|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
130-509 |
9.32e-166 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 476.56 E-value: 9.32e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 130 INSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMskssfctPE 209
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRA-------PQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 210 VIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDE 289
Cdd:COG0513 74 ALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 290 ADRMLDMGFISEIKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVSKFQKR 369
Cdd:COG0513 154 ADRMLDMGFIEDIERILKL----LPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 370 NKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKN 449
Cdd:COG0513 230 ELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDD 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 450 VAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDPlcdsHLAPALVKILSQAGQEIP 509
Cdd:COG0513 310 VSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP----DERRLLRAIEKLIGQKIE 365
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
88-350 |
1.10e-146 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 422.07 E-value: 1.10e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 88 YIPDDPTEDDNEIFgNHISSGINFEKYDDIEVKVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMS 167
Cdd:cd18052 1 YIPPPPPEDEDEIF-ATIQTGINFDKYDEIPVEVTGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 168 GRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFC-TPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTA 246
Cdd:cd18052 80 GRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEVqEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 247 VFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPTMKSSSQRQTLMFSATF 326
Cdd:cd18052 160 VGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKEDRQTLMFSATF 239
|
250 260
....*....|....*....|....*
gi 242012580 327 PSEVQHLAKTFLN-NYLFVVVGIVG 350
Cdd:cd18052 240 PEEIQRLAAEFLKeDYLFLTVGRVG 264
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
132-350 |
3.08e-139 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 401.09 E-value: 3.08e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQI--MSKSSFCTPE 209
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPsvGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 210 VIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDE 289
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242012580 290 ADRMLDMGFISEIKKMINHPTMKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVG 350
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHPDMPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
121-509 |
1.89e-115 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 352.54 E-value: 1.89e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 121 VSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIM 200
Cdd:PTZ00110 120 IAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLR 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 201 SKSSfctPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFS 280
Cdd:PTZ00110 200 YGDG---PIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLR 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 281 MTEFLILDEADRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNY-LFVVVGIVG-GACSDVVQ 358
Cdd:PTZ00110 277 RVTYLVLDEADRMLDMGFEPQIRKIVS----QIRPDRQTLMWSATWPKEVQSLARDLCKEEpVHVNVGSLDlTACHNIKQ 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 359 KFFSVSKFQKRNKLIELLES--NGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILV 436
Cdd:PTZ00110 353 EVFVVEEHEKRGKLKMLLQRimRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMI 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242012580 437 ATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDPlcDSH-LAPALVKILSQAGQEIP 509
Cdd:PTZ00110 433 ATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP--DKYrLARDLVKVLREAKQPVP 504
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
111-350 |
6.79e-107 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 319.68 E-value: 6.79e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 111 FEKYDDIEVKVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPII 190
Cdd:cd18051 1 FDKYEDIPVEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 191 NKLLEKNQIMSKSSFCT--------PEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILV 262
Cdd:cd18051 81 SQIYEQGPGESLPSESGyygrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 263 ATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPTMKSSSQRQTLMFSATFPSEVQHLAKTFLNNYL 342
Cdd:cd18051 161 ATPGRLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPTGERQTLMFSATFPKEIQMLARDFLDNYI 240
|
....*...
gi 242012580 343 FVVVGIVG 350
Cdd:cd18051 241 FLAVGRVG 248
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
129-487 |
2.06e-100 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 310.58 E-value: 2.06e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 129 SINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleknqimSKSSFCTp 208
Cdd:PRK11776 2 SMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL-------DVKRFRV- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 209 EVIIMTPTRELTIQIFEEARKFSRGTF-LKVaLTY-GGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLI 286
Cdd:PRK11776 74 QALVLCPTRELADQVAKEIRRLARFIPnIKV-LTLcGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 287 LDEADRMLDMGFISEIKKMINH-PTmksssQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGAcSDVVQKFFSVSK 365
Cdd:PRK11776 153 LDEADRMLDMGFQDAIDAIIRQaPA-----RRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDL-PAIEQRFYEVSP 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 366 FQKRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGL 445
Cdd:PRK11776 227 DERLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 242012580 446 DIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDP 487
Cdd:PRK11776 307 DIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAP 348
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
132-483 |
6.90e-98 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 304.04 E-value: 6.90e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIInKLLEKNQIMSKSSfcTP-EV 210
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLL-QHLITRQPHAKGR--RPvRA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 211 IIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEA 290
Cdd:PRK10590 79 LILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 291 DRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVSKFQKRN 370
Cdd:PRK10590 159 DRMLDMGFIHDIRRVLA----KLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 371 KLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNV 450
Cdd:PRK10590 235 LLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEEL 314
|
330 340 350
....*....|....*....|....*....|...
gi 242012580 451 AHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATS 483
Cdd:PRK10590 315 PHVVNYELPNVPEDYVHRIGRTGRAAATGEALS 347
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
142-344 |
6.03e-94 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 284.72 E-value: 6.03e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSsfctPEVIIMTPTRELTI 221
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRG----PQALVLAPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 222 QIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISE 301
Cdd:cd00268 77 QIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 242012580 302 IKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd00268 157 VEKILSA----LPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
126-501 |
7.08e-93 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 291.82 E-value: 7.08e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 126 PPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEkNQIMSKSSF 205
Cdd:PRK01297 82 PQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQ-TPPPKERYM 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 206 CTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIK-NGCNILVATPGRLLDFVQRGIIDFSMTEF 284
Cdd:PRK01297 161 GEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 285 LILDEADRMLDMGFISEIKKMINHPTMKSssQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVS 364
Cdd:PRK01297 241 MVLDEADRMLDMGFIPQVRQIIRQTPRKE--ERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 365 KFQKRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARG 444
Cdd:PRK01297 319 GSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRG 398
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 242012580 445 LDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDPlCDSHLAPALVKIL 501
Cdd:PRK01297 399 IHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGE-DDAFQLPEIEELL 454
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
133-484 |
2.73e-92 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 288.41 E-value: 2.73e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSfCTPEVII 212
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKV-NQPRALI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADR 292
Cdd:PRK04837 89 MAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 293 MLDMGFISEIKKMINHptMKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVSKFQKRNKL 372
Cdd:PRK04837 169 MFDLGFIKDIRWLFRR--MPPANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 373 IELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAH 452
Cdd:PRK04837 247 QTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTH 326
|
330 340 350
....*....|....*....|....*....|..
gi 242012580 453 VVNFDLPKTIDEYVHRIGRTGRVGNRGLATSF 484
Cdd:PRK04837 327 VFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
133-500 |
1.08e-90 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 284.91 E-value: 1.08e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimSKSSFctPEVII 212
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPR--RKSGP--PRILI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADR 292
Cdd:PRK11192 79 LTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 293 MLDMGFISEIKKMinhpTMKSSSQRQTLMFSATFPSE-VQHLAKTFLNNYLFVvvgivggacsDV---------VQKFF- 361
Cdd:PRK11192 159 MLDMGFAQDIETI----AAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEV----------EAepsrrerkkIHQWYy 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 362 -SVSKFQKRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSV 440
Cdd:PRK11192 225 rADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 441 AARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSfydpLCDSHLAPALVKI 500
Cdd:PRK11192 305 AARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAIS----LVEAHDHLLLGKI 360
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
132-486 |
4.94e-86 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 278.66 E-value: 4.94e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleknqimsKSSFCTPEVI 211
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL--------DPELKAPQIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 212 IMTPTRELTIQIFEEARKFS---RGtfLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILD 288
Cdd:PRK11634 79 VLAPTRELAVQVAEAMTDFSkhmRG--VNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 289 EADRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVSKFQK 368
Cdd:PRK11634 157 EADEMLRMGFIEDVETIMA----QIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 369 RNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIK 448
Cdd:PRK11634 233 NEALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVE 312
|
330 340 350
....*....|....*....|....*....|....*...
gi 242012580 449 NVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYD 486
Cdd:PRK11634 313 RISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVE 350
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
117-509 |
2.14e-84 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 271.28 E-value: 2.14e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 117 IEVKVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLlEK 196
Cdd:PLN00206 107 LEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRC-CT 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 197 NQIMSKSSFCTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGI 276
Cdd:PLN00206 186 IRSGHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHD 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 277 IDFSMTEFLILDEADRMLDMGFISEIKKMInhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDV 356
Cdd:PLN00206 266 IELDNVSVLVLDEVDCMLERGFRDQVMQIF-----QALSQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAV 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 357 VQKFFSVSKFQKRNKLIELLESNGSSK--CLVFVEQKRTTDFIATFLCE-KNFPATSIHGDRDQREREEALRDFKTGKMD 433
Cdd:PLN00206 341 KQLAIWVETKQKKQKLFDILKSKQHFKppAVVFVSSRLGADLLANAITVvTGLKALSIHGEKSMKERREVMKSFLVGEVP 420
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242012580 434 ILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDPLcDSHLAPALVKILSQAGQEIP 509
Cdd:PLN00206 421 VIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEE-DRNLFPELVALLKSSGAAIP 495
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
155-509 |
7.22e-81 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 263.35 E-value: 7.22e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 155 TPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFcTPEVIIMTPTRELTIQIFEEARKFSRGT 234
Cdd:PRK04537 33 TPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPE-DPRALILAPTRELAIQIHKDAVKFGADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 235 FLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFV-QRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINHptMKS 313
Cdd:PRK04537 112 GLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVkQHKVVSLHACEICVLDEADRMFDLGFIKDIRFLLRR--MPE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 314 SSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFSVSKFQKRNKLIELLESNGSSKCLVFVEQKRT 393
Cdd:PRK04537 190 RGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLLGLLSRSEGARTMVFVNTKAF 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 394 TDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTG 473
Cdd:PRK04537 270 VERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTA 349
|
330 340 350
....*....|....*....|....*....|....*.
gi 242012580 474 RVGNRGLATSFydpLCDSHlAPALVKILSQAGQEIP 509
Cdd:PRK04537 350 RLGEEGDAISF---ACERY-AMSLPDIEAYIEQKIP 381
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
120-340 |
1.72e-70 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 224.95 E-value: 1.72e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 120 KVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleKNQI 199
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHI--KDQR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 200 MSKSSfCTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFV---QRGI 276
Cdd:cd17953 79 PVKPG-EGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGRV 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242012580 277 IDFSMTEFLILDEADRMLDMGFISEIKKMINH--PtmksssQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17953 158 TNLRRVTYVVLDEADRMFDMGFEPQIMKIVNNirP------DRQTVLFSATFPRKVEALARKVLHK 217
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
142-344 |
5.04e-69 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 221.04 E-value: 5.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFCTPEVIIMTPTRELTI 221
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 222 QIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISE 301
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 242012580 302 IKKMINH--PTMKS--------------SSQRQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd17945 161 VTKILDAmpVSNKKpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
142-347 |
6.98e-68 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 217.46 E-value: 6.98e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQImskssfCTPEVIIMTPTRELTI 221
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKK------KGLRALILAPTRELAS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 222 QIFEEARKFSRGTFLKVA-LTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFIS 300
Cdd:cd17957 75 QIYRELLKLSKGTGLRIVlLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFRE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 242012580 301 EIKKMInhpTMKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVG 347
Cdd:cd17957 155 QTDEIL---AACTNPNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
142-345 |
2.34e-65 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 210.73 E-value: 2.34e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSfctPEVIIMTPTRELTI 221
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGEG---PIAVIVAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 222 QIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISE 301
Cdd:cd17952 78 QIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQ 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 242012580 302 IKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVV 345
Cdd:cd17952 158 VRSIVGH----VRPDRQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
125-487 |
3.58e-64 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 214.69 E-value: 3.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 125 NPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleknqimsKSS 204
Cdd:PTZ00424 22 NYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI--------DYD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 205 FCTPEVIIMTPTRELTIQIFEEArkFSRGTFLKVAL--TYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMT 282
Cdd:PTZ00424 94 LNACQALILAPTRELAQQIQKVV--LALGDYLKVRChaCVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 283 EFLILDEADRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVGIVGGACSDVVQKFFS 362
Cdd:PTZ00424 172 KLFILDEADEMLSRGFKGQIYDVFK----KLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 363 VSKFQ-KRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVA 441
Cdd:PTZ00424 248 VEKEEwKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 242012580 442 ARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDP 487
Cdd:PTZ00424 328 ARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTP 373
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
142-345 |
1.20e-63 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 206.45 E-value: 1.20e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSfctPEVIIMTPTRELTI 221
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGDG---PIVLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 222 QIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISE 301
Cdd:cd17966 78 QIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQ 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 242012580 302 IKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVV 345
Cdd:cd17966 158 IRKIVD----QIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
146-340 |
2.73e-62 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 202.87 E-value: 2.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKnqimsKSSFCTPEVIIMTPTRELTIQIFE 225
Cdd:cd17947 5 LSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYR-----PKKKAATRVLVLVPTRELAMQCFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 226 EARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGI-IDFSMTEFLILDEADRMLDMGFISEIKK 304
Cdd:cd17947 80 VLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPsFDLDSIEILVLDEADRMLEEGFADELKE 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 242012580 305 MINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17947 160 ILRL----CPRTRQTMLFSATMTDEVKDLAKLSLNK 191
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
132-344 |
3.05e-60 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 197.91 E-value: 3.05e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSfctpevI 211
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVGARA------L 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 212 IMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEAD 291
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEAD 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 242012580 292 RMLDMGFISEIKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd17959 156 RLFEMGFAEQLHEILSR----LPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
155-333 |
4.59e-60 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 195.92 E-value: 4.59e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 155 TPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfcTPEVIIMTPTRELTIQIFEEARKFSRGT 234
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN--------GPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 235 FLKVALTYGGTAVFHQVEKIKnGCNILVATPGRLLDFVQRgIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPtmksS 314
Cdd:pfam00270 73 GLKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL----P 146
|
170
....*....|....*....
gi 242012580 315 SQRQTLMFSATFPSEVQHL 333
Cdd:pfam00270 147 KKRQILLLSATLPRNLEDL 165
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
140-344 |
2.02e-59 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 195.88 E-value: 2.02e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 140 STLINLINKCQYHKPTPIQKHCIPIIMS-GRDLMGCAQTGSGKTAAFLIPIINKLLeKNQIMSKSSfcTPEVIIMTPTRE 218
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLL-NTKPAGRRS--GVSALIISPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 219 LTIQIFEEARKFSRG-TFLKVALTYGGTAVFHQVEKI-KNGCNILVATPGRLLDFV--QRGIIDFSMTEFLILDEADRML 294
Cdd:cd17964 80 LALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLenPGVAKAFTDLDYLVLDEADRLL 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 295 DMGFISEIKKMINHPTMKSSSQRQTLMFSATFPSEVQHLAKTFLN-NYLFV 344
Cdd:cd17964 160 DMGFRPDLEQILRHLPEKNADPRQTLLFSATVPDEVQQIARLTLKkDYKFI 210
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
356-485 |
8.14e-58 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 188.49 E-value: 8.14e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 356 VVQKFFSVSKFQKRNKLI-ELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDI 434
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 435 LVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFY 485
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
133-343 |
3.34e-57 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 189.74 E-value: 3.34e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKnqimSKSSFCtpevII 212
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSED----PYGIFA----LV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQ---RGIIDFSMTEFLILDE 289
Cdd:cd17955 73 LTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDE 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 242012580 290 ADRMLDMGFISEIKKMINH-PTmksssQRQTLMFSATFPSEVQHLAKTFLNNYLF 343
Cdd:cd17955 153 ADRLLTGSFEDDLATILSAlPP-----KRQTLLFSATLTDALKALKELFGNKPFF 202
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
142-340 |
1.20e-56 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 188.17 E-value: 1.20e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLL------EKNQIMSkssfctpevIIMTP 215
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLkrkanlKKGQVGA---------LIISP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 216 TRELTIQIFEEARKFSRGTF--LKVALTYGGTAVFHQVEKIK-NGCNILVATPGRLLDFVQR--GIIDFSMTEFLILDEA 290
Cdd:cd17960 72 TRELATQIYEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELLSRkaDKVKVKSLEVLVLDEA 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 291 DRMLDMGFISEIKKMINH-PtmkssSQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17960 152 DRLLDLGFEADLNRILSKlP-----KQRRTGLFSATQTDAVEELIKAGLRN 197
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
118-347 |
1.42e-56 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 189.06 E-value: 1.42e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 118 EVKVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPII-----NK 192
Cdd:cd18049 11 EITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIvhinhQP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 193 LLEKNQimskssfcTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFV 272
Cdd:cd18049 91 FLERGD--------GPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFL 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242012580 273 QRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVG 347
Cdd:cd18049 163 EAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD----QIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
133-340 |
1.45e-53 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 180.19 E-value: 1.45e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKL-LEKNQImskssfctpEVI 211
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIdPKKDVI---------QAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 212 IMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEAD 291
Cdd:cd17940 72 ILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEAD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 242012580 292 RMLDMGFISEIKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17940 152 KLLSQDFQPIIEKILNF----LPKERQILLFSATFPLTVKNFMDRHMHN 196
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
146-347 |
1.45e-53 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 180.00 E-value: 1.45e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSG-RDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMskssfctpeVIIMTPTRELTIQIF 224
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGGR---------VLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 225 EEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGC-NILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIK 303
Cdd:smart00487 72 EELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 242012580 304 KMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVG 347
Cdd:smart00487 152 KLLKL----LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVG 191
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
132-340 |
2.02e-53 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 179.82 E-value: 2.02e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMskssFCtpevI 211
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRF----FA----L 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 212 IMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQR--GiidFSMT--EFLIL 287
Cdd:cd17954 73 VLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENtkG---FSLKslKFLVM 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 242012580 288 DEADRMLDMGFISEIKKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17954 150 DEADRLLNMDFEPEIDKILKV----IPRERTTYLFSATMTTKVAKLQRASLKN 198
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
150-346 |
6.63e-53 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 178.25 E-value: 6.63e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 150 QYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKL-LEKnqimskssfCTPE----VIIMTPTRELTIQIF 224
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyRER---------WTPEdglgALIISPTRELAMQIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 225 EEARKFSRGTFLKVALTYGGTAVFHQVEKIkNGCNILVATPGRLLDFVQRGI-IDFSMTEFLILDEADRMLDMGFISEIK 303
Cdd:cd17941 80 EVLRKVGKYHSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPgFDTSNLQMLVLDEADRILDMGFKETLD 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 242012580 304 KMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVV 346
Cdd:cd17941 159 AIVEN----LPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
118-347 |
2.20e-52 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 179.44 E-value: 2.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 118 EVKVSGKNPPKSINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKN 197
Cdd:cd18050 49 EITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 198 QIMSKSSfctPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGII 277
Cdd:cd18050 129 YLERGDG---PICLVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKT 205
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 278 DFSMTEFLILDEADRMLDMGFISEIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVVVG 347
Cdd:cd18050 206 NLRRCTYLVLDEADRMLDMGFEPQIRKIVD----QIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
146-345 |
1.12e-51 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 174.96 E-value: 1.12e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEknQIMSKSSFCTPEVIIMTPTRELTIQIFE 225
Cdd:cd17958 5 IKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDL--QPIPREQRNGPGVLVLTPTRELALQIEA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 226 EARKFS-RGtfLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKK 304
Cdd:cd17958 83 ECSKYSyKG--LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 242012580 305 MINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVV 345
Cdd:cd17958 161 ILLD----IRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
144-345 |
1.30e-51 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 175.47 E-value: 1.30e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 144 NLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFCTpeVIIMTPTRELTIQI 223
Cdd:cd17949 4 HLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTL--ALVLVPTRELALQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 224 FEEARKF-SRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQR-GIIDFSMTEFLILDEADRMLDMGFISE 301
Cdd:cd17949 82 YEVLEKLlKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGFEKD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 242012580 302 IKKMIN---------HPTMKSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFVV 345
Cdd:cd17949 162 ITKILEllddkrskaGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
152-338 |
1.68e-51 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 174.83 E-value: 1.68e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 152 HKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFCTPEVIIMTPTRELTIQIFEE----A 227
Cdd:cd17951 11 KKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGEGPYGLIVCPSRELARQTHEVieyyC 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 228 RKFSRGTF--LKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKKM 305
Cdd:cd17951 91 KALQEGGYpqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMGFEEDIRTI 170
|
170 180 190
....*....|....*....|....*....|...
gi 242012580 306 INHPTmkssSQRQTLMFSATFPSEVQHLAKTFL 338
Cdd:cd17951 171 FSYFK----GQRQTLLFSATMPKKIQNFAKSAL 199
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
146-340 |
3.05e-49 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 168.69 E-value: 3.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIInKLLEKNQIMSKSSfctPEVIIMTPTRELTIQIFE 225
Cdd:cd17942 5 IEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAI-ELLYKLKFKPRNG---TGVIIISPTRELALQIYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 226 EAR---KFSRGTFLKVAltyGGTAVFHQVEKIKNGCNILVATPGRLLDFVQ--RGIIdFSMTEFLILDEADRMLDMGFIS 300
Cdd:cd17942 81 VAKellKYHSQTFGIVI---GGANRKAEAEKLGKGVNILVATPGRLLDHLQntKGFL-YKNLQCLIIDEADRILEIGFEE 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 242012580 301 EIKKMINhptmKSSSQRQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17942 157 EMRQIIK----LLPKRRQTMLFSATQTRKVEDLARISLKK 192
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
142-326 |
1.07e-48 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 168.19 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIP-IIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFCTP-EVIIMTPTREL 219
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQKPlRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 220 TIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRG---IIDFSMTEFLILDEADRMLDM 296
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGnehLANLKSLRFLVLDEADRMLEK 160
|
170 180 190
....*....|....*....|....*....|...
gi 242012580 297 G-F--ISEIKKMINHPTMKSSSQRQTLMFSATF 326
Cdd:cd17946 161 GhFaeLEKILELLNKDRAGKKRKRQTFVFSATL 193
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
133-334 |
8.17e-48 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 164.80 E-value: 8.17e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIInklleknQIMSkssfctpeVII 212
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-------QIVV--------ALI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSR---GTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDE 289
Cdd:cd17938 66 LEPSRELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDE 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 242012580 290 ADRMLDMGFISEIKKMINH-PTMKSSSQR-QTLMFSATFPS-EVQHLA 334
Cdd:cd17938 146 ADRLLSQGNLETINRIYNRiPKITSDGKRlQVIVCSATLHSfEVKKLA 193
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
146-344 |
1.83e-46 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 160.79 E-value: 1.83e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfcTPEVIIMTPTRELTIQIFE 225
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHR--------NPSALILTPTRELAVQIED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 226 EARKFSRGTF-LKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKK 304
Cdd:cd17962 77 QAKELMKGLPpMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLD 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 242012580 305 MINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd17962 157 ILEN----ISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
156-338 |
4.60e-44 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 155.01 E-value: 4.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 156 PIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSfcTPEVIIMTPTRELTIQIFEEARKFSRGtf 235
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGR--APKVLVLAPTRELANQVTKDFKDITRK-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 236 LKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPTMKSSS 315
Cdd:cd17944 91 LSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSYKKDSE 170
|
170 180
....*....|....*....|....
gi 242012580 316 QR-QTLMFSATFPSEVQHLAKTFL 338
Cdd:cd17944 171 DNpQTLLFSATCPDWVYNVAKKYM 194
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
146-340 |
6.16e-42 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 149.27 E-value: 6.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSSFctPEVIIMTPTRELTIQIFE 225
Cdd:cd17961 9 IAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQG--TRALILVPTRELAQQVSK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 226 EARKFSRGTFLKVALTYGGTAVFHQVEK--IKNGCNILVATPGRLLDFVQRG-IIDFSMTEFLILDEADRMLDMGFISEI 302
Cdd:cd17961 87 VLEQLTAYCRKDVRVVNLSASSSDSVQRalLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVLSYGYEEDL 166
|
170 180 190
....*....|....*....|....*....|....*....
gi 242012580 303 KKMINH-PTMKsssqrQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17961 167 KSLLSYlPKNY-----QTFLMSATLSEDVEALKKLVLHN 200
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
146-344 |
6.31e-39 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 140.48 E-value: 6.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 146 INKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfcTPEVIIMTPTRELTIQI-- 223
Cdd:cd17943 5 LKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERR--------HPQVLILAPTREIAVQIhd 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 224 -FEEARKFSRGtfLKVALTYGGTAVFHQVEKIKnGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEI 302
Cdd:cd17943 77 vFKKIGKKLEG--LKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDV 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 242012580 303 KKMINHptmkSSSQRQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd17943 154 NWIFSS----LPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
367-476 |
2.97e-37 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 133.10 E-value: 2.97e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 367 QKRNKLIELLESNGSSKCLVFVEQKRTTDfIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLD 446
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 242012580 447 IKNVAHVVNFDLPKTIDEYVHRIGRTGRVG 476
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
132-346 |
3.79e-37 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 136.32 E-value: 3.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINklleknQIMSKSSFCtpEVI 211
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQ------QLEPVDGQV--SVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 212 IMTPTRELTIQIFEEARKFSRgtFL---KVALTYGGTAVFHQVEKIKNGC-NILVATPGRLLDFVQRGIIDFSMTEFLIL 287
Cdd:cd17950 75 VICHTRELAFQISNEYERFSK--YMpnvKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVL 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242012580 288 DEADRM---LDM-GFISEIKKMINHptmksssQRQTLMFSATFPSEVQHLAKTFLNNYLFVVV 346
Cdd:cd17950 153 DECDKMleqLDMrRDVQEIFRATPH-------DKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
150-344 |
3.68e-36 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 133.08 E-value: 3.68e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 150 QYHKPTPIQKHCIPIIMSG--RDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfcTPEVIIMTPTRELTIQIFEEA 227
Cdd:cd17963 13 GFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLK--------SPQALCLAPTRELARQIGEVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 228 RKFSRGTFLKVALTYGGTAVFHQvEKIKNgcNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDM-GF---ISEIK 303
Cdd:cd17963 85 EKMGKFTGVKVALAVPGNDVPRG-KKITA--QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHgdqSIRIK 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 242012580 304 KMINHPTmksssqrQTLMFSATFPSEVQHLAKTFLNNYLFV 344
Cdd:cd17963 162 RMLPRNC-------QILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
153-333 |
1.84e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 132.49 E-value: 1.84e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 153 KPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKnQIMSKSSFCTPEVIIMTPTRELTIQIFEEARKFSR 232
Cdd:cd17948 12 KPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRY-KLLAEGPFNAPRGLVITPSRELAEQIGSVAQSLTE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 233 GTFLKVALTYGGtavfHQVEKIKN----GCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINH 308
Cdd:cd17948 91 GLGLKVKVITGG----RTKRQIRNphfeEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKLSHFLRR 166
|
170 180 190
....*....|....*....|....*....|....
gi 242012580 309 ---------PTMKSSSQRQTLMFSATFPSEVQHL 333
Cdd:cd17948 167 fplasrrseNTDGLDPGTQLVLVSATMPSGVGEV 200
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
151-340 |
3.38e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 127.83 E-value: 3.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 151 YHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleknqimsKSSFCTPEVIIMTPTRELTIQIfeEARKF 230
Cdd:cd17939 17 FEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRI--------DTTVRETQALVLAPTRELAQQI--QKVVK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 231 SRGTFL--KVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRMLDMGF---ISEIKKM 305
Cdd:cd17939 87 ALGDYMgvKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFkdqIYDIFQF 166
|
170 180 190
....*....|....*....|....*....|....*
gi 242012580 306 INHPTmksssqrQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd17939 167 LPPET-------QVVLFSATMPHEVLEVTKKFMRD 194
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
133-340 |
6.01e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 127.56 E-value: 6.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLleknqimsKSSFCTPEVII 212
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI--------DTSLKATQALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADR 292
Cdd:cd18046 73 LAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADE 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 293 MLDMGF---ISEIKKMINHPTmksssqrQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd18046 153 MLSRGFkdqIYDIFQKLPPDT-------QVVLLSATMPNDVLEVTTKFMRD 196
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
395-476 |
7.04e-31 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 114.62 E-value: 7.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 395 DFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGR 474
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 242012580 475 VG 476
Cdd:smart00490 81 AG 82
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
133-340 |
8.09e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 118.72 E-value: 8.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 133 FNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINklleknqiMSKSSFCTPEVII 212
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQ--------CLDIQVRETQALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEArkFSRGTFLKVAL--TYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEA 290
Cdd:cd18045 73 LSPTRELAVQIQKVL--LALGDYMNVQChaCIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEA 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 242012580 291 DRMLDMGF---ISEIKKMINHPTmksssqrQTLMFSATFPSEVQHLAKTFLNN 340
Cdd:cd18045 151 DEMLNKGFkeqIYDVYRYLPPAT-------QVVLVSATLPQDILEMTNKFMTD 196
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
142-334 |
2.26e-29 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 115.81 E-value: 2.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 142 LINLINKCQYHKPTPIQKHCIPIIMSG---------RDLMGCAQTGSGKTAAFLIPIInklleknQIMSKSSFCTPEVII 212
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIV-------QALSKRVVPRLRALI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 213 MTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQVEKIKNGC--------NILVATPGRLLDFVQRGI-IDFSMTE 283
Cdd:cd17956 74 VVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTsgrylsrvDILVATPGRLVDHLNSTPgFTLKHLR 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242012580 284 FLILDEADRMLDMGF-------ISEIKKMINHPTMK---------SSSQRQTLMFSATFPSEVQHLA 334
Cdd:cd17956 154 FLVIDEADRLLNQSFqdwletvMKALGRPTAPDLGSfgdanllerSVRPLQKLLFSATLTRDPEKLS 220
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
150-329 |
9.23e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 103.23 E-value: 9.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 150 QYHKPTPIQKHCIPIIMsgRDLMG------------------CAQTGSGKTAAFLIPIINKL---------LEKNQIMSK 202
Cdd:cd17965 27 EEIKPSPIQTLAIKKLL--KTLMRkvtkqtsneepklevfllAAETGSGKTLAYLAPLLDYLkrqeqepfeEAEEEYESA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 203 SSFCTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFHQ--VEKIKNGCNILVATPGRLLDFVQRGIIDFS 280
Cdd:cd17965 105 KDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQrlQLAFKGRIDILVTTPGKLASLAKSRPKILS 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 242012580 281 MTEFLILDEADRMLDMGFISEIKKMInhptmKSSSQRQTLMF-SATFPSE 329
Cdd:cd17965 185 RVTHLVVDEADTLFDRSFLQDTTSII-----KRAPKLKHLILcSATIPKE 229
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
119-335 |
2.42e-20 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 90.08 E-value: 2.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 119 VKVSGKNPPK---SINSFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSG--RDLMGCAQTGSGKTAAFLIPIINKl 193
Cdd:cd18048 3 VEVLQRDPTSplfSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSR- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 194 leknqIMSKSSFctPEVIIMTPTRELTIQ---IFEEARKFSRGTFLKVALTYGGTAVFHQVEKikngcNILVATPGRLLD 270
Cdd:cd18048 82 -----VDALKLY--PQCLCLSPTFELALQtgkVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEA-----QIVIGTPGTVLD 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242012580 271 FV-QRGIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPTMKSSsqrQTLMFSATFPSEVQHLAK 335
Cdd:cd18048 150 WCfKLRLIDVTNISVFVLDEADVMINVQGHSDHSVRVKRSMPKEC---QMLLFSATFEDSVWAFAE 212
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
358-471 |
1.13e-18 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 82.64 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 358 QKFFSVSKFQKrnkLIELL----ESNGSSKCLVFVEQKRTTDFIATFL-----CEKNFPATSI--HGDRDQRER------ 420
Cdd:cd18802 1 EEIVVIPKLQK---LIEILreyfPKTPDFRGIIFVERRATAVVLSRLLkehpsTLAFIRCGFLigRGNSSQRKRslmtqr 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 242012580 421 --EEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGR 471
Cdd:cd18802 78 kqKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
177-486 |
2.33e-18 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 88.16 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 177 TGSGKT--AAFlipIINKLLEKNQimskssfctpeVIIMTPTRELTIQIFEEARKFsrgtfLKVALTYGGtavfhqveKI 254
Cdd:COG1061 109 TGTGKTvlALA---LAAELLRGKR-----------VLVLVPRRELLEQWAEELRRF-----LGDPLAGGG--------KK 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 255 KNGCNILVATPGRL-----LDFVQRgiiDFSMtefLILDEADRMLDMGFiseiKKMINHptmksSSQRQTLMFSAT-FPS 328
Cdd:COG1061 162 DSDAPITVATYQSLarrahLDELGD---RFGL---VIIDEAHHAGAPSY----RRILEA-----FPAAYRLGLTATpFRS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 329 EVQHLAKTFLNN--------------YL--FVVVGIVGG---------ACSDVVQKFFSVSKFQKRNKLIELLESNGS-S 382
Cdd:COG1061 227 DGREILLFLFDGivyeyslkeaiedgYLapPEYYGIRVDltderaeydALSERLREALAADAERKDKILRELLREHPDdR 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 383 KCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTI 462
Cdd:COG1061 307 KTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSP 386
|
330 340
....*....|....*....|....
gi 242012580 463 DEYVHRIGRTGRVGNRGLATSFYD 486
Cdd:COG1061 387 REFIQRLGRGLRPAPGKEDALVYD 410
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
368-474 |
1.46e-17 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 85.94 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 368 KRNKLIEL----LESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHG--DRD------QREREEALRDFKTGKMDIL 435
Cdd:COG1111 336 KLSKLREIlkeqLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaSKEgdkgltQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 242012580 436 VATSVAARGLDIKNVAHVVNFDL-PKTIdEYVHRIGRTGR 474
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEPvPSEI-RSIQRKGRTGR 454
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
367-487 |
4.04e-17 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 84.04 E-value: 4.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 367 QKRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSvaARGL- 445
Cdd:COG0514 216 DKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATI--AFGMg 293
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 242012580 446 -DIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDP 487
Cdd:COG0514 294 iDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGP 336
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
132-335 |
8.68e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 70.52 E-value: 8.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 132 SFNEAGLCSTLINLINKCQYHKPTPIQKHCIPIIMSG--RDLMGCAQTGSGKTAAFLIPIINKLleknQIMSKSSFCtpe 209
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV----EPANKYPQC--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 210 vIIMTPTRELTIQ---IFEEARKFsrgtFLKVALTYGGTAvfHQVEK-IKNGCNILVATPGRLLDF-VQRGIIDFSMTEF 284
Cdd:cd18047 75 -LCLSPTYELALQtgkVIEQMGKF----YPELKLAYAVRG--NKLERgQKISEQIVIGTPGTVLDWcSKLKFIDPKKIKV 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 285 LILDEADRMLDMGFISEIKKMINHPTMKSSsqrQTLMFSATFPSEVQHLAK 335
Cdd:cd18047 148 FVLDEADVMIATQGHQDQSIRIQRMLPRNC---QMLLFSATFEDSVWKFAQ 195
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
368-470 |
6.23e-13 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 65.96 E-value: 6.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 368 KRNKLIELLESNGSS--KCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMD--ILVATSVAAR 443
Cdd:cd18793 12 KLEALLELLEELREPgeKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGGV 91
|
90 100 110
....*....|....*....|....*....|...
gi 242012580 444 GLDIKNVAHVVNFDLP--KTIDEY----VHRIG 470
Cdd:cd18793 92 GLNLTAANRVILYDPWwnPAVEEQaidrAHRIG 124
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
360-485 |
7.80e-13 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 65.69 E-value: 7.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 360 FFSVS-KFQKRNKLIELLESNGSSK---CLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDIL 435
Cdd:cd18794 5 FYSVRpKDKKDEKLDLLKRIKVEHLggsGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVI 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 242012580 436 VATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFY 485
Cdd:cd18794 85 VATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
368-474 |
1.24e-12 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 70.67 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 368 KRNKLIEL----LESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHG--DRD------QREREEALRDFKTGKMDIL 435
Cdd:PRK13766 348 KLEKLREIvkeqLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGqaSKDgdkgmsQKEQIEILDKFRAGEFNVL 427
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 242012580 436 VATSVAARGLDIKNVAHVVNFD-LPKTIdEYVHRIGRTGR 474
Cdd:PRK13766 428 VSTSVAEEGLDIPSVDLVIFYEpVPSEI-RSIQRKGRTGR 466
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
174-325 |
6.48e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 63.19 E-value: 6.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 174 CAQTGSGKTAAFLIPIINKLLEKNqimskssfctPEVIIMTPTRELTIQIFEEARKFSRGTfLKVALTYGGTAVFHQVEK 253
Cdd:cd00046 7 TAPTGSGKTLAALLAALLLLLKKG----------KKVLVLVPTKALALQTAERLRELFGPG-IRVAVLVGGSSAEEREKN 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242012580 254 IKNGCNILVATPGRLLDFVQR-GIIDFSMTEFLILDEADRMLDMGFISEIKKMINHPTMKSSSQRqtLMFSAT 325
Cdd:cd00046 76 KLGDADIIIATPDMLLNLLLReDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQV--ILLSAT 146
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
368-475 |
1.78e-11 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 66.79 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 368 KRNKLIELLESNGSS--KCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGK--MDILVATSVAAR 443
Cdd:COG0553 534 KLEALLELLEELLAEgeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGE 613
|
90 100 110
....*....|....*....|....*....|....*....
gi 242012580 444 GLDIKNVAHVVNFDLP-------KTIDEyVHRIGRTGRV 475
Cdd:COG0553 614 GLNLTAADHVIHYDLWwnpaveeQAIDR-AHRIGQTRDV 651
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
372-474 |
7.09e-11 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 60.36 E-value: 7.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 372 LIELLESngSSKCLVFVEQKRTTDFIAT---FLCEKNFPATSI---HG--DRDQREREEAlrDFKTGKMDILVATSVAAR 443
Cdd:cd18796 31 VIFLLER--HKSTLVFTNTRSQAERLAQrlrELCPDRVPPDFIalhHGslSRELREEVEA--ALKRGDLKVVVATSSLEL 106
|
90 100 110
....*....|....*....|....*....|.
gi 242012580 444 GLDIKNVAHVVNFDLPKTIDEYVHRIGRTGR 474
Cdd:cd18796 107 GIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
165-481 |
5.10e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 62.16 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 165 IMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfCTpeVIIMTPTRELTIQIFEEARKFSRGTFLKV-ALTYG 243
Cdd:COG1205 68 ARAGKNVVIATPTASGKSLAYLLPVLEALLEDPG-------AT--ALYLYPTKALARDQLRRLRELAEALGLGVrVATYD 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 244 GTAVFHQVEKIKNGCNILVATPgrllDFVQRGIID--------FSMTEFLILDEA---------------DRMLDMgfis 300
Cdd:COG1205 139 GDTPPEERRWIREHPDIVLTNP----DMLHYGLLPhhtrwarfFRNLRYVVIDEAhtyrgvfgshvanvlRRLRRI---- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 301 eIKKMINHPTMksssqrqtLMFSATFPSEVQHLAKtflnnyLF---VVVgiVGGACS------------DVVQKFFSVSK 365
Cdd:COG1205 211 -CRHYGSDPQF--------ILASATIGNPAEHAER------LTgrpVTV--VDEDGSprgertfvlwnpPLVDDGIRRSA 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 366 FQKRNKLIELLESNGsSKCLVFVEQKRTTDFIATFLceKNFPATSIHGDR--------DQREREEALRDFKTGKMDILVA 437
Cdd:COG1205 274 LAEAARLLADLVREG-LRTLVFTRSRRGAELLARYA--RRALREPDLADRvaayragyLPEERREIERGLRSGELLGVVS 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 242012580 438 TSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLA 481
Cdd:COG1205 351 TNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLV 394
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
153-325 |
7.37e-10 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 58.20 E-value: 7.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 153 KPTPIQKHCIPIIMSG------RDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfctpeVIIMTPTRELTIQIFEE 226
Cdd:cd17918 15 SLTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAALLAYKNGKQ-----------VAILVPTEILAHQHYEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 227 ARKFSrgTFLKVALTYGGTAvfhqvEKIKNGCNILVATPGRLLDFVQrgiidFSMTEFLILDEADRmldmgFISEIKKMI 306
Cdd:cd17918 84 ARKFL--PFINVELVTGGTK-----AQILSGISLLVGTHALLHLDVK-----FKNLDLVIVDEQHR-----FGVAQREAL 146
|
170
....*....|....*....
gi 242012580 307 NhptmkSSSQRQTLMFSAT 325
Cdd:cd17918 147 Y-----NLGATHFLEATAT 160
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
363-487 |
9.27e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 61.27 E-value: 9.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 363 VSKFQKRNKLIELLESNGSSKCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAA 442
Cdd:PRK11057 218 VEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFG 297
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 242012580 443 RGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFYDP 487
Cdd:PRK11057 298 MGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDP 342
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
155-290 |
1.14e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 57.66 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 155 TPIQKHCI-PIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQImskssfctpeVIIMTPTRELTIQIFEEARKFSRG 233
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGK----------AVYIAPTRALVNQKEADLRERFGP 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 242012580 234 TFLKVALTYGGTAVFHQVEkikNGCNILVATP----GRLLDFVQRGIIDFSMtefLILDEA 290
Cdd:cd17921 73 LGKNVGLLTGDPSVNKLLL---AEADILVATPekldLLLRNGGERLIQDVRL---VVVDEA 127
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
372-474 |
3.15e-09 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 55.44 E-value: 3.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 372 LIELLESNGS---SKCLVFVEQKRTTDFIATFLcEKNFP---ATSIHGDRD--------QREREEALRDFKTGKMDILVA 437
Cdd:cd18801 18 VKEHFKKKQEgsdTRVIIFSEFRDSAEEIVNFL-SKIRPgirATRFIGQASgksskgmsQKEQKEVIEQFRKGGYNVLVA 96
|
90 100 110
....*....|....*....|....*....|....*..
gi 242012580 438 TSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGR 474
Cdd:cd18801 97 TSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
364-484 |
5.61e-09 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 54.95 E-value: 5.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 364 SKFQKRNKLIELLESNGssKCLVFVEQKRTTDFIATFLcekNFPAtsIHGDRDQREREEALRDFKTGKMDILVATSVAAR 443
Cdd:cd18789 34 NKLRALEELLKRHEQGD--KIIVFTDNVEALYRYAKRL---LKPF--ITGETPQSEREEILQNFREGEYNTLVVSKVGDE 106
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 242012580 444 GLDI--KNVAHVVNFdLPKTIDEYVHRIGRTGRVGNRGLATSF 484
Cdd:cd18789 107 GIDLpeANVAIQISG-HGGSRRQEAQRLGRILRPKKGGGKNAF 148
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
177-290 |
1.09e-08 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 55.35 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 177 TGSGKTaafLIPI--INKLLEKNQIMSKSSfctPEVIIMTPTRELTIQIFEEARKFsrgTFLKVALTYGGTAVFHQVEKI 254
Cdd:cd18034 25 TGSGKT---LIAVmlIKEMGELNRKEKNPK---KRAVFLVPTVPLVAQQAEAIRSH---TDLKVGEYSGEMGVDKWTKER 95
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 242012580 255 KNGC----NILVATPGRLLDFVQRGIIDFSMTEFLILDEA 290
Cdd:cd18034 96 WKEElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
431-479 |
3.08e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.78 E-value: 3.08e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 242012580 431 KMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRG 479
Cdd:cd18785 22 SLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
383-471 |
1.42e-06 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 47.17 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 383 KCLVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQRERE-EALRDFKTG--KMDILVATSVAARGLDIKNVAHVVnFDLP 459
Cdd:cd18799 8 KTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGdEALILLFFGelKPPILVTVDLLTTGVDIPEVDNVV-FLRP 86
|
90
....*....|...
gi 242012580 460 -KTIDEYVHRIGR 471
Cdd:cd18799 87 tESRTLFLQMLGR 99
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
150-196 |
1.46e-06 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 51.26 E-value: 1.46e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 242012580 150 QYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKT-AAFLiPIINKLLEK 196
Cdd:COG1201 21 RFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAFL-PALDELARR 67
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
175-478 |
2.01e-06 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 50.12 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 175 AQTGSGKTAAFLIpIINKLLeKNQIMSKssfctpeVIIMTPTRELTIQIFEEAR-------------KFSR-------GT 234
Cdd:cd09639 6 APTGYGKTEAALL-WALHSL-KSQKADR-------VIIALPTRATINAMYRRAKeafgetglyhssiLSSRikemgdsEE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 235 FLK-VALTYGGTAVFHQveKIKNGCNILVATPGRLLDFVQRGIIDFSM-TEFLILDEADRMLD--MGFIS---EIKKMIN 307
Cdd:cd09639 77 FEHlFPLYIHSNDTLFL--DPITVCTIDQVLKSVFGEFGHYEFTLASIaNSLLIFDEVHFYDEytLALILavlEVLKDND 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 308 HPTMksssqrqtLMfSATFPSevqhLAKTFLNNYLFVVVGIvGGACSDVVQKFF------SVSKFQKRNKLIEllESNGS 381
Cdd:cd09639 155 VPIL--------LM-SATLPK----FLKEYAEKIGYVEENE-PLDLKPNERAPFikiesdKVGEISSLERLLE--FIKKG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 382 SKCLVFVEQKRTTDFIATFLCEKN--FPATSIHG-----DRDQRErEEALRDFKTGKMDILVATSVAARGLDIknvahvv 454
Cdd:cd09639 219 GSVAIIVNTVDRAQEFYQQLKEKGpeEEIMLIHSrftekDRAKKE-AELLLEFKKSEKFVIVATQVIEASLDI------- 290
|
330 340
....*....|....*....|....*...
gi 242012580 455 NFDL----PKTIDEYVHRIGRTGRVGNR 478
Cdd:cd09639 291 SVDVmiteLAPIDSLIQRLGRLHRYGEK 318
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
155-476 |
2.14e-06 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 50.28 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 155 TPIQKHCIP-IIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKnqimskssfctPEVIIMTPTRELTIQIFEEARKFSRG 233
Cdd:COG1204 24 YPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNG-----------GKALYIVPLRALASEKYREFKRDFEE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 234 TFLKVALTYGGtavFHQVEKIKNGCNILVATPGRLLDFVQRG---IIDFSMtefLILDEA------DRmldmGFISE--I 302
Cdd:COG1204 93 LGIKVGVSTGD---YDSDDEWLGRYDILVATPEKLDSLLRNGpswLRDVDL---VVVDEAhliddeSR----GPTLEvlL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 303 KKMinhptMKSSSQRQTLMFSATFPSeVQHLAKtFLNNYLFV--------VVGIVggacSDVVQKFFSVSKFQKRNKL-- 372
Cdd:COG1204 163 ARL-----RRLNPEAQIVALSATIGN-AEEIAE-WLDAELVKsdwrpvplNEGVL----YDGVLRFDDGSRRSKDPTLal 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 373 -IELLESNGSskCLVFVEQKRTT--------DFIATFLCEKN-----FPATSIHGDRDQREREEALRD------------ 426
Cdd:COG1204 232 aLDLLEEGGQ--VLVFVSSRRDAeslakklaDELKRRLTPEEreeleELAEELLEVSEETHTNEKLADclekgvafhhag 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242012580 427 ------------FKTGKMDILVATSVAARG--LDIKNVahVV-----NFDLPKTIDEYVHRIGRTGRVG 476
Cdd:COG1204 310 lpselrrlvedaFREGLIKVLVATPTLAAGvnLPARRV--IIrdtkrGGMVPIPVLEFKQMAGRAGRPG 376
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
166-292 |
4.73e-06 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 47.43 E-value: 4.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 166 MSGRDLMGCAQTGSGKTaaflipIINKLLEKNQIMSKSSFCTPEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGT 245
Cdd:cd17927 15 LKGKNTIICLPTGSGKT------FVAVLICEHHLKKFPAGRKGKVVFLANKVPLVEQQKEVFRKHFERPGYKVTGLSGDT 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 246 AVFHQVEKIKNGCNILVATPGRLLDFVQRGII----DFSMtefLILDEADR 292
Cdd:cd17927 89 SENVSVEQIVESSDVIIVTPQILVNDLKSGTIvslsDFSL---LVFDECHN 136
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
385-460 |
7.56e-06 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 46.47 E-value: 7.56e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242012580 385 LVFVEQKRTTDFIATFLCEKNFPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPK 460
Cdd:cd18790 31 LVTTLTKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADK 106
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
411-484 |
8.96e-06 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 45.80 E-value: 8.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 411 IHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNvAHVVnfdlpktIDEYVHRIGRT------GRVGnRGLATSF 484
Cdd:cd18811 67 LHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPN-ATVM-------VIEDAERFGLSqlhqlrGRVG-RGDHQSY 137
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
362-482 |
1.34e-05 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 44.94 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 362 SVSKFQKRNKLIELLESNGSsKCLVFVEQKRTTDFIATF----LCEKNFPATSIHGDR---DQREREEALRDFKTGKMDI 434
Cdd:cd18797 17 RGSARREAARLFADLVRAGV-KTIVFCRSRKLAELLLRYlkarLVEEGPLASKVASYRagyLAEDRREIEAELFNGELLG 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 242012580 435 LVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLAT 482
Cdd:cd18797 96 VVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
150-198 |
1.64e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 47.57 E-value: 1.64e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 242012580 150 QYHKPTPIQKHCIPIIMSGRDLMGCAQTGSGKT-AAFLIpIINKLLEKNQ 198
Cdd:PRK13767 29 KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFLA-IIDELFRLGR 77
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
167-290 |
1.97e-05 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 45.27 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 167 SGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSkssfctpevIIMTPTRELTIQIFEEARKFSRGTFLKVAL-TYGGT 245
Cdd:cd17923 14 AGRSVVVTTGTASGKSLCYQLPILEALLRDPGSRA---------LYLYPTKALAQDQLRSLRELLEQLGLGIRVaTYDGD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 242012580 246 AVFHQVEKI-KNGCNILVATPGRL----LDFVQRGIIDFSMTEFLILDEA 290
Cdd:cd17923 85 TPREERRAIiRNPPRILLTNPDMLhyalLPHHDRWARFLRNLRYVVLDEA 134
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
177-326 |
5.34e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 43.45 E-value: 5.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 177 TGSGKTaAFLIPIINKLLEKNqimskssfctpeVIIMTPTRELTIQIFEEARKFSRGTFLKVaLTYGgtavfhqVEKIKN 256
Cdd:cd17926 27 TGSGKT-LTALALIAYLKELR------------TLIVVPTDALLDQWKERFEDFLGDSSIGL-IGGG-------KKKDFD 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 257 GCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADRmLDMGFISEIKKMINHPTMksssqrqtLMFSATF 326
Cdd:cd17926 86 DANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHH-LPAKTFSEILKELNAKYR--------LGLTATP 146
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
411-450 |
6.93e-05 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 43.41 E-value: 6.93e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 242012580 411 IHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNV 450
Cdd:cd18792 66 LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNA 105
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
411-481 |
8.51e-05 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 43.10 E-value: 8.51e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242012580 411 IHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRI-GRTGRVGNRGLA 481
Cdd:cd18810 57 AHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLYQLrGRVGRSKERAYA 128
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
370-518 |
1.10e-04 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 43.06 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 370 NKLIELLESNGSSkCLVFV---EQKRTTDFIATFLCEKNFPATSIHgdrdqREREEALRDFKTGKMDILVATS----VAA 442
Cdd:cd18798 14 EKLLELVKKLGDG-GLIFVsidYGKEYAEELKEFLERHGIKAELAL-----SSTEKNLEKFEEGEIDVLIGVAsyygVLV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 443 RGLDI-KNVAHVVNFDLPKTidEYVHRIGRTGRVGN----RGLATSFYDplcDSHLAPALVKILSQAgqeIPDFLLEFKE 517
Cdd:cd18798 88 RGIDLpERIKYAIFYGVPVT--TYIQASGRTSRLYAggltKGLSVVLVD---DPELFEALKKRLKLI---LDEFIFKELE 159
|
.
gi 242012580 518 T 518
Cdd:cd18798 160 E 160
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
157-265 |
1.24e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 43.50 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 157 IQKHCIP-IIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskSSFCTPEVIIMTPTRELTIQIFEEAR-KFSRGT 234
Cdd:cd18023 5 IQSEVFPdLLYSDKNFVVSAPTGSGKTVLFELAILRLLKERNP----LPWGNRKVVYIAPIKALCSEKYDDWKeKFGPLG 80
|
90 100 110
....*....|....*....|....*....|.
gi 242012580 235 FLKVALTygGTAVFHQVEKIKNgCNILVATP 265
Cdd:cd18023 81 LSCAELT--GDTEMDDTFEIQD-ADIILTTP 108
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
177-327 |
2.13e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 41.89 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 177 TGSGKT--AAFLIpiinKLLEKNQIMSKssfctpeVIIMTPTRELTIQIFEEARKFSRGTFLKVALTYGGTAVFhqvekI 254
Cdd:pfam04851 32 TGSGKTltAAKLI----ARLFKKGPIKK-------VLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKDE-----S 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 242012580 255 KNGCNILVATPGRLLDFVQRGIIDFSMTEF--LILDEADRMLDMGFiSEIKKMINHPTMksssqrqtLMFSATFP 327
Cdd:pfam04851 96 VDDNKIVVTTIQSLYKALELASLELLPDFFdvIIIDEAHRSGASSY-RNILEYFKPAFL--------LGLTATPE 161
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
168-289 |
5.60e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 40.64 E-value: 5.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 168 GRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskSSFctpEVIIMTPTRELTIQIFEEARKFSRGTFL--KVALTYGGT 245
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPE----KGV---QVLYISPLKALINDQERRLEEPLDEIDLeiPVAVRHGDT 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 242012580 246 AvfhQVEK---IKNGCNILVATPGRL-LDFVQRGII-DFSMTEFLILDE 289
Cdd:cd17922 74 S---QSEKakqLKNPPGILITTPESLeLLLVNKKLReLFAGLRYVVVDE 119
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
411-440 |
7.59e-04 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 42.34 E-value: 7.59e-04
10 20 30
....*....|....*....|....*....|
gi 242012580 411 IHGDRDQREREEALRDFKTGKMDILVATSV 440
Cdd:COG1200 509 LHGRMKPAEKDAVMAAFKAGEIDVLVATTV 538
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
175-292 |
1.25e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.19 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 175 AQTGSGKTAAFLIPIINKLLEKNQimskssfctpEVIIMTPTRELTIQIFEEARKFSRGTFLKVALTygGTAVFHQVEKI 254
Cdd:cd18035 23 LPTGLGKTIIAILVAADRLTKKGG----------KVLILAPSRPLVEQHAENLKRVLNIPDKITSLT--GEVKPEERAER 90
|
90 100 110
....*....|....*....|....*....|....*...
gi 242012580 255 KNGCNILVATPGRLLDFVQRGIIDFSMTEFLILDEADR 292
Cdd:cd18035 91 WDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
153-289 |
1.49e-03 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 40.15 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 153 KPTPIQKHCIPIIMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQIMSKSsfctpEVIIMTPTRELTIQIFEEARKFSR 232
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKG-----RVVVLVNKVPLVEQQLEKFFKYFR 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242012580 233 GTFlKVALTYGGTAVFHQVEKIKNGCNILVATPGRLLDFVQRGII-------DFSMtefLILDE 289
Cdd:cd18036 77 KGY-KVTGLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSGREeervylsDFSL---LIFDE 136
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
411-440 |
1.56e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 41.29 E-value: 1.56e-03
10 20 30
....*....|....*....|....*....|
gi 242012580 411 IHGDRDQREREEALRDFKTGKMDILVATSV 440
Cdd:PRK10917 511 LHGRMKPAEKDAVMAAFKAGEIDILVATTV 540
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
406-487 |
1.80e-03 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 41.45 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242012580 406 FPATSIHGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTG-RVGnrGLATSF 484
Cdd:PRK09751 302 FIARSHHGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAGhQVG--GVSKGL 379
|
...
gi 242012580 485 YDP 487
Cdd:PRK09751 380 FFP 382
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
412-485 |
4.41e-03 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 39.88 E-value: 4.41e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242012580 412 HGDRDQREREEALRDFKTGKMDILVATSVAARGLDIKNVAHVVNFDLPKTIDEYVHRIGRTGRVGNRGLATSFY 485
Cdd:PLN03137 711 HGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYY 784
|
|
| PRK05580 |
PRK05580 |
primosome assembly protein PriA; Validated |
414-458 |
6.41e-03 |
|
primosome assembly protein PriA; Validated
Pssm-ID: 235514 [Multi-domain] Cd Length: 679 Bit Score: 39.37 E-value: 6.41e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 242012580 414 DRD----QREREEALRDFKTGKMDILVATSVAARGLDIKNV--AHVVNFDL 458
Cdd:PRK05580 459 DRDttrrKGALEQLLAQFARGEADILIGTQMLAKGHDFPNVtlVGVLDADL 509
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
165-243 |
9.16e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 37.31 E-value: 9.16e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242012580 165 IMSGRDLMGCAQTGSGKTAAFLIPIINKLLEKNQimskssfctpeVIIMTPTRELTIQIFEEARKFSRgTFLKVALTYG 243
Cdd:cd18028 14 LLKGENLLISIPTASGKTLIAEMAMVNTLLEGGK-----------ALYLVPLRALASEKYEEFKKLEE-IGLKVGISTG 80
|
|
| |
