|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
17-344 |
6.96e-162 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 456.50 E-value: 6.96e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 17 RLLSPNASVRVSPLCLGGMSkpfgFGTNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGR 96
Cdd:cd19146 1 RQLSPTAGVRVSPLCLGAMS----FGEAWKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 97 HNEMIIATKYAMT-PMAGKSVNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKV 175
Cdd:cd19146 77 RDEMVLATKYTTGyRRGGPIKIKSNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 176 LYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKT---LGSEGAG 252
Cdd:cd19146 157 LYLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTeeeFKRRGRS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 253 ARRIPPTILigREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIETG 332
Cdd:cd19146 237 GRKGGPQTE--KERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIEDA 314
|
330
....*....|..
gi 242820009 333 YNFDIGFTHNFI 344
Cdd:cd19146 315 YPFDVGFPMNFL 326
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
19-330 |
1.63e-122 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 355.76 E-value: 1.63e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 19 LSPNASVRVSPLCLGGMSkpfgFGTNWGMGlgeCTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKdrGRHN 98
Cdd:cd19080 2 LLGRSGLRVSPLALGTMT----FGTEWGWG---ADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIA--GNRD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 99 EMIIATKYAMTPMAGKSvnqsNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYL 178
Cdd:cd19080 73 RIVLATKYTMNRRPGDP----NAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 179 GISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFK---TLGSEGAGARR 255
Cdd:cd19080 149 GISDTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTgkyQRGEEGRAGEA 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 256 IPPT----ILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19080 229 KGVTvgfgKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
18-330 |
2.49e-121 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 353.36 E-value: 2.49e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 18 LLSPNASVRVSPLCLGGMSkpfgFGTNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRH 97
Cdd:cd19147 1 VLSKTAGIRVSPLILGAMS----IGDAWSGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 98 NEMIIATKYAMTPMAGK--SVNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKV 175
Cdd:cd19147 77 DQIVIATKFTTDYKAYEvgKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 176 LYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKtlgSEGAGARR 255
Cdd:cd19147 157 LYLGVSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQ---SKKAVEER 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 256 I-----PPTILIGREQ-----QVSQVLDNVAKRHNV-PLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPE 324
Cdd:cd19147 234 KkngegLRSFVGGTEQtpeevKISEALEKVAEEHGTeSVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPE 313
|
....*.
gi 242820009 325 DVAEIE 330
Cdd:cd19147 314 EIEYLE 319
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
26-330 |
1.02e-77 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 241.72 E-value: 1.02e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 26 RVSPLCLGGMSkpFGFGTNWGMGLGEctkEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNEMIIATK 105
Cdd:cd19079 11 KVSRLCLGCMS--FGDPKWRPWVLDE---EESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDEVVIATK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 YAMtPMAgksvNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPA 185
Cdd:cd19079 86 VYF-PMG----DGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 186 WFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKTLGSEGAGARRIPPTILIGRE 265
Cdd:cd19079 161 WQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTTDTAKLKY 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242820009 266 -------QQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19079 241 dyfteadKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
25-330 |
3.68e-76 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 237.77 E-value: 3.68e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 25 VRVSPLCLGGMskpfgfgtNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIAT 104
Cdd:COG0667 11 LKVSRLGLGTM--------TFGGPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRPRD-DVVIAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 105 KYAMTPMAGKsvNQSNYGGTgnkcmHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISD 182
Cdd:COG0667 82 KVGRRMGPGP--NGRGLSRE-----HIrrAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 183 APAWFVTKANAYARhhGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVNGYFK--TLGSEGAGARR 255
Cdd:COG0667 155 YSAEQLRRALAIAE--GLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYsplagGLLTGKYRRgaTFPEGDRAATN 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 256 IPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:COG0667 233 FVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALD 307
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
25-329 |
9.32e-73 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 229.02 E-value: 9.32e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 25 VRVSPLCLGGMskpfGFGtnWgmglgECTKEMAYELLDTFYYLDGNFVDTANTY-------QGSQSEEWIGDWMKDRGRH 97
Cdd:cd19081 7 LSVSPLCLGTM----VFG--W-----TADEETSFALLDAFVDAGGNFIDTADVYsawvpgnAGGESETIIGRWLKSRGKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 98 NEMIIATKYAMtPMAGksvnqsNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLY 177
Cdd:cd19081 76 DRVVIATKVGF-PMGP------NGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRY 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 178 LGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDM-EREIIPMAREEGMAILAFGVLVNGyFKTlgseGAGARRI 256
Cdd:cd19081 149 IGASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGG-FLT----GKYRSEA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 257 PPTILIGREQQVSQ-----------VLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPED 325
Cdd:cd19081 224 DLPGSTRRGEAAKRylnerglrildALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEE 303
|
....
gi 242820009 326 VAEI 329
Cdd:cd19081 304 VARL 307
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
15-331 |
2.21e-71 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 225.57 E-value: 2.21e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 15 RHRLLSpNASVRVSPLCLGGMSkpFGFGTNWGMGLGECTKEMAYELLDtfYYLDG--NFVDTANTYQGSQSEEWIGDWMK 92
Cdd:cd19091 2 EYRTLG-RSGLKVSELALGTMT--FGGGGGFFGAWGGVDQEEADRLVD--IALDAgiNFFDTADVYSEGESEEILGKALK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 93 drGRHNEMIIATKYAMtPMaGKSVNQSnygGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIH 172
Cdd:cd19091 77 --GRRDDVLIATKVRG-RM-GEGPNDV---GLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 173 GKVLYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFK---TLGSE 249
Cdd:cd19091 150 GKVRYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSgkyRRGQP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 250 GAGARRI-------PPtilIGREQ--QVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLR 320
Cdd:cd19091 230 APEGSRLrrtgfdfPP---VDRERgyDVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLS 306
|
330
....*....|.
gi 242820009 321 LTPEDVAEIET 331
Cdd:cd19091 307 LTPEEIARLDK 317
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
25-330 |
8.07e-68 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 216.28 E-value: 8.07e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 25 VRVSPLCLGGMSkpfgFGtnwgmglGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRgRHnEMIIAT 104
Cdd:cd19087 11 LKVSRLCLGTMN----FG-------GRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGR-RD-DIVLAT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 105 KYAMtPMaGKSVNQSnyggtGNKCMHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISD 182
Cdd:cd19087 78 KVFG-PM-GDDPNDR-----GLSRRHIrrAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 183 APAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVNGYFKTLGSE-GAGARRI 256
Cdd:cd19087 151 FAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYsplagGLLTGKYGKGKRPEsGRLVERA 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 257 PPTILIGREQQVSQV--LDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19087 231 RYQARYGLEEYRDIAerFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLTPELLAEID 306
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
28-315 |
4.02e-66 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 209.30 E-value: 4.02e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 28 SPLCLGGMSkpfgFGTNWgmglgecTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNEMIIATKYA 107
Cdd:cd06660 1 SRLGLGTMT----FGGDG-------DEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 108 MTPMAGKSVNqsnygGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWF 187
Cdd:cd06660 70 HPPGGDPSRS-----RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAER 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 188 VTKANAYARHHGLRTFSVYQGRYS-AQQRDMEREIIPMAREEGMAILAFGVLVNGyfktlgsegagarripptiligreq 266
Cdd:cd06660 145 LAEALAYAKAHGLPGFAAVQPQYSlLDRSPMEEELLDWAEENGLPLLAYSPLARG------------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 242820009 267 qvsqvldnvakrhnvpLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIE 315
Cdd:cd06660 200 ----------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
40-330 |
3.01e-64 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 206.39 E-value: 3.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTN-WGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNE-MIIATKYAMTPMAGKSvn 117
Cdd:pfam00248 2 GLGTWqLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDkVVIATKVPDGDGPWPS-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 118 qsnyGGTGNKCMHiSIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAyarh 197
Cdd:pfam00248 80 ----GGSKENIRK-SLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALT---- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 198 HGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKTLGSEGA----GARRIPPTILIGREQQVSQVLD 273
Cdd:pfam00248 151 KGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPdkgpGERRRLLKKGTPLNLEALEALE 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 274 NVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:pfam00248 231 EIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARID 287
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-317 |
1.52e-55 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 184.07 E-value: 1.52e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 28 SPLCLGGMSkpfgFGTNwgmglgeCTKEMAYELLDTFYYLDGNFVDTANTY-------QGSQSEEWIGDWMKDRGRHNEM 100
Cdd:cd19752 1 SELCLGTMY----FGTR-------TDEETSFAILDRYVAAGGNFLDTANNYafwteggVGGESERLIGRWLKDRGNRDDV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 101 IIATKYAMTPMAGKSVNQsNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGI 180
Cdd:cd19752 70 VIATKVGAGPRDPDGGPE-SPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 181 SDAPAWFVTKANAYARHHGLRTFSVYQGRYS----------AQQRDMEREIIPMAREEG-MAILAFGVLVNGYFktlgse 249
Cdd:cd19752 149 SNFAAWRLERARQIARQQGWAEFSAIQQRHSylrprpgadfGVQRIVTDELLDYASSRPdLTLLAYSPLLSGAY------ 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 250 GAGARRIPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEAL 317
Cdd:cd19752 223 TRPDRPLPEQYDGPDSDARLAVLEEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAAL 290
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
26-330 |
1.07e-51 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 174.25 E-value: 1.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 26 RVSPLCLGGMskPFGfGTNWGmglgECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRgRHNeMIIATK 105
Cdd:cd19084 3 KVSRIGLGTW--AIG-GTWWG----EVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR-RDD-VVIATK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 YamtpmaGKSVNQSNYGGTGNKCMHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDA 183
Cdd:cd19084 74 C------GLRWDGGKGVTKDLSPESIrkEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 184 PAWFVTKANAYARhhglrtFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGY----FKTLGSEGAGARRIPPT 259
Cdd:cd19084 148 SVEQLEEARKYGP------IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLltgkYKKEPTFPPDDRRSRFP 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 260 ILIG----REQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19084 222 FFRGenfeKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
28-317 |
1.02e-49 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 168.89 E-value: 1.02e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 28 SPLCLGGMSkpfgFGTNWgmglgecTKEMAYELLDTFYYLDGNFVDTANTYQG----SQSEEWIGDWMKDRGRHNEMIIA 103
Cdd:cd19082 1 SRIVLGTAD----FGTRI-------DEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRGNRDKVVIA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 104 TKYAMTPMAGKSVNQSNyggtgNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDa 183
Cdd:cd19082 70 TKGGHPDLEDMSRSRLS-----PEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 184 paWF---VTKANAYARHHGLRTFSVYQGRYS-AQQRD----------MEREIIPMAREEGMAILAFGVLVNGYFktlgse 249
Cdd:cd19082 144 --WSterIAEANAYAKAHGLPGFAASSPQWSlARPNEppwpgptlvaMDEEMRAWHEENQLPVFAYSSQARGFF------ 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 250 gagARRIPPTILIGREQQVS----------QVLDNVAKRHNVPLTSVTLAYAM-QKTPYFyPIIGGRKVEHLKANIEAL 317
Cdd:cd19082 216 ---SKRAAGGAEDDSELRRVyyseenferlERAKELAEEKGVSPTQIALAYVLnQPFPTV-PIIGPRTPEQLRDSLAAA 290
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
40-324 |
8.50e-49 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 166.61 E-value: 8.50e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKyAMTPMaGKSVNQS 119
Cdd:cd19074 8 SLGT-WLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWPRE-SYVISTK-VFWPT-GPGPNDR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 120 nygGTGNKcmHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARH 197
Cdd:cd19074 84 ---GLSRK--HIfeSIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 198 HGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNG-----YFKTLgSEGAGARRIPPTI--LIGR---EQQ 267
Cdd:cd19074 159 FGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGlltgkYRDGI-PPPSRSRATDEDNrdKKRRlltDEN 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 268 VSQV--LDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPE 324
Cdd:cd19074 238 LEKVkkLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
27-330 |
3.22e-42 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 150.02 E-value: 3.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 27 VSPLCLGGMskpfgfgtNWGmglGECTKEMAYELLDTFYYLDGNFVDTANTY--------QGSqSEEWIGDWMKDRGRHN 98
Cdd:cd19094 1 VSEICLGTM--------TWG---EQNTEAEAHEQLDYAFDEGVNFIDTAEMYpvppspetQGR-TEEIIGSWLKKKGNRD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 99 EMIIATKyamtpMAGKSVnQSNYGGTGNKCM---HI--SIEASLKAMNTDYIDIYYVHAWD-----------------YA 156
Cdd:cd19094 69 KVVLATK-----VAGPGE-GITWPRGGGTRLdreNIreAVEGSLKRLGTDYIDLYQLHWPDrytplfgggyytepseeED 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 157 S-SILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARHHGL-RTFSVyQGRYSAQQRDMEREIIPMAREEGMAI-- 232
Cdd:cd19094 143 SvSFEEQLEALGELVKAGKIRHIGLSNETPWGVMKFLELAEQLGLpRIVSI-QNPYSLLNRNFEEGLAEACHRENVGLla 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 233 ---LAFGVL----VNGYFKTLGS-----EGAGARRipptiliGREQQVSQVLDNV--AKRHNVPLTSVTLAYAMQKtpyf 298
Cdd:cd19094 222 yspLAGGVLtgkyLDGAARPEGGrlnlfPGYMARY-------RSPQALEAVAEYVklARKHGLSPAQLALAWVRSR---- 290
|
330 340 350
....*....|....*....|....*....|....*..
gi 242820009 299 yP-----IIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19094 291 -PfvtstIIGATTLEQLKENIDAFDVPLSDELLAEID 326
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
15-329 |
1.75e-39 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 142.35 E-value: 1.75e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 15 RHRLLSpNASVRVSPLCLGGMskpfgfgtnwGM--GLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMK 92
Cdd:cd19076 1 PTRKLG-TQGLEVSALGLGCM----------GMsaFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 93 DRgRHnEMIIATKYAMTPMAGKSVNqsnygGTGNKCMHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALV 170
Cdd:cd19076 70 DR-RD-EVVIATKFGIVRDPGSGFR-----GVDGRPEYVraACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 171 IHGKVLYLGISDAPAWFVTKANAYarhHGLrtfSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVNGYFKT 245
Cdd:cd19076 143 EEGKVRYIGLSEASADTIRRAHAV---HPI---TAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYsplgrGFLTGAIKSP 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 246 LGSEGAGARRIPPtiligREQ--------QVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEAL 317
Cdd:cd19076 217 EDLPEDDFRRNNP-----RFQgenfdknlKLVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGAL 291
|
330
....*....|..
gi 242820009 318 KLRLTPEDVAEI 329
Cdd:cd19076 292 DVVLTPEELAEI 303
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
27-331 |
1.95e-39 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 141.99 E-value: 1.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 27 VSPLCLGGMSKPFGFGTnwgmglgECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKdrGRHNEMIIATKY 106
Cdd:cd19078 4 VSAIGLGCMGMSHGYGP-------PPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALK--PFRDQVVIATKF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 107 AMTPMAGKSVNQsnygGTGNKCMHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAP 184
Cdd:cd19078 75 GFKIDGGKPGPL----GLDSRPEHIrkAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 185 AWFVTKAnayarhHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYF------KTLGSEGAGARRIPP 258
Cdd:cd19078 151 VETIRRA------HAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLtgkideNTKFDEGDDRASLPR 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 259 TILIGRE--QQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:cd19078 225 FTPEALEanQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIED 299
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
38-330 |
1.16e-38 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 140.49 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTnWGMG----LGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKdrGRHNEMIIATKYAMT---- 109
Cdd:cd19149 13 VIGLGT-WAIGggpwWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIK--GRRDKVVLATKCGLRwdre 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 110 ----PMAGKSVNQSNYggTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPA 185
Cdd:cd19149 90 ggsfFFVRDGVTVYKN--LSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAIGASNVSV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 186 WFVtkaNAYARHHGLrtfSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVNGYFKTLGSEGAGARRIPPTI 260
Cdd:cd19149 168 EQI---KEYVKAGQL---DIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYspleqGLLTGKITPDREFDAGDARSGIPWF 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242820009 261 LIGREQQVSQVLDN---VAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19149 242 SPENREKVLALLEKwkpLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAEDIATMR 314
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
27-331 |
2.37e-36 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 133.48 E-value: 2.37e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 27 VSPLCLGGMSkpFGFGTNWGmglgECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKdrGRHNEMIIATKY 106
Cdd:cd19085 1 VSRLGLGCWQ--FGGGYWWG----DQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALK--GRRDDVVIATKV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 107 AMTPMAGKSVNQSnyggtgnkcmhisIEASLKAMNTDYIDIYYVHaW-DYASSILELMQSLNALVIHGKVLYLGISDAPA 185
Cdd:cd19085 73 SPDNLTPEDVRKS-------------CERSLKRLGTDYIDLYQIH-WpSSDVPLEETMEALEKLKEEGKIRAIGVSNFGP 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 186 WFVTKANAYARhhglrtFSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVnGYFKTLGSEGAGARR--IPP 258
Cdd:cd19085 139 AQLEEALDAGR------IDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYsplaqGLLT-GKFSSAEDFPPGDARtrLFR 211
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 259 TILIGREQQVSQVLDNV---AKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:cd19085 212 HFEPGAEEETFEALEKLkeiADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
38-330 |
3.29e-36 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 132.35 E-value: 3.29e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTnWGMGLGECT----KEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNeMIIATKyamtpmag 113
Cdd:cd19072 6 VLGLGT-WGIGGGMSKdysdDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFDRED-LFITTK-------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 114 ksVNQSNYGGtgnKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANA 193
Cdd:cd19072 76 --VSPDHLKY---DDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 194 YARHHGLrtfSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYfktlgsegagarripptiLIGREQqvSQVLD 273
Cdd:cd19072 151 YLKKGPI---VANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGK------------------LSNAKG--SPLLD 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 274 NVAKRHNVPLTSVTLAYAMQKtPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19072 208 EIAKKYGKTPAQIALNWLISK-PNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
26-330 |
5.10e-36 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 132.74 E-value: 5.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 26 RVSPLCLGGMSkpfgFGTNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNEMIIATK 105
Cdd:cd19093 1 EVSPLGLGTWQ----WGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 YAMTPMAGKSvnqsnyggtgnKCMHISIEASLKAMNTDYIDIYYVHaWDYA--SSILELMQSLNALVIHGKVLYLGISDA 183
Cdd:cd19093 77 FAPLPWRLTR-----------RSVVKALKASLERLGLDSIDLYQLH-WPGPwySQIEALMDGLADAVEEGLVRAVGVSNY 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 184 PAWFVTKANAYARHHGLRTFSVyQGRYSAQQRDMER-EIIPMAREEGMAILAF-----GVLVNGYfkTLGSEGAGARRIP 257
Cdd:cd19093 145 SADQLRRAHKALKERGVPLASN-QVEYSLLYRDPEQnGLLPACDELGITLIAYsplaqGLLTGKY--SPENPPPGGRRRL 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242820009 258 PTILIGRE-QQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPyfYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19093 222 FGRKNLEKvQPLLDALEEIAEKYGKTPAQVALNWLIAKGV--VPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
41-328 |
1.60e-35 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 131.91 E-value: 1.60e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 41 FGT-NWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIG--DWMKDRGRhnemiIATKYAMTPmagksvn 117
Cdd:cd19075 5 LGTmTFGSQGRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGelGLGERGFK-----IDTKANPGV------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 118 qsnyGGTGNKCMHI-SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYAR 196
Cdd:cd19075 73 ----GGGLSPENVRkQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 197 HHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAF----GVLVNGYFKTLGSEGAGARRIPPTILIGREQQ----- 267
Cdd:cd19075 149 ENGWVLPTVYQGMYNAITRQVETELFPCLRKLGIRFYAYsplaGGFLTGKYKYSEDKAGGGRFDPNNALGKLYRDrywkp 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 268 ----VSQVLDNVAKRHNVPLTSVTLAYAmqktpYFYP----------IIGGRKVEHLKANIEALK---LrltPEDVAE 328
Cdd:cd19075 229 syfeALEKVEEAAEKEGISLAEAALRWL-----YHHSaldgekgdgvILGASSLEQLEENLAALEkgpL---PEEVVK 298
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
16-330 |
6.62e-34 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 128.43 E-value: 6.62e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 16 HRLlsPNASVRVSPLCLGGMSkpfgfgtnwgmgLGECTKEM-AYELLDTFYYLDGNFVDTANTY--------QGsQSEEW 86
Cdd:PRK10625 4 HRI--PHSSLEVSTLGLGTMT------------FGEQNSEAdAHAQLDYAVAQGINLIDVAEMYpvpprpetQG-LTETY 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 87 IGDWMKDRGRHNEMIIATKYAmTPMAGKSVNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVH------------AWD 154
Cdd:PRK10625 69 IGNWLAKRGSREKLIIASKVS-GPSRNNDKGIRPNQALDRKNIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklGYS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 155 YASS-----ILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEG 229
Cdd:PRK10625 148 WTDSapavsLLETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 230 MAILA-----FGVLVNGYFKtlGSEGAGARrippTILIGR---------EQQVSQVLDnVAKRHNVPLTSVTLAYAMQKT 295
Cdd:PRK10625 228 VELLAysclaFGTLTGKYLN--GAKPAGAR----NTLFSRftrysgeqtQKAVAAYVD-IAKRHGLDPAQMALAFVRRQP 300
|
330 340 350
....*....|....*....|....*....|....*
gi 242820009 296 PYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:PRK10625 301 FVASTLLGATTMEQLKTNIESLHLTLSEEVLAEIE 335
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
40-330 |
1.38e-33 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 127.17 E-value: 1.38e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnwgMGL-----GECTKEMAYELLDTFYYLDGNFVDTANTYQgsQSEEWIGDWMK-DRGRHNEMIIATK--YAMTPM 111
Cdd:cd19144 17 GFGA---MGLsafygPPKPDEERFAVLDAAFELGCTFWDTADIYG--DSEELIGRWFKqNPGKREKIFLATKfgIEKNVE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 112 AGK-SVNQS-NYggtgnkcMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAwfVT 189
Cdd:cd19144 92 TGEySVDGSpEY-------VKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSECSA--ET 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 190 KANAYARHHglrtFSVYQGRYSAQQRDMER---EIIPMAREEGMAILAFGVLVNGYFK-TLGS-----EGAGARRIP--- 257
Cdd:cd19144 163 LRRAHAVHP----IAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGRGFLTgAIRSpddfeEGDFRRMAPrfq 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 258 ----PTILigreqQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19144 239 aenfPKNL-----ELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIR 310
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
22-327 |
2.56e-33 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 125.83 E-value: 2.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 22 NASVRVSPLCLGgMSKPFGFGTNWgmglgECTKEMAYELLDtfyyLDGNFVDTANTY---QGSqSEEWIGDWMKD--RGR 96
Cdd:cd19089 6 RSGLHLPAISLG-LWHNFGDYTSP-----EEARELLRTAFD----LGITHFDLANNYgppPGS-AEENFGRILKRdlRPY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 97 HNEMIIATKyamtpmAGKSVNQSNYGGTGNKcMHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGK 174
Cdd:cd19089 75 RDELVISTK------AGYGMWPGPYGDGGSR-KYLlaSLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 175 VLYLGISDAPAWFVTKANAYARHHGLRtFSVYQGRYSAQQRDMEREIIPMAREEGMAILAF-----GVLVNGYFK--TLG 247
Cdd:cd19089 148 ALYVGISNYPGAKARRAIALLRELGVP-LIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFsplaqGLLTDKYLNgiPPD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 248 SEGAGARR--IPPTILIGREQQVSQvLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALK-LRLTPE 324
Cdd:cd19089 227 SRRAAESKflTEEALTPEKLEQLRK-LNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKnLDFSEE 305
|
...
gi 242820009 325 DVA 327
Cdd:cd19089 306 ELA 308
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
37-330 |
3.26e-32 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 122.91 E-value: 3.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 37 KPFGFGTNWGMG------LGECT-KEMAYELLDtfyylDG-NFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKYAM 108
Cdd:cd19083 12 NPIGLGTNAVGGhnlypnLDEEEgKDLVREALD-----NGvNLLDTAFIYGLGRSEELVGEVLKEYNRN-EVVIATKGAH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 109 TPMAGKSV--NQSNYggtgnkcMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAW 186
Cdd:cd19083 86 KFGGDGSVlnNSPEF-------LRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 187 FVTKANayarHHGLrtFSVYQGRYSAQQRDMEREIIPMAREEGMAI-----LAFGVLVNGYFK-TLGSEGAGARRIPPTI 260
Cdd:cd19083 159 QLKEAN----KDGY--VDVLQGEYNLLQREAEEDILPYCVENNISFipyfpLASGLLAGKYTKdTKFPDNDLRNDKPLFK 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 261 ligrEQQVSQVLDNV------AKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19083 233 ----GERFSENLDKVdklksiADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFID 304
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
71-329 |
1.21e-31 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 121.39 E-value: 1.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 71 FVDTANTYQGSQSEEWIGDWMKDrGRHNEMIIATKYAMTpmagkSVNQSNYGGTGNKC-MHISIEASLKAMNTDYIDIYY 149
Cdd:cd19145 49 FLDTSDIYGPNTNEVLLGKALKD-GPREKVQLATKFGIH-----EIGGSGVEVRGDPAyVRAACEASLKRLDVDYIDLYY 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 150 VHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKAnayarhHGLRTFSVYQGRYSAQQRDMEREIIPMAREEG 229
Cdd:cd19145 123 QHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTIRRA------HAVHPITAVQLEWSLWTRDIEEEIIPTCRELG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 230 MAILAFGVLVNGYFKT------LGSEGAGARRIPptiligREQQ--------VSQVLDNVAKRHNVPLTSVTLAYAMQKT 295
Cdd:cd19145 197 IGIVPYSPLGRGFFAGkakleeLLENSDVRKSHP------RFQGenleknkvLYERVEALAKKKGCTPAQLALAWVLHQG 270
|
250 260 270
....*....|....*....|....*....|....
gi 242820009 296 PYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEI 329
Cdd:cd19145 271 EDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
26-316 |
1.22e-29 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 114.11 E-value: 1.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 26 RVSPLCLGGMskpfGFGTNWGmglGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKdrGRHNEMIIATK 105
Cdd:cd19086 2 EVSEIGFGTW----GLGGDWW---GDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALK--GRRDKVVIATK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 YAMTPMAGKSVNQsNYGGTgnkcmHI--SIEASLKAMNTDYIDIYYVHAWDYA-SSILELMQSLNALVIHGKVLYLGISD 182
Cdd:cd19086 73 FGNRFDGGPERPQ-DFSPE-----YIreAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVSV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 183 APAWfvtKANAYARHhglRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGyfktlgsegagarripptILI 262
Cdd:cd19086 147 GDPE---EALAALRR---GGIDVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASG------------------LLT 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 242820009 263 GReqqvsqvldnvakrhnvpLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEA 316
Cdd:cd19086 203 GK------------------LAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-330 |
3.84e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 111.61 E-value: 3.84e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGT------NWGMGLG--ECTKEMA--YELLDTFYyldgNFVDTANTYQGSQSEEWIGDWMKDRGRhnEMIIATKYA 107
Cdd:cd19102 3 TIGLGTwaigggGWGGGWGpqDDRDSIAaiRAALDLGI----NWIDTAAVYGLGHSEEVVGRALKGLRD--RPIVATKCG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 108 MTPMAGKSVNQSNYGGTgnkcMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPawf 187
Cdd:cd19102 77 LLWDEEGRIRRSLKPAS----IRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFS--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 188 vtkANAYARHHGLRTFSVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYF------KTLGSEGAGARR------ 255
Cdd:cd19102 150 ---VDQMKRCQAIHPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLtgkmtpERVASLPADDWRrrspff 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 256 IPPtiLIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19102 227 QEP--NLARNLALVDALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIE 299
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
22-330 |
1.78e-27 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 110.38 E-value: 1.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 22 NASVRVSPLCLGGMskpfgfgTNWGMGLGEctkEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRG-RHNEM 100
Cdd:cd19143 8 RSGLKVSALSFGSW-------VTFGNQVDV---DEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGwPRSDY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 101 IIATKYamtpmagksvnqsnYGGTGNKCM--------HI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALV 170
Cdd:cd19143 78 VVSTKI--------------FWGGGGPPPndrglsrkHIveGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 171 IHGKVLYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRD-MEREIIPMAREEGMAI-----LAFGVLVNGYFK 244
Cdd:cd19143 144 DQGKAFYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTttwspLASGLLTGKYNN 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 245 TL--GSEGA--GARRIPPTILIGREQQVSQV--LDNVAKRHNVPLTSVTLAYAMqKTPYFYPII-GGRKVEHLKANIEAL 317
Cdd:cd19143 224 GIpeGSRLAlpGYEWLKDRKEELGQEKIEKVrkLKPIAEELGCSLAQLAIAWCL-KNPNVSTVItGATKVEQLEENLKAL 302
|
330
....*....|....*
gi 242820009 318 KL--RLTPEDVAEIE 330
Cdd:cd19143 303 EVlpKLTPEVMEKIE 317
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
38-316 |
1.83e-27 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 108.86 E-value: 1.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTNW-GMGLGECTKEMAYELLDTFYYLDGNFVDTANTYqgSQSEEWIGDWMKDRGRhNEMIIATKYAMTPMAGKSV 116
Cdd:cd19095 2 VLGLGTSGiGRVWGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGLRR-DDLFIATKVGTHGEGGRDR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 117 NQSNYggtgnKCMHISIEASLKAMNTDYIDIYYVH---AWDYASSILELMQslnALVIHGKVLYLGISdapawfvTKANA 193
Cdd:cd19095 79 KDFSP-----AAIRASIERSLRRLGTDYIDLLQLHgpsDDELTGEVLETLE---DLKAAGKVRYIGVS-------GDGEE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 194 YARHHGLRTFSVYQGRYSAQQRDmEREIIPMAREEGMailafGVLVNGYFktlgsegAGARRIPPTILIGREQQVSQVLD 273
Cdd:cd19095 144 LEAAIASGVFDVVQLPYNVLDRE-EEELLPLAAEAGL-----GVIVNRPL-------ANGRLRRRVRRRPLYADYARRPE 210
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 242820009 274 NVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEA 316
Cdd:cd19095 211 FAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
28-326 |
2.34e-26 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 106.48 E-value: 2.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 28 SPLCLGGmskpFGFGTNWGMGlgecTKEMAYELLDTFYYLDGNFVDTANTYQGSqsEEWIGDWMKDRGRhNEMIIATKya 107
Cdd:cd19090 1 SALGLGT----AGLGGVFGGV----DDDEAVATIRAALDLGINYIDTAPAYGDS--EERLGLALAELPR-EPLVLSTK-- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 108 mtpmAGKsvNQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVH-----AWDYASSILELMQSLNALVIHGKVLYLGISD 182
Cdd:cd19090 68 ----VGR--LPEDTADYSADRVRRSVEESLERLGRDRIDLLMIHdpervPWVDILAPGGALEALLELKEEGLIKHIGLGG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 183 APAWFVTKAnayarhhgLRT--FSV---YqGRYSAQQRDMEREIIPMAREEGMAI-----LAFGVLVNGYFKTLGSEGag 252
Cdd:cd19090 142 GPPDLLRRA--------IETgdFDVvltA-NRYTLLDQSAADELLPAAARHGVGVinaspLGMGLLAGRPPERVRYTY-- 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 253 aRRIPPTILigreQQVSQVLDnVAKRHNVPLTSVTLAYAMQ-----KTpyfypIIGGRKVEHLKANIEALKLRLtPEDV 326
Cdd:cd19090 211 -RWLSPELL----DRAKRLYE-LCDEHGVPLPALALRFLLRdprisTV-----LVGASSPEELEQNVAAAEGPL-PEEL 277
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
73-327 |
1.25e-24 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 102.48 E-value: 1.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 73 DTANTY---QGSqSEEWIGDWMKD--RGRHNEMIIATKyamtpmAGKSVNQSNYGGTGNKCMHI-SIEASLKAMNTDYID 146
Cdd:cd19151 48 DLANNYgppPGS-AEENFGRILKEdlKPYRDELIISTK------AGYTMWPGPYGDWGSKKYLIaSLDQSLKRMGLDYVD 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 147 IYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARHHGLRTFsVYQGRYSAQQRDMEREIIPMAR 226
Cdd:cd19151 121 IFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAILKDLGTPCL-IHQPKYSMFNRWVEEGLLDVLE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 227 EEGMAILAF-----GVLVNGYFKTLgseGAGARRIPPTILIGREQQVSQVLDNV------AKRHNVPLTSVTLAYAMQKT 295
Cdd:cd19151 200 EEGIGCIAFsplaqGLLTDRYLNGI---PEDSRAAKGSSFLKPEQITEEKLAKVrrlneiAQARGQKLAQMALAWVLRNK 276
|
250 260 270
....*....|....*....|....*....|...
gi 242820009 296 PYFYPIIGGRKVEHLKANIEAL-KLRLTPEDVA 327
Cdd:cd19151 277 RVTSVLIGASKPSQIEDAVGALdNREFSEEELA 309
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
73-330 |
2.00e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 101.52 E-value: 2.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 73 DTANTYQGSqsEEWIG----DWMKDRGRHNEMIIATKYamtpmagksVNQSNYGGTGNKCMHISIEASLKAMNTDYIDIY 148
Cdd:cd19101 41 DCADIYGPA--EELIGefrkRLRRERDAADDVQIHTKW---------VPDPGELTMTRAYVEAAIDRSLKRLGVDRLDLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 149 YVHAWDYAS-SILELMQSLNALVIHGKVLYLGISDapawFVTKANAYARHHGLRTFSVyQGRYSAQQRDMEREIIPMARE 227
Cdd:cd19101 110 QFHWWDYSDpGYLDAAKHLAELQEEGKIRHLGLTN----FDTERLREILDAGVPIVSN-QVQYSLLDRRPENGMAALCED 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 228 EGMAILAFGVLVNGYF--KTLGsEGAGARRIPPT-------ILI------GREQQVSQVLDNVAKRHNVPLTSVTLAYAM 292
Cdd:cd19101 185 HGIKLLAYGTLAGGLLseKYLG-VPEPTGPALETrslqkykLMIdewggwDLFQELLRTLKAIADKHGVSIANVAVRWVL 263
|
250 260 270
....*....|....*....|....*....|....*...
gi 242820009 293 QKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19101 264 DQPGVAGVIVGARNSEHIDDNVRAFSFRLDDEDRAAID 301
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
70-322 |
3.07e-23 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 97.29 E-value: 3.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 70 NFVDTANTYQGSQSEEWIGDWMKDRGRhnEMIIATKYAMTPMAGksvnqsNYGGTGNKCMHI--SIEASLKAMNTDYIDI 147
Cdd:cd19088 39 NFIDTADSYGPDVNERLIAEALHPYPD--DVVIATKGGLVRTGP------GWWGPDGSPEYLrqAVEASLRRLGLDRIDL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 148 YYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYArhhglRTFSVyQGRYSAQQRDMErEIIPMARE 227
Cdd:cd19088 111 YQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIV-----RIVSV-QNRYNLANRDDE-GVLDYCEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 228 EGMAILAFGVLvngyfktlgsegaGARRIPptiligreqQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKV 307
Cdd:cd19088 184 AGIAFIPWFPL-------------GGGDLA---------QPGGLLAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSV 241
|
250
....*....|....*
gi 242820009 308 EHLKANIEALKLRLT 322
Cdd:cd19088 242 EHLEENLAAAGLRLS 256
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
40-330 |
1.48e-22 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 95.78 E-value: 1.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMkdRGRHNEMIIATKyamtpmagksVNQS 119
Cdd:cd19138 15 GQGT-WYMGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAI--RGRRDKVFLVSK----------VLPS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 120 NYGGTGnkcMHISIEASLKAMNTDYIDIYYVHaWDYASSILELMQSLNALVIHGKVLYLGIS--DAP----AWFVTKANA 193
Cdd:cd19138 82 NASRQG---TVRACERSLRRLGTDYLDLYLLH-WRGGVPLAETVAAMEELKKEGKIRAWGVSnfDTDdmeeLWAVPGGGN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 194 YArhhglrtfsVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGyfktlGSEGAGARRIPptiligreqqvsqVLD 273
Cdd:cd19138 158 CA---------ANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQG-----GLLRRGLLENP-------------TLK 210
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 274 NVAKRHNVPLTSVTLAYAMqKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19138 211 EIAARHGATPAQVALAWVL-RDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
70-317 |
2.75e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 94.57 E-value: 2.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 70 NFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKyAMTPMAGKSVNQsnyggtgnkcMHISIEASLKAMNTDYIDIYY 149
Cdd:cd19105 40 NYFDTAEGYGNGNSEEIIGEALKGLRRD-KVFLATK-ASPRLDKKDKAE----------LLKSVEESLKRLQTDYIDIYQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 150 VHAWDYASSILELMQSLNALVI---HGKVLYLGIS--DAPAWFVTKAnayARHHGlrtFSVYQGRYS-AQQRDMEREIIP 223
Cdd:cd19105 108 LHGVDTPEERLLNEELLEALEKlkkEGKVRFIGFSthDNMAEVLQAA---IESGW---FDVIMVAYNfLNQPAELEEALA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 224 MAREEGMAILAfgvlvngyFKTLGseGAGARRIPPTILIGREQQVSQVLdnvakrhnvpltsvtLAYAMQKtPYFY-PII 302
Cdd:cd19105 182 AAAEKGIGVVA--------MKTLA--GGYLQPALLSVLKAKGFSLPQAA---------------LKWVLSN-PRVDtVVP 235
|
250
....*....|....*
gi 242820009 303 GGRKVEHLKANIEAL 317
Cdd:cd19105 236 GMRNFAELEENLAAA 250
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
40-325 |
1.97e-21 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 92.25 E-value: 1.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMGlGECT-----KEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKYAMTPMAGK 114
Cdd:cd19137 8 GLGT-WGIG-GFLTpdysrDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFPRE-DLFIVTKVWPTNLRYD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 115 SvnqsnyggtgnkcMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAY 194
Cdd:cd19137 85 D-------------LLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 195 ARhhglRTFSVYQGRYSAQQRDMERE-IIPMAREEGMAILAFGVLVNGYFKTlgsegagarripptiligreqqvSQVLD 273
Cdd:cd19137 152 SQ----TPIVCNQVKYNLEDRDPERDgLLEYCQKNGITVVAYSPLRRGLEKT-----------------------NRTLE 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 242820009 274 NVAKRHNVPLTSVTLAYAMQKtPYFYPIIGGRKVEHLKANIEALKLRLTPED 325
Cdd:cd19137 205 EIAKNYGKTIAQIALAWLIQK-PNVVAIPKAGRVEHLKENLKATEIKLSEEE 255
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
40-331 |
8.83e-21 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 91.21 E-value: 8.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMG---LGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHNEMIIATKYAMtpmagksv 116
Cdd:cd19148 8 ALGT-WAIGgwmWGGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATKVGL-------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 117 nqsNYGGTGNKCMHIS-------IEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISD-APAwfv 188
Cdd:cd19148 79 ---EWDEGGEVVRNSSparirkeVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNfSPE--- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 189 tkanayarhhGLRTF------SVYQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYF-----KTLGSEGAGARRIP 257
Cdd:cd19148 153 ----------QMETFrkvaplHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLsgkmtKDTKFEGDDLRRTD 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 258 PTIligREQQVSQVLDNVAK-------RHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19148 223 PKF---QEPRFSQYLAAVEEldklaqeRYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLNDEDMKEID 299
|
.
gi 242820009 331 T 331
Cdd:cd19148 300 A 300
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
27-325 |
1.32e-20 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 90.69 E-value: 1.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 27 VSPLCLGGMskpfGFGtNWGMglgecTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMK-DRGRHNEMIIATK 105
Cdd:cd19092 6 VSRLVLGCM----RLA-DWGE-----SAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALAlNPGLREKIEIQTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 YAMTPMAGKSVNQSNYGGTGNKcmHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDa 183
Cdd:cd19092 76 CGIRLGDDPRPGRIKHYDTSKE--HIlaSVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSN- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 184 pawfvtkanayarhhglrtFSVYQgrYSAQQRDMEREII-------PM------------AREEGMAILAFGVLVNGYFK 244
Cdd:cd19092 153 -------------------FTPSQ--IELLQSYLDQPLVtnqielsLLhteaiddgtldyCQLLDITPMAWSPLGGGRLF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 245 TLGSEgagarripptiligREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPE 324
Cdd:cd19092 212 GGFDE--------------RFQRLRAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTRE 277
|
.
gi 242820009 325 D 325
Cdd:cd19092 278 E 278
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-315 |
3.50e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 88.31 E-value: 3.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 25 VRVSPLCLGGMSkpfgfgtnwgmgLGECTKEMAYELLDtfYYLDG--NFVDTANTYqgSQSEEWIGDWMKDRgRHnEMII 102
Cdd:cd19100 9 LKVSRLGFGGGP------------LGRLSQEEAAAIIR--RALDLgiNYFDTAPSY--GDSEEKIGKALKGR-RD-KVFL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 103 ATKYamtpmagksvnqsnYGGTGNKCMhISIEASLKAMNTDYIDIYYVHA------WDYASS---ILELMQSLNAlviHG 173
Cdd:cd19100 71 ATKT--------------GARDYEGAK-RDLERSLKRLGTDYIDLYQLHAvdteedLDQVFGpggALEALLEAKE---EG 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 174 KVLYLGISdapawfvTKANAYARhHGLRT--FSVYQGRYSAQQRDM---EREIIPMAREEGMAILAfgvlvngyFKTLgs 248
Cdd:cd19100 133 KIRFIGIS-------GHSPEVLL-RALETgeFDVVLFPINPAGDHIdsfREELLPLAREKGVGVIA--------MKVL-- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 249 egaGARRIPPTILIGREQQvsqvldnvakrhnvpltsvtLAYAMQKTPYFYPIIGGRKVEHLKANIE 315
Cdd:cd19100 195 ---AGGRLLSGDPLDPEQA--------------------LRYALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
55-327 |
9.47e-20 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 88.67 E-value: 9.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 55 EMAYELLDTFYYLDGNFVDTANTY---QGSqSEEWIGDWMKD--RGRHNEMIIATK--YAMTPmagksvnqSNYGGTGN- 126
Cdd:cd19150 30 ETQRAILRTAFDLGITHFDLANNYgppPGS-AEENFGRILREdfAGYRDELIISTKagYDMWP--------GPYGEWGSr 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 127 KCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARHHGLRTFsVY 206
Cdd:cd19150 101 KYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAILRELGTPLL-IH 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 207 QGRYSAQQRDMER-EIIPMAREEGMAILAFGVLVNGYF--KTLGSEGAGARRIPPTILIGR---EQQVSQV--LDNVAKR 278
Cdd:cd19150 180 QPSYNMLNRWVEEsGLLDTLQELGVGCIAFTPLAQGLLtdKYLNGIPEGSRASKERSLSPKmltEANLNSIraLNEIAQK 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 242820009 279 HNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALK-LRLTPEDVA 327
Cdd:cd19150 260 RGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALDnLTFSADELA 309
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
70-330 |
2.47e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 87.39 E-value: 2.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 70 NFVDTANTYQGSQSEEWIGDWMKDRGRHNeMIIATKYamTP-MAGKSVNQsnyggtgnkcMHISIEASLKAMNTDYIDIY 148
Cdd:cd19103 47 NLWDTAAVYGMGASEKILGEFLKRYPRED-YIISTKF--TPqIAGQSADP----------VADMLEGSLARLGTDYIDIY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 149 YVH-AWDYASSILELMqslnALVIHGKVLYLGISDAPAWFVTKANAYARHHGLRTFSVyQGRYSAQQRDMERE-IIPMAR 226
Cdd:cd19103 114 WIHnPADVERWTPELI----PLLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAV-QNHYSLLYRSSEEAgILDYCK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 227 EEGMAILAFGVLVNGYF------KTLGSEGAGA----RRIPPTIligreQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTP 296
Cdd:cd19103 189 ENGITFFAYMVLEQGALsgkydtKHPLPEGSGRaetyNPLLPQL-----EELTAVMAEIGAKHGASIAQVAIAWAIAKGT 263
|
250 260 270
....*....|....*....|....*....|....
gi 242820009 297 yfYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19103 264 --TPIIGVTKPHHVEDAARAASITLTDDEIKELE 295
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
39-330 |
1.19e-18 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 86.03 E-value: 1.19e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGtnwGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYqgSQSEEWIGDWMKdrGRHNEMIIATKyamTPMAGKSVNQ 118
Cdd:COG1453 16 LGFG---GMRLPRKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALK--GPRDKVILATK---LPPWVRDPED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 119 snyggtgnkcMHISIEASLKAMNTDYIDIYYVHA------WDYASSILELMQSLNALVIHGKVLYLGIS--DAPAWFVTK 190
Cdd:COG1453 86 ----------MRKDLEESLKRLQTDYIDLYLIHGlnteedLEKVLKPGGALEALEKAKAEGKIRHIGFSthGSLEVIKEA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 191 ANAYArhhglrtFSVYQGRYSA--QQRDMEREIIPMAREEGMAI-----LAFGVLVNgyfktlgsegagarriPPtilig 263
Cdd:COG1453 156 IDTGD-------FDFVQLQYNYldQDNQAGEEALEAAAEKGIGViimkpLKGGRLAN----------------PP----- 207
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 264 reqqvsqvlDNVAKRHNVPLTSVTLA--YAMQktpyfYP-----IIGGRKVEHLKANIEALKL--RLTPEDVAEIE 330
Cdd:COG1453 208 ---------EKLVELLCPPLSPAEWAlrFLLS-----HPevttvLSGMSTPEQLDENLKTADNlePLTEEELAILE 269
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
39-330 |
1.44e-18 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 83.86 E-value: 1.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTnWGMGLGECTKEMAyELLDTFYyldgNFVDTANTYQgsqSEEWIGDWMKDRGRHNEMI-IATKyamtpmagksVN 117
Cdd:cd19073 4 LGLGT-WQLRGDDCANAVK-EALELGY----RHIDTAEIYN---NEAEVGEAIAESGVPREDLfITTK----------VW 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 118 QSNYGgtgNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDapawFVTKANAYARH 197
Cdd:cd19073 65 RDHLR---PEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSN----FTIELLEEALD 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 198 HGLRTFSVYQGRY--SAQQRDMereiIPMAREEGMAILAFGVLVNGyfktlgsegagarripptiligrEQQVSQVLDNV 275
Cdd:cd19073 138 ISPLPIAVNQVEFhpFLYQAEL----LEYCRENDIVITAYSPLARG-----------------------EVLRDPVIQEI 190
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 276 AKRHNVPLTSVTLAYAMQKTpyFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19073 191 AEKYDKTPAQVALRWLVQKG--IVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
73-330 |
7.92e-18 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 83.50 E-value: 7.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 73 DTANTY---QGSqSEEWIGDWMKD--RGRHNEMIIATK--YAMTPmagksvnqSNYG-GTGNKCMHISIEASLKAMNTDY 144
Cdd:PRK09912 61 DLANNYgppPGS-AEENFGRLLREdfAAYRDELIISTKagYDMWP--------GPYGsGGSRKYLLASLDQSLKRMGLEY 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 145 IDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISD-APAwfVTKANAYARHHGLRTFSVYQGRYSAQQRDMERE-II 222
Cdd:PRK09912 132 VDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSySPE--RTQKMVELLREWKIPLLIHQPSYNLLNRWVDKSgLL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 223 PMAREEGMAILAF-----GVLVNGYFKTL--GS----EGAGARRIPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYA 291
Cdd:PRK09912 210 DTLQNNGVGCIAFtplaqGLLTGKYLNGIpqDSrmhrEGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWL 289
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 242820009 292 MQKTPYFYPIIGGRKVEHLKANIEALK-LRLTPEDVAEIE 330
Cdd:PRK09912 290 LKDERVTSVLIGASRAEQLEENVQALNnLTFSTEELAQID 329
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
39-329 |
4.67e-17 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 80.48 E-value: 4.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTNWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKyamtpmAGKSVNQ 118
Cdd:cd19162 3 LGLGAASLGNLARAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARHPRA-EYVVSTK------VGRLLEP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 119 SNYGGTGNKCMHI---------SIEASLKAMNTDYIDIYYVH----AWDYAssILELMQSLNALVIHGKVLYLGIS--DA 183
Cdd:cd19162 76 GAAGRPAGADRRFdfsadgirrSIEASLERLGLDRLDLVFLHdpdrHLLQA--LTDAFPALEELRAEGVVGAIGVGvtDW 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 184 PAwfvtkANAYARHHGLRTFSVyQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKTLGSEGAG--ARRIPPTIL 261
Cdd:cd19162 154 AA-----LLRAARRADVDVVMV-AGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRydYRPATPEVL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 262 IgREQQvsqvLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEI 329
Cdd:cd19162 228 A-RARR----LAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLRTPIPAEFWAEL 290
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
39-331 |
6.10e-17 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 79.71 E-value: 6.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTnWGMGLGECTK--EMAyelLDTFYYLdgnfVDTANTYQgsqSEEWIGDWMKDRG-RHNEMIIATKyamtpmagks 115
Cdd:COG0656 8 LGLGT-WQLPGEEAAAavRTA---LEAGYRH----IDTAAMYG---NEEGVGEAIAASGvPREELFVTTK---------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 116 VNQSNYGGTGnkcMHISIEASLKAMNTDYIDIYYVHaWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYA 195
Cdd:COG0656 67 VWNDNHGYDD---TLAAFEESLERLGLDYLDLYLIH-WPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAET 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 196 R----------HHGLRtfsvyqgrysaqqrdmEREIIPMAREEGMAILAFGVLVNGyfKTLGSEgagarripptiligre 265
Cdd:COG0656 143 GvkpavnqvelHPYLQ----------------QRELLAFCREHGIVVEAYSPLGRG--KLLDDP---------------- 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 266 qqvsqVLDNVAKRHNVPLTSVTLAYAMQKTpyFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:COG0656 189 -----VLAEIAEKHGKTPAQVVLRWHLQRG--VVVIPKSVTPERIRENLDAFDFELSDEDMAAIDA 247
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
39-330 |
1.14e-16 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 78.68 E-value: 1.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTNWGmglgecTKEMAYELLDtfYYLDGNF--VDTANTYQgsqSEEWIGDWMKDRG-RHNEMIIATKYAMTPMAGKS 115
Cdd:cd19071 4 IGLGTYKL------KPEETAEAVL--AALEAGYrhIDTAAAYG---NEAEVGEAIRESGvPREELFITTKLWPTDHGYER 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 116 VNQSnyggtgnkcmhisIEASLKAMNTDYIDIYYVH---AWDYASSILELMQS---LNALVIHGKVLYLGISdapawfvt 189
Cdd:cd19071 73 VREA-------------LEESLKDLGLDYLDLYLIHwpvPGKEGGSKEARLETwraLEELVDEGLVRSIGVS-------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 190 kaNAYARH------HGLRTFSVYQGRYSA--QQRDMeREIipmAREEGMAILAFGVLVNGYFKTLGSEgagarripptil 261
Cdd:cd19071 132 --NFNVEHleellaAARIKPAVNQIELHPylQQKEL-VEF---CKEHGIVVQAYSPLGRGRRPLLDDP------------ 193
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 262 igreqqvsqVLDNVAKRHNVPLTSVTLAYAMQKTpyFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19071 194 ---------VLKEIAKKYGKTPAQVLLRWALQRG--VVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
38-330 |
3.62e-16 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 78.05 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTnwgMGL----GECTKEMAYELLDTFYYLDGNFVDTANTYQGSQ---SEEWIGDWMKDRGRHNE-MIIATKYAMT 109
Cdd:cd19077 7 PIGLGL---MGLtwrpNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYPEYADkVVLSVKGGLD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 110 PMAGKSVnqsnyggTGNKCMHISIEASLKAMN-TDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDApawfv 188
Cdd:cd19077 84 PDTLRPD-------GSPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEV----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 189 tKANAYARHHGLRTFSVYQGRYSAQQRDME-REIIPMAREEGMAILAFGVL----VNGYFKTLGSEGAGARRIpptiLIG 263
Cdd:cd19077 152 -SAETIRRAHAVHPIAAVEVEYSLFSREIEeNGVLETCAELGIPIIAYSPLgrglLTGRIKSLADIPEGDFRR----HLD 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 264 REQ--------QVSQVLDNVAKRHNVPLTSVTLAYAM-QKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19077 227 RFNgenfeknlKLVDALQELAEKKGCTPAQLALAWILaQSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
39-331 |
3.39e-14 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 72.81 E-value: 3.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTnWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRG-RHNEMIIATKYAMtpmAGKSVN 117
Cdd:cd19158 16 LGLGT-WVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGwRRSSLVITTKIFW---GGKAET 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 118 QSnygGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYARH 197
Cdd:cd19158 92 ER---GLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 198 HGLRTFSVYQGRYSAQQRD-MEREIIPMAREEGMAILAFGVLVNGYFKtlGSEGAGarrIPP--------------TILI 262
Cdd:cd19158 169 FNLIPPICEQAEYHMFQREkVEVQLPELFHKIGVGAMTWSPLACGIVS--GKYDSG---IPPysraslkgyqwlkdKILS 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242820009 263 --GREQQVS-QVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKL--RLTPEDVAEIET 331
Cdd:cd19158 244 eeGRRQQAKlKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVlpKLSSSIVHEIDS 317
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
40-323 |
9.27e-14 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 71.32 E-value: 9.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMGLGECTKEMAYELLdTFYYLDG-NFVDTANTYQGSQSEEWIGDWMKDRG-RHNEMIIATKYAMtpmAGKSVN 117
Cdd:cd19141 16 GLGT-WVTFGSQISDEVAEELV-TLAYENGiNLFDTAEVYAAGKAEIVLGKILKKKGwRRSSYVITTKIFW---GGKAET 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 118 QSnygGTGNKcmHI--SIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYA 195
Cdd:cd19141 91 ER---GLSRK--HIieGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEAYSVA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 196 RHHGLRTFSVYQGRYSAQQRDMEREIIP-MAREEGMAI-----LAFGVLVNGYFKTL--GSEGA--GARRIPPTILI--G 263
Cdd:cd19141 166 RQFNLIPPIVEQAEYHLFQREKVEMQLPeLFHKIGVGAmtwspLACGILSGKYDDGVpeYSRASlkGYQWLKEKILSeeG 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242820009 264 REQQVS-QVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLR--LTP 323
Cdd:cd19141 246 RRQQAKlKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQVLpkLTP 308
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
15-331 |
2.79e-13 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 70.07 E-value: 2.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 15 RHRLLSpNASVRVSplCLGgmskpfgFGTnWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDR 94
Cdd:cd19159 2 KYRNLG-KSGLRVS--CLG-------LGT-WVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 95 G-RHNEMIIATKYAMtpmAGKSVNQSnygGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHG 173
Cdd:cd19159 71 GwRRSSLVITTKLYW---GGKAETER---GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 174 KVLYLGISDAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRD-MEREIIPMAREEGMAI-----LAFGVLVNGYFKTLG 247
Cdd:cd19159 145 MAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREkVEVQLPELYHKIGVGAmtwspLACGIISGKYGNGVP 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 248 SEGAGARR----IPPTILI--GREQQVS-QVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKL- 319
Cdd:cd19159 225 ESSRASLKcyqwLKERIVSeeGRKQQNKlKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVl 304
|
330
....*....|...
gi 242820009 320 -RLTPEDVAEIET 331
Cdd:cd19159 305 pKMTSHVVNEIDN 317
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-198 |
4.92e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 69.27 E-value: 4.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTNWGmGLGECTKEMAYELLDTFyyLDG--NFVDTANTYQGSQSEEWIGDWMKDRGRHN-----EMIIATK----- 105
Cdd:cd19099 5 SLGLGTYRG-DSDDETDEEYREALKAA--LDSgiNVIDTAINYRGGRSERLIGKALRELIEKGgikrdEVVIVTKagyip 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 106 ----YAMTPM------AGKSVNQSNYGGTGNKCMH-----ISIEASLKAMNTDYIDIYYVH------AWDYASSILELMQ 164
Cdd:cd19099 82 gdgdEPLRPLkyleekLGRGLIDVADSAGLRHCISpayleDQIERSLKRLGLDTIDLYLLHnpeeqlLELGEEEFYDRLE 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 242820009 165 S----LNALVIHGKVLYLGISdapAWFVTKANAYARHH 198
Cdd:cd19099 162 EafeaLEEAVAEGKIRYYGIS---TWDGFRAPPALPGH 196
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
28-181 |
5.60e-13 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 67.97 E-value: 5.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 28 SPLCLGGMSKPfgfgTNWGMGLGEctkEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRhNEMIIATKya 107
Cdd:cd19096 1 SVLGFGTMRLP----ESDDDSIDE---EKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGPR-EKFYLATK-- 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 108 MTPMAGKSVNQsnyggtgnkcMHISIEASLKAMNTDYIDIYYVHA-----WDYASSILELMQSLNALVIHGKVLYLGIS 181
Cdd:cd19096 71 LPPWSVKSAED----------FRRILEESLKRLGVDYIDFYLLHGlnspeWLEKARKGGLLEFLEKAKKEGLIRHIGFS 139
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
38-325 |
1.09e-12 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 68.12 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 38 PFGFGTnwgMGLG----ECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRGRHnEMIIATKYA--MTPM 111
Cdd:cd19161 2 ELGLGT---AGLGnlytAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKPRD-EFVLSTKVGrlLKPA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 112 AGKSVNQSN---------------YGGTgnkcMHiSIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHG--- 173
Cdd:cd19161 78 REGSVPDPNgfvdplpfeivydysYDGI----MR-SFEDSLQRLGLNRIDILYVHDIGVYTHGDRKERHHFAQLMSGgfk 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 174 -----------KVLYLGISDAPAwfvtkANAYARHHGLRTFSVyQGRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGY 242
Cdd:cd19161 153 aleelkkagviKAFGLGVNEVQI-----CLEALDEADLDCFLL-AGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGI 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 243 FKTLGSEGA--GARRIPPTILigreQQVSqVLDNVAKRHNVPLTSVTLAYamqktPYFYPI-----IGGRKVEHLKANIE 315
Cdd:cd19161 227 LATGTKSGAkfNYGDAPAEII----SRVM-EIEKICDAYNVPLAAAALQF-----PLRHPAvasvlTGARNPAQLRQNVE 296
|
330
....*....|
gi 242820009 316 ALKlRLTPED 325
Cdd:cd19161 297 AFQ-TDIPEE 305
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
40-330 |
1.82e-12 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 67.49 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGT--NWGMGLGEctkEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRG-RHNEMIIATKYAMTpmagksv 116
Cdd:cd19142 17 GLGTwsTFSTAISE---EQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGwKRSSYIVSTKIYWS------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 117 NQSNYGGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAYAR 196
Cdd:cd19142 87 YGSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFSIAR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 197 HHGLRTFSVYQGRYSAQQRD-MEREI----------------IPMAREEGMAILAFGVLVNGYFKTLGSEGAG-ARRIPP 258
Cdd:cd19142 167 QFNCPTPICEQSEYHMFCREkMELYMpelynkvgvglitwspLSLGLDPGISEETRRLVTKLSFKSSKYKVGSdGNGIHE 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242820009 259 TilIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKL--RLTPEDVAEIE 330
Cdd:cd19142 247 E--TRRASHKLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQLlpKLNSAVMEELE 318
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
23-330 |
3.57e-12 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 66.55 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 23 ASVRVSplCLGgmskpfgFGTnWGMGLGECTKEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRG-RHNEMI 101
Cdd:cd19160 11 SGLRVS--CLG-------LGT-WVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGwRRSSYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 102 IATKYAMtpmAGKSVNQSnygGTGNKCMHISIEASLKAMNTDYIDIYYVHAWDYASSILELMQSLNALVIHGKVLYLGIS 181
Cdd:cd19160 81 VTTKIYW---GGQAETER---GLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 182 DAPAWFVTKANAYARHHGLRTFSVYQGRYSAQQRD-MEREIIPMAREEGMAILAFGVLVNGYFKtlgseGAGARRIPPTI 260
Cdd:cd19160 155 RWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREkVEMQLPELYHKIGVGSVTWSPLACGLIT-----GKYDGRVPDTC 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 261 LI----------------GREQQvSQVLD--NVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKL--R 320
Cdd:cd19160 230 RAavkgyqwlkekvqseeGKKQQ-AKVKElhPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGSIQVlsQ 308
|
330
....*....|
gi 242820009 321 LTPEDVAEIE 330
Cdd:cd19160 309 LTPQTVMEID 318
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
40-330 |
1.24e-11 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 64.20 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 40 GFGTnWGMGLGECTK--EMAyelLDTFYyldgNFVDTANTYQgsqSEEWIGDWMKDRG-RHNEMIIATKYAMTPMAGKSV 116
Cdd:cd19140 12 GLGT-YPLTGEECTRavEHA---LELGY----RHIDTAQMYG---NEAQVGEAIAASGvPRDELFLTTKVWPDNYSPDDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 117 NQSnyggtgnkcmhisIEASLKAMNTDYIDIYYVHaWDYAS-SILELMQSLNALVIHGKVLYLGISDAPAWFVTKAnayA 195
Cdd:cd19140 81 LAS-------------VEESLRKLRTDYVDLLLLH-WPNKDvPLAETLGALNEAQEAGLARHIGVSNFTVALLREA---V 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 196 RHHGLRTFSVyQGRYSA--QQRDmereIIPMAREEGMAILAFGVLVNGyfktlgsegagarripptiligreqQVSQ--V 271
Cdd:cd19140 144 ELSEAPLFTN-QVEYHPylDQRK----LLDAAREHGIALTAYSPLARG-------------------------EVLKdpV 193
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 242820009 272 LDNVAKRHNVPLTSVTLAYAMQKtPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19140 194 LQEIGRKHGKTPAQVALRWLLQQ-EGVAAIPKATNPERLEENLDIFDFTLSDEEMARIA 251
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-331 |
1.88e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 64.29 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 13 LGRHRLLSPNASVrvsplclggmskpfgfgtnwgmglgECTKEMAYELLDTFYYLDGNFVDTANTYqgSQSEEWIGDWMK 92
Cdd:cd19098 18 LGHAADLGSGRSV-------------------------EAMRAHTHAVLDAAWAAGVRYFDAARSY--GRAEEFLGSWLR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 93 DRG-RHNEMIIATKYAMTPMAGKSVNQSnyggtgnkcMHISIEASL-----KAMNT-----DYIDIYYVHAWDYASSILE 161
Cdd:cd19098 71 SRNiAPDAVFVGSKWGYTYTADWQVDAA---------VHEVKDHSLarllkQWEETrsllgKHLDLYQIHSATLESGVLE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 162 LMQSLNALV-IHGKVLYLGIS-DAPAWFVTKANAYA-RHHGLRTFSVYQGRYSAqqrdMER---EIIPMAREEGMAILAF 235
Cdd:cd19098 142 DADVLAALAeLKAEGVKIGLSlSGPQQAETLRRALEiEIDGARLFDSVQATWNL----LEQsagEALEEAHEAGMGVIVK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 236 GVLVNGyfktlgsegagarRIPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTpyFYPII--GGRKVEHLKAN 313
Cdd:cd19098 218 EALANG-------------RLTDRNPSPELAPLMAVLKAVADRLGVTPDALALAAVLAQP--FVDVVlsGAATPEQLRSN 282
|
330
....*....|....*...
gi 242820009 314 IEALKLRLTPEDVAEIET 331
Cdd:cd19098 283 LRALDVSLDLELLAALAD 300
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
72-329 |
5.02e-11 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 62.37 E-value: 5.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 72 VDTANTYQgsqSEEWIGDWMKDRG-RHNEMIIATKyamtpmagksVNQSNYGGtgNKCMHiSIEASLKAMNTDYIDIYYV 150
Cdd:cd19139 31 IDTAQIYD---NEAAVGQAIAESGvPRDELFITTK----------IWIDNLSK--DKLLP-SLEESLEKLRTDYVDLTLI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 151 HaWDYASSILELMQSLNALvihgkvlylgiSDApawfvtKANAYARHHGLRTFSVYQ----------GRYSAQQRDME-- 218
Cdd:cd19139 95 H-WPSPNDEVPVEEYIGAL-----------AEA------KEQGLTRHIGVSNFTIALldeaiavvgaGAIATNQIELSpy 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 219 ---REIIPMAREEGMAILAFGVLvnGYFKTLGSEgagarripptiligreqqvsqVLDNVAKRHNVPLTSVTLAYAMQKT 295
Cdd:cd19139 157 lqnRKLVAHCKQHGIHVTSYMTL--AYGKVLDDP---------------------VLAAIAERHGATPAQIALAWAMARG 213
|
250 260 270
....*....|....*....|....*....|....*
gi 242820009 296 pyfYPII-GGRKVEHLKANIEALKLRLTPEDVAEI 329
Cdd:cd19139 214 ---YAVIpSSTKREHLRSNLLALDLTLDADDMAAI 245
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
71-331 |
8.53e-11 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 61.86 E-value: 8.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 71 FVDTANTYQgsqSEEWIG----DWMKDRgrhNEMIIATKYamtpmagksvnqsnygGTGNKCMHISIEASLKAMNTDYID 146
Cdd:cd19120 41 HIDTAEMYG---NEKEVGealkESGVPR---EDLFITTKV----------------SPGIKDPREALRKSLAKLGVDYVD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 147 IYYVHA-WDYASSILELMQS---LNALVIHGKVLYLGISdapawfvtkaNAYARHhgLRTF--------SVYQGRYSAQQ 214
Cdd:cd19120 99 LYLIHSpFFAKEGGPTLAEAwaeLEALKDAGLVRSIGVS----------NFRIED--LEELldtakikpAVNQIEFHPYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 215 RDMEREIIPMAREEGMAILAFGVLvngyfktlgsegagarrIPptILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQK 294
Cdd:cd19120 167 YPQQPALLEYCREHGIVVSAYSPL-----------------SP--LTRDAGGPLDPVLEKIAEKYGVTPAQVLLRWALQK 227
|
250 260 270
....*....|....*....|....*....|....*..
gi 242820009 295 TpyFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:cd19120 228 G--IVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDK 262
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
70-331 |
1.15e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 61.90 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 70 NFVDTANTYQGSQSEEWIGDWMKDRGrhNEMIIATKYAMTPMAGKSVNQsnyggtgnkcmHI--SIEASLKAMNTDYIDI 147
Cdd:cd19104 47 NFFDTAPSYGDGKSEENLGRALKGLP--AGPYITTKVRLDPDDLGDIGG-----------QIerSVEKSLKRLKRDSVDL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 148 YYVH------------------AWDYASSILElmqSLNALVIHGKVLYLGISdapAWFVTKANAYARHHGLrtFSVYQ-- 207
Cdd:cd19104 114 LQLHnrigderdkpvggtlsttDVLGLGGVAD---AFERLRSEGKIRFIGIT---GLGNPPAIRELLDSGK--FDAVQvy 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 208 ----------GRYSAQQRDMEREIIPMAREEGMAILAFGVLVNGYFKTlgSEGAGaRRIPPTILIGREQQVSQV--LDNV 275
Cdd:cd19104 186 ynllnpsaaeARPRGWSAQDYGGIIDAAAEHGVGVMGIRVLAAGALTT--SLDRG-REAPPTSDSDVAIDFRRAaaFRAL 262
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 276 AKRHNVPLTSVTLAYAMqKTPYFYPIIGGRK-VEHLKANIEA-LKLRLTPEDVAEIET 331
Cdd:cd19104 263 AREWGETLAQLAHRFAL-SNPGVSTVLVGVKnREELEEAVAAeAAGPLPAENLARLEA 319
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
39-318 |
2.26e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 60.62 E-value: 2.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGT-NWGMG------LGECTKEMAYELLDTFYYLDGNFVDTANTYqGSqSEEWIGDWMKDRGRHNemiIATKYAMTPM 111
Cdd:cd19097 3 LALGTaQFGLDygiankSGKPSEKEAKKILEYALKAGINTLDTAPAY-GD-SEKVLGKFLKRLDKFK---IITKLPPLKE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 112 AGKSVNQSnyggtgnkcMHISIEASLKAMNTDYIDIYYVHAW-DYASSILELMQSLNALVIHGKVLYLGISdapAWFVTK 190
Cdd:cd19097 78 DKKEDEAA---------IEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVS---VYSPEE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 191 ANAYARHHGlrtFSVYQGRYSA-QQRDMEREIIPMAREEGMAILA---F--GVLVNGYFKtlgsegagarriPPTILIGR 264
Cdd:cd19097 146 LEKALESFK---IDIIQLPFNIlDQRFLKSGLLAKLKKKGIEIHArsvFlqGLLLMEPDK------------LPAKFAPA 210
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 242820009 265 EQQVSQvLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALK 318
Cdd:cd19097 211 KPLLKK-LHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFK 263
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
132-331 |
9.67e-10 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 58.88 E-value: 9.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 132 SIEASLKAMNTDYIDIYYVHaW---DYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTKANAyarhhglrtfSVYQG 208
Cdd:PRK11172 78 SLKESLQKLRTDYVDLTLIH-WpspNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIA----------AVGAE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 209 RYSAQQRDME-----REIIPMAREEGMAILAFGVLvnGYFKTLGSEgagarripptiligreqqvsqVLDNVAKRHNVPL 283
Cdd:PRK11172 147 NIATNQIELSpylqnRKVVAFAKEHGIHVTSYMTL--AYGKVLKDP---------------------VIARIAAKHNATP 203
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 242820009 284 TSVTLAYAMQKTpyfYPII-GGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:PRK11172 204 AQVILAWAMQLG---YSVIpSSTKRENLASNLLAQDLQLDAEDMAAIAA 249
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
70-324 |
2.70e-09 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 57.56 E-value: 2.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 70 NFVDTANTYQGSQSEEWIGDWMKDRGRhNEMIIATKyamtpmAGKsvnqsnYGGTGNK-----CMHI--SIEASLKAMNT 142
Cdd:cd19163 48 NYIDTAPWYGQGRSETVLGKALKGIPR-DSYYLATK------VGR------YGLDPDKmfdfsAERItkSVEESLKRLGL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 143 DYIDIYYVHAWDYASS---IL-ELMQSLNALVIHGKVLYLGISDAPAWFVTKanAYARHHG-LRTFSVYqGRYSAQQRDM 217
Cdd:cd19163 115 DYIDIIQVHDIEFAPSldqILnETLPALQKLKEEGKVRFIGITGYPLDVLKE--VLERSPVkIDTVLSY-CHYTLNDTSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 218 ErEIIPMAREEGMAI-----LAFGVLVNgyfktlgsegAGAR---RIPPTIligreQQVSQVLDNVAKRHNVPLTSVTLA 289
Cdd:cd19163 192 L-ELLPFFKEKGVGVinaspLSMGLLTE----------RGPPdwhPASPEI-----KEACAKAAAYCKSRGVDISKLALQ 255
|
250 260 270
....*....|....*....|....*....|....*
gi 242820009 290 YAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPE 324
Cdd:cd19163 256 FALSNPDIATTLVGTASPENLRKNLEAAEEPLDAH 290
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
34-331 |
2.81e-09 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 57.51 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 34 GMSKPF-GFGTnWGMGLGECTkemayELLDTFYYLDGNFVDTANTYQgsqSEEWIGD---WMKDRG--RHNEMIIATKYA 107
Cdd:cd19111 1 GFPMPViGLGT-YQSPPEEVR-----AAVDYALFVGYRHIDTALSYQ---NEKAIGEalkWWLKNGklKREEVFITTKLP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 108 MTPMAGKSVNQSnyggtgnkcmhisIEASLKAMNTDYIDIYYVHA-W------------DYASSILELMQSLNALVIHGK 174
Cdd:cd19111 72 PVYLEFKDTEKS-------------LEKSLENLKLPYVDLYLIHHpCgfvnkkdkgereLASSDVTSVWRAMEALVSEGK 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 175 VLYLGISDAPAWFVTKANAYAR---HHGLRTFSVYqgrysAQQrdmeREIIPMAREEGMAILAFGvlvngyfkTLGSEG- 250
Cdd:cd19111 139 VKSIGLSNFNPRQINKILAYAKvkpSNLQLECHAY-----LQQ----RELRKFCNKKNIVVTAYA--------PLGSPGr 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 251 AGARRIPPTILIGREQQVSQvldnVAKRHNVPLTSVTLAYAMQKTpyFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:cd19111 202 ANQSLWPDQPDLLEDPTVLA----IAKELDKTPAQVLLRFVLQRG--TGVLPKSTNKERIEENFEVFDFELTEEHFKKLK 275
|
.
gi 242820009 331 T 331
Cdd:cd19111 276 T 276
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
22-191 |
6.61e-08 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 53.31 E-value: 6.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 22 NASVRVSPLCLGGMskpfGFGTNWGMGLGEctkEMAYELLDTFYYLDGNFVDTANTYQGSQSEEWIGDWMKDRG--RHnE 99
Cdd:cd19153 7 IALGNVSPVGLGTA----ALGGVYGDGLEQ---DEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQvpRS-S 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 100 MIIATKyamtpmagksVNQSNYGG--TGNKCMHISIEASLKAMNTDYIDIYYVHA---WDYASSILELMQSLNALVIHGK 174
Cdd:cd19153 79 YTVATK----------VGRYRDSEfdYSAERVRASVATSLERLHTTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGV 148
|
170
....*....|....*..
gi 242820009 175 VLYLGISDAPAWFVTKA 191
Cdd:cd19153 149 IKRIGIAGYPLDTLTRA 165
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
34-330 |
1.23e-07 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 52.80 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 34 GMSKP-FGFGTnWGMGlGECTKEMAYELLDTFYYLdgnfVDTANTYQgsqSEEWIGDWMKD-----RGRHNEMIIATKYA 107
Cdd:cd19154 9 GVKMPlIGLGT-WQSK-GAEGITAVRTALKAGYRL----IDTAFLYQ---NEEAIGEALAElleegVVKREDLFITTKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 108 MTPMAGKSVNQSnyggtgnkcmhisIEASLKAMNTDYIDIYYVHA-WDYASSILELMQSLNALVIHGKVLYLGISDAPAW 186
Cdd:cd19154 80 THEHAPEDVEEA-------------LRESLKKLQLEYVDLYLIHApAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 187 FVTKanAYARHHGLRTFSVYQgrysaQQRDMEREIIPMAREE--------GMAILAF----GVLVNGYfKTLGSEGAGAR 254
Cdd:cd19154 147 VYDE--GLTKAIGVSNFNNDQ-----IQRILDNARVKPHNNQvechlyfpQKELVEFckkhNISVTSY-ATLGSPGRANF 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 255 RIPPTILIGREQQVSQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYP--IIGGRKVEhlkaNIEALKLRLTPEDVAEIE 330
Cdd:cd19154 219 TKSTGVSPAPNLLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPksATPSRIKE----NFNIFDFSLSEEDMATLE 292
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
71-324 |
3.82e-07 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 51.07 E-value: 3.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 71 FVDTANTYQGSQSEEWIGDWMKDRGRhNEMIIATKYA--MTPMAG-------------KSVNQSNYGGTGnkcmhI--SI 133
Cdd:cd19152 36 YFDTAPWYGAGLSEERLGAALRELGR-EDYVISTKVGrlLVPLQEveptfepgfwnplPFDAVFDYSYDG-----IlrSI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 134 EASLKAMNTDYIDIYYVH---------AWD--YASSILELMQSLNALVIHGKVLY--LGISDAPAwfvtkANAYARHHGL 200
Cdd:cd19152 110 EDSLQRLGLSRIDLLSIHdpdedlagaESDehFAQAIKGAFRALEELREEGVIKAigLGVNDWEV-----ILRILEEADL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 201 RTFSVyQGRYSAQQRDMEREIIPMAREEGM-----AILAFGVLVNG-YFKTLGSEGAgarriPPTILIGREQqvsqvLDN 274
Cdd:cd19152 185 DWVML-AGRYTLLDHSAARELLPECEKRGVkvvnaGPFNSGFLAGGdNFDYYEYGPA-----PPELIARRDR-----IEA 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 242820009 275 VAKRHNVPLTSVTLAYAMQktpyfyP------IIGGRKVEHLKANIEALKLRLTPE 324
Cdd:cd19152 254 LCEQHGVSLAAAALQFALA------PpavasvAPGASSPERVEENVALLATEIPAA 303
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
39-151 |
4.07e-06 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 47.57 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGTnWGMGLGECTKEMAYELLDTFYYLdgnfVDTANTYQgsqSEEWIGDWMKDRG-RHNEMIIATKyamtpmagksVN 117
Cdd:cd19133 12 LGFGV-FQIPDPEECERAVLEAIKAGYRL----IDTAAAYG---NEEAVGRAIKKSGiPREELFITTK----------LW 73
|
90 100 110
....*....|....*....|....*....|....
gi 242820009 118 QSNYGGTGNKcmhISIEASLKAMNTDYIDIYYVH 151
Cdd:cd19133 74 IQDAGYEKAK---KAFERSLKRLGLDYLDLYLIH 104
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
72-329 |
4.17e-06 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 47.91 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 72 VDTANTYQgsqSEEWIGDWMK---DRGR--HNEMIIATKYAMTPMAGKSVNqsnyggtgnKCmhisIEASLKAMNTDYID 146
Cdd:cd19155 42 IDTAYVYR---NEAAIGNVLKkwiDSGKvkREELFIVTKLPPGGNRREKVE---------KF----LLKSLEKLQLDYVD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 147 IYYVHA---------------------WDYASSILELMQSLNALVIHGKVLYLGISDAPAWFVTK---------ANAYAR 196
Cdd:cd19155 106 LYLIHFpvgslskeddsgkldptgehkQDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARilknarikpANLQVE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 197 HHglrtfsVYqgrysAQQRDMereiIPMAREEGMAILAFGvlvngyfkTLGSEGAG---ARRIPPTILIGREQQVSQVLD 273
Cdd:cd19155 186 LH------VY-----LQQKDL----VDFCSTHSITVTAYA--------PLGSPGAAhfsPGTGSPSGSSPDLLQDPVVKA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 242820009 274 nVAKRHNVPLTSVTLAYAMQKTPYFYPiiggRKVE--HLKANIEALKLRLTPEDVAEI 329
Cdd:cd19155 243 -IAERHGKSPAQVLLRWLMQRGVVVIP----KSTNaaRIKENFQVFDFELTEADMAKL 295
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
132-339 |
4.61e-06 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 47.79 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 132 SIEASLKAMNTDYIDIYYVHaWDYAssilelmqsLNALVI--HGKVLYLGISDAP---AWFVTKA---NAYARHHGLRTF 203
Cdd:cd19123 91 ALEKTLADLQLDYLDLYLMH-WPVA---------LKKGVGfpESGEDLLSLSPIPledTWRAMEElvdKGLCRHIGVSNF 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 204 SVYQGR-YSAQQR---DMER-EIIPMAREEGMaiLAF----GVLVNGYfKTLGSegaGARriPPTILIGREQQVSQ--VL 272
Cdd:cd19123 161 SVKKLEdLLATARikpAVNQvELHPYLQQPEL--LAFcrdnGIHLTAY-SPLGS---GDR--PAAMKAEGEPVLLEdpVI 232
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242820009 273 DNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRkvEHLKANIEALKLRLTPEDVAEIEtgyNFDIGF 339
Cdd:cd19123 233 NKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNP--ERIQQNLEAAEVELDASDMATIA---ALDRHH 294
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
269-330 |
1.72e-05 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 46.12 E-value: 1.72e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242820009 269 SQVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGGRKVEHLKANIEALKLRLTPEDVAEIE 330
Cdd:PRK10376 223 SSTLSDVAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELD 284
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
39-331 |
4.79e-04 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 41.54 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 39 FGFGT-NWGmglGECTKEMAYELLDTFYYLdgnfVDTANTYQgsqSEEWIGDWMKDRG--RHnEMIIATKyaMTPmagks 115
Cdd:cd19135 16 LGLGTsHSG---GYSHEAVVYALKECGYRH----IDTAKRYG---CEELLGKAIKESGvpRE-DLFLTTK--LWP----- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 116 vnqSNYG--GTGNKCmhisiEASLKAMNTDYIDIYYVHaWDYA--------SSILELMQSLNALVIHGKVLYLGISDapa 185
Cdd:cd19135 78 ---SDYGyeSTKQAF-----EASLKRLGVDYLDLYLLH-WPDCpssgknvkETRAETWRALEELYDEGLCRAIGVSN--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 186 wfvtkanaYARHH--GLRTFS-----VYQGRYSAQQRDMerEIIPMAREEGMAILAFGVLVNGyfKTLGSegagarripP 258
Cdd:cd19135 146 --------FLIEHleQLLEDCsvvphVNQVEFHPFQNPV--ELIEYCRDNNIVFEGYCPLAKG--KALEE---------P 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242820009 259 TILigreqqvsqvldNVAKRHNVPLTSVTLAYAMQKTpyfYPII-GGRKVEHLKANIEALKLRLTPEDVAEIET 331
Cdd:cd19135 205 TVT------------ELAKKYQKTPAQILIRWSIQNG---VVTIpKSTKEERIKENCQVFDFSLSEEDMATLDS 263
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
132-184 |
5.80e-04 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 41.49 E-value: 5.80e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 242820009 132 SIEASLKAMNTDYIDIYYVHAWDYAS--SILELMQSLNALVIHGKVLYLGISDAP 184
Cdd:cd19164 104 SVERSLRRLHTDYLDLVYLHDVEFVAdeEVLEALKELFKLKDEGKIRNVGISGYP 158
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
136-336 |
5.21e-03 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 38.31 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 136 SLKAMNTDYIDIYYVH----------------AWDYA---------SSILELMQSLNALVIHGKVLYLGISDAPAWFVTK 190
Cdd:cd19114 87 QLKDYGLDYIDLYLIHfpipaayvdpaenypfLWKDKelkkfpleqSPMQECWREMEKLVDAGLVRNIGIANFNVQLILD 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242820009 191 ANAYARhhgLR--TFSVYQGRYSAQQRdmereIIPMAREEGMAILAFGVLVNGYFKTLGSEGAGArrippTILIGREqqv 268
Cdd:cd19114 167 LLTYAK---IKpaVLQIEHHPYLQQKR-----LIDWAKKQGIQITAYSSFGNAVYTKVTKHLKHF-----TNLLEHP--- 230
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242820009 269 sqVLDNVAKRHNVPLTSVTLAYAMQKTPYFYPIIGgrKVEHLKANIEALKLRLTPED---VAEIETGYNFD 336
Cdd:cd19114 231 --VVKKLADKHKRDTGQVLLRWAVQRNITVIPKSV--NVERMKTNLDITSYKLDEEDmeaLYELEANARFN 297
|
|
| |
