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Conserved domains on  [gi|242784923|ref|XP_002480489|]
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c-14 sterol reductase [Talaromyces stipitatus ATCC 10500]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 22-497 1.38e-157

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 454.59  E-value: 1.38e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923   22 YEFGGPLGALGIVFGLPvliyCFTFFCNDISGCPAPSLLHPSTLTWDKLKQEIGWPENGIIGLYDTEVTLWV--LAYYTL 99
Cdd:pfam01222   5 YEFGGEIGALGIKIGLP----VFMLYLNGCSGFFMLMFFLPKSFDIAVLMNFIKDPSLMVFPGLEWERYLWTvfLLWYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  100 LLLLQIFLPGQEVEGVELACGGRHKYKFNTFRSSLLILgglAAGTFIYGAEFPIWTFLWDNYVQVITANLLIVVVLSILV 179
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTL---AAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  180 YVRSFSIPepgqpnpDLRELAPGGHTGNVLYDFFIGRELNSRVTlpipfvseasrIIDIGVFCEIRPGLLGYIILDLSNV 259
Cdd:pfam01222 158 YVRSLKAP-------EEDKDAPGGNSGNLIYDFFIGRELNPRIG-----------SLDIKMFFELRPGLLGWVFINLAAL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  260 AHQYRTYGYVTDSILFVAIAQAFYVLDAFYMEPAILTTMDIIMDGFGFMLCFGDLVWVPFLYSIQTRYLAMFPAKMGLQG 339
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWST 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  340 IALS-FAVTGLGYYIFRSANNEKNRFRTDPNDPRVAHLKYITTASGSKLLISGWWGTARHINYLGDWLMSWAYCLPTGFA 418
Cdd:pfam01222 300 YAVAiYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFN 379

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242784923  419 gytiieainsstkelekhavqtpesrgwgSIFTYFYILYFGILLLHREGRDEEKCHRKYGKDWERYTSLVRSKIIPGIY 497
Cdd:pfam01222 380 -----------------------------SVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
22-497 1.38e-157

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 454.59  E-value: 1.38e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923   22 YEFGGPLGALGIVFGLPvliyCFTFFCNDISGCPAPSLLHPSTLTWDKLKQEIGWPENGIIGLYDTEVTLWV--LAYYTL 99
Cdd:pfam01222   5 YEFGGEIGALGIKIGLP----VFMLYLNGCSGFFMLMFFLPKSFDIAVLMNFIKDPSLMVFPGLEWERYLWTvfLLWYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  100 LLLLQIFLPGQEVEGVELACGGRHKYKFNTFRSSLLILgglAAGTFIYGAEFPIWTFLWDNYVQVITANLLIVVVLSILV 179
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTL---AAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  180 YVRSFSIPepgqpnpDLRELAPGGHTGNVLYDFFIGRELNSRVTlpipfvseasrIIDIGVFCEIRPGLLGYIILDLSNV 259
Cdd:pfam01222 158 YVRSLKAP-------EEDKDAPGGNSGNLIYDFFIGRELNPRIG-----------SLDIKMFFELRPGLLGWVFINLAAL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  260 AHQYRTYGYVTDSILFVAIAQAFYVLDAFYMEPAILTTMDIIMDGFGFMLCFGDLVWVPFLYSIQTRYLAMFPAKMGLQG 339
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWST 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  340 IALS-FAVTGLGYYIFRSANNEKNRFRTDPNDPRVAHLKYITTASGSKLLISGWWGTARHINYLGDWLMSWAYCLPTGFA 418
Cdd:pfam01222 300 YAVAiYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFN 379

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242784923  419 gytiieainsstkelekhavqtpesrgwgSIFTYFYILYFGILLLHREGRDEEKCHRKYGKDWERYTSLVRSKIIPGIY 497
Cdd:pfam01222 380 -----------------------------SVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
22-497 1.38e-157

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 454.59  E-value: 1.38e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923   22 YEFGGPLGALGIVFGLPvliyCFTFFCNDISGCPAPSLLHPSTLTWDKLKQEIGWPENGIIGLYDTEVTLWV--LAYYTL 99
Cdd:pfam01222   5 YEFGGEIGALGIKIGLP----VFMLYLNGCSGFFMLMFFLPKSFDIAVLMNFIKDPSLMVFPGLEWERYLWTvfLLWYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  100 LLLLQIFLPGQEVEGVELACGGRHKYKFNTFRSSLLILgglAAGTFIYGAEFPIWTFLWDNYVQVITANLLIVVVLSILV 179
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTL---AAIGVLHYTQLFELTYLYDNFVQIMSSAILFSFALAIYL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  180 YVRSFSIPepgqpnpDLRELAPGGHTGNVLYDFFIGRELNSRVTlpipfvseasrIIDIGVFCEIRPGLLGYIILDLSNV 259
Cdd:pfam01222 158 YVRSLKAP-------EEDKDAPGGNSGNLIYDFFIGRELNPRIG-----------SLDIKMFFELRPGLLGWVFINLAAL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  260 AHQYRTYGYVTDSILFVAIAQAFYVLDAFYMEPAILTTMDIIMDGFGFMLCFGDLVWVPFLYSIQTRYLAMFPAKMGLQG 339
Cdd:pfam01222 220 LKQYETYGYVTPSLLFVLLNQLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWST 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242784923  340 IALS-FAVTGLGYYIFRSANNEKNRFRTDPNDPRVAHLKYITTASGSKLLISGWWGTARHINYLGDWLMSWAYCLPTGFA 418
Cdd:pfam01222 300 YAVAiYALLLCGYYIFRSANSQKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFN 379

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242784923  419 gytiieainsstkelekhavqtpesrgwgSIFTYFYILYFGILLLHREGRDEEKCHRKYGKDWERYTSLVRSKIIPGIY 497
Cdd:pfam01222 380 -----------------------------SVLPYFYPLYFAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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