|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
219-590 |
1.93e-61 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 209.23 E-value: 1.93e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAKGVVLVPTHALRMQTS 298
Cdd:COG0513 9 LSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQALILAPTRELALQVA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIK---IVGG----SERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIR 366
Cdd:COG0513 89 EELRKLAKYLGLRvatVYGGvsigRQIRALKRGVDIVVATPGrlldlIERGALDLSGVETLVLDEADRMLDMGFIEDIER 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 367 LLgplkirhsvidkNATDGVR--LIFSsATYPDQLQLIAESIV-DYEYlycVKTENLHRIMPHIKQTFIRIREIDKLEKl 443
Cdd:COG0513 169 IL------------KLLPKERqtLLFS-ATMPPEIRKLAKRYLkNPVR---IEVAPENATAETIEQRYYLVDKRDKLEL- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 444 kellekgL-----SFPHGQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGGR----RiEQLIDELRSGAVRIIIATDVASR 514
Cdd:COG0513 232 -------LrrllrDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLsqgqR-ERALDAFRNGKIRVLVATDVAAR 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312077716 515 GLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGSLHKCLmtSFVRRAwEVKHVNSIELAARLHRPLQDVELNDPAR 590
Cdd:COG0513 304 GIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAI--SLVTPD-ERRLLRAIEKLIGQKIEEEELPGFEPVE 376
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
223-406 |
1.67e-41 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 148.74 E-value: 1.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAKGV---VLVPTHALRMQTSL 299
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGPqalVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 300 MISKLAEGTNIK---IVGGSERWRSEEDW----DILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIRL 367
Cdd:cd00268 81 VARKLGKGTGLKvaaIYGGAPIKKQIEALkkgpDIVVGTPGrlldlIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 312077716 368 LGPLKIRHsvidknatdgvRLIFSSATYPDQLQLIAESI 406
Cdd:cd00268 161 LSALPKDR-----------QTLLFSATLPEEVKELAKKF 188
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
223-433 |
4.82e-39 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 143.28 E-value: 4.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLR------NVNRHAKGVVLVPTHALRMQ 296
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRykllaeGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 297 TSLMISKLAEGTNIK---IVGGSERWR----SEEDWDILVSTPSFSPEFFTPHNID-----YIVLDEADMLLDDSFLNDI 364
Cdd:cd17948 81 IGSVAQSLTEGLGLKvkvITGGRTKRQirnpHFEEVDILVATPGALSKLLTSRIYSleqlrHLVLDEADTLLDDSFNEKL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312077716 365 IRLLG--PLKIRHSVIDKNATDGVRLIFSSATYPDQLQLIAESIVDYEYLYCVKTENLHRIMPHIKQTFIR 433
Cdd:cd17948 161 SHFLRrfPLASRRSENTDGLDPGTQLVLVSATMPSGVGEVLSKVIDVDSIETVTSDKLHRLMPHVKQKFLR 231
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
427-558 |
8.15e-34 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 125.31 E-value: 8.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 427 IKQTFIRIREIDKLEKLKELLEKGLSFphGQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGGRRIEQ---LIDELRSGAV 503
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKP--GKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEErerALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 312077716 504 RIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGslHKCLMTSFV 558
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAG--RKGTAITFV 131
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
223-548 |
5.92e-33 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 132.97 E-value: 5.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVN-RHAKG---VVLVPTHALRMQTS 298
Cdd:PTZ00110 141 ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLlRYGDGpivLVLAPTRELAEQIR 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIK---IVGG----SERWRSEEDWDILVSTPSFSPEFFTPH-----NIDYIVLDEADMLLDDSFLNDIIR 366
Cdd:PTZ00110 221 EQCNKFGASSKIRntvAYGGvpkrGQIYALRRGVEILIACPGRLIDFLESNvtnlrRVTYLVLDEADRMLDMGFEPQIRK 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 367 LLGplKIRhsvidknaTDGVRLIFSsATYPDQLQLIAESIVDYEYLYcVKTENLHRIMPH-IKQTFIRIREIDKLEKLKE 445
Cdd:PTZ00110 301 IVS--QIR--------PDRQTLMWS-ATWPKEVQSLARDLCKEEPVH-VNVGSLDLTACHnIKQEVFVVEEHEKRGKLKM 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 446 LLEKgLSFPHGQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGGRRIEQ---LIDELRSGAVRIIIATDVASRGLDLPQLR 522
Cdd:PTZ00110 369 LLQR-IMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEErtwVLNEFKTGKSPIMIATDVASRGLDVKDVK 447
|
330 340
....*....|....*....|....*.
gi 312077716 523 HIINYDFPRQISDYVHRCGRIGRIGS 548
Cdd:PTZ00110 448 YVINFDFPNQIEDYVHRIGRTGRAGA 473
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
219-547 |
1.07e-32 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 130.45 E-value: 1.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRH---AKGVVLVPTHALRM 295
Cdd:PRK11192 8 LDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKsgpPRILILTPTRELAM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 296 QTSLMISKLAEGTNIKIV---GG----SERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLND 363
Cdd:PRK11192 88 QVADQARELAKHTHLDIAtitGGvaymNHAEVFSENQDIVVATPGrllqyIKEENFDCRAVETLILDEADRMLDMGFAQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 364 IIRLLGPLKIRHSVIDKNAT---DGVRLiFSSATYPDQLQLIAES-------IVDYEYL---YCVKTENLHRImphIKQt 430
Cdd:PRK11192 168 IETIAAETRWRKQTLLFSATlegDAVQD-FAERLLNDPVEVEAEPsrrerkkIHQWYYRaddLEHKTALLCHL---LKQ- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 431 firireidkleklkellekglsfPH-GQTLIFCKNLKNVGLVSRSLREMGIEHTSLSG----GRRiEQLIDELRSGAVRI 505
Cdd:PRK11192 243 -----------------------PEvTRSIVFVRTRERVHELAGWLRKAGINCCYLEGemvqAKR-NEAIKRLTDGRVNV 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 312077716 506 IIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIG 547
Cdd:PRK11192 299 LVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAG 340
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
219-545 |
3.04e-31 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 126.85 E-value: 3.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSaLLRNVNRHAKG------VVLVPTHA 292
Cdd:PRK10590 8 LSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQ-HLITRQPHAKGrrpvraLILTPTRE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 293 LRMQTSLMISKLAEGTNIK---IVGG----SERWRSEEDWDILVSTPSFSPEFftPH-------NIDYIVLDEADMLLDD 358
Cdd:PRK10590 87 LAAQIGENVRDYSKYLNIRslvVFGGvsinPQMMKLRGGVDVLVATPGRLLDL--EHqnavkldQVEILVLDEADRMLDM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 359 SFLNDIIRLLGPLKIRHSvidknatdgvRLIFSsATYPDQLQLIAESIVDYEYLYCVKTENL--HRIMPHIKqtFI---R 433
Cdd:PRK10590 165 GFIHDIRRVLAKLPAKRQ----------NLLFS-ATFSDDIKALAEKLLHNPLEIEVARRNTasEQVTQHVH--FVdkkR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 434 IREIdkleklkellekgLSFPHG-----QTLIFCKNLKNVGLVSRSLREMGIE----HTSLSGGRRIEQLIDeLRSGAVR 504
Cdd:PRK10590 232 KREL-------------LSQMIGkgnwqQVLVFTRTKHGANHLAEQLNKDGIRsaaiHGNKSQGARTRALAD-FKSGDIR 297
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 312077716 505 IIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGR 545
Cdd:PRK10590 298 VLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGR 338
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
209-591 |
8.09e-31 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 125.68 E-value: 8.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 209 SFSwdenvSL-LDPVIIENARKLGFRVPTVIQRRAFRAFKsDAHLLIA-AETGSGKTAAYAAPLLSALlrNVNRHA-KGV 285
Cdd:PRK11776 5 AFS-----TLpLPPALLANLNELGYTEMTPIQAQSLPAIL-AGKDVIAqAKTGSGKTAAFGLGLLQKL--DVKRFRvQAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 286 VLVPTHALRMQTSLMISKLAEGT-NIKIV---GGS----ERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEA 352
Cdd:PRK11776 77 VLCPTRELADQVAKEIRRLARFIpNIKVLtlcGGVpmgpQIDSLEHGAHIIVGTPGrildhLRKGTLDLDALNTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 353 DMLLDDSFLNDIirllgplkirHSVIDKNATDGVRLIFSsATYPDQLQLIAESIvdyeyLY---CVKTENLHrIMPHIKQ 429
Cdd:PRK11776 157 DRMLDMGFQDAI----------DAIIRQAPARRQTLLFS-ATYPEGIAAISQRF-----QRdpvEVKVESTH-DLPAIEQ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 430 TFIrirEIDKLEKLKELLEKGLSFPHGQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGG---RRIEQLIDELRSGAVRII 506
Cdd:PRK11776 220 RFY---EVSPDERLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDleqRDRDQVLVRFANRSCSVL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 507 IATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGSlhKCLMTSFVRRAwEVKHVNSIELAarLHRPLQDVELN 586
Cdd:PRK11776 297 VATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGS--KGLALSLVAPE-EMQRANAIEDY--LGRKLNWEPLP 371
|
....*
gi 312077716 587 DPARL 591
Cdd:PRK11776 372 SLSPL 376
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
236-402 |
1.01e-29 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 115.03 E-value: 1.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 236 TVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNrHAKGVVLVPTHALRMQTSLMISKLAEGTNIK---I 312
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN-GPQALVLAPTRELAEQIYEELKKLGKGLGLKvasL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 313 VGGSERWRSEEDW---DILVSTP----SFSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIRLLGPLKIrhsvidknatdG 385
Cdd:pfam00270 80 LGGDSRKEQLEKLkgpDILVGTPgrllDLLQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPK-----------K 148
|
170
....*....|....*..
gi 312077716 386 VRLIFSSATYPDQLQLI 402
Cdd:pfam00270 149 RQILLLSATLPRNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
228-423 |
2.00e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.81 E-value: 2.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 228 RKLGFRVPTVIQRRAFRAFKSDA-HLLIAAETGSGKTAAYAAPLLSALLRNVNRHAkgVVLVPTHALRMQTSLMISKLAE 306
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRGKGGRV--LVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 307 GTNIKIV---GGSERWRSEEDW-----DILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIRLLGPLKi 373
Cdd:smart00487 80 SLGLKVVglyGGDSKREQLRKLesgktDILVTTPGrlldlLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLP- 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 312077716 374 rhsvidknatDGVRLIFSSATYPDQLQLIAESIVDYEYLYCVKTENLHRI 423
Cdd:smart00487 159 ----------KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
223-596 |
8.00e-25 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 109.17 E-value: 8.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSallrNVNRHAKG---VVLVPTHALRMQTSL 299
Cdd:PRK11634 17 ILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLH----NLDPELKApqiLVLAPTRELAVQVAE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 300 MI---SKLAEGTNIKIVGGSERWRSE-----EDWDILVSTPSFSPEFFTPHNIDY-----IVLDEADMLLDDSFLNDIIR 366
Cdd:PRK11634 93 AMtdfSKHMRGVNVVALYGGQRYDVQlralrQGPQIVVGTPGRLLDHLKRGTLDLsklsgLVLDEADEMLRMGFIEDVET 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 367 LLGPLKIRHSVIDKNAT----------------DGVRLIFSSATYPDqlqlIAESivdYEYLYCV-KTENLHRimphikq 429
Cdd:PRK11634 173 IMAQIPEGHQTALFSATmpeairritrrfmkepQEVRIQSSVTTRPD----ISQS---YWTVWGMrKNEALVR------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 430 tFIRIREIDKleklkellekglsfphgqTLIFCKNlKNVGL-VSRSLREMGIEHTSLSGGRRI---EQLIDELRSGAVRI 505
Cdd:PRK11634 239 -FLEAEDFDA------------------AIIFVRT-KNATLeVAEALERNGYNSAALNGDMNQalrEQTLERLKDGRLDI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 506 IIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGSLHKCLMtsFVRRAwEVKHVNSIELAARLHRPlqDVEL 585
Cdd:PRK11634 299 LIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALL--FVENR-ERRLLRNIERTMKLTIP--EVEL 373
|
410
....*....|.
gi 312077716 586 NDpARLLGLQR 596
Cdd:PRK11634 374 PN-AELLGKRR 383
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
219-548 |
1.39e-23 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 104.22 E-value: 1.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFrAFKSDAHLLIA-AETGSGKTAAYAAPLLSALLRN---VNRH---AKGVVLVPTH 291
Cdd:PRK01297 94 LAPELMHAIHDLGFPYCTPIQAQVL-GYTLAGHDAIGrAQTGTGKTAAFLISIINQLLQTpppKERYmgePRALIIAPTR 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 292 ALRMQTSLMISKLAEGTNIKI---VGGSE-----RWRSEEDWDILVSTPSFSPEFFTPHN-----IDYIVLDEADMLLDD 358
Cdd:PRK01297 173 ELVVQIAKDAAALTKYTGLNVmtfVGGMDfdkqlKQLEARFCDILVATPGRLLDFNQRGEvhldmVEVMVLDEADRMLDM 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 359 SFL---NDIIRLLGPLKIRHSvidknatdgvrLIFSsATYPDQLQLIAE------SIVDYE-----------YLYCVKTE 418
Cdd:PRK01297 253 GFIpqvRQIIRQTPRKEERQT-----------LLFS-ATFTDDVMNLAKqwttdpAIVEIEpenvasdtveqHVYAVAGS 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 419 NLHRIMphikQTFIRIREIDkleklkellekglsfphgQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGG----RRIEQL 494
Cdd:PRK01297 321 DKYKLL----YNLVTQNPWE------------------RVMVFANRKDEVRRIEERLVKDGINAAQLSGDvpqhKRIKTL 378
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 312077716 495 iDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGS 548
Cdd:PRK01297 379 -EGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGA 431
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
223-408 |
1.69e-23 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 98.43 E-value: 1.69e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLR-NVNRHAKGVVLVPTHALRMQTSLMI 301
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKpRKKKGLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 302 SKLAEGTNIKIV--------GGSERWRSEEDWDILVSTP------------SFSpefftphNIDYIVLDEADMLLDDSFL 361
Cdd:cd17957 81 LKLSKGTGLRIVllsksleaKAKDGPKSITKYDILVSTPlrlvfllkqgpiDLS-------SVEYLVLDEADKLFEPGFR 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 312077716 362 N---DIIRLLGPLKIRhsvidknatdgvRLIFsSATYPDQLQLIAESIVD 408
Cdd:cd17957 154 EqtdEILAACTNPNLQ------------RSLF-SATIPSEVEELARSVMK 190
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
219-547 |
3.36e-23 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 103.88 E-value: 3.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRN---VNRHA---KGVVLVPTHA 292
Cdd:PRK04537 16 LHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRpalADRKPedpRALILAPTRE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 293 LRMQTSLMISKLAEGTNIK---IVGG----SERWRSEEDWDILVSTPSFSPEFFTPHNI------DYIVLDEADMLLDDS 359
Cdd:PRK04537 96 LAIQIHKDAVKFGADLGLRfalVYGGvdydKQRELLQQGVDVIIATPGRLIDYVKQHKVvslhacEICVLDEADRMFDLG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 360 FLNDIIRLLGPLKIRhsvidknatdGVR--LIFSSATYPDQLQLIAESIVDYEYLyCVKTENlhrimphIKQTFIRIREI 437
Cdd:PRK04537 176 FIKDIRFLLRRMPER----------GTRqtLLFSATLSHRVLELAYEHMNEPEKL-VVETET-------ITAARVRQRIY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 438 DKLEKLKELLEKGL-SFPHG-QTLIFCKNLKNVGLVSRSLREMGIEHTSLSGG---RRIEQLIDELRSGAVRIIIATDVA 512
Cdd:PRK04537 238 FPADEEKQTLLLGLlSRSEGaRTMVFVNTKAFVERVARTLERHGYRVGVLSGDvpqKKRESLLNRFQKGQLEILVATDVA 317
|
330 340 350
....*....|....*....|....*....|....*
gi 312077716 513 SRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIG 547
Cdd:PRK04537 318 ARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLG 352
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
230-368 |
1.40e-22 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 95.78 E-value: 1.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 230 LGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHA--KGVVLVPTHALRMQTSLMISKLAEG 307
Cdd:cd17947 8 LGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAatRVLVLVPTRELAMQCFSVLQQLAQF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 308 TNIK---IVGGSERwRSEEDW-----DILVSTP---------SFSpefFTPHNIDYIVLDEADMLLDDSF---LNDIIRL 367
Cdd:cd17947 88 TDITfalAVGGLSL-KAQEAAlrarpDIVIATPgrlidhlrnSPS---FDLDSIEILVLDEADRMLEEGFadeLKEILRL 163
|
.
gi 312077716 368 L 368
Cdd:cd17947 164 C 164
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
231-571 |
2.19e-22 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 99.52 E-value: 2.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 231 GFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNrHAKGVVLVPTHALRMQTSLMISKLAEGTNI 310
Cdd:PTZ00424 47 GFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLN-ACQALILAPTRELAQQIQKVVLALGDYLKV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 311 KI---VGGS----ERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSF---LNDIIRLLGPlkirh 375
Cdd:PTZ00424 126 RChacVGGTvvrdDINKLKAGVHMVVGTPGrvydmIDKRHLRVDDLKLFILDEADEMLSRGFkgqIYDVFKKLPP----- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 376 svidknatdGVRLIFSSATYPDQ-LQLIAESIVDYEYLYcVKTENLhrIMPHIKQTFIRIREIDKLEKLKELLEKGLSFP 454
Cdd:PTZ00424 201 ---------DVQVALFSATMPNEiLELTTKFMRDPKRIL-VKKDEL--TLEGIRQFYVAVEKEEWKFDTLCDLYETLTIT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 455 hgQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGG---RRIEQLIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPR 531
Cdd:PTZ00424 269 --QAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDmdqKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPA 346
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 312077716 532 QISDYVHRCGRIGRIGslHKCLMTSFVRRAwEVKHVNSIE 571
Cdd:PTZ00424 347 SPENYIHRIGRSGRFG--RKGVAINFVTPD-DIEQLKEIE 383
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
219-547 |
2.19e-22 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 101.02 E-value: 2.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLS--ALLR----NVNRHAKGVVLVPTHA 292
Cdd:PLN00206 128 LPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcCTIRsghpSEQRNPLAMVLTPTRE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 293 LRMQTSLMISKLAEGTNIK---IVGGS----ERWRSEEDWDILVSTPSFSPEFFTPHNIDY-----IVLDEADMLLDDSF 360
Cdd:PLN00206 208 LCVQVEDQAKVLGKGLPFKtalVVGGDampqQLYRIQQGVELIVGTPGRLIDLLSKHDIELdnvsvLVLDEVDCMLERGF 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 361 LNDIIRLLGPLkirhsvidknATDGVrLIFSsATYPDQLQLIAESIVDYEYLYCVKTENlhRIMPHIKQTFIRIREIDKL 440
Cdd:PLN00206 288 RDQVMQIFQAL----------SQPQV-LLFS-ATVSPEVEKFASSLAKDIILISIGNPN--RPNKAVKQLAIWVETKQKK 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 441 EKLKELLEKGLSF-PHGqtLIFCKNLKNVGLVSRSLREM-GIEHTSLSGGRRIEQLIDELRS---GAVRIIIATDVASRG 515
Cdd:PLN00206 354 QKLFDILKSKQHFkPPA--VVFVSSRLGADLLANAITVVtGLKALSIHGEKSMKERREVMKSflvGEVPVIVATGVLGRG 431
|
330 340 350
....*....|....*....|....*....|..
gi 312077716 516 LDLPQLRHIINYDFPRQISDYVHRCGRIGRIG 547
Cdd:PLN00206 432 VDLLRVRQVIIFDMPNTIKEYIHQIGRASRMG 463
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
219-403 |
8.14e-22 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 94.09 E-value: 8.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRN-------VNRHAK--GVVLVP 289
Cdd:cd17967 7 LRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDgppsvgrGRRKAYpsALILAP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 290 THALRMQTSLMISKLAEGTNIKIV---GGSE----RWRSEEDWDILVSTP------------SFSpefftphNIDYIVLD 350
Cdd:cd17967 87 TRELAIQIYEEARKFSYRSGVRSVvvyGGADvvhqQLQLLRGCDILVATPgrlvdfiergriSLS-------SIKFLVLD 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 312077716 351 EADMLLDDSFLNDIIRLlgplkIRHSVIDKNatdGVR--LIFsSATYPDQLQLIA 403
Cdd:cd17967 160 EADRMLDMGFEPQIRKI-----VEHPDMPPK---GERqtLMF-SATFPREIQRLA 205
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
454-547 |
1.23e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 89.96 E-value: 1.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 454 PHGQTLIFCKNLKNVGLvSRSLREMGIEHTSLSGGRRIEQ---LIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFP 530
Cdd:pfam00271 14 RGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEreeILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLP 92
|
90
....*....|....*..
gi 312077716 531 RQISDYVHRCGRIGRIG 547
Cdd:pfam00271 93 WNPASYIQRIGRAGRAG 109
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
214-422 |
1.30e-21 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 94.37 E-value: 1.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 214 ENVSLLDPV---IIENARK-----LGFRVPTVIQRRAFRAF-----------------KSDAHLlIAAETGSGKTAAYAA 268
Cdd:cd17965 2 DQLKLLPSVreaIIKEILKgsnktDEEIKPSPIQTLAIKKLlktlmrkvtkqtsneepKLEVFL-LAAETGSGKTLAYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 269 PLLSALLR-----------NVNRHAK-----GVVLVPTHALRMQTSLMISKLAEGTNIKIvgGSERW-----------RS 321
Cdd:cd17965 81 PLLDYLKRqeqepfeeaeeEYESAKDtgrprSVILVPTHELVEQVYSVLKKLSHTVKLGI--KTFSSgfgpsyqrlqlAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 322 EEDWDILVSTPSFSPEFFTPHN-----IDYIVLDEADMLLDDSFLNDIirllgplkirHSVIdKNATDGVRLIFSSATYP 396
Cdd:cd17965 159 KGRIDILVTTPGKLASLAKSRPkilsrVTHLVVDEADTLFDRSFLQDT----------TSII-KRAPKLKHLILCSATIP 227
|
250 260
....*....|....*....|....*.
gi 312077716 397 DQLQLIAESIvdYEYLYCVKTENLHR 422
Cdd:cd17965 228 KEFDKTLRKL--FPDVVRIATPRLHA 251
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
219-399 |
2.24e-21 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 92.37 E-value: 2.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNR-HAKGVVLVPTHALRMQT 297
Cdd:cd17959 8 LSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTvGARALILSPTRELALQT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 298 SLMISKLAEGTNIK---IVGGSerwRSEEDW-------DILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSF-- 360
Cdd:cd17959 88 LKVTKELGKFTDLRtalLVGGD---SLEEQFealasnpDIIIATPGrllhlLVEMNLKLSSVEYVVFDEADRLFEMGFae 164
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 312077716 361 -LNDIIRLLGPLKirhsvidknatdgVRLIFsSATYPDQL 399
Cdd:cd17959 165 qLHEILSRLPENR-------------QTLLF-SATLPKLL 190
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
229-412 |
3.19e-21 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 92.26 E-value: 3.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 229 KLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAK-----GVVLVPTHALRMQTSLMISK 303
Cdd:cd17949 8 KMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRsdgtlALVLVPTRELALQIYEVLEK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 304 LAEG-TNI---KIVGG----SERWRSEEDWDILVSTP-----------SFSPEfftphNIDYIVLDEADMLLDDSFLNDI 364
Cdd:cd17949 88 LLKPfHWIvpgYLIGGekrkSEKARLRKGVNILIATPgrlldhlkntqSFDVS-----NLRWLVLDEADRLLDMGFEKDI 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 312077716 365 IRLLGPLKIRHSVIDKNATDGVRL--IFSSATYPDQLQLIAE-SIVDYEYL 412
Cdd:cd17949 163 TKILELLDDKRSKAGGEKSKPSRRqtVLVSATLTDGVKRLAGlSLKDPVYI 213
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
219-413 |
3.87e-21 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 91.88 E-value: 3.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAH-LLIAAETGSGKTAAYAAPLLSALLRN----VNRHAKGVVLVPTHAL 293
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGDdVLARAKTGTGKTLAFLLPAIQSLLNTkpagRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 294 RMQTSLMISKLAEG-TNIKI---VGGSERWRSEEDW-----DILVSTP---------SFSPEFFTphNIDYIVLDEADML 355
Cdd:cd17964 81 ALQIAAEAKKLLQGlRKLRVqsaVGGTSRRAELNRLrrgrpDILVATPgrlidhlenPGVAKAFT--DLDYLVLDEADRL 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 312077716 356 LDDSFLNDIIRLLGPLKirhsviDKNATDGVRLIFsSATYPDQLQLIAESIVDYEYLY 413
Cdd:cd17964 159 LDMGFRPDLEQILRHLP------EKNADPRQTLLF-SATVPDEVQQIARLTLKKDYKF 209
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
219-413 |
6.20e-21 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 92.72 E-value: 6.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRN--------VNRHAKGVVLVPT 290
Cdd:cd18052 50 LCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEgltassfsEVQEPQALIVAPT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 291 HALRMQTSLMISKLAEGTNIKIV---GG-----SERwRSEEDWDILVSTPSFSPEFFTP-----HNIDYIVLDEADMLLD 357
Cdd:cd18052 130 RELANQIFLEARKFSYGTCIRPVvvyGGvsvghQIR-QIEKGCHILVATPGRLLDFIGRgkislSKLKYLILDEADRMLD 208
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312077716 358 DSFLNDIIRLL-----GPLKIRHSvidknatdgvrLIFsSATYPDQLQLIAESIVDYEYLY 413
Cdd:cd18052 209 MGFGPEIRKLVsepgmPSKEDRQT-----------LMF-SATFPEEIQRLAAEFLKEDYLF 257
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
219-383 |
7.09e-21 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 91.11 E-value: 7.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLR----NVNRHA-KGVVLVPTHAL 293
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKakaeSGEEQGtRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 294 RMQTSLMISKLAEGTN--IKIV-----GGSERWRS--EEDWDILVSTPS------FSPEFFTPHNIDYIVLDEADMLLDD 358
Cdd:cd17961 81 AQQVSKVLEQLTAYCRkdVRVVnlsasSSDSVQRAllAEKPDIVVSTPArllshlESGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180
....*....|....*....|....*
gi 312077716 359 SFLNDIIRLLGPLKIRHSVIDKNAT 383
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSAT 185
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
471-547 |
7.14e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 86.88 E-value: 7.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 471 VSRSLREMGIEHTSLSGGRRIEQ---LIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIG 547
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEreeILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
223-394 |
3.62e-20 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 89.61 E-value: 3.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLI-AAETGSGKTAAYAAPLLSALLR--------NVNRHAKGVVLVPTHAL 293
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIgAAETGSGKTLAFGIPILERLLSqkssngvgGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 294 RMQTSLMISKLAEGTNIK---IVGG-----SERWRSEEDwDILVSTP-------SFSPEFFTP-HNIDYIVLDEAD-MLL 356
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKiasIVGGlavqkQERLLKKRP-EIVVATPgrlweliQEGNEHLANlKSLRFLVLDEADrMLE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 312077716 357 DDSF--LNDIIRLLGplKIRHSVIDKNATdgvrLIFsSAT 394
Cdd:cd17946 160 KGHFaeLEKILELLN--KDRAGKKRKRQT----FVF-SAT 192
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
252-394 |
3.46e-19 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 86.92 E-value: 3.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 252 LLIAAETGSGKTAAYAAPLLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAEGTNIKIV---GGSERWRSEEDW--- 325
Cdd:cd17956 39 LCVSAPTGSGKTLAYVLPIVQALSKRVVPRLRALIVVPTKELVQQVYKVFESLCKGTGLKVVslsGQKSFKKEQKLLlvd 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 326 ---------DILVSTPS------FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIRLLGPLKIRHSVIDKNATDG----- 385
Cdd:cd17956 119 tsgrylsrvDILVATPGrlvdhlNSTPGFTLKHLRFLVIDEADRLLNQSFQDWLETVMKALGRPTAPDLGSFGDAnller 198
|
170
....*....|...
gi 312077716 386 ----VRLIFSSAT 394
Cdd:cd17956 199 svrpLQKLLFSAT 211
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
223-403 |
7.85e-19 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 85.45 E-value: 7.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLR-------NVNRHAKGVVLVPTHALRM 295
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRlppldeeTKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 296 QTSLMISKLAEGTNIK---IVGGserwRSEEDW--------DILVSTP-----SFSPEFFTPHNIDYIVLDEADMLLDDS 359
Cdd:cd17945 81 QIEEETQKFAKPLGIRvvsIVGG----HSIEEQafslrngcEILIATPgrlldCLERRLLVLNQCTYVVLDEADRMIDMG 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 312077716 360 F---LNDIIRLLGP--LKIRHSVIDKNATDGVR-----LIFsSATYPDQLQLIA 403
Cdd:cd17945 157 FepqVTKILDAMPVsnKKPDTEEAEKLAASGKHryrqtMMF-TATMPPAVEKIA 209
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
219-400 |
1.64e-18 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 84.20 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAkGVVLVPTHALRMQTS 298
Cdd:cd17955 6 LSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIF-ALVLTPTRELAYQIA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIK---IVGGSERWRSEEDWD----ILVSTP--------SFSPEFFTPHNIDYIVLDEADMLLDDSF--- 360
Cdd:cd17955 85 EQFRALGAPLGLRccvIVGGMDMVKQALELSkrphIVVATPgrladhlrSSDDTTKVLSRVKFLVLDEADRLLTGSFedd 164
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 312077716 361 LNDIIRLLGPlkirhsvidKNATdgvrLIFsSATYPDQLQ 400
Cdd:cd17955 165 LATILSALPP---------KRQT----LLF-SATLTDALK 190
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
219-547 |
7.47e-18 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 86.18 E-value: 7.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALL-------RNVNrHAKGVVLVPTH 291
Cdd:PRK04837 15 LHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLshpapedRKVN-QPRALIMAPTR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 292 ALRMQTSLMISKLAEGTNIK--IVGGSERWRS-----EEDWDILVSTpsfspeffTPHNIDY-------------IVLDE 351
Cdd:PRK04837 94 ELAVQIHADAEPLAQATGLKlgLAYGGDGYDKqlkvlESGVDILIGT--------TGRLIDYakqnhinlgaiqvVVLDE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 352 ADMLLDDSFLNDIIRLLGPLKirhsvidkNATDGVRLIFSsATYPDQLQLIA-ESIVDYEYLycvktenlhRIMPHIKqT 430
Cdd:PRK04837 166 ADRMFDLGFIKDIRWLFRRMP--------PANQRLNMLFS-ATLSYRVRELAfEHMNNPEYV---------EVEPEQK-T 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 431 FIRIREidkleklkellekGLSFPHG-------QTLI----------F------CKNL--------KNVGLvsrslremg 479
Cdd:PRK04837 227 GHRIKE-------------ELFYPSNeekmrllQTLIeeewpdraiiFantkhrCEEIwghlaadgHRVGL--------- 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312077716 480 iehtsLSGG---RRIEQLIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIG 547
Cdd:PRK04837 285 -----LTGDvaqKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAG 350
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
223-405 |
9.69e-18 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 81.74 E-value: 9.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAP----LLSALLRNVNRHAKGV-VLVPTHALRMQT 297
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgfihLDLQPIPREQRNGPGVlVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 298 SLMISKLAEgTNIKIV---GGSERWRSEEDW----DILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDII 365
Cdd:cd17958 81 EAECSKYSY-KGLKSVcvyGGGNRNEQIEDLskgvDIIIATPGrlndlQMNNVINLKSITYLVLDEADRMLDMGFEPQIR 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 312077716 366 RLLgpLKIRHsviDKnatdgvRLIFSSATYPDQLQLIAES 405
Cdd:cd17958 160 KIL--LDIRP---DR------QTIMTSATWPDGVRRLAQS 188
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
219-407 |
2.85e-17 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 80.31 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSD--AHLLIAAETGSGKTAAYAAPLLSALLRNvNRHAKGVVLVPTHALRMQ 296
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPT-LKSPQALCLAPTRELARQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 297 TSLMISKLAEGTNIKI---VGGSERWRSEE-DWDILVSTP-----SFSPEFFTPHNIDYIVLDEAD-MLLDDSFLNDIIR 366
Cdd:cd17963 80 IGEVVEKMGKFTGVKValaVPGNDVPRGKKiTAQIVIGTPgtvldWLKKRQLDLKKIKILVLDEADvMLDTQGHGDQSIR 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 312077716 367 LlgplkirhsvidKNA-TDGVRLIFSSATYPDQLQLIAESIV 407
Cdd:cd17963 160 I------------KRMlPRNCQILLFSATFPDSVRKFAEKIA 189
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
219-369 |
6.84e-17 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 79.28 E-value: 6.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFrAFKSDAHLLIA-AETGSGKTAAYAAPLLSALLRNVNR-HAkgVVLVPTHALRMQ 296
Cdd:cd17954 7 VCEELCEACEKLGWKKPTKIQEEAI-PVALQGRDIIGlAETGSGKTAAFALPILQALLENPQRfFA--LVLAPTRELAQQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 297 TSLMISKLAEGTNIK---IVGG----SERWRSEEDWDILVSTPSF------SPEFFTPHNIDYIVLDEADMLLDDSFLND 363
Cdd:cd17954 84 ISEQFEALGSSIGLKsavLVGGmdmmAQAIALAKKPHVIVATPGRlvdhleNTKGFSLKSLKFLVMDEADRLLNMDFEPE 163
|
....*.
gi 312077716 364 IIRLLG 369
Cdd:cd17954 164 IDKILK 169
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
221-409 |
8.77e-17 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 79.29 E-value: 8.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 221 PVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALlrnvnrhaKGVVLVPTHALRMQTSLM 300
Cdd:cd17938 8 PELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV--------VALILEPSRELAEQTYNC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 301 ISKLA-EGTNIKI-----VGG----SERWRSEEDWDILVSTPSFSPEFFTPHNID-----YIVLDEADMLLDDSFLNDII 365
Cdd:cd17938 80 IENFKkYLDNPKLrvallIGGvkarEQLKRLESGVDIVVGTPGRLEDLIKTGKLDlssvrFFVLDEADRLLSQGNLETIN 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 312077716 366 RLlgplkirHSVIDKNATDGVRL--IFSSAT-YPDQLQLIAESIVDY 409
Cdd:cd17938 160 RI-------YNRIPKITSDGKRLqvIVCSATlHSFEVKKLADKIMHF 199
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
161-543 |
1.70e-16 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 82.77 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 161 EYNHYEGMRYPPGNILLASTYWVKSKYKNDWFTIHPVMRKNPSFNRDESFSWDENVSLLDPVIIENARKLGFRVPTVI-- 238
Cdd:COG1061 1 VLLRGIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSfe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 239 ----QRRAFRAFKSDA-----HLLIAAETGSGKTAayaapLLSALLRNVNRHAKGVVLVPTHALRMQTslmISKLAEGTN 309
Cdd:COG1061 81 lrpyQQEALEALLAALergggRGLVVAPTGTGKTV-----LALALAAELLRGKRVLVLVPRRELLEQW---AEELRRFLG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 310 IKIVGGSERwrsEEDWDILVST-PSFSPEFF---TPHNIDYIVLDEADMLLDDSFLnDIIRLLGPLKI--------Rhsv 377
Cdd:COG1061 153 DPLAGGGKK---DSDAPITVATyQSLARRAHldeLGDRFGLVIIDEAHHAGAPSYR-RILEAFPAAYRlgltatpfR--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 378 idknaTDGVRLIFS-------SATYPDQLQliAESIVDYEYL------------YCVKTENL-HRIMPHIKQTFIRIREI 437
Cdd:COG1061 226 -----SDGREILLFlfdgivyEYSLKEAIE--DGYLAPPEYYgirvdltderaeYDALSERLrEALAADAERKDKILREL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 438 DKLEKLKEllekglsfphgQTLIFCKNLKNVGLVSRSLREMGIEHTSLSGG---RRIEQLIDELRSGAVRIIIATDVASR 514
Cdd:COG1061 299 LREHPDDR-----------KTLVFCSSVDHAEALAELLNEAGIRAAVVTGDtpkKEREEILEAFRDGELRILVTVDVLNE 367
|
410 420 430
....*....|....*....|....*....|..
gi 312077716 515 GLDLPQLRHII---NYDFPRQisdYVHRCGRI 543
Cdd:COG1061 368 GVDVPRLDVAIllrPTGSPRE---FIQRLGRG 396
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
251-394 |
3.17e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 75.90 E-value: 3.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 251 HLLIAAETGSGKTAAYaapLLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLA-EGTNIKIVGGSE-----RWRSEED 324
Cdd:cd00046 3 NVLITAPTGSGKTLAA---LLAALLLLLKKGKKVLVLVPTKALALQTAERLRELFgPGIRVAVLVGGSsaeerEKNKLGD 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312077716 325 WDILVSTPSF------SPEFFTPHNIDYIVLDEADMLLDDSFLNDIIRLLgplkirhsvIDKNATDGVRLIFSSAT 394
Cdd:cd00046 80 ADIIIATPDMllnlllREDRLFLKDLKLIIVDEAHALLIDSRGALILDLA---------VRKAGLKNAQVILLSAT 146
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
229-371 |
1.15e-15 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 75.69 E-value: 1.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 229 KLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLR----NVNRHAKGVVLVPTHALRMQTSLMISKL 304
Cdd:cd17960 7 ELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKrkanLKKGQVGALIISPTRELATQIYEVLQSF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 305 AEGTNIKI-----VGGSE-----RWRSEEDWDILVSTPSFSPEFFT-------PHNIDYIVLDEADMLLDDSFLNDIIRL 367
Cdd:cd17960 87 LEHHLPKLkcqllIGGTNveedvKKFKRNGPNILVGTPGRLEELLSrkadkvkVKSLEVLVLDEADRLLDLGFEADLNRI 166
|
....
gi 312077716 368 LGPL 371
Cdd:cd17960 167 LSKL 170
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
231-414 |
1.03e-14 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 73.09 E-value: 1.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 231 GFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAKG---VVLVPTHALRMQTSLMISKLAEG 307
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGlgaLIISPTRELAMQIFEVLRKVGKY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 308 TNIK---IVGGS----ERWRSEEdWDILVSTPSF-------SPEFFTPhNIDYIVLDEADMLLDDSF---LNDIIRLLGP 370
Cdd:cd17941 89 HSFSaglIIGGKdvkeEKERINR-MNILVCTPGRllqhmdeTPGFDTS-NLQMLVLDEADRILDMGFketLDAIVENLPK 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 312077716 371 lkirhsvidKNATdgvrLIFsSATYPDQLQLIAE-SIVDYEYLYC 414
Cdd:cd17941 167 ---------SRQT----LLF-SATQTKSVKDLARlSLKNPEYISV 197
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
223-408 |
2.39e-14 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 72.06 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAK----GVVLVPTHALRMQTS 298
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGegpiAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIKIV---GGSERWRS----EEDWDILVSTPSFSPEFF-----TPHNIDYIVLDEADMLLDDSFlndiir 366
Cdd:cd17952 81 LEAKKFGKAYNLRVVavyGGGSKWEQakalQEGAEIVVATPGRLIDMVkkkatNLQRVTYLVLDEADRMFDMGF------ 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 312077716 367 llGPlKIRhSVIDKNATDGVRLIFsSATYPDQLQLIAESIVD 408
Cdd:cd17952 155 --EY-QVR-SIVGHVRPDRQTLLF-SATFKKKIEQLARDILS 191
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
231-406 |
2.80e-14 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 71.59 E-value: 2.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 231 GFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRhAKGVVLVPTHALRMQTSLMISKLAEGTNI 310
Cdd:cd17939 16 GFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRE-TQALVLAPTRELAQQIQKVVKALGDYMGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 311 KI---VGGS----ERWRSEEDWDILVSTP-----SFSPEFFTPHNIDYIVLDEADMLLDDSF---LNDIIRLLgPLKIrh 375
Cdd:cd17939 95 KVhacIGGTsvreDRRKLQYGPHIVVGTPgrvfdMLQRRSLRTDKIKMFVLDEADEMLSRGFkdqIYDIFQFL-PPET-- 171
|
170 180 190
....*....|....*....|....*....|.
gi 312077716 376 svidknatdgvRLIFSSATYPDQLQLIAESI 406
Cdd:cd17939 172 -----------QVVLFSATMPHEVLEVTKKF 191
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
228-368 |
3.33e-14 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 71.62 E-value: 3.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 228 RKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSAL--LRNVNRHAKGV-VLVPTHALRMQT-----SL 299
Cdd:cd17942 6 EEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLykLKFKPRNGTGViIISPTRELALQIygvakEL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 300 MisKLAEGTNIKIVGGSERwRSEED-----WDILVSTP-------SFSPEFFTpHNIDYIVLDEADMLLDDSF---LNDI 364
Cdd:cd17942 86 L--KYHSQTFGIVIGGANR-KAEAEklgkgVNILVATPgrlldhlQNTKGFLY-KNLQCLIIDEADRILEIGFeeeMRQI 161
|
....
gi 312077716 365 IRLL 368
Cdd:cd17942 162 IKLL 165
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
228-406 |
4.49e-14 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 71.64 E-value: 4.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 228 RKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLsallrnvnRHAK------------GVVLVPTHALRM 295
Cdd:cd17953 28 KKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMF--------RHIKdqrpvkpgegpiGLIMAPTRELAL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 296 QTSLMISKLAEGTNIKIV---GGS-------ERWRSEEdwdILVSTPSFSPEFFTPHN--------IDYIVLDEADMLLD 357
Cdd:cd17953 100 QIYVECKKFSKALGLRVVcvyGGSgiseqiaELKRGAE---IVVCTPGRMIDILTANNgrvtnlrrVTYVVLDEADRMFD 176
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 312077716 358 DSFLNDIIRllgplkirhsvIDKNATDGVRLIFSSATYPDQLQLIAESI 406
Cdd:cd17953 177 MGFEPQIMK-----------IVNNIRPDRQTVLFSATFPRKVEALARKV 214
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
219-396 |
8.30e-14 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 70.40 E-value: 8.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALlRNVNRHAKGVVLVPTHALRMQTS 298
Cdd:cd17940 6 LKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-DPKKDVIQALILVPTRELALQTS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIKI---VGGS----ERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIIR 366
Cdd:cd17940 85 QVCKELGKHMGVKVmvtTGGTslrdDIMRLYQTVHVLVGTPGrildlAKKGVADLSHCKTLVLDEADKLLSQDFQPIIEK 164
|
170 180 190
....*....|....*....|....*....|
gi 312077716 367 LLGPLKIRHSVidknatdgvrLIFsSATYP 396
Cdd:cd17940 165 ILNFLPKERQI----------LLF-SATFP 183
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
223-405 |
3.11e-13 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 68.55 E-value: 3.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAP-LLSALLRNVNRHAKG---VVLVPTHALRMQTS 298
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPaIVHINAQPPLERGDGpivLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 299 LMISKLAEGTNIK---IVGGSERWRSEEDW----DILVSTPSFSPEFF-----TPHNIDYIVLDEADMLLDDSFLNDIIR 366
Cdd:cd17966 81 QEANKFGGSSRLRntcVYGGAPKGPQIRDLrrgvEICIATPGRLIDFLdqgktNLRRVTYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 312077716 367 LLGplKIRhsvidknaTDGVRLIFsSATYPDQLQLIAES 405
Cdd:cd17966 161 IVD--QIR--------PDRQTLMW-SATWPKEVRRLAED 188
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
226-383 |
1.15e-12 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 66.80 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 226 NARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVnRHAKGVVLVPTHALRMQTSLMISKLA 305
Cdd:cd17962 4 NLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEH-RNPSALILTPTRELAVQIEDQAKELM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 306 EGT-NIK---IVGG----SERWRSEEDWDILVSTPSFSPEFFTPH-----NIDYIVLDEADMLLDDSFLNDIIRLLGPLK 372
Cdd:cd17962 83 KGLpPMKtalLVGGlplpPQLYRLQQGVKVIIATPGRLLDILKQSsveldNIKIVVVDEADTMLKMGFQQQVLDILENIS 162
|
170
....*....|.
gi 312077716 373 IRHSVIDKNAT 383
Cdd:cd17962 163 HDHQTILVSAT 173
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
219-545 |
1.35e-12 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 70.63 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRnvNRHAKGVVLVPTHAL----- 293
Cdd:COG1205 41 LPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE--DPGATALYLYPTKALardql 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 294 -RMQTslMISKLAEGTNIKIVGG----SERWRSEEDWDILVSTP-----SFSP------EFFTphNIDYIVLDEAD---- 353
Cdd:COG1205 119 rRLRE--LAEALGLGVRVATYDGdtppEERRWIREHPDIVLTNPdmlhyGLLPhhtrwaRFFR--NLRYVVIDEAHtyrg 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 354 -------MLLDDsfLNDIIRLLG--PlkirhsvidknatdgvRLIFSSATY--PDQLqliAESIVDYEYLycVKTEN--- 419
Cdd:COG1205 195 vfgshvaNVLRR--LRRICRHYGsdP----------------QFILASATIgnPAEH---AERLTGRPVT--VVDEDgsp 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 420 ---LHRIM--PHIKQTFIR------IREIdklekLKELLEKGLsfphgQTLIFCKNLKNVGLVSRSLREMGIEH------ 482
Cdd:COG1205 252 rgeRTFVLwnPPLVDDGIRrsalaeAARL-----LADLVREGL-----RTLVFTRSRRGAELLARYARRALREPdladrv 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312077716 483 TSLSGG------RRIEQlidELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGR 545
Cdd:COG1205 322 AAYRAGylpeerREIER---GLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGR 387
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
238-397 |
1.88e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 63.05 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 238 IQRRAFR-AFKSDAHLLIAAETGSGKT-AAYAapllsALLRNVNRHAKGVV-LVPTHALRMQtslMISKLAE-----GTN 309
Cdd:cd17921 5 IQREALRaLYLSGDSVLVSAPTSSGKTlIAEL-----AILRALATSGGKAVyIAPTRALVNQ---KEADLRErfgplGKN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 310 IKIVGGSERWRSEE--DWDILVSTP-------SFSPEFFTPHnIDYIVLDEADMLLDDS---FLNDIIRLLgplkirhsv 377
Cdd:cd17921 77 VGLLTGDPSVNKLLlaEADILVATPekldlllRNGGERLIQD-VRLVVVDEAHLIGDGErgvVLELLLSRL--------- 146
|
170 180
....*....|....*....|
gi 312077716 378 idKNATDGVRLIFSSATYPD 397
Cdd:cd17921 147 --LRINKNARFVGLSATLPN 164
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
223-413 |
2.37e-11 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 64.29 E-value: 2.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLG-FRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLS---------ALLRNVNRHAK------GVV 286
Cdd:cd18051 31 IIRNNIELArYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSqiyeqgpgeSLPSESGYYGRrkqyplALV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 287 LVPTHALRMQTSLMISKLAEGTNIK---IVGGSERWRSEEDWD----ILVSTPSFSPEFFTP-----HNIDYIVLDEADM 354
Cdd:cd18051 111 LAPTRELASQIYDEARKFAYRSRVRpcvVYGGADIGQQMRDLErgchLLVATPGRLVDMLERgkiglDYCKYLVLDEADR 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312077716 355 LLDDSFLNDIIRllgplkirhsVIDKNAT--DGVR--LIFsSATYPDQLQLIAESIVDyEYLY 413
Cdd:cd18051 191 MLDMGFEPQIRR----------IVEQDTMppTGERqtLMF-SATFPKEIQMLARDFLD-NYIF 241
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
227-411 |
6.12e-11 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 62.17 E-value: 6.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 227 ARKLGFRVPtvIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHAKG-----VVLVPTHALRMQTSLMI 301
Cdd:cd17944 7 ARGVTYLFP--IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGrapkvLVLAPTRELANQVTKDF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 302 SKLAEGTNIKIVGGSERWRSEEDW-----DILVSTPSFSPEFFTPHNID-----YIVLDEADMLLDDSFLNDIIRLLgpl 371
Cdd:cd17944 85 KDITRKLSVACFYGGTPYQQQIFAirngiDILVGTPGRIKDHLQNGRLDltklkHVVLDEVDQMLDMGFAEQVEEIL--- 161
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 312077716 372 kirHSVIDKNATDGVRLIFSSATYPDQLQLIAESIVDYEY 411
Cdd:cd17944 162 ---SVSYKKDSEDNPQTLLFSATCPDWVYNVAKKYMKSQY 198
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
223-399 |
6.84e-11 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 61.90 E-value: 6.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNvNRHAKGVVLVPTHALRMQTSLMIS 302
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLE-RRHPQVLILAPTREIAVQIHDVFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 303 KLAE-GTNIKI---VGGSERWRSEEDWD---ILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSFLNDIirllgp 370
Cdd:cd17943 80 KIGKkLEGLKCevfIGGTPVKEDKKKLKgchIAVGTPGrikqlIELGALNVSHVRLFVLDEADKLMEGSFQKDV------ 153
|
170 180
....*....|....*....|....*....
gi 312077716 371 lkirhSVIDKNATDGVRLIFSSATYPDQL 399
Cdd:cd17943 154 -----NWIFSSLPKNKQVIAFSATYPKNL 177
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
231-396 |
1.77e-10 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 60.92 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 231 GFRVPTVIQRRAFRAFkSDAHLLIA-AETGSGKTAAYAAPLLSALLRNVnRHAKGVVLVPTHALRMQTSLMISKLAEGTN 309
Cdd:cd18046 18 GFEKPSAIQQRAIMPC-IKGYDVIAqAQSGTGKTATFSISILQQIDTSL-KATQALVLAPTRELAQQIQKVVMALGDYMG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 310 IKI---VGGS----ERWRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLDDSF---LNDIIRLLGPlkir 374
Cdd:cd18046 96 IKChacIGGTsvrdDAQKLQAGPHIVVGTPGrvfdmINRRYLRTDYIKMFVLDEADEMLSRGFkdqIYDIFQKLPP---- 171
|
170 180
....*....|....*....|..
gi 312077716 375 hsvidknatdGVRLIFSSATYP 396
Cdd:cd18046 172 ----------DTQVVLLSATMP 183
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
231-370 |
1.79e-10 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 60.56 E-value: 1.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 231 GFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVnRHAKGVVLVPTHALRMQTSLMISKLAEGTNI 310
Cdd:cd18045 18 GFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQV-RETQALILSPTRELAVQIQKVLLALGDYMNV 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 312077716 311 KI---VGGS----ERWRSEEDWDILVSTPSFSPEFFT-----PHNIDYIVLDEADMLLDDSF---LNDIIRLLGP 370
Cdd:cd18045 97 QChacIGGTsvgdDIRKLDYGQHIVSGTPGRVFDMIRrrslrTRHIKMLVLDEADEMLNKGFkeqIYDVYRYLPP 171
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
217-394 |
3.05e-10 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 62.99 E-value: 3.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 217 SLLDPVIIENARKLGFRVPTVIQRRAFRA-FKSDAHLLIAAETGSGKTA-AYaapllSALLRNVNRHAKGVVLVPTHALR 294
Cdd:COG1204 5 ELPLEKVIEFLKERGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLiAE-----LAILKALLNGGKALYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 295 MQTSLMISKLAEGTNIKIVGGSERWRSEEDW----DILVSTP-------SFSPEFFTphNIDYIVLDEADMLLDDSflnd 363
Cdd:COG1204 80 SEKYREFKRDFEELGIKVGVSTGDYDSDDEWlgryDILVATPekldsllRNGPSWLR--DVDLVVVDEAHLIDDES---- 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 312077716 364 iiRllGPL------KIRHSVidknatDGVRLIFSSAT 394
Cdd:COG1204 154 --R--GPTlevllaRLRRLN------PEAQIVALSAT 180
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
230-420 |
4.08e-10 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 60.42 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 230 LGFRVPTVIQRRAFRAFKSD--AHLLIAAETGSGKTAAYAAPLLSALLRNvNRHAKGVVLVPTHALRMQTSLMISKLAEG 307
Cdd:cd18048 36 MGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDAL-KLYPQCLCLSPTFELALQTGKVVEEMGKF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 308 TN-IKIV----GGSERWRSEEDWDILVSTPS------FSPEFFTPHNIDYIVLDEADMLLDDSFLNDiirllgplkirHS 376
Cdd:cd18048 115 CVgIQVIyairGNRPGKGTDIEAQIVIGTPGtvldwcFKLRLIDVTNISVFVLDEADVMINVQGHSD-----------HS 183
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 312077716 377 V-IDKNATDGVRLIFSSATYPDQLQLIAESIVDYEYLYCVKTENL 420
Cdd:cd18048 184 VrVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
505-548 |
1.51e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 54.63 E-value: 1.51e-09
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 312077716 505 IIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGRIGS 548
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGK 68
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
223-409 |
4.20e-09 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 57.33 E-value: 4.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYaapLLSALLrNVN-----RHAKG---VVLVPTHALR 294
Cdd:cd18049 35 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSY---LLPAIV-HINhqpflERGDGpicLVLAPTRELA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 295 MQTSLMISKLAEGTNIK---IVGGSERWRSEEDW----DILVSTPSFSPEFFTPHNID-----YIVLDEADMLLDDSFLN 362
Cdd:cd18049 111 QQVQQVAAEYGRACRLKstcIYGGAPKGPQIRDLergvEICIATPGRLIDFLEAGKTNlrrctYLVLDEADRMLDMGFEP 190
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 312077716 363 DIirllgplkirHSVIDKNATDGVRLIFsSATYPDQLQLIAESIV-DY 409
Cdd:cd18049 191 QI----------RKIVDQIRPDRQTLMW-SATWPKEVRQLAEDFLkDY 227
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
232-409 |
7.49e-09 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 56.94 E-value: 7.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 232 FRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYaapLLSALLrNVNRHA---KG-----VVLVPTHALRMQTSLMISK 303
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAY---LLPAIV-HINHQPyleRGdgpicLVLAPTRELAQQVQQVADD 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 304 LAEGTNIK---IVGGSERWRSEEDW----DILVSTPSFSPEFFTPHNID-----YIVLDEADMLLDDSFLNDIirllgpl 371
Cdd:cd18050 158 YGKSSRLKstcIYGGAPKGPQIRDLergvEICIATPGRLIDFLEAGKTNlrrctYLVLDEADRMLDMGFEPQI------- 230
|
170 180 190
....*....|....*....|....*....|....*....
gi 312077716 372 kirHSVIDKNATDGVRLIFsSATYPDQLQLIAESIV-DY 409
Cdd:cd18050 231 ---RKIVDQIRPDRQTLMW-SATWPKEVRQLAEDFLrDY 265
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
239-394 |
8.70e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 55.28 E-value: 8.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 239 QRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRnvNRHAKGVVLVPTHAL-RMQTSLM---ISKLAEGTNIKIVG 314
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLR--DPGSRALYLYPTKALaQDQLRSLrelLEQLGLGIRVATYD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 315 GSERWRSEEDW-----DILVSTP-----------SFSPEFFTphNIDYIVLDEADMlLDDSFLNDIIRLLGPLKIRHSVI 378
Cdd:cd17923 83 GDTPREERRAIirnppRILLTNPdmlhyallphhDRWARFLR--NLRYVVLDEAHT-YRGVFGSHVALLLRRLRRLCRRY 159
|
170
....*....|....*.
gi 312077716 379 DKNatdgVRLIFSSAT 394
Cdd:cd17923 160 GAD----PQFILTSAT 171
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
239-352 |
1.34e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 54.22 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 239 QRRAFRAFKS-----DAHLLIAAETGSGKTAAYAAplLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAEGT--NIK 311
Cdd:pfam04851 8 QIEAIENLLEsikngQKRGLIVMATGSGKTLTAAK--LIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYveIGE 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 312077716 312 IVGGSERWRSEEDWDILVSTP-SFSPEF------FTPHNIDYIVLDEA 352
Cdd:pfam04851 86 IISGDKKDESVDDNKIVVTTIqSLYKALelasleLLPDFFDVIIIDEA 133
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
219-407 |
2.27e-08 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 54.73 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 219 LDPVIIENARKLGFRVPTVIQRRAFRAFKSD--AHLLIAAETGSGKTAAYAAPLLSAlLRNVNRHAKGVVLVPTHALRMQ 296
Cdd:cd18047 8 LKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQ-VEPANKYPQCLCLSPTYELALQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 297 TSLMISKLA----EGTNIKIVGGSERWRSEEDWD-ILVSTPS------FSPEFFTPHNIDYIVLDEADMLLDDSFLNDii 365
Cdd:cd18047 87 TGKVIEQMGkfypELKLAYAVRGNKLERGQKISEqIVIGTPGtvldwcSKLKFIDPKKIKVFVLDEADVMIATQGHQD-- 164
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 312077716 366 rllgpLKIRhsvIDKNATDGVRLIFSSATYPDQLQLIAESIV 407
Cdd:cd18047 165 -----QSIR---IQRMLPRNCQMLLFSATFEDSVWKFAQKVV 198
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
453-554 |
1.17e-07 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 51.06 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 453 FPHGQTLIFCKNLKNVGLVSRSLREMGIE----HTSL-SGGRRIEQ---LIDELRsgavrIIIATDVASRGLDLPQLRHI 524
Cdd:cd18794 28 HLGGSGIIYCLSRKECEQVAARLQSKGISaaayHAGLePSDRRDVQrkwLRDKIQ-----VIVATVAFGMGIDKPDVRFV 102
|
90 100 110
....*....|....*....|....*....|
gi 312077716 525 INYDFPRQISDYVHRCGRIGRIGSLHKCLM 554
Cdd:cd18794 103 IHYSLPKSMESYYQESGRAGRDGLPSECIL 132
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
223-351 |
1.34e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 52.03 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRvPTVIQRRAFRAFKSDAH------LLIAAETGSGKTAAYaapLLSALLrNVNRHAKGVVLVPTHALRMQ 296
Cdd:cd17918 5 IQELCKSLPFS-LTKDQAQAIKDIEKDLHspepmdRLLSGDVGSGKTLVA---LGAALL-AYKNGKQVAILVPTEILAHQ 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 312077716 297 TSLMISKLAEGTNIKIVGGSERWRSEEDWDILVSTPSFSPEFFTPHNIDYIVLDE 351
Cdd:cd17918 80 HYEEARKFLPFINVELVTGGTKAQILSGISLLVGTHALLHLDVKFKNLDLVIVDE 134
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
228-394 |
1.74e-07 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 51.56 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 228 RKLGFRvPTVIQRR-AFRAFKSDAHLLIAAeTGSGKTAAyaapLLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAE 306
Cdd:cd17924 12 KKTGFP-PWGAQRTwAKRLLRGKSFAIIAP-TGVGKTTF----GLATSLYLASKGKRSYLIFPTKSLVKQAYERLSKYAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 307 --GTNIKIV---GGSERWRSEE--------DWDILVSTPSFSPEFF---TPHNIDYIVLDEADMLLDDSflNDIIRLLGP 370
Cdd:cd17924 86 kaGVEVKILvyhSRLKKKEKEEllekiekgDFDILVTTNQFLSKNFdllSNKKFDFVFVDDVDAVLKSS--KNIDRLLKL 163
|
170 180
....*....|....*....|....
gi 312077716 371 LKIRhsvidknatdgvRLIFSSAT 394
Cdd:cd17924 164 LGFG------------QLVVSSAT 175
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
489-542 |
3.51e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 49.90 E-value: 3.51e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 312077716 489 RRIEQLIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGR 542
Cdd:cd18802 77 RKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
241-352 |
3.75e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 49.61 E-value: 3.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 241 RAFRAFKSDAHLLIAAETGSGKTAAYAAplLSALLRNvnrhAKGVVLVPTHALRMQTSlmiSKLAEGTNIKIVG--GSER 318
Cdd:cd17926 10 EAWLAHKNNRRGILVLPTGSGKTLTALA--LIAYLKE----LRTLIVVPTDALLDQWK---ERFEDFLGDSSIGliGGGK 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 312077716 319 WRSEEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEA 352
Cdd:cd17926 81 KKDFDDANVVVATYQslsnlAEEEKDLFDQFGLLIVDEA 119
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
252-547 |
6.25e-07 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 51.66 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 252 LLIAAETGSGKT---AAYAAPLLSALLRNvnrhaKGVVLVPTHAL------RMQTSL----MISKLAEGTNIKIVGGSER 318
Cdd:cd09639 2 LVIEAPTGYGKTeaaLLWALHSLKSQKAD-----RVIIALPTRATinamyrRAKEAFgetgLYHSSILSSRIKEMGDSEE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 319 WRSEEDW------------------DILVS--TPSFSPEFFTPHNIDY--IVLDEADmLLDDSFLNDIIRLLGPLKirhs 376
Cdd:cd09639 77 FEHLFPLyihsndtlfldpitvctiDQVLKsvFGEFGHYEFTLASIANslLIFDEVH-FYDEYTLALILAVLEVLK---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 377 viDKnatdGVRLIFSSATYPDQLQLIAESIvdyeyLYCVKTENLHRImpHIKQTFIRIREIDKLEKLKELLEKGLSFPH- 455
Cdd:cd09639 152 --DN----DVPILLMSATLPKFLKEYAEKI-----GYVEENEPLDLK--PNERAPFIKIESDKVGEISSLERLLEFIKKg 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 456 GQTLIFCKNLKNVGLVSRSLREMGIE------HTSLSGGRRIE---QLIDELRSGAVRIIIATDVASRGLDlpqlrhiIN 526
Cdd:cd09639 219 GSVAIIVNTVDRAQEFYQQLKEKGPEeeimliHSRFTEKDRAKkeaELLLEFKKSEKFVIVATQVIEASLD-------IS 291
|
330 340
....*....|....*....|....*
gi 312077716 527 YDF----PRQISDYVHRCGRIGRIG 547
Cdd:cd09639 292 VDVmiteLAPIDSLIQRLGRLHRYG 316
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
238-545 |
1.05e-06 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 51.62 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 238 IQRRAFRAFKSDAHL-----LIAAETGSGKT-AA-----------------YAAPLLSALLRNVNRhakgVVLVPTHALR 294
Cdd:COG1203 131 LQNEALELALEAAEEepglfILTAPTGGGKTeAAllfalrlaakhggrriiYALPFTSIINQTYDR----LRDLFGEDVL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 295 MQTSLmiSKLAEGTNIKIVGGSERWRSE--EDWD--ILVSTP------SFSP--EFFTP-HNIDY--IVLDEADMLlDDS 359
Cdd:COG1203 207 LHHSL--ADLDLLEEEEEYESEARWLKLlkELWDapVVVTTIdqlfesLFSNrkGQERRlHNLANsvIILDEVQAY-PPY 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 360 FLNDIIRLLGPLKIRhsvidknatdGVRLIFSSATYPdqlQLIAESIVDYEYLYCVKTENLHRIMPHIKQTFIRIREIDK 439
Cdd:COG1203 284 MLALLLRLLEWLKNL----------GGSVILMTATLP---PLLREELLEAYELIPDEPEELPEYFRAFVRKRVELKEGPL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 440 LEKLKELLEKGLSFPHGQTLIFCKNLKNVGLVSRSLREMGIE------HTSLSGGRR---IEQLIDELRSGAVRIIIATD 510
Cdd:COG1203 351 SDEELAELILEALHKGKSVLVIVNTVKDAQELYEALKEKLPDeevyllHSRFCPADRseiEKEIKERLERGKPCILVSTQ 430
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 312077716 511 VASRGLDLpqlrhiinyDFPRQISDY------VHRCGRIGR 545
Cdd:COG1203 431 VVEAGVDI---------DFDVVIRDLapldslIQRAGRCNR 462
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
457-545 |
4.52e-06 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 46.48 E-value: 4.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 457 QTLIFCKNLKNVGLVSRSLREMGIEHTSLS-------GG------RRIEqliDELRSGAVRIIIATDVASRGLDLPQLRH 523
Cdd:cd18797 37 KTIVFCRSRKLAELLLRYLKARLVEEGPLAskvasyrAGylaedrREIE---AELFNGELLGVVATNALELGIDIGGLDA 113
|
90 100
....*....|....*....|..
gi 312077716 524 IINYDFPRQISDYVHRCGRIGR 545
Cdd:cd18797 114 VVLAGYPGSLASLWQQAGRAGR 135
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
223-405 |
5.34e-06 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 47.72 E-value: 5.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 223 IIENARKLGFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHA-------KGVVLVPTHALRM 295
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPfikgegpYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 296 QTSLMIS----KLAEGTNIKI-----VGG---SERWRS-EEDWDILVSTPS-----FSPEFFTPHNIDYIVLDEADMLLD 357
Cdd:cd17951 81 QTHEVIEyyckALQEGGYPQLrcllcIGGmsvKEQLEViRKGVHIVVATPGrlmdmLNKKKINLDICRYLCLDEADRMID 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 312077716 358 DSFLNDIIRLLGPLKirhsvidknatdGVR--LIFsSATYPDQLQLIAES 405
Cdd:cd17951 161 MGFEEDIRTIFSYFK------------GQRqtLLF-SATMPKKIQNFAKS 197
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
211-293 |
6.21e-06 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 49.33 E-value: 6.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 211 SWDENVSLLDPVIIE--NARklgFRVPTVIQRRAFRAFKSDAHLLIAAETGSGKTaaYAApLLSALLRNVNRHAKGVVLV 288
Cdd:COG1201 2 SAEDVLSLLHPAVRAwfAAR---FGAPTPPQREAWPAIAAGESTLLIAPTGSGKT--LAA-FLPALDELARRPRPGELPD 75
|
....*
gi 312077716 289 PTHAL 293
Cdd:COG1201 76 GLRVL 80
|
|
| DEXHc_RE_I_III_res |
cd18032 |
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ... |
240-352 |
7.90e-06 |
|
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350790 [Multi-domain] Cd Length: 163 Bit Score: 46.40 E-value: 7.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 240 RRAFRAFKSDA--HLLIAAeTGSGKTaaYAAPLLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAEGTNIKIVGGSE 317
Cdd:cd18032 10 EALEEAREKGQrrALLVMA-TGTGKT--YTAAFLIKRLLEANRKKRILFLAHREELLEQAERSFKEVLPDGSFGNLKGGK 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 312077716 318 rwRSEEDWDILVST-PS---------FSPEFFtphniDYIVLDEA 352
Cdd:cd18032 87 --KKPDDARVVFATvQTlnkrkrlekFPPDYF-----DLIIIDEA 124
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
239-358 |
1.45e-05 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 45.79 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 239 QRRAFRA-FKSDAHLLIAAETGSGKTaayaapLLS--ALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAE-GTNIKIVG 314
Cdd:cd18028 6 QAEAVRAgLLKGENLLISIPTASGKT------LIAemAMVNTLLEGGKALYLVPLRALASEKYEEFKKLEEiGLKVGIST 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 312077716 315 GSerWRSEEDW----DILVSTPS-------FSPEFFtpHNIDYIVLDEADMLLDD 358
Cdd:cd18028 80 GD--YDEDDEWlgdyDIIVATYEkfdsllrHSPSWL--RDVGVVVVDEIHLISDE 130
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
459-547 |
5.40e-05 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 46.37 E-value: 5.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 459 LIFCKNLKNVGLVSRSLREMGIEHTSLSGG----RRiEQLIDELRSG--AVRIIIATDVASRGLDLPQLRHIINYDFP-- 530
Cdd:COG0553 553 LVFSQFTDTLDLLEERLEERGIEYAYLHGGtsaeER-DELVDRFQEGpeAPVFLISLKAGGEGLNLTAADHVIHYDLWwn 631
|
90 100
....*....|....*....|.
gi 312077716 531 ----RQisdyvhRCGRIGRIG 547
Cdd:COG0553 632 paveEQ------AIDRAHRIG 646
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
251-410 |
1.15e-04 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 42.75 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 251 HLLIAAETGSGKTAayaapLLSALLRNVNRHAKGVVLVPTHALRMQTSLMISKLAEGTNIKIVGGSERwrsEEDWDILVS 330
Cdd:smart00382 4 VILIVGPPGSGKTT-----LARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELR---LRLALALAR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 331 TpsfspefftpHNIDYIVLDEADMLLDDSFLNDIIRLLgplkIRHSVIDKNATDGVRLIFSSATYPDQLQLIAESIVDYE 410
Cdd:smart00382 76 K----------LKPDVLILDEITSLLDAEQEALLLLLE----ELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRR 141
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
459-547 |
2.68e-04 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 41.31 E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 459 LIFCKNLKNVGLVSRSLREMGIEHTSLSGGRRIEQ---LIDELR--SGAVRIIIATDVASRGLDLPQLRHIINYDFP--- 530
Cdd:cd18793 31 LIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKErqkLVDRFNedPDIRVFLLSTKAGGVGLNLTAANRVILYDPWwnp 110
|
90 100
....*....|....*....|
gi 312077716 531 ---RQisdyvhRCGRIGRIG 547
Cdd:cd18793 111 aveEQ------AIDRAHRIG 124
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
239-352 |
3.36e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 42.25 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 239 QRRAFRAFKsDAHLLIAAETGSGKTAAyAAPLLSALLRNVNRHAKG----VVLVPTHAL--------RMQTSLMISKLAE 306
Cdd:cd18034 7 QLELFEAAL-KRNTIVVLPTGSGKTLI-AVMLIKEMGELNRKEKNPkkraVFLVPTVPLvaqqaeaiRSHTDLKVGEYSG 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 312077716 307 GTNIKIvGGSERWRSE-EDWDILVSTP-----SFSPEFFTPHNIDYIVLDEA 352
Cdd:cd18034 85 EMGVDK-WTKERWKEElEKYDVLVMTAqilldALRHGFLSLSDINLLIFDEC 135
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
459-547 |
3.38e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 43.55 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 459 LIFCKNLKNVGLVSRSLREMGIE----HTSLSGGRRiEQLIDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQIS 534
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISaaayHAGLDNDVR-ADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIE 318
|
90
....*....|...
gi 312077716 535 DYVHRCGRIGRIG 547
Cdd:PRK11057 319 SYYQETGRAGRDG 331
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
492-548 |
7.01e-04 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 42.79 E-value: 7.01e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 312077716 492 EQLIDELRSGAVRIIIATDVASRGLDLPQLRHIINYD-FPRQISdYVHRCGRIGRIGS 548
Cdd:COG1111 401 IEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGRKRE 457
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
454-547 |
8.10e-04 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 40.23 E-value: 8.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 454 PHGQTLIFCKNLKNVGLVSRSLREMGIEHTSLSggrRIE-QLIDEL-RSGAVRIIIATDVASRGLDLPQLRHII------ 525
Cdd:cd18795 42 EGKPVLVFCSSRKECEKTAKDLAGIAFHHAGLT---REDrELVEELfREGLIKVLVATSTLAAGVNLPARTVIIkgtqry 118
|
90 100
....*....|....*....|....
gi 312077716 526 NYDFPRQIS--DYVHRCGRIGRIG 547
Cdd:cd18795 119 DGKGYRELSplEYLQMIGRAGRPG 142
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
484-545 |
1.25e-03 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 39.65 E-value: 1.25e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312077716 484 SLSGGRRIEQL--IDELRSGAVRIIIATDVASRGLDLPQLRHIINYDFPRQISDYVHRCGRIGR 545
Cdd:cd18801 70 SSKGMSQKEQKevIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
455-545 |
1.48e-03 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 39.55 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 455 HGQTLIFCKNLKNVGLVSRSLREM----------GIEHTSLSGGRRiEQLIDELRSGAVRIIIATDVASRGLDLPQLRHI 524
Cdd:cd18796 38 HKSTLVFTNTRSQAERLAQRLRELcpdrvppdfiALHHGSLSRELR-EEVEAALKRGDLKVVVATSSLELGIDIGDVDLV 116
|
90 100
....*....|....*....|.
gi 312077716 525 INYDFPRQISDYVHRCGRIGR 545
Cdd:cd18796 117 IQIGSPKSVARLLQRLGRSGH 137
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
238-397 |
1.56e-03 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 40.43 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 238 IQRRAFR-AFKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNRHA-------KGVVLVPTHALRMQTSLMISKLAEGTN 309
Cdd:cd18019 21 IQSKLFPaAFETDENLLLCAPTGAGKTNVALLTILREIGKHRNPDGtinldafKIVYIAPMKALVQEMVGNFSKRLAPYG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312077716 310 IKI---VGGSERWRSE-EDWDILVSTPS-------FSPEFFTPHNIDYIVLDEADMLLDDSflndiirllGPL------- 371
Cdd:cd18019 101 ITVaelTGDQQLTKEQiSETQIIVTTPEkwdiitrKSGDRTYTQLVRLIIIDEIHLLHDDR---------GPVlesivar 171
|
170 180
....*....|....*....|....*.
gi 312077716 372 KIRHSvidKNATDGVRLIFSSATYPD 397
Cdd:cd18019 172 TIRQI---EQTQEYVRLVGLSATLPN 194
|
|
| DHOD_e_trans |
cd06218 |
FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. ... |
472-541 |
3.85e-03 |
|
FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.
Pssm-ID: 99814 [Multi-domain] Cd Length: 246 Bit Score: 39.45 E-value: 3.85e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312077716 472 SRSLREMGIEHTSLSGGRRIEQLI--DELRSGAVRIIIATDVASRGL--DLPQLrhiINYDFPRQISDYVHRCG 541
Cdd:cd06218 117 AKQLAERGIKVTVLLGFRSADDLFlvEEFEALGAEVYVATDDGSAGTkgFVTDL---LKELLAEARPDVVYACG 187
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
458-525 |
5.15e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.15 E-value: 5.15e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 312077716 458 TLIFCKNLKNVGLVSRSLREMGIEHTSLSGG-----RRIEQLI-DELRSGAVRIIIATDVASRGLDLPQLRHII 525
Cdd:cd18799 9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDysdreRGDEALIlLFFGELKPPILVTVDLLTTGVDIPEVDNVV 82
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
238-293 |
8.30e-03 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 38.01 E-value: 8.30e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 312077716 238 IQRRAFRA-FKSDAHLLIAAETGSGKTAAYAAPLLSALLRNVNrhAKGVVLVPTHAL 293
Cdd:cd18021 7 IQTQVFNSlYNTDDNVFVGAPTGSGKTVCAELALLRHWRQNPK--GRAVYIAPMQEL 61
|
|
| |
