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Conserved domains on  [gi|1158605801|ref|XP_003150616|]
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hypothetical protein LOAG_15076, partial [Loa loa]

Protein Classification

CLPTM1 family protein( domain architecture ID 37038)

CLPTM1 family protein similar to Homo sapiens cleft lip and palate transmembrane protein 1 (CLPTM1) involved in GABAergic, but not glutamatergic transmission, and CLPTM1-like protein (CLPTM1L) that enhances cisplatin-mediated apoptosis, when overexpressed

Gene Ontology:  GO:0016020
TCDB:  8.A.125

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLPTM1 super family cl12311
Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several ...
 40-281 6.71e-66

Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.


The actual alignment was detected with superfamily member pfam05602:

Pssm-ID: 461689  Cd Length: 431  Bit Score: 211.63  E-value: 6.71e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801  40 KGMLYRIMIVYFVTSFLknFMSGrsgniGYNNTGVSNRGASLPS----RNLFQPGQKFDLYIYLSDSQdRFDEFDDESAL 115
Cdd:pfam05602   1 LSIILRVFLIYILHSFF--MFFG-----LGPIPPCSTRPSGLSIpqclAPIWPEGPPLDLYVYVSPSP-RFSDLNSPDSL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 116 FWKETGLTYSDWTSgpdgdgSRTKSATFPTPKSLANNGSLYIHVFIVKKDQSPDRKSRHHVKREVLYNVRQLNKYKKKYY 195
Cdd:pfam05602  73 VWKEKNFTYGDWTD------SREIELTIDVPKKVQNNGTLYAHVFLTKSGSSPDPSDPDYDPSSAVHFTAPLTQYLPKKV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 196 KKTQNLLTGKTEqTEEEQKKAEVMSFEVLNYWHPNLTISLVDDQTAWQRGSLPSPLDEAVKFDPIDNTYKPIFFFNDYWN 275
Cdd:pfam05602 147 KKTKNLLGGKEE-TEEEEPEEEPDGPVIVSHWHPNLTLNLVPDTTVLPRGQLPPPIRQYIRLEPTGGWYYPILFVNEFWQ 225


                  ....*.
gi 1158605801 276 LAADYM 281
Cdd:pfam05602 226 LRSHLI 231
 
Name Accession Description Interval E-value
CLPTM1 pfam05602
Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several ...
 40-281 6.71e-66

Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.


Pssm-ID: 461689  Cd Length: 431  Bit Score: 211.63  E-value: 6.71e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801  40 KGMLYRIMIVYFVTSFLknFMSGrsgniGYNNTGVSNRGASLPS----RNLFQPGQKFDLYIYLSDSQdRFDEFDDESAL 115
Cdd:pfam05602   1 LSIILRVFLIYILHSFF--MFFG-----LGPIPPCSTRPSGLSIpqclAPIWPEGPPLDLYVYVSPSP-RFSDLNSPDSL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 116 FWKETGLTYSDWTSgpdgdgSRTKSATFPTPKSLANNGSLYIHVFIVKKDQSPDRKSRHHVKREVLYNVRQLNKYKKKYY 195
Cdd:pfam05602  73 VWKEKNFTYGDWTD------SREIELTIDVPKKVQNNGTLYAHVFLTKSGSSPDPSDPDYDPSSAVHFTAPLTQYLPKKV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 196 KKTQNLLTGKTEqTEEEQKKAEVMSFEVLNYWHPNLTISLVDDQTAWQRGSLPSPLDEAVKFDPIDNTYKPIFFFNDYWN 275
Cdd:pfam05602 147 KKTKNLLGGKEE-TEEEEPEEEPDGPVIVSHWHPNLTLNLVPDTTVLPRGQLPPPIRQYIRLEPTGGWYYPILFVNEFWQ 225


                  ....*.
gi 1158605801 276 LAADYM 281
Cdd:pfam05602 226 LRSHLI 231
 
Name Accession Description Interval E-value
CLPTM1 pfam05602
Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several ...
 40-281 6.71e-66

Cleft lip and palate transmembrane protein 1 (CLPTM1); This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.


Pssm-ID: 461689  Cd Length: 431  Bit Score: 211.63  E-value: 6.71e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801  40 KGMLYRIMIVYFVTSFLknFMSGrsgniGYNNTGVSNRGASLPS----RNLFQPGQKFDLYIYLSDSQdRFDEFDDESAL 115
Cdd:pfam05602   1 LSIILRVFLIYILHSFF--MFFG-----LGPIPPCSTRPSGLSIpqclAPIWPEGPPLDLYVYVSPSP-RFSDLNSPDSL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 116 FWKETGLTYSDWTSgpdgdgSRTKSATFPTPKSLANNGSLYIHVFIVKKDQSPDRKSRHHVKREVLYNVRQLNKYKKKYY 195
Cdd:pfam05602  73 VWKEKNFTYGDWTD------SREIELTIDVPKKVQNNGTLYAHVFLTKSGSSPDPSDPDYDPSSAVHFTAPLTQYLPKKV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1158605801 196 KKTQNLLTGKTEqTEEEQKKAEVMSFEVLNYWHPNLTISLVDDQTAWQRGSLPSPLDEAVKFDPIDNTYKPIFFFNDYWN 275
Cdd:pfam05602 147 KKTKNLLGGKEE-TEEEEPEEEPDGPVIVSHWHPNLTLNLVPDTTVLPRGQLPPPIRQYIRLEPTGGWYYPILFVNEFWQ 225


                  ....*.
gi 1158605801 276 LAADYM 281
Cdd:pfam05602 226 LRSHLI 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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