|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
6-603 |
0e+00 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 746.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 6 PILPVKGKNNVLVTSALPYVNNTPHLGNVIGSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRK 85
Cdd:PLN02610 9 PKLPIPGKRNILITSALPYVNNVPHLGNIIGCVLSADVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 86 YHAVHKGIYEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGEC--SLCGYNDA 163
Cdd:PLN02610 89 YHAIHKEVYDWFDISFDKFGRTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGTCptEGCNYDSA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 164 RGDQCDKCGNLLDPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEG 243
Cdd:PLN02610 169 RGDQCEKCGKLLNPTE---------------------LIDPKCKVCKNTPRIRDTDHLFLELPLLKDKLVEYINETSVAG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 244 AWSTSAQTITQAWIDKGLKPRGITRDLKWGVPVPTdvtgEDYAAKVFYVWFDACIGYVSITKNYTdgadlagKKWEQWWK 323
Cdd:PLN02610 228 GWSQNAIQTTNAWLRDGLKPRCITRDLKWGVPVPL----EKYKDKVFYVWFDAPIGYVSITACYT-------PEWEKWWK 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 324 NPDEVKLYQFLGKDNVQFHSTVFPASQLGTNENWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETGVPSDVWRYYL 403
Cdd:PLN02610 297 NPENVELYQFMGKDNVPFHTVMFPSTLLGTGENWTMMKTISVTEYLNYEGGKFSKSKGVGVFGNDAKDTNIPVEVWRYYL 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 404 LSRRPETSDSEFMWQELVDGNNNELLKNLGNFCQRVIKF----AQAKLDTTVPDYTKFGLNDYLKNHVKEVNVNLKEYIA 479
Cdd:PLN02610 377 LTNRPEVSDTLFTWADLQAKLNSELLNNLGNFINRVLSFiakpPGAGYGSVIPDAPGAESHPLTKKLAEKVGKLVEQYVE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 480 NMEGTKFRDGLRSILSISALGNKLLQDNKLdNKLLTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEP- 558
Cdd:PLN02610 457 AMEKVKLKQGLKTAMSISSEGNAYLQESQF-WKLYKEDKPSCAIVVKTSVGLVYLLACLLEPFMPSFSKEVLKQLNLPPe 535
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 302417150 559 TPTIPDE--WVTGAIKP------GQKLGEAKHLFSQIPASKIEEWREAFGGEE 603
Cdd:PLN02610 536 SLSLSDEkgEVARAKRPwelvpaGHKIGTPEPLFKELKDEEVEAYREKFAGSQ 588
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
14-595 |
0e+00 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 570.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 14 NNVLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGI 93
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLY-TYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 94 YEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGN 173
Cdd:COG0143 80 FEKLGISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYVEGTCPKCGAEDAYGDQCENCGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 174 LLDPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKkasTEGAWSTSAQTIT 253
Cdd:COG0143 160 TLEPTE---------------------LINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIE---ENPDIQPEVRNEV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 254 QAWIDKGLKPRGITRDLKWGVPVPTDvtgEDyaaKVFYVWFDACIGYVSITKNYTDGADLAGkKWEQWWKNPDeVKLYQF 333
Cdd:COG0143 216 LSWLKEGLQDLSISRDFDWGIPVPGD---PG---KVFYVWFDALIGYISATKGYADDRGLPE-DFEKYWPAPD-TELVHF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 334 LGKDNVQFHSTVFPASQLGTneNWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETgVPSDVWRYYLLSRRPETSDS 413
Cdd:COG0143 288 IGKDIIRFHAIIWPAMLMAA--GLPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDR-YGPDALRYYLLREVPFGQDG 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 414 EFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTKFGLNDylKNHVKEVNVNLKEYIANMEGTKFRDGLRSI 493
Cdd:COG0143 365 DFSWEDFVARVNSDLANDLGNLASRTLSMIHKYFDGKVPEPGELTEAD--EELLAEAEAALEEVAEAMEAFEFRKALEEI 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 494 LSISALGNKLLQDNK--LDNKllTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEPTPTIPDEwVTGAI 571
Cdd:COG0143 443 MALARAANKYIDETApwKLAK--DEDPERLATVLYTLLEALRILAILLKPFLPETAEKILEQLGLEGDELTWED-AGWPL 519
|
570 580
....*....|....*....|....
gi 302417150 572 KPGQKLGEAKHLFSQIPASKIEEW 595
Cdd:COG0143 520 PAGHKIGKPEPLFPRIEDEQIEAL 543
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
16-587 |
0e+00 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 556.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 16 VLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYE 95
Cdd:TIGR00398 1 ILITTALPYANGKPHLGHAY-TTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTPKELVDKYHEEFKDDWK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 96 WFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGNLL 175
Cdd:TIGR00398 80 WLNISFDRFIRTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVEGTCPKCGSEDARGDHCEVCGRHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 176 DPlepepeagnakpdddiaakatGWLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEGAWSTSAQTITQA 255
Cdd:TIGR00398 160 EP---------------------TELINPRCKICGAKPELRDSEHYFFRLSAFEKELEEWIRKNPESGSPASNVKNKAQN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 256 WIDKGLKPRGITRDLK-WGVPVPTDvtgedyAAKVFYVWFDACIGYVS---ITKNYTdgadlagKKWEQWWKNPDEVKLY 331
Cdd:TIGR00398 219 WLKGGLKDLAITRDLVyWGIPVPND------PNKVVYVWFDALIGYISslgILSGDT-------EDWKKWWNNDEDAELI 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 332 QFLGKDNVQFHSTVFPASQLGTNenWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQEtGVPSDVWRYYLLSRRPETS 411
Cdd:TIGR00398 286 HFIGKDIVRFHTIYWPAMLMGLG--LPLPTQVFSHGYLTVEGGKMSKSLGNVVDPSDLLA-RFGADILRYYLLKERPLGK 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 412 DSEFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTKfgLNDYLKNHVKEVNVNLKEYIANMEGTKFRDGLR 491
Cdd:TIGR00398 363 DGDFSWEDFVERVNADLANKLGNLLNRTLGFIKKYFNGVLPSEDI--TDEEDKKLLKLINEALEQIDEAIESFEFRKALR 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 492 SILSISALGNKLLQDNKlDNKLLTEEPdRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEptptipDEWVT-GA 570
Cdd:TIGR00398 441 EIMKLADRGNKYIDENK-PWELFKQSP-RLKELLAVCSMLIRVLSILLYPIMPKLSEKILKFLNFE------LEWDFkLK 512
|
570
....*....|....*..
gi 302417150 571 IKPGQKLGEAKHLFSQI 587
Cdd:TIGR00398 513 LLEGHKLNKAEPLFSKI 529
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
16-439 |
0e+00 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 532.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 16 VLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYE 95
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLY-SYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 96 WFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGNLL 175
Cdd:pfam09334 80 KFNISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTCPHCGSEDARGDQCENCGRHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 176 DPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEgaWSTSAQTITQA 255
Cdd:pfam09334 160 EPTE---------------------LINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPE--WPENVKNMVLE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 256 WIDKGLKPRGITRDLKWGVPVPtdvtgeDYAAKVFYVWFDACIGYVSITKNYTDgadlAGKKWEQWWKNPDEVKLYQFLG 335
Cdd:pfam09334 217 WLKEGLKDRAISRDLDWGIPVP------GAEGKVFYVWLDAPIGYISATKELSG----NEEKWKEWWPNDPDTELVHFIG 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 336 KDNVQFHSTVFPASQLGtnENWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETgVPSDVWRYYLLSRRPETSDSEF 415
Cdd:pfam09334 287 KDIIYFHTIFWPAMLLG--AGYRLPTTVFAHGYLTYEGGKMSKSRGNVVWPSEALDR-FPPDALRYYLARNRPETKDTDF 363
|
410 420
....*....|....*....|....
gi 302417150 416 MWQELVDGNNNELLKNLGNFCQRV 439
Cdd:pfam09334 364 SWEDFVERVNSELADDLGNLVNRV 387
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
15-415 |
4.57e-143 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 419.63 E-value: 4.57e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 15 NVLVTSALPYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIY 94
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVL-ADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 95 EWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLadrfvegecslcgyndargdqcdkcgnl 174
Cdd:cd00814 80 KWLNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFL---------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 175 ldplepepeagnakpdddiaakatgwlinprckldgakPDKKQTKHLFLRLDALKEPLIDWFKKaSTEGAWSTSAQTITQ 254
Cdd:cd00814 132 --------------------------------------PEWREEEHYFFRLSKFQDRLLEWLEK-NPDFIWPENARNEVL 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 255 AWIDKGLKPRGITRDL-KWGVPVPtdvtgeDYAAKVFYVWFDACIGYVSITKNYTDgadlagKKWEQWWKNPDEVKLYQF 333
Cdd:cd00814 173 SWLKEGLKDLSITRDLfDWGIPVP------LDPGKVIYVWFDALIGYISATGYYNE------EWGNSWWWKDGWPELVHF 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 334 LGKDNVQFHSTVFPASQLGTneNWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETGvPSDVWRYYLLSRRPETSDS 413
Cdd:cd00814 241 IGKDIIRFHAIYWPAMLLGA--GLPLPTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERY-GADALRYYLLRERPEGKDS 317
|
..
gi 302417150 414 EF 415
Cdd:cd00814 318 DF 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
6-603 |
0e+00 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 746.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 6 PILPVKGKNNVLVTSALPYVNNTPHLGNVIGSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRK 85
Cdd:PLN02610 9 PKLPIPGKRNILITSALPYVNNVPHLGNIIGCVLSADVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 86 YHAVHKGIYEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGEC--SLCGYNDA 163
Cdd:PLN02610 89 YHAIHKEVYDWFDISFDKFGRTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGTCptEGCNYDSA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 164 RGDQCDKCGNLLDPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEG 243
Cdd:PLN02610 169 RGDQCEKCGKLLNPTE---------------------LIDPKCKVCKNTPRIRDTDHLFLELPLLKDKLVEYINETSVAG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 244 AWSTSAQTITQAWIDKGLKPRGITRDLKWGVPVPTdvtgEDYAAKVFYVWFDACIGYVSITKNYTdgadlagKKWEQWWK 323
Cdd:PLN02610 228 GWSQNAIQTTNAWLRDGLKPRCITRDLKWGVPVPL----EKYKDKVFYVWFDAPIGYVSITACYT-------PEWEKWWK 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 324 NPDEVKLYQFLGKDNVQFHSTVFPASQLGTNENWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETGVPSDVWRYYL 403
Cdd:PLN02610 297 NPENVELYQFMGKDNVPFHTVMFPSTLLGTGENWTMMKTISVTEYLNYEGGKFSKSKGVGVFGNDAKDTNIPVEVWRYYL 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 404 LSRRPETSDSEFMWQELVDGNNNELLKNLGNFCQRVIKF----AQAKLDTTVPDYTKFGLNDYLKNHVKEVNVNLKEYIA 479
Cdd:PLN02610 377 LTNRPEVSDTLFTWADLQAKLNSELLNNLGNFINRVLSFiakpPGAGYGSVIPDAPGAESHPLTKKLAEKVGKLVEQYVE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 480 NMEGTKFRDGLRSILSISALGNKLLQDNKLdNKLLTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEP- 558
Cdd:PLN02610 457 AMEKVKLKQGLKTAMSISSEGNAYLQESQF-WKLYKEDKPSCAIVVKTSVGLVYLLACLLEPFMPSFSKEVLKQLNLPPe 535
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 302417150 559 TPTIPDE--WVTGAIKP------GQKLGEAKHLFSQIPASKIEEWREAFGGEE 603
Cdd:PLN02610 536 SLSLSDEkgEVARAKRPwelvpaGHKIGTPEPLFKELKDEEVEAYREKFAGSQ 588
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
14-595 |
0e+00 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 570.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 14 NNVLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGI 93
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLY-TYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 94 YEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGN 173
Cdd:COG0143 80 FEKLGISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDRYVEGTCPKCGAEDAYGDQCENCGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 174 LLDPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKkasTEGAWSTSAQTIT 253
Cdd:COG0143 160 TLEPTE---------------------LINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIE---ENPDIQPEVRNEV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 254 QAWIDKGLKPRGITRDLKWGVPVPTDvtgEDyaaKVFYVWFDACIGYVSITKNYTDGADLAGkKWEQWWKNPDeVKLYQF 333
Cdd:COG0143 216 LSWLKEGLQDLSISRDFDWGIPVPGD---PG---KVFYVWFDALIGYISATKGYADDRGLPE-DFEKYWPAPD-TELVHF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 334 LGKDNVQFHSTVFPASQLGTneNWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETgVPSDVWRYYLLSRRPETSDS 413
Cdd:COG0143 288 IGKDIIRFHAIIWPAMLMAA--GLPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDR-YGPDALRYYLLREVPFGQDG 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 414 EFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTKFGLNDylKNHVKEVNVNLKEYIANMEGTKFRDGLRSI 493
Cdd:COG0143 365 DFSWEDFVARVNSDLANDLGNLASRTLSMIHKYFDGKVPEPGELTEAD--EELLAEAEAALEEVAEAMEAFEFRKALEEI 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 494 LSISALGNKLLQDNK--LDNKllTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEPTPTIPDEwVTGAI 571
Cdd:COG0143 443 MALARAANKYIDETApwKLAK--DEDPERLATVLYTLLEALRILAILLKPFLPETAEKILEQLGLEGDELTWED-AGWPL 519
|
570 580
....*....|....*....|....
gi 302417150 572 KPGQKLGEAKHLFSQIPASKIEEW 595
Cdd:COG0143 520 PAGHKIGKPEPLFPRIEDEQIEAL 543
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
13-598 |
0e+00 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 560.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 13 KNNVLVTSALPYVNNTPHLGNVIGsVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKG 92
Cdd:PRK00133 1 MRKILVTCALPYANGPIHLGHLVE-YIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEELIARYHAEHKR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 93 IYEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCG 172
Cdd:PRK00133 80 DFAGFGISFDNYGSTHSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLPDRFVKGTCPKCGAEDQYGDNCEVCG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 173 NLLDPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFkkaSTEGAWSTSAQTI 252
Cdd:PRK00133 160 ATYSPTE---------------------LINPKSAISGATPVLKESEHFFFKLPRFEEFLKEWI---TRSGELQPNVANK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 253 TQAWIDKGLKPRGITRDLKW-GVPVPtDVTGedyaaKVFYVWFDACIGYVSITKNYTDgaDLAGKKWEQWWKNPDEVKLY 331
Cdd:PRK00133 216 MKEWLEEGLQDWDISRDAPYfGFEIP-GAPG-----KVFYVWLDAPIGYISSTKNLCD--KRGGLDWDEYWKKDSDTELY 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 332 QFLGKDNVQFHSTVFPASQLGTneNWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETgVPSDVWRYYLLSRRPET- 410
Cdd:PRK00133 288 HFIGKDIIYFHTLFWPAMLEGA--GYRLPTNVFAHGFLTVEGAKMSKSRGTFIWARTYLDH-LDPDYLRYYLAAKLPETi 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 411 SDSEFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDytkfglNDYLKNHVKEVNVNLKEYIANMEGTKFRDGL 490
Cdd:PRK00133 365 DDLDFNWEDFQQRVNSELVGKVVNFASRTAGFINKRFDGKLPD------ALADPELLEEFEAAAEKIAEAYEAREFRKAL 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 491 RSILSISALGNKLLQDNKlDNKLLTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEPTptipdEW-VTG 569
Cdd:PRK00133 439 REIMALADFANKYVDDNE-PWKLAKQDGERLQAVCSVGLNLFRALAIYLKPVLPELAERAEAFLNLEEL-----TWdDAQ 512
|
570 580
....*....|....*....|....*....
gi 302417150 570 AIKPGQKLGEAKHLFSQIPASKIEEWREA 598
Cdd:PRK00133 513 QPLAGHPINKFKILFTRIEDKQIEALIEA 541
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
16-587 |
0e+00 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 556.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 16 VLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYE 95
Cdd:TIGR00398 1 ILITTALPYANGKPHLGHAY-TTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTPKELVDKYHEEFKDDWK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 96 WFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGNLL 175
Cdd:TIGR00398 80 WLNISFDRFIRTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPDRYVEGTCPKCGSEDARGDHCEVCGRHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 176 DPlepepeagnakpdddiaakatGWLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEGAWSTSAQTITQA 255
Cdd:TIGR00398 160 EP---------------------TELINPRCKICGAKPELRDSEHYFFRLSAFEKELEEWIRKNPESGSPASNVKNKAQN 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 256 WIDKGLKPRGITRDLK-WGVPVPTDvtgedyAAKVFYVWFDACIGYVS---ITKNYTdgadlagKKWEQWWKNPDEVKLY 331
Cdd:TIGR00398 219 WLKGGLKDLAITRDLVyWGIPVPND------PNKVVYVWFDALIGYISslgILSGDT-------EDWKKWWNNDEDAELI 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 332 QFLGKDNVQFHSTVFPASQLGTNenWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQEtGVPSDVWRYYLLSRRPETS 411
Cdd:TIGR00398 286 HFIGKDIVRFHTIYWPAMLMGLG--LPLPTQVFSHGYLTVEGGKMSKSLGNVVDPSDLLA-RFGADILRYYLLKERPLGK 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 412 DSEFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTKfgLNDYLKNHVKEVNVNLKEYIANMEGTKFRDGLR 491
Cdd:TIGR00398 363 DGDFSWEDFVERVNADLANKLGNLLNRTLGFIKKYFNGVLPSEDI--TDEEDKKLLKLINEALEQIDEAIESFEFRKALR 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 492 SILSISALGNKLLQDNKlDNKLLTEEPdRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEptptipDEWVT-GA 570
Cdd:TIGR00398 441 EIMKLADRGNKYIDENK-PWELFKQSP-RLKELLAVCSMLIRVLSILLYPIMPKLSEKILKFLNFE------LEWDFkLK 512
|
570
....*....|....*..
gi 302417150 571 IKPGQKLGEAKHLFSQI 587
Cdd:TIGR00398 513 LLEGHKLNKAEPLFSKI 529
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
16-439 |
0e+00 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 532.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 16 VLVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYE 95
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLY-SYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 96 WFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGECSLCGYNDARGDQCDKCGNLL 175
Cdd:pfam09334 80 KFNISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTCPHCGSEDARGDQCENCGRHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 176 DPLEpepeagnakpdddiaakatgwLINPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFKKASTEgaWSTSAQTITQA 255
Cdd:pfam09334 160 EPTE---------------------LINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPE--WPENVKNMVLE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 256 WIDKGLKPRGITRDLKWGVPVPtdvtgeDYAAKVFYVWFDACIGYVSITKNYTDgadlAGKKWEQWWKNPDEVKLYQFLG 335
Cdd:pfam09334 217 WLKEGLKDRAISRDLDWGIPVP------GAEGKVFYVWLDAPIGYISATKELSG----NEEKWKEWWPNDPDTELVHFIG 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 336 KDNVQFHSTVFPASQLGtnENWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETgVPSDVWRYYLLSRRPETSDSEF 415
Cdd:pfam09334 287 KDIIYFHTIFWPAMLLG--AGYRLPTTVFAHGYLTYEGGKMSKSRGNVVWPSEALDR-FPPDALRYYLARNRPETKDTDF 363
|
410 420
....*....|....*....|....
gi 302417150 416 MWQELVDGNNNELLKNLGNFCQRV 439
Cdd:pfam09334 364 SWEDFVERVNSELADDLGNLVNRV 387
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
15-415 |
4.57e-143 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 419.63 E-value: 4.57e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 15 NVLVTSALPYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIY 94
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVL-ADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 95 EWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLadrfvegecslcgyndargdqcdkcgnl 174
Cdd:cd00814 80 KWLNISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFL---------------------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 175 ldplepepeagnakpdddiaakatgwlinprckldgakPDKKQTKHLFLRLDALKEPLIDWFKKaSTEGAWSTSAQTITQ 254
Cdd:cd00814 132 --------------------------------------PEWREEEHYFFRLSKFQDRLLEWLEK-NPDFIWPENARNEVL 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 255 AWIDKGLKPRGITRDL-KWGVPVPtdvtgeDYAAKVFYVWFDACIGYVSITKNYTDgadlagKKWEQWWKNPDEVKLYQF 333
Cdd:cd00814 173 SWLKEGLKDLSITRDLfDWGIPVP------LDPGKVIYVWFDALIGYISATGYYNE------EWGNSWWWKDGWPELVHF 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 334 LGKDNVQFHSTVFPASQLGTneNWTKVHKISATEYLNYEGGKFSKSRGVGVFGNQVQETGvPSDVWRYYLLSRRPETSDS 413
Cdd:cd00814 241 IGKDIIRFHAIYWPAMLLGA--GLPLPTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERY-GADALRYYLLRERPEGKDS 317
|
..
gi 302417150 414 EF 415
Cdd:cd00814 318 DF 319
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
18-587 |
1.51e-83 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 272.53 E-value: 1.51e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 18 VTSALPYVNNTPHLGNViGSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYEWF 97
Cdd:PRK11893 5 ITTPIYYPNGKPHIGHA-YTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWEAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 98 NLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPvhhsfladrfvegecslcgyndargdqcdKCGNLLDP 177
Cdd:PRK11893 84 NISYDDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCV-----------------------------RCEEFYTE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 178 lepepeagnakpdDDIAAKatgwliNPRCKLDGAKPDKKQTKHLFLRLDALKEPLIDWFkKASTEGAWSTSAQTITQAWI 257
Cdd:PRK11893 135 -------------SELIED------GYRCPPTGAPVEWVEEESYFFRLSKYQDKLLELY-EANPDFIQPASRRNEVISFV 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 258 DKGLKPRGITR-DLKWGVPVPTDvtgEDYaakVFYVWFDACIGYVSiTKNYTDGADLAGKKWEQWWknPDEVklyQFLGK 336
Cdd:PRK11893 195 KSGLKDLSISRtNFDWGIPVPGD---PKH---VIYVWFDALTNYLT-ALGYPDDEELLAELFNKYW--PADV---HLIGK 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 337 DNVQFHSTVFPA--SQLG--------TNENWTKvhkisateylnyEGGKFSKSRG--VGVFgNQVQETGVpsDVWRYYLL 404
Cdd:PRK11893 263 DILRFHAVYWPAflMAAGlplpkrvfAHGFLTL------------DGEKMSKSLGnvIDPF-DLVDEYGV--DAVRYFLL 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 405 SRRPETSDSEFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTKFGLNDylKNHVKEVNVNLKEYIANMEGT 484
Cdd:PRK11893 328 REIPFGQDGDFSREAFINRINADLANDLGNLAQRTLSMIAKNFDGKVPEPGALTEAD--EALLEAAAALLERVRAAMDNL 405
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 485 KFRDGLRSILSISALGNKLLQDNKLDNkLLTEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEPTPTIP- 563
Cdd:PRK11893 406 AFDKALEAILALVRAANKYIDEQAPWS-LAKTDPERLATVLYTLLEVLRGIAVLLQPVMPELAAKILDQLGVEEDENRDf 484
|
570 580
....*....|....*....|....
gi 302417150 564 DEWVTGAIKPGQKLGEAKHLFSQI 587
Cdd:PRK11893 485 AALSWGRLAPGTTLPKPEPIFPRL 508
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
13-587 |
1.26e-46 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 175.37 E-value: 1.26e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 13 KNNVLVTSALPYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKG 92
Cdd:PRK12267 3 KKTFYITTPIYYPNGKPHIGHAYTTIA-ADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 93 IYEWFNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYI--EERETtqpfcpvHHSFLADRFVegecslcgyndargdqcdk 170
Cdd:PRK12267 82 LWKKLDISYDKFIRTTDERHKKVVQKIFEKLYEQGDIykGEYEG-------WYCVSCETFF------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 171 cgnlldpLEPEPEAGNAKPDDdiaakatgwlinprckldGAKPDKKQTKHLFLRLDALKEPLIDWFKK-------AS--T 241
Cdd:PRK12267 136 -------TESQLVDGGKCPDC------------------GREVELVKEESYFFRMSKYQDRLLEYYEEnpdfiqpESrkN 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 242 EgawstsaqtITQAWIDKGLKPRGITRD-LKWGVPVPTDvtgEDYaakVFYVWFDACIGYVSITKNYTDGADLAGKKWeq 320
Cdd:PRK12267 191 E---------MINNFIKPGLEDLSISRTsFDWGIPVPFD---PKH---VVYVWIDALLNYITALGYGSDDDELFKKFW-- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 321 wwknPDEVklyQFLGKDNVQFHSTVFPA----------SQLGtnenwtkVHKisateYLNYEGGKFSKSRG--------V 382
Cdd:PRK12267 254 ----PADV---HLVGKDILRFHAIYWPImlmalglplpKKVF-------AHG-----WWLMKDGKMSKSKGnvvdpeelV 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 383 GVFGNqvqetgvpsDVWRYYLLSRRPETSDSEFMWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTTVP---DYTKFgl 459
Cdd:PRK12267 315 DRYGL---------DALRYYLLREVPFGSDGDFSPEALVERINSDLANDLGNLLNRTVAMINKYFDGEIPapgNVTEF-- 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 460 NDYLKNHVKEVnvnLKEYIANMEGTKFRDGLRSILSISALGNKLLQDN------KLDNKllteePDRCAAIIGLALNQIA 533
Cdd:PRK12267 384 DEELIALAEET---LKNYEELMEELQFSRALEEVWKLISRANKYIDETapwvlaKDEGK-----KERLATVMYHLAESLR 455
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 302417150 534 LIASILNPYMPVTSKAIFEQLGVEPTPTIPDEWVT-GAIKPGQKLGEAKHLFSQI 587
Cdd:PRK12267 456 KVAVLLSPFMPETSKKIFEQLGLEEELTSWESLLEwGGLPAGTKVAKGEPLFPRI 510
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
424-554 |
1.85e-33 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 124.52 E-value: 1.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 424 NNNELLKNLGNFCQRVIKFAQAKLDTTVPDYTkfGLNDYLKNHVKEVNVNLKEYIANMEGTKFRDGLRSILSISALGNKL 503
Cdd:cd07957 1 INSELANNLGNLVNRTLNMASKYFGGVVPEFG--GLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARAANKY 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 302417150 504 LQDNKlDNKLL-TEEPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQL 554
Cdd:cd07957 79 IDETA-PWKLAkEEDPERLATVLYVLLELLRILAILLSPFMPETAEKILDQL 129
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
17-587 |
1.80e-32 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 133.30 E-value: 1.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 17 LVTSALPYVNNTPHLGNVIgSVLSADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYEW 96
Cdd:PLN02224 72 VLTTPLYYVNAPPHMGSAY-TTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYRTLWKD 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 97 FNLSFDIFGRTPTEQQTEIVQDIFRKLWQNGYIEERettqpfcpvhhsfladrfvegecslcgynDARGDQCDKCGNLLD 176
Cdd:PLN02224 151 LDIAYDKFIRTTDPKHEAIVKEFYARVFANGDIYRA-----------------------------DYEGLYCVNCEEYKD 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 177 plEPEPEAGNAKPDDDIAAKAtgwlinprckldgakpdkKQTKHLFLRLDALKEPLIDWFKKASTEGAWSTSAQTItQAW 256
Cdd:PLN02224 202 --EKELLENNCCPVHQMPCVA------------------RKEDNYFFALSKYQKPLEDILAQNPRFVQPSYRLNEV-QSW 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 257 IDKGLKPRGITRDL-KWGVPVPTDvtgedyAAKVFYVWFDACIGYVSITKNYTDGADLAGKKWEQWwknPDEVKLyqfLG 335
Cdd:PLN02224 261 IKSGLRDFSISRALvDWGIPVPDD------DKQTIYVWFDALLGYISALTEDNKQQNLETAVSFGW---PASLHL---IG 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 336 KDNVQFHSTVFPASQLGTNENWTKVhkISATEYLNYEGGKFSKSRGVGVFGNQVQETGVPsDVWRYYLLSRRPETSDSEF 415
Cdd:PLN02224 329 KDILRFHAVYWPAMLMSAGLELPKM--VFGHGFLTKDGMKMGKSLGNTLEPFELVQKFGP-DAVRYFFLREVEFGNDGDY 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 416 MWQELVDGNNNELLKNLGNFCQRVIKFAQAKLDTT-VPDYTKFGLNDYLKNHVKEVnvnLKEYIANMEGTKFRDGLRSIL 494
Cdd:PLN02224 406 SEDRFIKIVNAHLANTIGNLLNRTLGLLKKNCESTlVEDSTVAAEGVPLKDTVEKL---VEKAQTNYENLSLSSACEAVL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 495 SISALGNKLLqDNKLDNKLLTE---EPDRCAAIIGLALNQIALIASILNPYMPVTSKAIFEQLGVEPTPTIPDEWVT--- 568
Cdd:PLN02224 483 EIGNAGNTYM-DQRAPWFLFKQggvSAEEAAKDLVIILEVMRVIAVALSPIAPCLSLRIYSQLGYSEDQFNSITWSDtkw 561
|
570
....*....|....*....
gi 302417150 569 GAIKPGQKLGEAKHLFSQI 587
Cdd:PLN02224 562 GGLKGGQVMEQASPVFARI 580
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
17-415 |
3.24e-27 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 112.51 E-value: 3.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 17 LVTSALPYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETKALEEGV-------------DPETLC 83
Cdd:cd00668 3 YVTTPPPYANGSLHLGHALTHII-ADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGrkkktiwieefreDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 84 RKYHAVHKGIYEWFNLSFDI--FGRTPTEQQTEIVQDIFRKLWQNGYIeerettqpfcpvhhsfladrfvegecslcgYN 161
Cdd:cd00668 82 EEMSGEHKEDFRRLGISYDWsdEYITTEPEYSKAVELIFSRLYEKGLI------------------------------YR 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 162 DARgdqcdkcgnlldPLEPEPeagnakpdddiaakatgwlinprckldgakpdkkqtkHLFLRLDALKEPLIDWFKkast 241
Cdd:cd00668 132 GTH------------PVRITE-------------------------------------QWFFDMPKFKEKLLKALR---- 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 242 EGAW-STSAQTITQAWIDKGLKpRGITRDLKWGVPVPTDvtgedyaakVFYVWFDACIGYVSITKNYTDGADLagkkwEQ 320
Cdd:cd00668 159 RGKIvPEHVKNRMEAWLESLLD-WAISRQRYWGTPLPED---------VFDVWFDSGIGPLGSLGYPEEKEWF-----KD 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 321 WWKnpdevKLYQFLGKDNVQFHSTVFPASQLGTN-ENWTK---VHKISATEylnyEGGKFSKSRG-VGVFGNQVQETGVp 395
Cdd:cd00668 224 SYP-----ADWHLIGKDILRGWANFWITMLVALFgEIPPKnllVHGFVLDE----GGQKMSKSKGnVIDPSDVVEKYGA- 293
|
410 420
....*....|....*....|
gi 302417150 396 sDVWRYYLLSRRPETSDSEF 415
Cdd:cd00668 294 -DALRYYLTSLAPYGDDIRL 312
|
|
| Anticodon_3 |
pfam19303 |
Anticodon binding domain of methionyl tRNA ligase; This domain is found in methionyl tRNA ... |
469-601 |
3.21e-12 |
|
Anticodon binding domain of methionyl tRNA ligase; This domain is found in methionyl tRNA ligase. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 437135 [Multi-domain] Cd Length: 152 Bit Score: 64.83 E-value: 3.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 469 EVNVNLKEYIANMEGTKFRDG---LRSILsisALGNKLLQDN------KLDnkllteePDRCAAIIGLALNQIALIASIL 539
Cdd:pfam19303 17 DLTTRLAAYEGHMEAMEVRKAaaeLRAIW---VAGNEYLQEAapwttfKTD-------PEAAAAQVRLALNLIRLYAVLS 86
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302417150 540 NPYMPVTSKAIFEQLGVEPTPtipdeWVT------GAIKPGQKLGEAKHLFSQIPASKIEEWREAFGG 601
Cdd:pfam19303 87 APFIPDAAAAMLAAMGTDDAA-----WPDdvaaalTALPAGHAFTVPEVLFAKITDEQREEWQERFAG 149
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
18-133 |
1.73e-07 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 53.41 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 18 VTSALPYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRKYHAVHKGIYEWF 97
Cdd:cd00812 4 ILVMFPYPSGALHVGHVRTYTI-GDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLKRM 82
|
90 100 110
....*....|....*....|....*....|....*....
gi 302417150 98 NLSFDiFGR---TPTEQQTEIVQDIFRKLWQNGYIEERE 133
Cdd:cd00812 83 GFSYD-WRReftTCDPEYYKFTQWLFLKLYEKGLAYKKE 120
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
23-320 |
4.16e-07 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 52.63 E-value: 4.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 23 PYVNNTPHLGNVIGSVLsADVFARFSRARGNPTIFICGSDEYGTATETK-----ALEEG----VDPETLCRKYHAV---- 89
Cdd:cd00817 10 PNVTGSLHMGHALNNTI-QDIIARYKRMKGYNVLWPPGTDHAGIATQVVvekklGIEGKtrhdLGREEFLEKCWEWkees 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 90 HKGIYEWFN---LSFDiFGR---TPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVegecslcgynda 163
Cdd:cd00817 89 GGKIREQLKrlgASVD-WSReyfTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 164 rgdqCDKCGnllDPLEPEPEagnakpdddiaakaTGWLINPRCKLDGAkpdkkqtkhlflrLDALKEPLIDWF-KKASTE 242
Cdd:cd00817 156 ----CSRSG---DVIEPLLK--------------PQWFVKVKDLAKKA-------------LEAVKEGDIKFVpERMEKR 201
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302417150 243 gaWStsaqtitqAWIdKGLKPRGITRDLKWGVPVPtdvtgedyaakvfyVWFDACIGYVSITKNYTDGADLAGKKWEQ 320
Cdd:cd00817 202 --YE--------NWL-ENIRDWCISRQLWWGHRIP--------------AWYCKDGGHWVVAREEDEAIDKAAPEACV 254
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
23-152 |
2.10e-06 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 51.21 E-value: 2.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 23 PYVNNTPHLGNVIGSVLSaDVFARFSRARGNPTIFICGSDEYGTATETK----ALEEGVDPETLCRkyHAVHKGIYEWFN 98
Cdd:TIGR00422 42 PNVTGSLHIGHALNWSIQ-DIIARYKRMKGYNVLWLPGTDHAGIATQVKvekkLGAEGKTKHDLGR--EEFREKIWEWKE 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 99 LSFDIFGR----------------TPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVE 152
Cdd:TIGR00422 119 ESGGTIKNqikrlgasldwsrerfTMDEGLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVE 188
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
23-154 |
4.14e-04 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 43.83 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 23 PYVNNTPHLGNVIGSVLSaDVFARFSRARGNPTIFICGSDEYGTATETKALEEGVDPETLCRK---YHAVHKGIYEW--- 96
Cdd:PRK14900 57 PNVTGSLHLGHALTATLQ-DVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHdlgREAFLERVWAWkeq 135
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302417150 97 -----------FNLSFDiFGR---TPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVEGE 154
Cdd:PRK14900 136 ygsrigeqhkaLGASLD-WQRerfTMDEGLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHE 206
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
23-96 |
2.20e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 41.46 E-value: 2.20e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 302417150 23 PYVNNTPHLGNVIGSVLSaDVFARFSRARGNPTIFICGSDEYGTAT----ETKALEEGVDPETLCRKyhAVHKGIYEW 96
Cdd:PLN02943 97 PNVTGSLHMGHAMFVTLE-DIMVRYNRMKGRPTLWIPGTDHAGIATqlvvEKMLASEGIKRTDLGRD--EFTKRVWEW 171
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
23-152 |
2.35e-03 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 41.24 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 23 PYVNNTPHLGNVIGSVLSaDVFARFSRARGNPTIFICGSDEYGTATETK-----ALEEGVDPETL--------CRK---- 85
Cdd:pfam00133 32 PNATGSLHIGHALAKTLK-DIVIRYKRMKGYYVLWVPGWDHHGLPTEQVvekklGIKEKKTRHKYgreefrekCREwkme 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302417150 86 YHAVHKGIYEWFNLSFDiFGR---TPTEQQTEIVQDIFRKLWQNGYIEERETTQPFCPVHHSFLADRFVE 152
Cdd:pfam00133 111 YADEIRKQFRRLGRSID-WDReyfTMDPELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVE 179
|
|
| |
