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Conserved domains on  [gi|242008315|ref|XP_002424952|]
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vacuolar protein sorting protein, putative [Pediculus humanus corporis]

Protein Classification

VPS52 family protein( domain architecture ID 140488)

VPS52 family protein such as yeast vacuolar protein sorting-associated protein 52(Vps52, also called Sac2), which is part of a multi subunit complex required for protein sorting at yeast late golgi.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec3_C super family cl19950
Exocyst complex component Sec3; This entry is the conserved middle and C-terminus of the Sec3 ...
 38-412 9.24e-122

Exocyst complex component Sec3; This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.


The actual alignment was detected with superfamily member pfam04129:

Pssm-ID: 418729  Cd Length: 508  Bit Score: 367.18  E-value: 9.24e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   38 VENKSIQDYIKESQNIASLHNQICDCDNILAQ-------------------------------------AVTHPLSQFID 80
Cdd:pfam04129   1 NEDKSIFDYIKESSNIASLHNQIAACDSVLEQmedmltefqsdlsnissdidflqeksnemqlrlenrqAVESKLSPFVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   81 DISVSETLINSILDIPVVDKAFISQLMILNHKINFVKEQNFKDAKCSQDVMEVLEKLRIKAVTKIRLYLLEQVSKFRKPL 160
Cdd:pfam04129  81 DLIVPPELIDDIIEGPVNEPFFATQLEILNKKLSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  161 ANYQVPQSVLLKNKFLFEFLMGQERNTAAEISSEYVETMSKVYFSYFKSYDSRLMKLSYEEAATKDDLMGIEDTgSRGGL 240
Cdd:pfam04129 161 TNYQIIQNALLKYKFIFPFLLDNNRSLALELRQAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETT-AKGLF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  241 FHK-ATLKHKTTVFTIGNRGDILTTQIEAPVIVPHAAQKSGTKVT---LFRSEQYALLDNACREYLFLSEFFVVKG---- 312
Cdd:pfam04129 240 FSKpVSLKKRNTIFTIGKRGNILTMQLDAPILVPHIAENNTTKYYieaLFRSLHLALLDNATSEYLFLKEFFAVSGdqae 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315      --------------------------------------------------------------------------------
Cdd:pfam04129 320 difeqifgktlseatkyleqlisdcydaigvllsiriinrlqliaerrgvpaldsylnsvliqlwprfqlvfdmhceslr 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  313 ---------KEMGPHYVARRYAELSGAMIGLSESFPNDLVNDLLTQLQEEVELFILKMAAVFQQRKDQLIFLINNYDMIL 383
Cdd:pfam04129 400 kanittlvePDTRPHYLTRRYAEFLSSFVTLSVTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLL 479

                         490       500
                  ....*....|....*....|....*....
gi 242008315  384 SVLMERTKDHCKEAEAFRNQLTTRSNEYV 412
Cdd:pfam04129 480 GVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Name Accession Description Interval E-value
Vps52 pfam04129
Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex ...
 38-412 9.24e-122

Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 282044  Cd Length: 508  Bit Score: 367.18  E-value: 9.24e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   38 VENKSIQDYIKESQNIASLHNQICDCDNILAQ-------------------------------------AVTHPLSQFID 80
Cdd:pfam04129   1 NEDKSIFDYIKESSNIASLHNQIAACDSVLEQmedmltefqsdlsnissdidflqeksnemqlrlenrqAVESKLSPFVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   81 DISVSETLINSILDIPVVDKAFISQLMILNHKINFVKEQNFKDAKCSQDVMEVLEKLRIKAVTKIRLYLLEQVSKFRKPL 160
Cdd:pfam04129  81 DLIVPPELIDDIIEGPVNEPFFATQLEILNKKLSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  161 ANYQVPQSVLLKNKFLFEFLMGQERNTAAEISSEYVETMSKVYFSYFKSYDSRLMKLSYEEAATKDDLMGIEDTgSRGGL 240
Cdd:pfam04129 161 TNYQIIQNALLKYKFIFPFLLDNNRSLALELRQAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETT-AKGLF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  241 FHK-ATLKHKTTVFTIGNRGDILTTQIEAPVIVPHAAQKSGTKVT---LFRSEQYALLDNACREYLFLSEFFVVKG---- 312
Cdd:pfam04129 240 FSKpVSLKKRNTIFTIGKRGNILTMQLDAPILVPHIAENNTTKYYieaLFRSLHLALLDNATSEYLFLKEFFAVSGdqae 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315      --------------------------------------------------------------------------------
Cdd:pfam04129 320 difeqifgktlseatkyleqlisdcydaigvllsiriinrlqliaerrgvpaldsylnsvliqlwprfqlvfdmhceslr 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  313 ---------KEMGPHYVARRYAELSGAMIGLSESFPNDLVNDLLTQLQEEVELFILKMAAVFQQRKDQLIFLINNYDMIL 383
Cdd:pfam04129 400 kanittlvePDTRPHYLTRRYAEFLSSFVTLSVTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLL 479

                         490       500
                  ....*....|....*....|....*....
gi 242008315  384 SVLMERTKDHCKEAEAFRNQLTTRSNEYV 412
Cdd:pfam04129 480 GVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Name Accession Description Interval E-value
Vps52 pfam04129
Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex ...
 38-412 9.24e-122

Vps52 / Sac2 family; Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 282044  Cd Length: 508  Bit Score: 367.18  E-value: 9.24e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   38 VENKSIQDYIKESQNIASLHNQICDCDNILAQ-------------------------------------AVTHPLSQFID 80
Cdd:pfam04129   1 NEDKSIFDYIKESSNIASLHNQIAACDSVLEQmedmltefqsdlsnissdidflqeksnemqlrlenrqAVESKLSPFVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315   81 DISVSETLINSILDIPVVDKAFISQLMILNHKINFVKEQNFKDAKCSQDVMEVLEKLRIKAVTKIRLYLLEQVSKFRKPL 160
Cdd:pfam04129  81 DLIVPPELIDDIIEGPVNEPFFATQLEILNKKLSNVLDQSFKSSKAPKDVDQLLDKLRNKAIEKIRRYIVQKIKTFRKPM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  161 ANYQVPQSVLLKNKFLFEFLMGQERNTAAEISSEYVETMSKVYFSYFKSYDSRLMKLSYEEAATKDDLMGIEDTgSRGGL 240
Cdd:pfam04129 161 TNYQIIQNALLKYKFIFPFLLDNNRSLALELRQAYIDTMNKIYLSYFRSYIRRLTKLQFEEIDTKDDLMGVETT-AKGLF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  241 FHK-ATLKHKTTVFTIGNRGDILTTQIEAPVIVPHAAQKSGTKVT---LFRSEQYALLDNACREYLFLSEFFVVKG---- 312
Cdd:pfam04129 240 FSKpVSLKKRNTIFTIGKRGNILTMQLDAPILVPHIAENNTTKYYieaLFRSLHLALLDNATSEYLFLKEFFAVSGdqae 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315      --------------------------------------------------------------------------------
Cdd:pfam04129 320 difeqifgktlseatkyleqlisdcydaigvllsiriinrlqliaerrgvpaldsylnsvliqlwprfqlvfdmhceslr 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242008315  313 ---------KEMGPHYVARRYAELSGAMIGLSESFPNDLVNDLLTQLQEEVELFILKMAAVFQQRKDQLIFLINNYDMIL 383
Cdd:pfam04129 400 kanittlvePDTRPHYLTRRYAEFLSSFVTLSVTHPNEIVERLLNRLQREVEDFILRLAKCFPKRKSQLRFLINNYDLLL 479

                         490       500
                  ....*....|....*....|....*....
gi 242008315  384 SVLMERTKDHCKEAEAFRNQLTTRSNEYV 412
Cdd:pfam04129 480 GVLMELHLDLSKEQEDFQEYLNSNTENFV 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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