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Conserved domains on  [gi|326676097|ref|XP_003200506|]
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ankyrin repeat domain-containing protein 34C [Danio rerio]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-154 4.68e-24

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNGADP 111
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAAEN--GHlEIVKLLLEAGADV 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 326676097 112 SLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKEVIIITTD 154
Cdd:COG0666  213 NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-154 4.68e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNGADP 111
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAAEN--GHlEIVKLLLEAGADV 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 326676097 112 SLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKEVIIITTD 154
Cdd:COG0666  213 NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 3.95e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 3.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097   47 LMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNgADPSLEDrHGSSALVYA 125
Cdd:pfam12796   1 LHLAAKNGNLE--------LVKLLLENGADANLQDKNGRTALHLAAKN--GHlEIVKLLLEH-ADVNLKD-NGRTALHYA 68

                          90
                  ....*....|....
gi 326676097  126 VNADDKETLKVLLD 139
Cdd:pfam12796  69 ARSGHLEIVKLLLE 82
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-140 2.31e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.57  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  31 EGGAYINESNDRGETPLmvacmskHSDQQSVSKAKLVKYLLDNKADPNIQDKAGRSAL-MHACSHRAGHEVVSLLLTNGA 109
Cdd:PHA03095  71 EAGADVNAPERCGFTPL-------HLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhVYLSGFNINPKVIRLLLRKGA 143

                         90       100       110
                 ....*....|....*....|....*....|...
gi 326676097 110 DPSLEDRHGSSAL-VYAVNAD-DKETLKVLLDA 140
Cdd:PHA03095 144 DVNALDLYGMTPLaVLLKSRNaNVELLRLLIDA 176
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 3.38e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 326676097    42 RGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-154 4.68e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNGADP 111
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAAEN--GHlEIVKLLLEAGADV 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 326676097 112 SLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKEVIIITTD 154
Cdd:COG0666  213 NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-140 1.44e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 1.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  14 LLKAVWLRRLRLTRLLLEGGAYINESNDRGETPLMVACMSKHsdqqsvskAKLVKYLLDNKADPNIQDKAGRSALMHACs 93
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD--------LEIVKLLLEAGADVNARDKDGETPLHLAA- 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 326676097  94 hRAGH-EVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLDA 140
Cdd:COG0666  129 -YNGNlEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
31-154 3.04e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.31  E-value: 3.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  31 EGGAYINESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHRAgHEVVSLLLTNGAD 110
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLE--------IVKLLLEAGADVNAKDNDGKTALDLAAENGN-LEIVKLLLEAGAD 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 326676097 111 PSLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKEVIIITTD 154
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-139 3.95e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 3.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097   47 LMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNgADPSLEDrHGSSALVYA 125
Cdd:pfam12796   1 LHLAAKNGNLE--------LVKLLLENGADANLQDKNGRTALHLAAKN--GHlEIVKLLLEH-ADVNLKD-NGRTALHYA 68

                          90
                  ....*....|....
gi 326676097  126 VNADDKETLKVLLD 139
Cdd:pfam12796  69 ARSGHLEIVKLLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
31-115 8.53e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.06  E-value: 8.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097   31 EGGAYINESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDnKADPNIQDKaGRSALMHACSHRAgHEVVSLLLTNGAD 110
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLE-HADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 326676097  111 PSLED 115
Cdd:pfam12796  87 INVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-140 7.24e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.35  E-value: 7.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  14 LLKAVWLRRLRLTRLLLEGGAYINESNDRGETPLMVAcmskhsdqQSVSKAKLVKYLLDNKADPNIQDKAGRSALMHACs 93
Cdd:COG0666   25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAA--------ALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 326676097  94 hRAGH-EVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLDA 140
Cdd:COG0666   96 -RNGDlEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-140 2.31e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.57  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  31 EGGAYINESNDRGETPLmvacmskHSDQQSVSKAKLVKYLLDNKADPNIQDKAGRSAL-MHACSHRAGHEVVSLLLTNGA 109
Cdd:PHA03095  71 EAGADVNAPERCGFTPL-------HLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhVYLSGFNINPKVIRLLLRKGA 143

                         90       100       110
                 ....*....|....*....|....*....|...
gi 326676097 110 DPSLEDRHGSSAL-VYAVNAD-DKETLKVLLDA 140
Cdd:PHA03095 144 DVNALDLYGMTPLaVLLKSRNaNVELLRLLIDA 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 4.28e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 4.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKhsdqqsVSKAKLVKYLLDNKADPNIQDKAGRSAL-MHACSHRAGHEVVSLLLTNGADP 111
Cdd:PHA03100  96 GANVNAPDNNGITPLLYAISKK------SNSYSIVEYLLDNGANVNIKNSDGENLLhLYLESNKIDLKILKLLIDKGVDI 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 326676097 112 SLEDR----------------HGSSALVYAVNADDKETLKVLLD 139
Cdd:PHA03100 170 NAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLD 213
Ank_4 pfam13637
Ankyrin repeats (many copies);
45-105 1.10e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 1.10e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 326676097   45 TPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLL 105
Cdd:pfam13637   3 TALHAAAASGHLE--------LLRLLLEKGADINAVDGNGETALHFAASN--GNvEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 3.80e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 3.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKHSDQQSVS-----KAKL-----VKYLLDNKADPNIQDKAGRSALMHACsHRAGHEVVS 102
Cdd:PHA03100 131 GANVNIKNSDGENLLHLYLESNKIDLKILKllidkGVDInaknrVNYLLSYGVPINIKDVYGFTPLHYAV-YNNNPEFVK 209

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 326676097 103 LLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLD 139
Cdd:PHA03100 210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 67-198 9.91e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.44  E-value: 9.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  67 VKYLLDNKADPNIQDKAGRSALMHACSHraGH-EVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLDACKAkg 145
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACAN--GHvQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQC-- 173

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 326676097 146 keviiittDKSPSGTKTTKQYLNVPPSPELderaTPAPCASPseiDLHASPSP 198
Cdd:PTZ00322 174 --------HFELGANAKPDSFTGKPPSLED----SPISSHHP---DFSAVPQP 211
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-139 1.89e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMvacmsKHSDQQSVSKA--KLVKYLLDNKADPNIQDKAGRSALMHACSHRAGH-EVVSLLLTNGA 109
Cdd:PHA03100  58 GADINSSTKNNSTPLH-----YLSNIKYNLTDvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSySIVEYLLDNGA 132

                         90       100       110
                 ....*....|....*....|....*....|..
gi 326676097 110 DPSLEDRHGSSALVYAV--NADDKETLKVLLD 139
Cdd:PHA03100 133 NVNIKNSDGENLLHLYLesNKIDLKILKLLID 164
Ank_5 pfam13857
Ankyrin repeats (many copies);
70-125 2.30e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 2.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 326676097   70 LLDNK-ADPNIQDKAGRSALMHACSHRAGhEVVSLLLTNGADPSLEDRHGSSALVYA 125
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGAL-EIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-140 7.47e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 7.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINES-NDRGETPLMVACMSKhsdqqsvsKAKLVKYLLDNKADPNIQDkAGRSALMHACSHRAGHEVVSLLLTNGADP 111
Cdd:PHA02875  91 GKFADDVfYKDGMTPLHLATILK--------KLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         90       100
                 ....*....|....*....|....*....
gi 326676097 112 SLEDRHGSSALVYAVNADDKETLKVLLDA 140
Cdd:PHA02875 162 DIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
88-147 7.70e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 7.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097   88 LMHACSHRAgHEVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLDACKAKGKE 147
Cdd:pfam12796   1 LHLAAKNGN-LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD 59
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-133 9.08e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 9.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  33 GAYINESNDRGETPLMVACMSKHSDqqsvskAKLVKYLLDNKADPNIQDKAGRSALmhAC---SHRAGHEVVSLLLTNGA 109
Cdd:PHA03095 107 GADVNAKDKVGRTPLHVYLSGFNIN------PKVIRLLLRKGADVNALDLYGMTPL--AVllkSRNANVELLRLLIDAGA 178

                         90       100
                 ....*....|....*....|....*
gi 326676097 110 DPSLEDRHGSSAL-VYAVNADDKET 133
Cdd:PHA03095 179 DVYAVDDRFRSLLhHHLQSFKPRAR 203
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-139 1.96e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  31 EGGAYINESNDRGETPLMVACmsKHSDQQSVskaklvKYLLDNKADPNIQDKAGRSALMHACSHRAgHEVVSLLLTNGAD 110
Cdd:PHA02874 112 DCGIDVNIKDAELKTFLHYAI--KKGDLESI------KMLFEYGADVNIEDDNGCYPIHIAIKHNF-FDIIKLLLEKGAY 182

                         90       100
                 ....*....|....*....|....*....
gi 326676097 111 PSLEDRHGSSALVYAVNADDKETLKVLLD 139
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLID 211
Ank_5 pfam13857
Ankyrin repeats (many copies);
36-91 6.95e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 6.95e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 326676097   36 INESNDRGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNIQDKAGRSALMHA 91
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALE--------IVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-138 8.61e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 8.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  31 EGGAYINESNDRGETPLMVAcmSKHSDQqsvskaKLVKYLLDNKADPNIQDKAGRSALMHACSHraGHEVVSLLLTNgAD 110
Cdd:PHA02874 178 EKGAYANVKDNNGESPLHNA--AEYGDY------ACIKLLIDHGNHIMNKCKNGFTPLHNAIIH--NRSAIELLINN-AS 246

                         90       100
                 ....*....|....*....|....*....
gi 326676097 111 PSLEDRHGSSALVYAVNAD-DKETLKVLL 138
Cdd:PHA02874 247 INDQDIDGSTPLHHAINPPcDIDIIDILL 275
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 84-116 1.02e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 326676097   84 GRSALMHACSHRAGHEVVSLLLTNGADPSLEDR 116
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-82 1.07e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 326676097   42 RGETPLMVACMSKhsdqqsvSKAKLVKYLLDNKADPNIQDK 82
Cdd:pfam00023   1 DGNTPLHLAAGRR-------GNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 63-146 1.51e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  63 KAKLVKYLLDNKADPNIQDKaGRSALMHACS---HRAGH--EVVSLLLTNGADPSLEDRHGSSALVYAVNA--DDKETLK 135
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTK-NNSTPLHYLSnikYNLTDvkEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVE 125

                         90
                 ....*....|..
gi 326676097 136 VLLD-ACKAKGK 146
Cdd:PHA03100 126 YLLDnGANVNIK 137
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-140 1.66e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  63 KAKLVKYLLDNKADPNIQDKAGRSALmHACSHRAGH---EVVSLLLTNGADPSLEDRHGSSAL-VYAVNADDKETLKVLL 138
Cdd:PHA03095  26 TVEEVRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLI 104


                 ..
gi 326676097 139 DA 140
Cdd:PHA03095 105 KA 106
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 42-79 3.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 3.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 326676097   42 RGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNI 79
Cdd:pfam13606   1 DGNTPLHLAARNGRLE--------IVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 42-79 3.38e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 326676097    42 RGETPLMVACMSKHSDqqsvskakLVKYLLDNKADPNI 79
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 65-131 4.29e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 42.73  E-value: 4.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 326676097  65 KLVKYLLDNKADPNIQDKAGRSALmHACSHRAGHEVVSLLLTNGADPSLEDRHGSSALVYAVNADDK 131
Cdd:PHA02946  53 RFVEELLHRGYSPNETDDDGNYPL-HIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDE 118
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 57-138 4.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.95  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  57 DQQSVSKAKLVKYLLDNKADPNIQDKAGRSALMHACSHRAGHEVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKV 136
Cdd:PHA02878 140 SKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHI 219


                 ..
gi 326676097 137 LL 138
Cdd:PHA02878 220 LL 221
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 35-139 6.90e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.96  E-value: 6.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326676097  35 YINESNDRGETPLMvACMskhsDQQSVSKaKLVKYLLDNKADPNIQDKA-GRSALMHACSH--RAGHEVVSLLLTNGADP 111
Cdd:PHA02859  43 FVNDCNDLYETPIF-SCL----EKDKVNV-EILKFLIENGADVNFKTRDnNLSALHHYLSFnkNVEPEILKILIDSGSSI 116

                         90       100       110
                 ....*....|....*....|....*....|
gi 326676097 112 SLEDRHGSSAL-VYAVNADDK-ETLKVLLD 139
Cdd:PHA02859 117 TEEDEDGKNLLhMYMCNFNVRiNVIKLLID 146
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 65-139 1.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 1.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 326676097  65 KLVKYLLDNKADPNIQDKAGRSALmHACSHRAGHEVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLLD 139
Cdd:PHA02876 159 LIAEMLLEGGADVNAKDIYCITPI-HYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 60-137 1.49e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.39  E-value: 1.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 326676097  60 SVSKAKLVKYLLDNKADPNIQDKAGRSALMHACSHraGHE-VVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVL 137
Cdd:PLN03192 534 STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASK--GYEdCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
Ank_4 pfam13637
Ankyrin repeats (many copies);
84-138 3.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 326676097   84 GRSALMHACSHraGH-EVVSLLLTNGADPSLEDRHGSSALVYAVNADDKETLKVLL 138
Cdd:pfam13637   1 ELTALHAAAAS--GHlELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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