVKDNNGES 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465040 251 ALHRAAVTGQNEAIRFLVSClGVDIDVRAKTTqLTALHYAAKEGQtSTVQTLLSlGANINSKDERNRSALHLA 323
Cdd:PHA02874 193 PLHNAAEYGDYACIKLLIDH-GNHIMNKCKNG-FTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLHHA 261
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 46-139 1.24e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHGRQDILAYLVEtWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKN 125
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIA-RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180

                         90
                 ....*....|....
gi 354465040 126 LEVIQDLVEHGANP 139
Cdd:PHA02875 181 IAICKMLLDSGANI 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 84-178 1.54e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  84 LHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILR 163
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*
gi 354465040 164 YLLTVCPDAWKTESN 178
Cdd:PTZ00322 166 LLSRHSQCHFELGAN 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-180 1.55e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  71 MDIEAANRDYKRPLHEAASMGHRDC------------------VRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDL 132
Cdd:PHA03100 132 ANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYL 211

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 354465040 133 VEHGANPLLKNKDGWNSFHIASREGDPVILRYLLTVCPDAWKTESNIR 180
Cdd:PHA03100 212 LDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLL 259
PHA03095 PHA03095
ankyrin-like protein; Provisional
 178-321 3.04e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.79  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 178 NIRRTPLHT---AAMHGCFEAVQELLDRCHYePDCKDNCGVTPFMDAIQCGHV-DIAKLLLeKHKACSSAEDSLGAQALH 253
Cdd:PHA03095  45 EYGKTPLHLylhYSSEKVKDIVRLLLEAGAD-VNAPERCGFTPLHLYLYNATTlDVIKLLI-KAGADVNAKDKVGRTPLH 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354465040 254 rAAVTGQN---EAIRFLVScLGVDIDVRaKTTQLTALHYAAKEGQTS--TVQTLLSLGANINSKDERNRSALH 321
Cdd:PHA03095 123 -VYLSGFNinpKVIRLLLR-KGADVNAL-DLYGMTPLAVLLKSRNANveLLRLLIDAGADVYAVDDRFRSLLH 192
Ank_5 pfam13857
Ankyrin repeats (many copies);
99-153 3.33e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 3.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 354465040   99 LLDRGAV-VDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIA 153
Cdd:pfam13857   1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 291-365 1.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 291 AKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQSG----LKDSEDLT----------GTLAQQLTK 356
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGadptLLDKDGKTplelaeengfREVVQLLSR 169


                 ....*....
gi 354465040 357 CIDILQDFD 365
Cdd:PTZ00322 170 HSQCHFELG 178
Ank_5 pfam13857
Ankyrin repeats (many copies);
199-255 1.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 354465040  199 LLDRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHKACsSAEDSLGAQALHRA 255
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 182-304 2.69e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 182 TPLHTAAMHGCFEAVQELLDR-------------CHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLEKHkACSSAEDSLG 248
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARgadvvspratgtfFRPGPKNLIYYGEHPLSFAACVGNEEIVRLLIEHG-ADIRAQDSLG 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354465040 249 AQALHrAAVTGQN-----EAIRFLVSCLGVDIDVRAKTTQ----LTALHYAAKEGQTSTVQTLLS 304
Cdd:cd22192  170 NTVLH-ILVLQPNktfacQMYDLILSYDKEDDLQPLDLVPnnqgLTPFKLAAKEGNIVMFQHLVQ 233
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 78-135 3.03e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  78 RDY--KRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEH 135
Cdd:PTZ00322 111 RDYdgRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 46-166 3.36e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHGRQDILAYLVETWSMDIEAANRDYKRPLHEAASMG-HRDCVRYLLDRGAVVDSLKKADWTPLMMACTRK 124
Cdd:PHA02876 307 GETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRN 386

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 354465040 125 NLEVIQDLVEHGA--------------------NPL--------------LKNKDGWNSFHIASREG-DPVILRYLL 166
Cdd:PHA02876 387 NVVIINTLLDYGAdiealsqkigtalhfalcgtNPYmsvktlidrganvnSKNKDLSTPLHYACKKNcKLDVIEMLL 463
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 285-314 3.91e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 3.91e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 354465040  285 TALHYAA-KEGQTSTVQTLLSLGANINSKDE 314
Cdd:pfam00023   4 TPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 83-107 4.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 4.03e-04
                           10        20
                   ....*....|....*....|....*
gi 354465040    83 PLHEAASMGHRDCVRYLLDRGAVVD 107
Cdd:smart00248   5 PLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 114-144 6.09e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 6.09e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 354465040  114 WTPLMMACTR-KNLEVIQDLVEHGANPLLKNK 144
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 285-310 6.40e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 6.40e-04
                           10        20
                   ....*....|....*....|....*.
gi 354465040   285 TALHYAAKEGQTSTVQTLLSLGANIN 310
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 181-348 9.62e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 9.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 181 RTPLHTAAMHGCFEAVQELLDrCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLLeKHKACSSAEDSLGAQALHRAAVTGQ 260
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLD-IGINPNFEIYDGISPIKLAMKFRDSEAIKLLM-KHGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 261 NEAIRFLVScLGVDIDVRAKTTQLTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLACAGQHVACTRFLLQ-SG 339
Cdd:PHA02875  81 VKAVEELLD-LGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDhKA 159


                 ....*....
gi 354465040 340 LKDSEDLTG 348
Cdd:PHA02875 160 CLDIEDCCG 168
Ank_5 pfam13857
Ankyrin repeats (many copies);
267-323 1.01e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 1.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 354465040  267 LVSCLGVDIDVRAKTTQlTALHYAAKEGQTSTVQTLLSLGANINSKDERNRSALHLA 323
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGY-TPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 46-153 1.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHGRQDILAYLVETWSMdIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRkN 125
Cdd:PHA02874 157 GCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-N 234

                         90       100
                 ....*....|....*....|....*...
gi 354465040 126 LEVIQDLVEHgANPLLKNKDGWNSFHIA 153
Cdd:PHA02874 235 RSAIELLINN-ASINDQDIDGSTPLHHA 261
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 48-138 1.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  48 TLVHCAARHGRQDILAYLVEtWSMDIEAANRDYKRPLHEA-ASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRK-N 125
Cdd:PHA02876 377 TPIHYAAVRNNVVIINTLLD-YGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcK 455

                         90
                 ....*....|...
gi 354465040 126 LEVIQDLVEHGAN 138
Cdd:PHA02876 456 LDVIEMLLDNGAD 468
Ank_5 pfam13857
Ankyrin repeats (many copies);
65-120 1.61e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 354465040   65 LVETWSMDIEAANRDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMA 120
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 46-167 1.62e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  46 GDTLVHCAARHGRQD-ILAYLVETWSMDIEAANRDykRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWtpLMMACTRK 124
Cdd:PLN03192 558 GRTPLHIAASKGYEDcVLVLLKHACNVHIRDANGN--TALWNAISAKHHKIFRILYHFASISDPHAAGDL--LCTAAKRN 633

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 354465040 125 NLEVIQDLVEHGANPLLKNKDGWNSFHIASREGDPVILRYLLT 167
Cdd:PLN03192 634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIM 676
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 113-139 1.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.78e-03
                           10        20
                   ....*....|....*....|....*..
gi 354465040   113 DWTPLMMACTRKNLEVIQDLVEHGANP 139
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 171-345 2.01e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.13  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 171 DAWKTESNIR-RTPLHTAAMHGCFEAVQELLDR----------CHYEPDCKDNC---GVTPFMDAIQCGHVDIAKLLLEK 236
Cdd:cd22194  131 NAEYTEEAYEgQTALNIAIERRQGDIVKLLIAKgadvnahakgVFFNPKYKHEGfyfGETPLALAACTNQPEIVQLLMEK 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 237 HKACSSAEDSLGAQALHrAAVT------GQNEAI-----RFLVSCLGVDIDVRAKTTQLTALHYAAKEGQTSTVQTLLSl 305
Cdd:cd22194  211 ESTDITSQDSRGNTVLH-ALVTvaedskTQNDFVkrmydMILLKSENKNLETIRNNEGLTPLQLAAKMGKAEILKYILS- 288

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 354465040 306 gANINSKDERNRSALHLACAGQHVACTRFLLqSGLKDSED 345
Cdd:cd22194  289 -REIKEKPNRSLSRKFTDWAYGPVSSSLYDL-TNVDTTTD 326
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
230-339 2.36e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.55  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 230 AKLLLEKHKACSSAEDSLGAQALHRAAVTGQNEAIRFLVSCLGVDIDVRAKTTQLTALHYAAKEGQTSTVQTLLSLGANI 309
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 354465040 310 NSKDERNRSALHLACAGQHVACTRFLLQSG 339
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAG 110
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 78-166 2.67e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.59  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  78 RDYKRPLHEAASMGHRDCVRYLLDRGAVVDSLKKADWTPLMMACTRKNLEVIQDLVEHGANPLLKNKDGWNSFHIASREG 157
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179


                 ....*....
gi 354465040 158 DPVILRYLL 166
Cdd:PHA02875 180 DIAICKMLL 188
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 83-166 4.00e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  83 PLHEAASMGHRDCVRYLLDRGAVV---DSLKKadwTPLMMACTRKN-------LEVIQDLVEHGANP---LLKNKDGWNS 149
Cdd:cd22192  139 PLSFAACVGNEEIVRLLIEHGADIraqDSLGN---TVLHILVLQPNktfacqmYDLILSYDKEDDLQpldLVPNNQGLTP 215

                         90
                 ....*....|....*..
gi 354465040 150 FHIASREGDPVILRYLL 166
Cdd:cd22192  216 FKLAAKEGNIVMFQHLV 232
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 83-107 5.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 5.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 354465040   83 PLHEAA-SMGHRDCVRYLLDRGAVVD 107
Cdd:pfam00023   5 PLHLAAgRRGNLEIVKLLLSKGADVN 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 262-339 5.68e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040 262 EAIRFLVScLGVDIDVRaKTTQLTALHYAAKEGQT-STVQTLLSLGANINSKDERNRSALHLACAGQ--HVACTRFLLQS 338
Cdd:PHA03095  64 DIVRLLLE-AGADVNAP-ERCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRK 141


                 .
gi 354465040 339 G 339
Cdd:PHA03095 142 G 142
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 81-234 6.67e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 38.70  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354465040  81 KRPLHEAASMGHRDCVRYLLdrgavvdslkkadwtplmmactrknleviqdlvEHGANPLLKNKDG----WNSfhIASre 156
Cdd:PLN03192 559 RTPLHIAASKGYEDCVLVLL---------------------------------KHACNVHIRDANGntalWNA--ISA-- 601

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 354465040 157 GDPVILRYLLTVcpdAWKTESNIRRTPLHTAAMHGCFEAVQELLdRCHYEPDCKDNCGVTPFMDAIQCGHVDIAKLLL 234
Cdd:PLN03192 602 KHHKIFRILYHF---ASISDPHAAGDLLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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