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Conserved domains on  [gi|260945941|ref|XP_002617268|]
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WD domain, G-beta repeat family protein [Clavispora lusitaniae]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-389 1.98e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 1.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  93 RHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNN-VNI 171
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 172 VQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTPA 251
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 252 AVATLLGFKHTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPvHASLLTTAAYDGAMHH 331
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260945941 332 YFLDKYVPadvdqsgpasveaVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:cd00200  246 WDLRTGEC-------------VQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-389 1.98e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 1.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  93 RHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNN-VNI 171
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 172 VQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTPA 251
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 252 AVATLLGFKHTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPvHASLLTTAAYDGAMHH 331
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260945941 332 YFLDKYVPadvdqsgpasveaVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:cd00200  246 WDLRTGEC-------------VQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
73-391 5.56e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 5.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  73 GNAAAFDIQAKFVHLSSNKARHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLS 152
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 153 GDQDGAIKYWQPNYNN-VNIVQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLG 231
Cdd:COG2319  180 GSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 232 LVVSGSKDNLVKLWDPRTPAAVATLLGFKHTVTKTKFqkAGTARLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVE 311
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 312 WHPVHASLLtTAAYDGAMHHYFLDkyvpadvdqsgpaSVEAVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWSRA 391
Cdd:COG2319  338 FSPDGKTLA-SGSDDGTVRLWDLA-------------TGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 79-246 1.92e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  79 DIQAKFVHLSSnkaRHSINAVKWTPEGRRLVVASH-SGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLL-SGDQD 156
Cdd:PLN00181 521 DIHYPVVELAS---RSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDD 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 157 GAIKYWQPNYN----------NVNIVQAHGDAVRDIAFSPTDSKyVTCSDDSTLKIwsfasgrEERVLTGHHWDVKSADW 226
Cdd:PLN00181 598 GSVKLWSINQGvsigtiktkaNICCVQFPSESGRSLAFGSADHK-VYYYDLRNPKL-------PLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|
gi 260945941 227 HPTLGLVvSGSKDNLVKLWD 246
Cdd:PLN00181 670 VDSSTLV-SSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 207-246 4.07e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 260945941   207 SGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWD 246
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
208-246 7.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 260945941  208 GREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWD 246
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-389 1.98e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 1.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  93 RHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNN-VNI 171
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 172 VQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTPA 251
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 252 AVATLLGFKHTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPvHASLLTTAAYDGAMHH 331
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDG--EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260945941 332 YFLDKYVPadvdqsgpasveaVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:cd00200  246 WDLRTGEC-------------VQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
73-391 5.56e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 5.56e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  73 GNAAAFDIQAKFVHLSSNKARHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLS 152
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 153 GDQDGAIKYWQPNYNN-VNIVQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLG 231
Cdd:COG2319  180 GSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 232 LVVSGSKDNLVKLWDPRTPAAVATLLGFKHTVTKTKFqkAGTARLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVE 311
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 312 WHPVHASLLtTAAYDGAMHHYFLDkyvpadvdqsgpaSVEAVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWSRA 391
Cdd:COG2319  338 FSPDGKTLA-SGSDDGTVRLWDLA-------------TGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
93-391 2.92e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  93 RHSINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQP-NYNNVNI 171
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRT 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 172 VQAHGDAVRDIAFSPtDSKY-VTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTP 250
Cdd:COG2319  158 LTGHSGAVTSVAFSP-DGKLlASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 251 AAVATLLGFKHTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPvHASLLTTAAYDGAMH 330
Cdd:COG2319  237 KLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260945941 331 HYFLdkyvpadvdqsgpASVEAVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWSRA 391
Cdd:COG2319  314 LWDL-------------ATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-389 8.97e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.10  E-value: 8.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 132 QAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNNVNIV-QAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGRE 210
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 211 ERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTPAAVATLLGFKHTVTKTKFQkaGTARLLASVSRDRSCRVFD 290
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--PDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 291 LRAMADYTVIRDHEADLSCVEWHPVHASLLTTAAyDGAMHHYfldkyvpadvdqsGPASVEAVHRIPyAHEKAIHALEYH 370
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLW-------------DLSTGKCLGTLR-GHENGVNSVAFS 228

                        250
                 ....*....|....*....
gi 260945941 371 PLGHLLCSAGNDRSARFWS 389
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 168-389 1.47e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 1.47e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 168 NVNIVQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDP 247
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 248 RTPAAVATLLGFKHTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPVHaSLLTTAAYDG 327
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 260945941 328 AMHHYfldkyvpaDVDQSGPasveaVHRIpYAHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:cd00200  158 TIKLW--------DLRTGKC-----VATL-TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
95-249 7.98e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 7.98e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  95 SINAVKWTPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNN-VNIVQ 173
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKlLRTLT 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 260945941 174 AHGDAVRDIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRT 249
Cdd:COG2319  328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
102-391 4.99e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 4.99e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 102 TPEGRRLVVASHSGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYWQPNYNN-VNIVQAHGDAVR 180
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAlLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 181 DIAFSPTDSKYVTCSDDSTLKIWSFASGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWDPRTPAAVATLLGFK 260
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 261 HTVTKTKFQKAGtaRLLASVSRDRSCRVFDLRAMADYTVIRDHEADLSCVEWHPvHASLLTTAAYDGAMHhyFLDkyvpa 340
Cdd:COG2319  163 GAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVR--LWD----- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 260945941 341 dvdqsgPASVEAVHRIPyAHEKAIHALEYHPLGHLLCSAGNDRSARFWSRA 391
Cdd:COG2319  233 ------LATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 79-246 1.92e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.63  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941  79 DIQAKFVHLSSnkaRHSINAVKWTPEGRRLVVASH-SGEFTIWNGMTFNFETIMQAHDSAVLALRYSHSDEWLL-SGDQD 156
Cdd:PLN00181 521 DIHYPVVELAS---RSKLSGICWNSYIKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDD 597

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 157 GAIKYWQPNYN----------NVNIVQAHGDAVRDIAFSPTDSKyVTCSDDSTLKIwsfasgrEERVLTGHHWDVKSADW 226
Cdd:PLN00181 598 GSVKLWSINQGvsigtiktkaNICCVQFPSESGRSLAFGSADHK-VYYYDLRNPKL-------PLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|
gi 260945941 227 HPTLGLVvSGSKDNLVKLWD 246
Cdd:PLN00181 670 VDSSTLV-SSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 207-246 4.07e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 260945941   207 SGREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWD 246
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-204 3.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 260945941   169 VNIVQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWS 204
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
208-246 7.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 260945941  208 GREERVLTGHHWDVKSADWHPTLGLVVSGSKDNLVKLWD 246
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
169-204 3.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.52e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 260945941  169 VNIVQAHGDAVRDIAFSPTDSKYVTCSDDSTLKIWS 204
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 150-315 1.68e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 150 LLSGDQDGAIKYW--------QPNYNNVNIVQAHGDAVRDIAFSPTdSKYVTCSD--DSTLKIWSFASGREERVLTGHHW 219
Cdd:PTZ00421  91 LFTASEDGTIMGWgipeegltQNISDPIVHLQGHTKKVGIVSFHPS-AMNVLASAgaDMVVNVWDVERGKAVEVIKCHSD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 220 DVKSADWHPTLGLVVSGSKDNLVKLWDPRTPAAVATllGFKHTVTKTkfQKAGTAR-------LLASVSRDRSCRVFDLR 292
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS--VEAHASAKS--QRCLWAKrkdliitLGCSKSQQRQIMLWDTR 245

                        170       180
                 ....*....|....*....|....
gi 260945941 293 AMAD-YTVIrdhEADLSCVEWHPV 315
Cdd:PTZ00421 246 KMASpYSTV---DLDQSSALFIPF 266
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-162 4.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 260945941   124 TFNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYW 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 172-246 1.52e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260945941 172 VQAHGDAVRDIAFSPTDSKYV-TCSDDSTLKIWSFASGRE--------ERVLTGHHWDVKSADWHPTLGLVVSGSK-DNL 241
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEIPHNDEsvkeikdpQCILKGHKKKISIIDWNPMNYYIMCSSGfDSF 149


                 ....*
gi 260945941 242 VKLWD 246
Cdd:PTZ00420 150 VNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
125-162 1.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 260945941  125 FNFETIMQAHDSAVLALRYSHSDEWLLSGDQDGAIKYW 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 359-389 1.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.71e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 260945941   359 AHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
359-389 9.62e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.62e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 260945941  359 AHEKAIHALEYHPLGHLLCSAGNDRSARFWS 389
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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