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Conserved domains on  [gi|242818145|ref|XP_002487062|]
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WD repeat protein [Talaromyces stipitatus ATCC 10500]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
96-425 1.24e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFAsmTPSTLRAFKSvdpsakknsaaqETHTVHYVAFNPisPSQMLV 175
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTG------------HSGAVTSVAFSP--DGKLLA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 ipatpqpkILDRDGNV-LTEFVKGdmylRDMHNTKGHVSEVTSGAWSPTDyNLCATAGTDSTVRIWDVnvgRSQKEVIAY 254
Cdd:COG2319  179 --------SGSDDGTVrLWDLATG----KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL---ATGKLLRTL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 255 KSRAAGsagrtkITAVAWaSPrQGgpNVLVATGLDGSLVMWSgdgpyTRPAAEVRDAHTRDTWTSGLDVSADGRLVVTRG 334
Cdd:COG2319  243 TGHSGS------VRSVAF-SP-DG--RLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 335 GDDTIKLWDTRKFKQPITAVTHqstssHYPTSNIKFSPTGTNIITGSETGHLYILNPATLKpELVSPVTPGSPVITVLWH 414
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGH-----TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|.
gi 242818145 415 EKLNQILTGSA 425
Cdd:COG2319  382 PDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
96-425 1.24e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFAsmTPSTLRAFKSvdpsakknsaaqETHTVHYVAFNPisPSQMLV 175
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTG------------HSGAVTSVAFSP--DGKLLA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 ipatpqpkILDRDGNV-LTEFVKGdmylRDMHNTKGHVSEVTSGAWSPTDyNLCATAGTDSTVRIWDVnvgRSQKEVIAY 254
Cdd:COG2319  179 --------SGSDDGTVrLWDLATG----KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL---ATGKLLRTL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 255 KSRAAGsagrtkITAVAWaSPrQGgpNVLVATGLDGSLVMWSgdgpyTRPAAEVRDAHTRDTWTSGLDVSADGRLVVTRG 334
Cdd:COG2319  243 TGHSGS------VRSVAF-SP-DG--RLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 335 GDDTIKLWDTRKFKQPITAVTHqstssHYPTSNIKFSPTGTNIITGSETGHLYILNPATLKpELVSPVTPGSPVITVLWH 414
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGH-----TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|.
gi 242818145 415 EKLNQILTGSA 425
Cdd:COG2319  382 PDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-426 8.72e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 8.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFASMTPstLRAFKsvdpsakknsaaQETHTVHYVAFnpISPSQMLV 175
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLK------------GHTGPVRDVAA--SADGTYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 IPATP-QPKILD-RDGNVLTEFvkgdmylrdmhntKGHVSEVTSGAWSPTDYnLCATAGTDSTVRIWDVNVGrsqKEVIA 253
Cdd:cd00200   68 SGSSDkTIRLWDlETGECVRTL-------------TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG---KCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 254 YKSRAAGsagrtkITAVAWASPRQggpnvLVATG-LDGSLVMWSGDGPYTRpaaEVRDAHTRdtWTSGLDVSADGRLVVT 332
Cdd:cd00200  131 LRGHTDW------VNSVAFSPDGT-----FVASSsQDGTIKLWDLRTGKCV---ATLTGHTG--EVNSVAFSPDGEKLLS 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 333 RGGDDTIKLWDTRKFKQPITAVTHQSTSSHyptsnIKFSPTGTNIITGSETGHLYILNPATLKPelvSPVTPG--SPVIT 410
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNS-----VAFSPDGYLLASGSEDGTIRVWDLRTGEC---VQTLSGhtNSVTS 266

                        330
                 ....*....|....*.
gi 242818145 411 VLWHEKLNQILTGSAN 426
Cdd:cd00200  267 LAWSPDGKRLASGSAD 282
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-241 6.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.31e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 242818145   209 KGHVSEVTSGAWSPtDYNLCATAGTDSTVRIWD 241
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
206-241 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 242818145  206 HNTKGHVSEVTSGAWSPtDYNLCATAGTDSTVRIWD 241
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
96-425 1.24e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFAsmTPSTLRAFKSvdpsakknsaaqETHTVHYVAFNPisPSQMLV 175
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTG------------HSGAVTSVAFSP--DGKLLA 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 ipatpqpkILDRDGNV-LTEFVKGdmylRDMHNTKGHVSEVTSGAWSPTDyNLCATAGTDSTVRIWDVnvgRSQKEVIAY 254
Cdd:COG2319  179 --------SGSDDGTVrLWDLATG----KLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDL---ATGKLLRTL 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 255 KSRAAGsagrtkITAVAWaSPrQGgpNVLVATGLDGSLVMWSgdgpyTRPAAEVRDAHTRDTWTSGLDVSADGRLVVTRG 334
Cdd:COG2319  243 TGHSGS------VRSVAF-SP-DG--RLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 335 GDDTIKLWDTRKFKQPITAVTHqstssHYPTSNIKFSPTGTNIITGSETGHLYILNPATLKpELVSPVTPGSPVITVLWH 414
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLTGH-----TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAFS 381

                        330
                 ....*....|.
gi 242818145 415 EKLNQILTGSA 425
Cdd:COG2319  382 PDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
96-393 1.36e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFAsmTPSTLRAFKSvdpsakknsaaqETHTVHYVAFNPisPSQMLV 175
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTG------------HTGAVRSVAFSP--DGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 IpatpqpkiLDRDGNV-LTEFVKGdmylRDMHNTKGHVSEVTSGAWSPtDYNLCATAGTDSTVRIWDVNVGRSQKEVIAY 254
Cdd:COG2319  221 S--------GSADGTVrLWDLATG----KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 255 KSRaagsagrtkITAVAWaSPrQGgpNVLVATGLDGSLVMWSGDgpyTRPAAEVRDAHTRDTWTsgLDVSADGRLVVTRG 334
Cdd:COG2319  288 SGG---------VNSVAF-SP-DG--KLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRS--VAFSPDGKTLASGS 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242818145 335 GDDTIKLWDTRKFKQPITAVTHQStsshyPTSNIKFSPTGTNIITGSETGHLYILNPAT 393
Cdd:COG2319  350 DDGTVRLWDLATGELLRTLTGHTG-----AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-426 8.72e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 8.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHDFASMTPstLRAFKsvdpsakknsaaQETHTVHYVAFnpISPSQMLV 175
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLK------------GHTGPVRDVAA--SADGTYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 176 IPATP-QPKILD-RDGNVLTEFvkgdmylrdmhntKGHVSEVTSGAWSPTDYnLCATAGTDSTVRIWDVNVGrsqKEVIA 253
Cdd:cd00200   68 SGSSDkTIRLWDlETGECVRTL-------------TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG---KCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 254 YKSRAAGsagrtkITAVAWASPRQggpnvLVATG-LDGSLVMWSGDGPYTRpaaEVRDAHTRdtWTSGLDVSADGRLVVT 332
Cdd:cd00200  131 LRGHTDW------VNSVAFSPDGT-----FVASSsQDGTIKLWDLRTGKCV---ATLTGHTG--EVNSVAFSPDGEKLLS 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 333 RGGDDTIKLWDTRKFKQPITAVTHQSTSSHyptsnIKFSPTGTNIITGSETGHLYILNPATLKPelvSPVTPG--SPVIT 410
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNS-----VAFSPDGYLLASGSEDGTIRVWDLRTGEC---VQTLSGhtNSVTS 266

                        330
                 ....*....|....*.
gi 242818145 411 VLWHEKLNQILTGSAN 426
Cdd:cd00200  267 LAWSPDGKRLASGSAD 282
WD40 COG2319
WD40 repeat [General function prediction only];
206-426 2.67e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 2.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 206 HNTKGHVSEVTSGAWSPTDYNLcATAGTDSTVRIWDVNVGRSQKEVIAYKSR-------------AAGSAGRT------- 265
Cdd:COG2319  114 RTLTGHTGAVRSVAFSPDGKTL-ASGSADGTVRLWDLATGKLLRTLTGHSGAvtsvafspdgkllASGSDDGTvrlwdla 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 266 -------------KITAVAWaSPRQggpNVLVATGLDGSLVMWSGDGPytrpaAEVRDAHTRDTWTSGLDVSADGRLVVT 332
Cdd:COG2319  193 tgkllrtltghtgAVRSVAF-SPDG---KLLASGSADGTVRLWDLATG-----KLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 333 RGGDDTIKLWDTRKFKQPITAVTHQStsshyPTSNIKFSPTGTNIITGSETGHLYILNPATLKPeLVSPVTPGSPVITVL 412
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVA 337

                        250
                 ....*....|....
gi 242818145 413 WHEKLNQILTGSAN 426
Cdd:COG2319  338 FSPDGKTLASGSDD 351
WD40 COG2319
WD40 repeat [General function prediction only];
210-425 2.26e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 2.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 210 GHVSEVTSGAWSPtDYNLCATAGTDSTVRIWDVNVGRSQKEVIAYKSRaagsagrtkITAVAWaSPrQGgpNVLVATGLD 289
Cdd:COG2319   76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGA---------VRSVAF-SP-DG--KTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 290 GSLVMWSgdgpyTRPAAEVRDAHTRDTWTSGLDVSADGRLVVTRGGDDTIKLWDTRKFKQPITAVTHQStsshyPTSNIK 369
Cdd:COG2319  142 GTVRLWD-----LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-----AVRSVA 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242818145 370 FSPTGTNIITGSETGHLYILNPATLKpELVSPVTPGSPVITVLWHEKLNQILTGSA 425
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-343 2.25e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145  96 VFKTHERPVTTLSVdLPGSRFV-SGSADCTLKFHDFAsmTPSTLRAFKSVdpsakknsaaqeTHTVHYVAFnpiSPSQML 174
Cdd:cd00200   88 TLTGHTSYVSSVAF-SPDGRILsSSSRDKTIKVWDVE--TGKCLTTLRGH------------TDWVNSVAF---SPDGTF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 175 VIPAtpqpkilDRDGNVltefvkgdmYLRDMHNTK------GHVSEVTSGAWSPTDYNLCaTAGTDSTVRIWDVNVGRSQ 248
Cdd:cd00200  150 VASS-------SQDGTI---------KLWDLRTGKcvatltGHTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLSTGKCL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 249 KEVIAYKSRaagsagrtkITAVAWASPRqggpNVLVATGLDGSLVMWSGDGPytRPAAEVRdAHTrdTWTSGLDVSADGR 328
Cdd:cd00200  213 GTLRGHENG---------VNSVAFSPDG----YLLASGSEDGTIRVWDLRTG--ECVQTLS-GHT--NSVTSLAWSPDGK 274

                        250
                 ....*....|....*
gi 242818145 329 LVVTRGGDDTIKLWD 343
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-241 6.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.31e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 242818145   209 KGHVSEVTSGAWSPtDYNLCATAGTDSTVRIWD 241
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
256-396 3.26e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 256 SRAAGSAGRTKITAVAWASPRQGGPNVLVATGLDGSLVMWSGDGPytrpaAEVRDAHTRDTWTSGLDVSADGRLVVTRGG 335
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----ALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242818145 336 DDTIKLWDTRKFKQPITAVTHQStsshyPTSNIKFSPTGTNIITGSETGHLYILNPATLKP 396
Cdd:COG2319   99 DGTVRLWDLATGLLLRTLTGHTG-----AVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154
WD40 pfam00400
WD domain, G-beta repeat;
206-241 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 242818145  206 HNTKGHVSEVTSGAWSPtDYNLCATAGTDSTVRIWD 241
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-129 5.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 242818145    96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHD 129
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-129 3.53e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 242818145   96 VFKTHERPVTTLSVDLPGSRFVSGSADCTLKFHD 129
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
185-408 5.07e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.50  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 185 LDRDGnVLTEFVKgdmylRDMHNTKGHVSEVTSGA------WSPTDYNLCATA-GTDsTVRIWDVNVGRSQKEVIAYKSR 257
Cdd:COG2706  122 IDADG-SLGEPVQ-----VIQHEGSGPNPERQEGPhahsvvFDPDGRFLYVPDlGTD-RIYVYRLDPATGKLPEPPEVSL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 258 AAGSAgrtkitavawasPR-----QGGPNVLVATGLDGSLVMWS---GDGPYTrpAAEVRDAHTRD----TWTSGLDVSA 325
Cdd:COG2706  195 PPGSG------------PRhlafhPNGRFAYVINELDSTVSVYAydaATGTLT--LIQTVSTLPEDftgeNWAADIHISP 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 326 DGRLVVT--RgGDDTIKLWDTRKFKQPITAVTHQSTSSHYPTsNIKFSPTGTNIITGSETGH---LYILNPATLKPELVS 400
Cdd:COG2706  261 DGRFLYVsnR-GHNSIAVFAIDADGGKLTLVGHVPTGGKWPR-DFAIDPDGRFLLVANQKSDnitVFRIDADTGKLTPTG 338


                 ....*....
gi 242818145 401 PVTP-GSPV 408
Cdd:COG2706  339 RSVPvPSPV 347
FACL_fum10p_like cd05926
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...
 101-210 7.20e-03

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.


Pssm-ID: 341249 [Multi-domain]  Cd Length: 493  Bit Score: 39.22  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 101 ERPVTTLSVDLPGSRFV-SGSAdctlkfhdfaSMTPSTLRAFksvdpSAKKNSAAQE----THTVHYVAFNPISPSQ--- 172
Cdd:cd05926  254 NRPEPNPESPPPKLRFIrSCSA----------SLPPAVLEAL-----EATFGAPVLEaygmTEAAHQMTSNPLPPGPrkp 318

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 242818145 173 MLV-IPATPQPKILDRDGNVLTEFVKGDMYLRDMHNTKG 210
Cdd:cd05926  319 GSVgKPVGVEVRILDEDGEILPPGVVGEICLRGPNVTRG 357
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
257-396 9.15e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 9.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242818145 257 RAAGSAGRTKITAVAWASPRQGGPNVLVATGLDGSLVMWSGDGPYTRPAAEVRDAHTRDTWTSGLDVSADGRLVVTRGGD 336
Cdd:COG3391   10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGS 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242818145 337 DTIKLWDTRKFKqpitaVTHQSTSSHYPTsNIKFSPTGTNI-ITGSETGHLYILNPATLKP 396
Cdd:COG3391   90 GRVSVIDLATGK-----VVATIPVGGGPR-GLAVDPDGGRLyVADSGNGRVSVIDTATGKV 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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