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Conserved domains on  [gi|332262230|ref|XP_003280168|]
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GPI mannosyltransferase 4 isoform X2 [Nomascus leucogenys]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 44-434 1.23e-29

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 121.32  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230   44 FRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQATRPWEFYPSSSCRTVVFPLLISGSTFWLLRLWEElgpwpglvSGY 123
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  124 VLLVGPRLLLTALSFALDGAVYHLAPLL--GADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVMWGPT 201
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCDYYLYRAVCRKygLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  202 RKEpapgpwwHSWLLGGIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVAMDSWYF 280
Cdd:pfam03901 158 NYK-------YLKAVLLIAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDSYFY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  281 SSpatartLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQalqaawqqlqvglqasAQMGLLRALGAW 360
Cdd:pfam03901 230 GR------FVFTPLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLA----------------FILGPLVLLLRK 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  361 SLLSSPRSYLLLLyfmPLALLSAFSHQEARF-----------LIPLLVPLVLLCSPQTQPVPWKGIVVLFNVLGAFLFGC 429
Cdd:pfam03901 288 VSRLSQLLAPILI---WLFIYSLQPHKEERFlypvyplillsAAIALTRLSRRSWKVRKKLSLLFLLLFFNVSLARLFGL 364


                  ....*
gi 332262230  430 LHQGG 434
Cdd:pfam03901 365 VHQYG 369
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 44-434 1.23e-29

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 121.32  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230   44 FRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQATRPWEFYPSSSCRTVVFPLLISGSTFWLLRLWEElgpwpglvSGY 123
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  124 VLLVGPRLLLTALSFALDGAVYHLAPLL--GADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVMWGPT 201
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCDYYLYRAVCRKygLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  202 RKEpapgpwwHSWLLGGIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVAMDSWYF 280
Cdd:pfam03901 158 NYK-------YLKAVLLIAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDSYFY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  281 SSpatartLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQalqaawqqlqvglqasAQMGLLRALGAW 360
Cdd:pfam03901 230 GR------FVFTPLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLA----------------FILGPLVLLLRK 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  361 SLLSSPRSYLLLLyfmPLALLSAFSHQEARF-----------LIPLLVPLVLLCSPQTQPVPWKGIVVLFNVLGAFLFGC 429
Cdd:pfam03901 288 VSRLSQLLAPILI---WLFIYSLQPHKEERFlypvyplillsAAIALTRLSRRSWKVRKKLSLLFLLLFFNVSLARLFGL 364


                  ....*
gi 332262230  430 LHQGG 434
Cdd:pfam03901 365 VHQYG 369
PLN02816 PLN02816
mannosyltransferase
 44-312 1.38e-04

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 44.64  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  44 FRVLWCLLPQTgYVHPDEFFQSPEVMAEDILGVqATRPWEFypSSSCRTVVFPLLISgstfWLLRLWEElgpwPGLVSGY 123
Cdd:PLN02816  48 FRVVNALLIQT-YFNPDEHWQSLEVAHRTIFGY-GYMTWEW--KRGIRSYLHPMLFA----FLYKLLQV----TGLDTPY 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230 124 VLLVGPRLLLTALSFALDGAVYHLAPLLGADRWNALALLSGSYVTLVFY--TRTFSNTIEGLLftwllvLVSSHVMWGPT 201
Cdd:PLN02816 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFclNRTFSNCLETVL------TIMGLYYWPCI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230 202 RKEPAPGPWWHSWLLGgIVAAGFFNRPTFlafAVVPLYLWGTRGATNPGLKSLTreALVLLPGAALTAAVFVAMDSWYFS 281
Cdd:PLN02816 190 RDSSIDYPVNRKWGLV-IAALACAIRPTS---AVIWLYVGMLELFLTPNKVKFI--ILEVIPIGSLVLGFTCLLDRLMYG 263

                        250       260       270
                 ....*....|....*....|....*....|.
gi 332262230 282 SpatartLVLTPVNFLHYNLNPQNLARHGTH 312
Cdd:PLN02816 264 S------WVIVPLNFLKFNFLSSGGDYYGTH 288
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 44-434 1.23e-29

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 121.32  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230   44 FRVLWCLLPQTGyvHPDEFFQSPEVmAEDILGVQATRPWEFYPSSSCRTVVFPLLISGSTFWLLRLWEElgpwpglvSGY 123
Cdd:pfam03901   9 LRLLLALLVQTS--DPDEHFQSWEP-LHYLIFGYGFLTWEWSPKYGIRSYLYPLLFALPYYLLARLFGD--------SKY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  124 VLLVGPRLLLTALSFALDGAVYHLAPLL--GADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVMWGPT 201
Cdd:pfam03901  78 LVFYAPRLLLGLFSALCDYYLYRAVCRKygLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  202 RKEpapgpwwHSWLLGGIVAAGFFNRPTFLAFaVVPLYLWGTRGATNPGLKSLTREALVLLPGAA-LTAAVFVAMDSWYF 280
Cdd:pfam03901 158 NYK-------YLKAVLLIAALAILGRPTSALL-WLPLVLYLLLRLRGKRLKLFLFLAISLGLLVAlLVLGAVILIDSYFY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  281 SSpatartLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQalqaawqqlqvglqasAQMGLLRALGAW 360
Cdd:pfam03901 230 GR------FVFTPLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLA----------------FILGPLVLLLRK 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  361 SLLSSPRSYLLLLyfmPLALLSAFSHQEARF-----------LIPLLVPLVLLCSPQTQPVPWKGIVVLFNVLGAFLFGC 429
Cdd:pfam03901 288 VSRLSQLLAPILI---WLFIYSLQPHKEERFlypvyplillsAAIALTRLSRRSWKVRKKLSLLFLLLFFNVSLARLFGL 364


                  ....*
gi 332262230  430 LHQGG 434
Cdd:pfam03901 365 VHQYG 369
PLN02816 PLN02816
mannosyltransferase
 44-312 1.38e-04

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 44.64  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230  44 FRVLWCLLPQTgYVHPDEFFQSPEVMAEDILGVqATRPWEFypSSSCRTVVFPLLISgstfWLLRLWEElgpwPGLVSGY 123
Cdd:PLN02816  48 FRVVNALLIQT-YFNPDEHWQSLEVAHRTIFGY-GYMTWEW--KRGIRSYLHPMLFA----FLYKLLQV----TGLDTPY 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230 124 VLLVGPRLLLTALSFALDGAVYHLAPLLGADRWNALALLSGSYVTLVFY--TRTFSNTIEGLLftwllvLVSSHVMWGPT 201
Cdd:PLN02816 116 IMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFclNRTFSNCLETVL------TIMGLYYWPCI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332262230 202 RKEPAPGPWWHSWLLGgIVAAGFFNRPTFlafAVVPLYLWGTRGATNPGLKSLTreALVLLPGAALTAAVFVAMDSWYFS 281
Cdd:PLN02816 190 RDSSIDYPVNRKWGLV-IAALACAIRPTS---AVIWLYVGMLELFLTPNKVKFI--ILEVIPIGSLVLGFTCLLDRLMYG 263

                        250       260       270
                 ....*....|....*....|....*....|.
gi 332262230 282 SpatartLVLTPVNFLHYNLNPQNLARHGTH 312
Cdd:PLN02816 264 S------WVIVPLNFLKFNFLSSGGDYYGTH 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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