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Conserved domains on  [gi|1387196373|ref|XP_002690982|]
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solute carrier family 12 member 1 isoform X3 [Bos taurus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1506.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  339 ANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  418 AIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  658 LSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  818 GFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkagklniTKPTPKKDSSINTIQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQV------------------QEELENDCS---------------EDSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  898 ASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVI 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  977 GDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1387196373 1056 SLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1506.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  339 ANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  418 AIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  658 LSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  818 GFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkagklniTKPTPKKDSSINTIQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQV------------------QEELENDCS---------------EDSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  898 ASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVI 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  977 GDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1387196373 1056 SLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
694-1099 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 599.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  694 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 773
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  774 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQ-VQEELEKLEQERLALEATIKDNESEE 852
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  853 GNGGIRGLFKKAGKLNITKPTPKKDSsiNTIQSMHVGEFNQKLV------------------EASTQFKKKQGKGTIDVW 914
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS--TKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKKGTIDVW 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  915 WLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEE 993
Cdd:pfam03522  237 WLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  994 MIEPYCLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAW 1073
Cdd:pfam03522  317 LIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAW 388
                          410       420
                   ....*....|....*....|....*.
gi 1387196373 1074 LEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:pfam03522  389 LETLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
190-649 4.05e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 145.81  E-value: 4.05e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  190 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 269
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  270 VAVAMYVVGFAETVVDLLketdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLiaianFFIGTVIps 349
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFI-- 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  350 nnekrARGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGV 429
Cdd:COG0531    167 -----VVGLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  430 AICVGACVVRDATGSVNDTIisgmncngsaacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 507
Cdd:COG0531    241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  508 ALASLVSAPKVFQALCKDNIykALQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNTIAPIISNFFLASYALINFS 585
Cdd:COG0531    288 LNASILGASRLLYAMARDGL--LPKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387196373  586 CFHASYaKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWA---AVITYVIEFFLYIYVTYKKPDV 649
Cdd:COG0531    366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
104-1099 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1506.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  104 NTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAEN----KGEDQAGAVKFGW 179
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  180 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 259
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  260 IGLIFAFANAVAVAMYVVGFAETVVDLLKETDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAI 338
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  339 ANFFIGTVIPSNNeKRARGFFNYQASIFAENFGPSFTKGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTML 417
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  418 AIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmnCNGSAACglgydFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLA 577
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  578 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQA 657
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  658 LSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ 817
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  818 GFDISqVLQVqeelekleqerlaleatiKDNESEEGNggirglfkkagklniTKPTPKKDSSINTIQSMHvgefnqklVE 897
Cdd:TIGR00930  712 GLPIS-VLQV------------------QEELENDCS---------------EDSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  898 ASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVI 976
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  977 GDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAE-KLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1055
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 1387196373 1056 SLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
694-1099 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 599.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  694 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 773
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  774 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQ-VQEELEKLEQERLALEATIKDNESEE 852
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQdQDTEELGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  853 GNGGIRGLFKKAGKLNITKPTPKKDSsiNTIQSMHVGEFNQKLV------------------EASTQFKKKQGKGTIDVW 914
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDSNLSLSPDKS--TKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKKGTIDVW 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  915 WLFDDGGLILLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEE 993
Cdd:pfam03522  237 WLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDE 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  994 MIEPYCLHESCKDLttaeklkrETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAW 1073
Cdd:pfam03522  317 LIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAW 388
                          410       420
                   ....*....|....*....|....*.
gi 1387196373 1074 LEILTKNLPPVLLVRGNHKNVLTFYS 1099
Cdd:pfam03522  389 LETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
182-685 2.33e-125

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 391.68  E-value: 2.33e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  182 GVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGSIG 261
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  262 L------IFAFANAVAVAMYVVGFAETVVDLLKetdsmmvdptndIRIIGSITVVILLGISVAGMEWEAKAQVILLIILL 335
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPY------------LWVWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  336 IAIANFFIGTVIPSNNEKRARG--FFNYQASIFAENFGPSFTKGegFFSVFAIFFPAATGILAGANISGDLEDPQDAIPK 413
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG--FISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPK 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  414 GTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISgmncngsaacglgydfsrcrhepcqYGLMNNFQVMSMVSGFG 493
Cdd:pfam00324  226 AILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLA 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  494 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKalqFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIapIISN 573
Cdd:pfam00324  281 PLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLNPA--IVFN 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  574 FFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGS 653
Cdd:pfam00324  356 FLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGA 435
                          490       500       510
                   ....*....|....*....|....*....|..
gi 1387196373  654 STQALSYMSALDNALELTTVEDHVKNFRPQCI 685
Cdd:pfam00324  436 GSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
190-649 4.05e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 145.81  E-value: 4.05e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  190 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 269
Cdd:COG0531     25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  270 VAVAMYVVGFAETVVDLLketdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLiaianFFIGTVIps 349
Cdd:COG0531    103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKL-----LVLLLFI-- 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  350 nnekrARGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGV 429
Cdd:COG0531    167 -----VVGLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  430 AICVGACVVRDATGSVNDTIisgmncngsaacglgydfsrcrhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 507
Cdd:COG0531    241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  508 ALASLVSAPKVFQALCKDNIykALQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNTIAPIISNFFLASYALINFS 585
Cdd:COG0531    288 LNASILGASRLLYAMARDGL--LPKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387196373  586 CFHASYaKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWA---AVITYVIEFFLYIYVTYKKPDV 649
Cdd:COG0531    366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
90-157 2.33e-34

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 125.63  E-value: 2.33e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373   90 DSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNV--SVAPGSADVVANGEG 157
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSalAVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
207-644 8.87e-16

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 81.20  E-value: 8.87e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  207 AGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDL 286
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  287 LKETdsmMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPsnneKRARGFFNYqASIF 366
Cdd:pfam13520  107 LGPD---LVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNL-LSGE 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  367 AENFGPSFTKGegFFSVFAIFFPAATGILAGANISGdlEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVN 446
Cdd:pfam13520  179 WHTFFPDGWPG--VFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALSS 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  447 DTIISGmncngsaacglgydfsrcrhepcqyGLMNNFQVMSMVSGFgplITAGIFSATLSSALASLVSAPKVFQALCKDN 526
Cdd:pfam13520  255 GLGQVA-------------------------ALLFQAVGGKWGAII---VVILLALSLLGAVNTAIVGASRLLYALARDG 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387196373  527 IYKALQFFAKgYGKNNEPLRGYFLTFVIAMAFILI-----AELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRpay 601
Cdd:pfam13520  307 VLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLfllspAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGR--- 382
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1387196373  602 gIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTY 644
Cdd:pfam13520  383 -IPGRWPVAIFGILFSLFLIVALFFPPVGPATGSSLNYAIILI 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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