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Conserved domains on  [gi|330831830|ref|XP_003291958|]
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uncharacterized protein DICPUDRAFT_11345, partial [Dictyostelium purpureum]

Protein Classification

frataxin family protein( domain architecture ID 10478730)

frataxin family protein promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways; similar to Iron-sulfur cluster assembly protein CyaY and frataxin

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 43-150 2.58e-42

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


:

Pssm-ID: 460230  Cd Length: 106  Bit Score: 136.12  E-value: 2.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   43 LDLNTFHDLVDAEIELYSERLEILSEQNTipGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPISGPKRFDYNED 122
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS--DADVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPISGPFHFDYDDA 78

                          90       100
                  ....*....|....*....|....*...
gi 330831830  123 tQRWEENRDKEPMRELLTKEIKQLCKFD 150
Cdd:pfam01491  79 -GQWIYTRDGEELFELLSRELSEQLGEP 105
 
Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 43-150 2.58e-42

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 136.12  E-value: 2.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   43 LDLNTFHDLVDAEIELYSERLEILSEQNTipGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPISGPKRFDYNED 122
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS--DADVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPISGPFHFDYDDA 78

                          90       100
                  ....*....|....*....|....*...
gi 330831830  123 tQRWEENRDKEPMRELLTKEIKQLCKFD 150
Cdd:pfam01491  79 -GQWIYTRDGEELFELLSRELSEQLGEP 105
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 47-143 3.13e-34

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 115.41  E-value: 3.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   47 TFHDLVDAEIELYSERLEILSEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPISGPKRFDYneDTQRW 126
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGPKRYDY--VNGEW 78

                          90
                  ....*....|....*..
gi 330831830  127 EENRDKEPMRELLTKEI 143
Cdd:TIGR03422  79 IYLRDGSSLTELLEEEL 95
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 43-147 2.57e-27

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 98.11  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  43 LDLNTFHDLVDAEIELYSERLEilsEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNED 122
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLE---EQDDDADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASK-VGGYHFDYKNG 76

                         90       100
                 ....*....|....*....|....*
gi 330831830 123 tqRWEENRDKEPMRELLTKEIKQLC 147
Cdd:cd00503   77 --KWICTRSGEELWELLEEECSAQS 99
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 43-147 5.45e-20

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 79.07  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  43 LDLNTFHDLVDAEIElyseRLEILSEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNED 122
Cdd:COG1965    1 MTESEFHQLADALLE----AIEEALDRDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAK-SGGFHFDYDDG 75

                         90       100
                 ....*....|....*....|....*
gi 330831830 123 tqRWEENRDKEPMRELLTKEIKQLC 147
Cdd:COG1965   76 --KWIDTRSGEELFALLSRALSEQA 98
cyaY PRK00446
frataxin-like protein; Provisional
 48-145 1.03e-10

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 55.27  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  48 FHDLVDAEIELYSERLEILSEQNtipgFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNEDtqRWE 127
Cdd:PRK00446   6 FHQLADALWQAIEEQLDDDGDAD----IDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAK-SGGFHFDYKDG--EWI 78

                         90
                 ....*....|....*...
gi 330831830 128 ENRDKEPMRELLTKEIKQ 145
Cdd:PRK00446  79 CDRSGEEFWALLEEAATQ 96
 
Name Accession Description Interval E-value
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 43-150 2.58e-42

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 136.12  E-value: 2.58e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   43 LDLNTFHDLVDAEIELYSERLEILSEQNTipGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPISGPKRFDYNED 122
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDEGS--DADVEYSGGVLTLEFDNGGTYVINKQPPNRQIWLSSPISGPFHFDYDDA 78

                          90       100
                  ....*....|....*....|....*...
gi 330831830  123 tQRWEENRDKEPMRELLTKEIKQLCKFD 150
Cdd:pfam01491  79 -GQWIYTRDGEELFELLSRELSEQLGEP 105
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 47-143 3.13e-34

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 115.41  E-value: 3.13e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   47 TFHDLVDAEIELYSERLEILSEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPISGPKRFDYneDTQRW 126
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDLDFDVEYSSGVLTLELPSVGTYVINKQPPNKQIWLSSPVSGPKRYDY--VNGEW 78

                          90
                  ....*....|....*..
gi 330831830  127 EENRDKEPMRELLTKEI 143
Cdd:TIGR03422  79 IYLRDGSSLTELLEEEL 95
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 43-147 2.57e-27

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 98.11  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  43 LDLNTFHDLVDAEIELYSERLEilsEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNED 122
Cdd:cd00503    1 MNESEFHRLADDLLLKIEDTLE---EQDDDADIDVETQGGVLTLTFGNGSTIVINRQEPLRQIWLASK-VGGYHFDYKNG 76

                         90       100
                 ....*....|....*....|....*
gi 330831830 123 tqRWEENRDKEPMRELLTKEIKQLC 147
Cdd:cd00503   77 --KWICTRSGEELWELLEEECSAQS 99
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 46-145 1.02e-20

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 81.10  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830   46 NTFHDLVDAEIELYSERLEilsEQNtiPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNEDTqr 125
Cdd:TIGR03421   3 SEFHQLAEALLDAIEEAID---DGD--ADIDCERQGGVLTLTFENGSQIIINKQEPLHQIWLAAK-SGGFHFDYDGGA-- 74

                          90       100
                  ....*....|....*....|
gi 330831830  126 WEENRDKEPMRELLTKEIKQ 145
Cdd:TIGR03421  75 WIDTRDGEELWALLARACSE 94
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 43-147 5.45e-20

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 79.07  E-value: 5.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  43 LDLNTFHDLVDAEIElyseRLEILSEQNTIPGFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNED 122
Cdd:COG1965    1 MTESEFHQLADALLE----AIEEALDRDDDADIDCERSGGVLTLEFDNGSKIIINRQEPLRQIWLAAK-SGGFHFDYDDG 75

                         90       100
                 ....*....|....*....|....*
gi 330831830 123 tqRWEENRDKEPMRELLTKEIKQLC 147
Cdd:COG1965   76 --KWIDTRSGEELFALLSRALSEQA 98
cyaY PRK00446
frataxin-like protein; Provisional
 48-145 1.03e-10

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 55.27  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  48 FHDLVDAEIELYSERLEILSEQNtipgFDIESGDGVLTINTGSGGTYVLNKQTPNRQIWWSSPiSGPKRFDYNEDtqRWE 127
Cdd:PRK00446   6 FHQLADALWQAIEEQLDDDGDAD----IDCERNGGVLTLTFENGSKIIINRQEPLHELWLAAK-SGGFHFDYKDG--EWI 78

                         90
                 ....*....|....*...
gi 330831830 128 ENRDKEPMRELLTKEIKQ 145
Cdd:PRK00446  79 CDRSGEEFWALLEEAATQ 96
cyaY PRK01379
iron donor protein CyaY;
48-143 3.57e-08

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 48.39  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330831830  48 FHDLVDAEIELYSERLEilsEQNTIPGFDIESGDGVLTINTgSGGTYVLNKQTPNRQIWWSSPISGPKRFDYNEDtqRWe 127
Cdd:PRK01379   6 FSKIAETTIAYIADKIE---EQDKEASIDVDLQGDILNLDT-DKGIYVINKQSAAKEIWLSSPVSGPYHFFYEQG--KW- 78

                         90
                 ....*....|....*.
gi 330831830 128 ENRDKEPMRELLTKEI 143
Cdd:PRK01379  79 KNRAGLELMAILTEEL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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