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Conserved domains on  [gi|268565659|ref|XP_002639512|]
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Protein CBR-LRON-11 [Caenorhabditis briggsae]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-349 4.34e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 4.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  33 KGSSLRSIPILLDPRTTILDLSNNRISRLSADELSLYPNLEQLILKNNSITHLSADVFSTLPHLRLLDLSSNSLLSLPNE 112
Cdd:COG4886   28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 113 VFSKLKNLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSvLKPLSGLKSLDLSANKLLSIPASvLSNLGGIE 192
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 193 TLKLKQNLLSSLETgMFVAQKELKLLDISENLIGDIEEgALYGLEKLETLNFTNNQLVRLPgNTWSLSSLKCLDLSSNLF 272
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 273 VSLETASfdGLPSLQYLNISHSR----NLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYL 348
Cdd:COG4886  263 TDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340


                 .
gi 268565659 349 A 349
Cdd:COG4886  341 A 341
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-349 4.34e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 4.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  33 KGSSLRSIPILLDPRTTILDLSNNRISRLSADELSLYPNLEQLILKNNSITHLSADVFSTLPHLRLLDLSSNSLLSLPNE 112
Cdd:COG4886   28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 113 VFSKLKNLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSvLKPLSGLKSLDLSANKLLSIPASvLSNLGGIE 192
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 193 TLKLKQNLLSSLETgMFVAQKELKLLDISENLIGDIEEgALYGLEKLETLNFTNNQLVRLPgNTWSLSSLKCLDLSSNLF 272
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 273 VSLETASfdGLPSLQYLNISHSR----NLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYL 348
Cdd:COG4886  263 TDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340


                 .
gi 268565659 349 A 349
Cdd:COG4886  341 A 341
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-345 2.07e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  39 SIPILLDPRTTILDLSNNRISRLSADELSLYPNLEQLILKNN--------SITHLSADVFSTLphlrlldLSSNSLLSLP 110
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnSLTNLTSLEFLTL-------ASNQLVGQIP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 111 NEVfSKLKNLKTLIISSNDVQLE-PECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLL-SIPASVLSnL 188
Cdd:PLN00113 206 REL-GQMKSLKWIYLGYNNLSGEiPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-L 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 189 GGIETLKLKQNLLSSLETGMFVAQKELKLLDI-SENLIGDIeEGALYGLEKLETLNFTNNQLV-RLPGNTWSLSSLKCLD 266
Cdd:PLN00113 284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLfSNNFTGKI-PVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLD 362

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 267 LSSNlfvSLETASFDGLPSLQYLN--ISHSRNLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNE 344
Cdd:PLN00113 363 LSTN---NLTGEIPEGLCSSGNLFklILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNN 439


                 .
gi 268565659 345 L 345
Cdd:PLN00113 440 L 440
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-270 5.78e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 112 EVFSKLKNLKTLIISSNDVQlEPECFSGLSQLHTLSLADNRLSFLPPsvLKPLSGLKSLDLSANKLlsipaSVLSNLGG- 190
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKIT-KIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-----SVVEGLENl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 191 --IETLKL-KQNL-----LSSLETGMFVAQKELKLLDISENLIGDIEEgaLYGLEKLETLNFTNNQLVRLPGNTWSLSSL 262
Cdd:cd21340   90 tnLEELHIeNQRLppgekLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSW 167

                        170
                 ....*....|.
gi 268565659 263 KCL---DLSSN 270
Cdd:cd21340  168 PSLrelDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
119-177 9.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 9.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  119 NLKTLIISSNDVQ-LEPECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKL 177
Cdd:pfam13855   2 NLRSLDLSNNRLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-349 4.34e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 4.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  33 KGSSLRSIPILLDPRTTILDLSNNRISRLSADELSLYPNLEQLILKNNSITHLSADVFSTLPHLRLLDLSSNSLLSLPNE 112
Cdd:COG4886   28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 113 VFSKLKNLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSvLKPLSGLKSLDLSANKLLSIPASvLSNLGGIE 192
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 193 TLKLKQNLLSSLETgMFVAQKELKLLDISENLIGDIEEgALYGLEKLETLNFTNNQLVRLPgNTWSLSSLKCLDLSSNLF 272
Cdd:COG4886  186 ELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 273 VSLETASfdGLPSLQYLNISHSR----NLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYL 348
Cdd:COG4886  263 TDLPPLA--NLTNLKTLDLSNNQltdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340


                 .
gi 268565659 349 A 349
Cdd:COG4886  341 A 341
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-369 3.29e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 3.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  34 GSSLRSIPILLD--PRTTILDLSNNRISRLSaDELSLYPNLEQLILKNNSITHLSadvfstlphlrlldlssnsllslpn 111
Cdd:COG4886  122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP------------------------- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 112 EVFSKLKNLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSvLKPLSGLKSLDLSANKLLSIPAsvLSNLggi 191
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNL--- 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 192 etlklkqnllssletgmfvaqKELKLLDISENLIGDIEEgaLYGLEKLETLNFTNNQLVRLPGNTWSLSSLKcLDLSSNL 271
Cdd:COG4886  250 ---------------------TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGL-NSLLLLL 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 272 FVSLETASFDGLPSLQYLNISHSRNLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYLAPG 351
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                        330
                 ....*....|....*...
gi 268565659 352 MLQWQNIRNLYLANNDWQ 369
Cdd:COG4886  386 LLTLLLLLLTTTAGVLLL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-366 1.11e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 115 SKLKNLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLLSIPASVLSNLGGIETL 194
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 195 KLKQNLLSSLETGMFVAQKeLKLLDISENLIGDIEEgALYGLEKLETLNFTNNQLVRLPGNTWSLSSLKCLDLSSNLFVS 274
Cdd:COG4886   96 TNLTELDLSGNEELSNLTN-LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 275 LeTASFDGLPSLQYLNISHSRnLKTIQmASFVQLSSLHWLSVSSSALTYIhPSAFNQIPPLSHLDLSNNELRYLaPGMLQ 354
Cdd:COG4886  174 L-PEELGNLTNLKELDLSNNQ-ITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-PELGN 248

                        250
                 ....*....|..
gi 268565659 355 WQNIRNLYLANN 366
Cdd:COG4886  249 LTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
119-366 3.37e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 119 NLKTLIISSNDVQLEPECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLLSIPASVLSNLGGIETLKLKQ 198
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 199 NLLSSLETGMFVAQKELKLLDISENligdieeGALYGLEKLETLNFTNNQLVRLPGNTWSLSSLKCLDLSSNLFVSLEtA 278
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-E 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 279 SFDGLPSLQYLNISHSRnLKTIQmASFVQLSSLHWLSVSSSALTYIhPSAFNQIPPLSHLDLSNNELRYLAPGMLQWQNI 358
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQ-LTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230


                 ....*...
gi 268565659 359 RNLYLANN 366
Cdd:COG4886  231 ETLDLSNN 238
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-345 2.07e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  39 SIPILLDPRTTILDLSNNRISRLSADELSLYPNLEQLILKNN--------SITHLSADVFSTLphlrlldLSSNSLLSLP 110
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNvlvgkipnSLTNLTSLEFLTL-------ASNQLVGQIP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 111 NEVfSKLKNLKTLIISSNDVQLE-PECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLL-SIPASVLSnL 188
Cdd:PLN00113 206 REL-GQMKSLKWIYLGYNNLSGEiPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-L 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 189 GGIETLKLKQNLLSSLETGMFVAQKELKLLDI-SENLIGDIeEGALYGLEKLETLNFTNNQLV-RLPGNTWSLSSLKCLD 266
Cdd:PLN00113 284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLfSNNFTGKI-PVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLD 362

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 267 LSSNlfvSLETASFDGLPSLQYLN--ISHSRNLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNE 344
Cdd:PLN00113 363 LSTN---NLTGEIPEGLCSSGNLFklILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNN 439


                 .
gi 268565659 345 L 345
Cdd:PLN00113 440 L 440
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-253 2.90e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 2.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  37 LRSIPILLDPRTTILDLSNNRISRLSADelsLYPNLEQLILKNNSITHLSAdvfsTLPHLRLLDLSSNSL-LSLPNEVFS 115
Cdd:PRK15370 190 LTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA----TLPDTIQEMELSINRiTELPERLPS 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 116 KLKnlkTLIISSNDVQLEPECFSglSQLHTLSLADNRLSFLPPSVlkPlSGLKSLDLSANKLLSIPASVLSNLggiETLK 195
Cdd:PRK15370 263 ALQ---SLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--P-SGITHLNVQSNSLTALPETLPPGL---KTLE 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268565659 196 LKQNLLSSLETGMfvaQKELKLLDISENLIG-------------DIEEGALYGLEK-----LETLNFTNNQLVRLP 253
Cdd:PRK15370 332 AGENALTSLPASL---PPELQVLDVSKNQITvlpetlpptittlDVSRNALTNLPEnlpaaLQIMQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-345 2.10e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 112 EVFSKLKNLKTLIISSNDVQLE-PECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLL------------ 178
Cdd:PLN00113 302 ELVIQLQNLEILHLFSNNFTGKiPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgn 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 179 -------------SIPASvLSNLGGIETLKLKQNLLSSLETGMFVAQKELKLLDISEN-LIGDIEEGAlYGLEKLETLNF 244
Cdd:PLN00113 382 lfklilfsnslegEIPKS-LGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNnLQGRINSRK-WDMPSLQMLSL 459

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 245 TNNQLV-RLPGNTWSlSSLKCLDLSSNLFVSLETASFDGLPSLQYLNISHSRNLKTI--QMASFVQLSSLhwlSVSSSAL 321
Cdd:PLN00113 460 ARNKFFgGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIpdELSSCKKLVSL---DLSHNQL 535

                        250       260
                 ....*....|....*....|....
gi 268565659 322 TYIHPSAFNQIPPLSHLDLSNNEL 345
Cdd:PLN00113 536 SGQIPASFSEMPVLSQLDLSQNQL 559
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
70-295 1.65e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  70 PNLEQLI------LKNNSiTHLSADVF--STLPHLRLLDLSSNSLLSlpNEVFSKLKNL----KTLIISSNDVQLEPECF 137
Cdd:PRK15370 163 ANREEAVqrmrdcLKNNK-TELRLKILglTTIPACIPEQITTLILDN--NELKSLPENLqgniKTLYANSNQLTSIPATL 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 138 SGLSQLHTLSLadNRLSFLPPSVlkPlSGLKSLDLSANKLLSIPASVLSnlgGIETLKLKQNLLSSLE-------TGMFV 210
Cdd:PRK15370 240 PDTIQEMELSI--NRITELPERL--P-SALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIRTLPahlpsgiTHLNV 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 211 AQKELKLLDIS-----ENLIGDieEGALYGL-----EKLETLNFTNNQLVRLPGNTwsLSSLKCLDLSSNLFVSLEtasf 280
Cdd:PRK15370 312 QSNSLTALPETlppglKTLEAG--ENALTSLpaslpPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTNLP---- 383

                        250
                 ....*....|....*.
gi 268565659 281 DGLP-SLQYLNISHSR 295
Cdd:PRK15370 384 ENLPaALQIMQASRNN 399
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-294 3.52e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  49 TILDLSNNRISRLSADELSLYPNLEQLILKNNSithLSADVFSTLphlrlldlssnsllslpnevfSKLKNLKTLIISSN 128
Cdd:PLN00113 359 TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNS---LEGEIPKSL---------------------GACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 129 DVQLE-PECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLL-SIPASVLSNlgGIETLKLKQNLLSSLET 206
Cdd:PLN00113 415 SFSGElPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSGAVP 492

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 207 GMFVAQKELKLLDISENLI-GDIEEgALYGLEKLETLNFTNNQLV-RLPGNTWSLSSLKCLDLSSNLFVSLETASFDGLP 284
Cdd:PLN00113 493 RKLGSLSELMQLKLSENKLsGEIPD-ELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVE 571

                        250
                 ....*....|
gi 268565659 285 SLQYLNISHS 294
Cdd:PLN00113 572 SLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-270 5.78e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 5.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 112 EVFSKLKNLKTLIISSNDVQlEPECFSGLSQLHTLSLADNRLSFLPPsvLKPLSGLKSLDLSANKLlsipaSVLSNLGG- 190
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKIT-KIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI-----SVVEGLENl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 191 --IETLKL-KQNL-----LSSLETGMFVAQKELKLLDISENLIGDIEEgaLYGLEKLETLNFTNNQLVRLPGNTWSLSSL 262
Cdd:cd21340   90 tnLEELHIeNQRLppgekLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDLLSSW 167

                        170
                 ....*....|.
gi 268565659 263 KCL---DLSSN 270
Cdd:cd21340  168 PSLrelDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
119-177 9.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 9.13e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  119 NLKTLIISSNDVQ-LEPECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKL 177
Cdd:pfam13855   2 NLRSLDLSNNRLTsLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 139-357 1.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 139 GLSQLHTLSLADNRLSF-LPPSVLKPLSGLKSLDLSANKLL-SIPASVLSNLggiETLKLKQNLLSS---LETGMFvaqK 213
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNL---ETLDLSNNMLSGeipNDIGSF---S 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 214 ELKLLDISEN-LIGDIEeGALYGLEKLETLNFTNNQLV-------------------------RLPGNTWSLSSLKCLDL 267
Cdd:PLN00113 165 SLKVLDLGGNvLVGKIP-NSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 268 SSNLFVSLETASFDGLPSLQYL-------------NISHSRNLKTIQMAS----------FVQLSSLHWLSVSSSALTYI 324
Cdd:PLN00113 244 VYNNLTGPIPSSLGNLKNLQYLflyqnklsgpippSIFSLQKLISLDLSDnslsgeipelVIQLQNLEILHLFSNNFTGK 323

                        250       260       270
                 ....*....|....*....|....*....|...
gi 268565659 325 HPSAFNQIPPLSHLDLSNNELRYLAPGMLQWQN 357
Cdd:PLN00113 324 IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHN 356
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-225 1.64e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  34 GSSLRSIPILLDPRT-TILDLSNNRISRLsaDELSLYPNLEQLILKNNSITHLsadvfstlphlrlldlssnsllslpnE 112
Cdd:cd21340   11 DKNITKIDNLSLCKNlKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--------------------------E 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 113 VFSKLKNLKTLIISSNDVQ----LEpecfsGLSQLHTLSLADNRL------SFLPPSVLKPLSGLKSLDLSANKLLSIpa 182
Cdd:cd21340   63 NLENLVNLKKLYLGGNRISvvegLE-----NLTNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNIDSL-- 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 268565659 183 SVLSNLGGIETLKLKQNLLSSLE--TGMFVAQKELKLLDISENLI 225
Cdd:cd21340  136 EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
260-321 2.58e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268565659  260 SSLKCLDLSSNLFVSLETASFDGLPSLQYLNISHSrNLKTIQMASFVQLSSLHWLSVSSSAL 321
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
190-249 2.90e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  190 GIETLKLKQNLLSSLETGMFVAQKELKLLDISENLIGDIEEGALYGLEKLETLNFTNNQL 249
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
141-201 3.46e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565659  141 SQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLLSIPASVLSNLGGIETLKLKQNLL 201
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
165-225 6.35e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565659  165 SGLKSLDLSANKLLSIPASVLSNLGGIETLKLKQNLLSSLETGMFVAQKELKLLDISENLI 225
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
238-295 7.08e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 268565659  238 KLETLNFTNNQLVRLPGNTWS-LSSLKCLDLSSNLFVSLETASFDGLPSLQYLNISHSR 295
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
214-272 7.73e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 7.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  214 ELKLLDISENLIGDIEEGALYGLEKLETLNFTNNQLVRLPGNTWS-LSSLKCLDLSSNLF 272
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
284-345 1.69e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268565659  284 PSLQYLNISHSRnLKTIQMASFVQLSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNEL 345
Cdd:pfam13855   1 PNLRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 43-249 6.92e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 6.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  43 LLDPRTTILDLSNNRIS----RLSADELSLYPNLEQLILKNNSITHLSADVFStlphlrlldlssnsllslpnEVFSKLK 118
Cdd:COG5238  177 LQNNSVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIGDEGAEILA--------------------EALKGNK 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 119 NLKTLIISSNdvQLEPECFSGL-------SQLHTLSLADNRLS----FLPPSVLKPLSGLKSLDLSANKLLSIPASVLSN 187
Cdd:COG5238  237 SLTTLDLSNN--QIGDEGVIALaealknnTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 188 L----GGIETLKLKQN---------LLSSLETGmfvaqKELKLLDISENLIGDieEGA------LYGLEKLETLNFTNNQ 248
Cdd:COG5238  315 GlqgnKTLHTLNLAYNgigaqgaiaLAKALQEN-----TTLHSLDLSDNQIGD--EGAialakyLEGNTTLRELNLGKNN 387


                 .
gi 268565659 249 L 249
Cdd:COG5238  388 I 388
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-366 1.21e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 140 LSQLHTLSLADNRLSFLPpsVLKPLSGLKSLDLSANKLLSIPAsvLSNLGGIETLKLKQNLLSSLEtgMFVAQKELKLLD 219
Cdd:cd21340    1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 220 ISENLIGDIEegALYGLEKLETLNFtNNQlvRLPGNTwslsslkCLDLSSNLFVSLetasfdgLPSLQYLNISHSRnlkt 299
Cdd:cd21340   75 LGGNRISVVE--GLENLTNLEELHI-ENQ--RLPPGE-------KLTFDPRSLAAL-------SNSLRVLNISGNN---- 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 300 iqmasfvqLSSLHWLSVsssaLTYihpsafnqippLSHLDLSNNELR---YLAPGMLQWQNIRNLYLANN 366
Cdd:cd21340  132 --------IDSLEPLAP----LRN-----------LEQLDASNNQISdleELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
309-367 2.95e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  309 SSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYLAPGMLQ-WQNIRNLYLANND 367
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
46-95 1.30e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 268565659   46 PRTTILDLSNNRISRLSADELSLYPNLEQLILKNNSITHLSADVFSTLPH 95
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS 50
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 50-227 1.60e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  50 ILDLSNNRIS----RLSADEL-SLYPNLEQLILKNNSITHLSADVFStlphlrlldlssnsllslpnEVFSKLKNLKTLI 124
Cdd:cd00116  112 ELKLNNNGLGdrglRLLAKGLkDLPPALEKLVLGRNRLEGASCEALA--------------------KALRANRDLKELN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 125 ISSNDVQLEpecfsglsQLHTLSLAdnrlsflppsvLKPLSGLKSLDLSANKLLSIPAS----VLSNLGGIETLKLKQNL 200
Cdd:cd00116  172 LANNGIGDA--------GIRALAEG-----------LKANCNLEVLDLNNNGLTDEGASalaeTLASLKSLEVLNLGDNN 232

                        170       180       190
                 ....*....|....*....|....*....|..
gi 268565659 201 LSS-----LETGMFVAQKELKLLDISENLIGD 227
Cdd:cd00116  233 LTDagaaaLASALLSPNISLLTLSLSCNDITD 264
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 118-270 2.09e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 118 KNLKTLIISSND-------VQLEPECFSGLSQLHTLSLADNRLSFLPPSVLK---------------------------- 162
Cdd:cd00116   51 PSLKELCLSLNEtgriprgLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLEsllrssslqelklnnnglgdrglrllak 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 163 ----PLSGLKSLDLSANKLLSIP----ASVLSNLGGIETLKLKQNLLS-----SLETGmFVAQKELKLLDISENLIGDIE 229
Cdd:cd00116  131 glkdLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdagirALAEG-LKANCNLEVLDLNNNGLTDEG 209

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 268565659 230 EGALYG----LEKLETLNFTNNQLVR------LPGNTWSLSSLKCLDLSSN 270
Cdd:cd00116  210 ASALAEtlasLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCN 260
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 218-367 4.72e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 4.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 218 LDIS-ENLIGDIEEgALYGLEKLETLNFTNNQLV-RLPGNTWSL-SSLKCLDLSSNLFVSLETASFdgLPSLQYLNISHS 294
Cdd:PLN00113  74 IDLSgKNISGKISS-AIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN 150

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 268565659 295 RNLKTI--QMASFvqlSSLHWLSVSSSALTYIHPSAFNQIPPLSHLDLSNNELRYLAPGML-QWQNIRNLYLANND 367
Cdd:PLN00113 151 MLSGEIpnDIGSF---SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELgQMKSLKWIYLGYNN 223
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 215-329 7.46e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 7.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  215 LKLLDISENLIgDIEEGALYGLEKLETLNFTNNqLVRLPGNTWSLSSLKCLDLSSNLfVSLETASFDGLPSLQYLNIshS 294
Cdd:pfam13306  13 LTSITIPSSLT-SIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCSLTSITIPSSL-TSIGEYAFSNCSNLKSITL--P 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 268565659  295 RNLKTIQMASFVQlSSLHWLSVSSSaLTYIHPSAF 329
Cdd:pfam13306  88 SNLTSIGSYAFSN-CSLKSITIPSS-VTTIGSYAF 120
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 46-233 1.57e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  46 PRTTILDLSNNRISR----LSADELSLYPNLEQLILKNNSITHLSADVFSTLphlrlldlssnsllslpnevFSKLKNLK 121
Cdd:COG5238  236 KSLTTLDLSNNQIGDegviALAEALKNNTTVETLYLSGNQIGAEGAIALAKA--------------------LQGNTTLT 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 122 TLIISSNDVQLE-----PECFSGLSQLHTLSLADNRLS-----FLPPSvLKPLSGLKSLDLSANKLLSIPASVLSNL--- 188
Cdd:COG5238  296 SLDLSVNRIGDEgaialAEGLQGNKTLHTLNLAYNGIGaqgaiALAKA-LQENTTLHSLDLSDNQIGDEGAIALAKYleg 374

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 268565659 189 -GGIETLKLKQN---------LLSSLETGmfvaqkELKLLDISENLIGDIEEGAL 233
Cdd:COG5238  375 nTTLRELNLGKNnigkqgaeaLIDALQTN------RLHTLILDGNLIGAEAQQRL 423
PLN03150 PLN03150
hypothetical protein; Provisional
 134-202 1.61e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659 134 PECFSGLSQLHTLSLADNRLSFLPPSVLKPLSGLKSLDLSANKLL-SIPASvLSNLGGIETLKLKQNLLS 202
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPES-LGQLTSLRILNLNGNSLS 503
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-189 1.82e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.22  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  35 SSLRSIPILLDPRTTILDLSNNRISRLSAdelSLYPNLEQLILKNNSIThlsadvfstlphlrlldlssnsllSLPNEVF 114
Cdd:PRK15370 293 NSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALT------------------------SLPASLP 345

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 268565659 115 SKLKNLKtliISSNDVQLEPECFSglSQLHTLSLADNRLSFLPPSVlkPlSGLKSLDLSANKLLSIPASVLSNLG 189
Cdd:PRK15370 346 PELQVLD---VSKNQITVLPETLP--PTITTLDVSRNALTNLPENL--P-AALQIMQASRNNLVRLPESLPHFRG 412
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 44-177 6.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 6.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565659  44 LDPRTTILDLSNNRISRLS----ADELSLYPNLEQLILKNNSITHlsaDVFSTLPHLrlldlssnsllslpnevFSKLKN 119
Cdd:cd00116  135 LPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGD---AGIRALAEG-----------------LKANCN 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 268565659 120 LKTLIISSN------DVQLEpECFSGLSQLHTLSLADNRLSF-----LPPSVLKPLSGLKSLDLSANKL 177
Cdd:cd00116  195 LEVLDLNNNgltdegASALA-ETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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