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Conserved domains on  [gi|224013426|ref|XP_002296377|]
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predicted protein, partial [Thalassiosira pseudonana CCMP1335]

Protein Classification

aminopeptidase family protein P( domain architecture ID 11241377)

aminopeptidase family protein P (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
PubMed:  16229471|30536999

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 355-582 8.31e-119

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


:

Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 353.02  E-value: 8.31e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 355 GMRRAHIVDGAAMANFMAWLEQTiVVEGRAVSEVEIDEVLTGYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAAEGSDllK 434
Cdd:cd01085    1 GMRAAHIRDGVALVEFLAWLEQE-VPKGETITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESN--R 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 435 YLDRTNPILIDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPENTPGFVLDVFARKALWEIGKDYG 514
Cdd:cd01085   78 KISPDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224013426 515 HGTGHGVGAALNVHEGPHGISPRwTNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVDVNGSDNSG 582
Cdd:cd01085  158 HGTGHGVGSFLNVHEGPQSISPA-PNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFGG 224
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
190-352 1.65e-58

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 193.86  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  190 GRPALPKNPFRVQPMEYAGVSVFDKVNKIRSEMTEKKASLAVFSALDDIAYLFNVRCmGDVETCPVGIAYATISQDEVTL 269
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRG-SDVPYNPVFLSYALVTDDEATL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  270 YCDEEKVqPADVMEHLKKANVTIKPYGEVVSDIQShLSSNSrnKVWLDNTRSNYAISRVISTP-SLIDAQNAVTPMKACK 348
Cdd:pfam16189  80 FVDPEKL-SDEVRAHLEENGVEIRPYDDIYEDLAA-LAAGK--KVLLDPSRTSYALYSALPAGaKVVEAPSPITLMKAVK 155


                  ....
gi 224013426  349 NPSE 352
Cdd:pfam16189 156 NETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 596-651 7.86e-21

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 86.31  E-value: 7.86e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 224013426  596 QFLKFAKLTMIPIQKSLIDVGIMTEAELDWLDAYHEEVLQKVSPLLEVGSPAMNWL 651
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEEDALEWL 56
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 355-582 8.31e-119

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 353.02  E-value: 8.31e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 355 GMRRAHIVDGAAMANFMAWLEQTiVVEGRAVSEVEIDEVLTGYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAAEGSDllK 434
Cdd:cd01085    1 GMRAAHIRDGVALVEFLAWLEQE-VPKGETITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESN--R 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 435 YLDRTNPILIDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPENTPGFVLDVFARKALWEIGKDYG 514
Cdd:cd01085   78 KISPDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224013426 515 HGTGHGVGAALNVHEGPHGISPRwTNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVDVNGSDNSG 582
Cdd:cd01085  158 HGTGHGVGSFLNVHEGPQSISPA-PNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFGG 224
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
216-574 2.45e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 238.18  E-value: 2.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 216 NKIRSEMTEKKASLAVFSALDDIAYLFNVRCMgdvetcPVGIAYATISQD-EVTLYCDEekvqpadvmehlkkanvtikp 294
Cdd:COG0006    1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS------PERLAALLVTADgEPVLFVDE--------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 295 ygevvsdiqshlssnsrnkvwLDNTRSnyaisrvistpsLIDAQNAVTPMKACKNPSEMEGMRRAHIVDGAAMANFMAWL 374
Cdd:COG0006   54 ---------------------LEAERE------------LVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAAL 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 375 EqtivvEGraVSEVEIDEVLTGYRAQQpGFKEVSFPTIAGVGPNGAIVHYRAAEgsdllKYLDRTNPILIDSGGQYEYGT 454
Cdd:COG0006  101 R-----PG--VTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTPTD-----RPLKPGDLVLIDAGAEYDGYT 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 455 TDVTRTWHLGEPSEEFVDMYTRVLKGNI-GVDTMifPENTPGFVLDVFARKALWEIG--KDYGHGTGHGVGaaLNVHEGP 531
Cdd:COG0006  168 SDITRTVAVGEPSDEQREIYEAVLEAQEaAIAAL--KPGVTGGEVDAAARDVLAEAGygEYFPHGTGHGVG--LDVHEGP 243

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 224013426 532 HgISPRwtNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVD 574
Cdd:COG0006  244 Q-ISPG--NDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE 283
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
190-352 1.65e-58

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 193.86  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  190 GRPALPKNPFRVQPMEYAGVSVFDKVNKIRSEMTEKKASLAVFSALDDIAYLFNVRCmGDVETCPVGIAYATISQDEVTL 269
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRG-SDVPYNPVFLSYALVTDDEATL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  270 YCDEEKVqPADVMEHLKKANVTIKPYGEVVSDIQShLSSNSrnKVWLDNTRSNYAISRVISTP-SLIDAQNAVTPMKACK 348
Cdd:pfam16189  80 FVDPEKL-SDEVRAHLEENGVEIRPYDDIYEDLAA-LAAGK--KVLLDPSRTSYALYSALPAGaKVVEAPSPITLMKAVK 155


                  ....
gi 224013426  349 NPSE 352
Cdd:pfam16189 156 NETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 354-574 5.75e-58

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.38  E-value: 5.75e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  354 EGMRRAHIVDGAAMANFMAWLEqtivvEGraVSEVEIDEVLTGYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAaeGSDLL 433
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIR-----PG--VTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP--NDRVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  434 KYLDrtnPILIDSGGQYEYG-TTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPeNTPGFVLDVFARKALWEIG-- 510
Cdd:pfam00557  72 KPGD---LVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGlg 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224013426  511 KDYGHGTGHGVGaaLNVHEGPHGISPRwtNKEVLKEGMVTSNEPGFYD-DGNYGIRIENLLEIVD 574
Cdd:pfam00557 148 EYFPHGLGHGIG--LEVHEGPYISRGG--DDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 596-651 7.86e-21

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 86.31  E-value: 7.86e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 224013426  596 QFLKFAKLTMIPIQKSLIDVGIMTEAELDWLDAYHEEVLQKVSPLLEVGSPAMNWL 651
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEEDALEWL 56
PRK09795 PRK09795
aminopeptidase; Provisional
 340-570 8.45e-17

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 82.29  E-value: 8.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 340 AVTPMKACKNPSEMEGMRRA-HIVDGAA--MANFMAwleqtivvegRAVSEVEIDEVLTGYRAQQpGFKEVSFPTIAGVG 416
Cdd:PRK09795 120 TPDVLRQIKTPEEVEKIRLAcGIADRGAehIRRFIQ----------AGMSEREIAAELEWFMRQQ-GAEKASFDTIVASG 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 417 PNGAIVHYRAAEgsdllKYLDRTNPILIDSGGQYEYGTTDVTRTWHL---GEPSEEFV--DMYTRVLKGNIGVDTMIFPe 491
Cdd:PRK09795 189 WRGALPHGKASD-----KIVAAGEFVTLDFGALYQGYCSDMTRTLLVngeGVSAESHPlfNVYQIVLQAQLAAISAIRP- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 492 NTPGFVLDVFARKALWEIG-KDY-GHGTGHGVGaaLNVHEGPHgISPrwTNKEVLKEGMVTSNEPGFYDDGNYGIRIENL 569
Cdd:PRK09795 263 GVRCQQVDDAARRVITEAGyGDYfGHNTGHAIG--IEVHEDPR-FSP--RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDV 337


                 .
gi 224013426 570 L 570
Cdd:PRK09795 338 V 338
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 355-582 8.31e-119

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 353.02  E-value: 8.31e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 355 GMRRAHIVDGAAMANFMAWLEQTiVVEGRAVSEVEIDEVLTGYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAAEGSDllK 434
Cdd:cd01085    1 GMRAAHIRDGVALVEFLAWLEQE-VPKGETITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESN--R 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 435 YLDRTNPILIDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPENTPGFVLDVFARKALWEIGKDYG 514
Cdd:cd01085   78 KISPDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224013426 515 HGTGHGVGAALNVHEGPHGISPRwTNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVDVNGSDNSG 582
Cdd:cd01085  158 HGTGHGVGSFLNVHEGPQSISPA-PNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFGG 224
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
216-574 2.45e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 238.18  E-value: 2.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 216 NKIRSEMTEKKASLAVFSALDDIAYLFNVRCMgdvetcPVGIAYATISQD-EVTLYCDEekvqpadvmehlkkanvtikp 294
Cdd:COG0006    1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS------PERLAALLVTADgEPVLFVDE--------------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 295 ygevvsdiqshlssnsrnkvwLDNTRSnyaisrvistpsLIDAQNAVTPMKACKNPSEMEGMRRAHIVDGAAMANFMAWL 374
Cdd:COG0006   54 ---------------------LEAERE------------LVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAAL 100

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 375 EqtivvEGraVSEVEIDEVLTGYRAQQpGFKEVSFPTIAGVGPNGAIVHYRAAEgsdllKYLDRTNPILIDSGGQYEYGT 454
Cdd:COG0006  101 R-----PG--VTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTPTD-----RPLKPGDLVLIDAGAEYDGYT 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 455 TDVTRTWHLGEPSEEFVDMYTRVLKGNI-GVDTMifPENTPGFVLDVFARKALWEIG--KDYGHGTGHGVGaaLNVHEGP 531
Cdd:COG0006  168 SDITRTVAVGEPSDEQREIYEAVLEAQEaAIAAL--KPGVTGGEVDAAARDVLAEAGygEYFPHGTGHGVG--LDVHEGP 243

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 224013426 532 HgISPRwtNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVD 574
Cdd:COG0006  244 Q-ISPG--NDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE 283
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
190-352 1.65e-58

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 193.86  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  190 GRPALPKNPFRVQPMEYAGVSVFDKVNKIRSEMTEKKASLAVFSALDDIAYLFNVRCmGDVETCPVGIAYATISQDEVTL 269
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRG-SDVPYNPVFLSYALVTDDEATL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  270 YCDEEKVqPADVMEHLKKANVTIKPYGEVVSDIQShLSSNSrnKVWLDNTRSNYAISRVISTP-SLIDAQNAVTPMKACK 348
Cdd:pfam16189  80 FVDPEKL-SDEVRAHLEENGVEIRPYDDIYEDLAA-LAAGK--KVLLDPSRTSYALYSALPAGaKVVEAPSPITLMKAVK 155


                  ....
gi 224013426  349 NPSE 352
Cdd:pfam16189 156 NETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 354-574 5.75e-58

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 194.38  E-value: 5.75e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  354 EGMRRAHIVDGAAMANFMAWLEqtivvEGraVSEVEIDEVLTGYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAaeGSDLL 433
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIR-----PG--VTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP--NDRVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426  434 KYLDrtnPILIDSGGQYEYG-TTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPeNTPGFVLDVFARKALWEIG-- 510
Cdd:pfam00557  72 KPGD---LVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGlg 147

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224013426  511 KDYGHGTGHGVGaaLNVHEGPHGISPRwtNKEVLKEGMVTSNEPGFYD-DGNYGIRIENLLEIVD 574
Cdd:pfam00557 148 EYFPHGLGHGIG--LEVHEGPYISRGG--DDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 385-578 3.63e-33

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 126.47  E-value: 3.63e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 385 VSEVEIDEVLTgYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAaegSDllKYLDRTNPILIDSGGQYEYGTTDVTRTWHLG 464
Cdd:cd01092   26 MTEREVAAELE-YFMRKLGAEGPSFDTIVASGPNSALPHGVP---SD--RKIEEGDLVLIDFGAIYDGYCSDITRTVAVG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 465 EPSEEFVDMYTRVLKGN-IGVDtMIFPENTpGFVLDVFARKALWEIG-KDY-GHGTGHGVGaaLNVHEGPhGISPRwtNK 541
Cdd:cd01092  100 EPSDELKEIYEIVLEAQqAAIK-AVKPGVT-AKEVDKAARDVIEEAGyGEYfIHRTGHGVG--LEVHEAP-YISPG--SD 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 224013426 542 EVLKEGMVTSNEPGFYDDGNYGIRIENLLeIVDVNGS 578
Cdd:cd01092  173 DVLEEGMVFTIEPGIYIPGKGGVRIEDDV-LVTEDGC 208
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 353-574 1.17e-29

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 116.40  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 353 MEGMRRAHIVDGAAMANFMAWLEqtivvegRAVSEVEIDEVLtgYRAQQPGFKEVSFPTIAGVGPNGAIVHYRAAEGSdl 432
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIR-------PGVTEAEVAAAI--EQALRAAGGYPAGPTIVGSGARTALPHYRPDDRR-- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 433 lkyLDRTNPILIDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFPENTPG----FVLDVFARKALwe 508
Cdd:cd01066   70 ---LQEGDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEevdaAAREVLEEHGL-- 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224013426 509 iGKDYGHGTGHGVGaaLNVHEGPhgiSPRWTNKEVLKEGMVTSNEPGFYDDGNYGIRIENLLEIVD 574
Cdd:cd01066  145 -GPNFGHRTGHGIG--LEIHEPP---VLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTE 204
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 596-651 7.86e-21

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 86.31  E-value: 7.86e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 224013426  596 QFLKFAKLTMIPIQKSLIDVGIMTEAELDWLDAYHEEVLQKVSPLLEVGSPAMNWL 651
Cdd:pfam16188   1 PFLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEEDALEWL 56
PRK09795 PRK09795
aminopeptidase; Provisional
 340-570 8.45e-17

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 82.29  E-value: 8.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 340 AVTPMKACKNPSEMEGMRRA-HIVDGAA--MANFMAwleqtivvegRAVSEVEIDEVLTGYRAQQpGFKEVSFPTIAGVG 416
Cdd:PRK09795 120 TPDVLRQIKTPEEVEKIRLAcGIADRGAehIRRFIQ----------AGMSEREIAAELEWFMRQQ-GAEKASFDTIVASG 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 417 PNGAIVHYRAAEgsdllKYLDRTNPILIDSGGQYEYGTTDVTRTWHL---GEPSEEFV--DMYTRVLKGNIGVDTMIFPe 491
Cdd:PRK09795 189 WRGALPHGKASD-----KIVAAGEFVTLDFGALYQGYCSDMTRTLLVngeGVSAESHPlfNVYQIVLQAQLAAISAIRP- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 492 NTPGFVLDVFARKALWEIG-KDY-GHGTGHGVGaaLNVHEGPHgISPrwTNKEVLKEGMVTSNEPGFYDDGNYGIRIENL 569
Cdd:PRK09795 263 GVRCQQVDDAARRVITEAGyGDYfGHNTGHAIG--IEVHEDPR-FSP--RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDV 337


                 .
gi 224013426 570 L 570
Cdd:PRK09795 338 V 338
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 406-580 4.93e-16

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 78.00  E-value: 4.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 406 EVSFPTIAGVGPNGAIVHYRAA----EGSDLLkyldrtnpiLIDSGGQYEYGTTDVTRTWHL-GEPSEEFVDMYTRVLKG 480
Cdd:cd01087   45 RLAYSYIVAAGSNAAILHYVHNdqplKDGDLV---------LIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 481 NIGVDTMIFPENTPGFVLDVFARKALwEIGKDYG--------------------HGTGHGVGaaLNVH--EGPHGISPRW 538
Cdd:cd01087  116 QKAAIAACKPGVSYEDIHLLAHRVLA-EGLKELGilkgdvdeivesgayakffpHGLGHYLG--LDVHdvGGYLRYLRRA 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224013426 539 tnkEVLKEGMVTSNEPGFY---DDGNY-------GIRIENLLeIVDVNGSDN 580
Cdd:cd01087  193 ---RPLEPGMVITIEPGIYfipDLLDVpeyfrggGIRIEDDV-LVTEDGPEN 240
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 333-580 5.67e-08

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 55.50  E-value: 5.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 333 SLIDAQNAVTPMKACKNPSEMEGMRRAHIVDGAAMANFM-----AWLEQTIvvegravsEVEIDEVLTGYRAQQPgfkev 407
Cdd:PRK10879 159 TLTDWRPWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMekcrpGMFEYQL--------EGEIHHEFNRHGARYP----- 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 408 SFPTIAGVGPNGAIVHYRAAEGS----DLlkyldrtnpILIDSGGQYEYGTTDVTRTWHL-GEPSEEFVDMYTRVLKGNI 482
Cdd:PRK10879 226 SYNTIVGSGENGCILHYTENESEmrdgDL---------VLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLESLE 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 483 GVDTMIFPENTPGFVLDVFAR---KALWEIGKDYG----------------HGTGHGVGaaLNVHEGPHGISPRwtnKEV 543
Cdd:PRK10879 297 TSLRLYRPGTSIREVTGEVVRimvSGLVKLGILKGdvdqliaenahrpffmHGLSHWLG--LDVHDVGVYGQDR---SRI 371

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 224013426 544 LKEGMVTSNEPGFY--DDGNY-------GIRIENLLEIVDvNGSDN 580
Cdd:PRK10879 372 LEPGMVLTVEPGLYiaPDADVpeqyrgiGIRIEDDIVITE-TGNEN 416
PRK15173 PRK15173
peptidase; Provisional
 292-572 1.78e-03

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 40.86  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 292 IKPYGEVVSDIQSHLSSNSR---NKVWLD-NTRSN---YAISRVISTPSLIDAQNAVTPMKACKNPSEMEGMRRAhivdg 364
Cdd:PRK15173  33 IGPPIESVCNILKDALNDARvlnKKIAIDlNIMSNggkRVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKS----- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 365 aamanfmAWLEQTIVVEGRAVSEVEID--EVLTGYRAQQPGFKEVSFPTI------AGVGPNGAIVHYRAAEGsDLLKYl 436
Cdd:PRK15173 108 -------AEITEYGITEASKLIRVGCTsaELTAAYKAAVMSKSETHFSRFhlisvgADFSPKLIPSNTKACSG-DLIKF- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 437 drtnpiliDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFP----ENTPGFVLDVFARKALweigKD 512
Cdd:PRK15173 179 --------DCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPgvkmKDVFDSTMEVIKKSGL----PN 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224013426 513 YGHG-TGHGVGAALNVHEGPHgISPRWTnkEVLKEGMVTSNEPGFYDDGNYGIRIENLLEI 572
Cdd:PRK15173 247 YNRGhLGHGNGVFLGLEESPF-VSTHAT--ESFTSGMVLSLETPYYGYNLGSIMIEDMILI 304
PRK14576 PRK14576
putative endopeptidase; Provisional
 325-574 1.82e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 41.15  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 325 ISRVISTPSLIDAQNAVTPMKACKNPSEMEGMRRAhivdgAAMANF-MAWLEQTIVVEGRAVseveidEVLTGYRAQQPG 403
Cdd:PRK14576 155 LDKVAPGLKLVDSTALFNEIRMIKSPWEIEHLRKS-----AEITEYgIASAAKKIRVGCTAA------ELTAAFKAAVMS 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 404 FKEVSFP--TIAGVGPNGA---IVHYRAAEGSDLLKYldrtnPILIDSGGqyeYGTtDVTRTWHLGEPSEEFVDMYTRVL 478
Cdd:PRK14576 224 FPETNFSrfNLISVGDNFSpkiIADTTPAKVGDLIKF-----DCGIDVAG---YGA-DLARTFVLGEPDKLTQQIYDTIR 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 479 KGNIGVDTMIFP----ENTPGFVLDVFARKALWEIGKdyGHgTGHGVGAALNVHEGPHgISPRWTnkEVLKEGMVTSNEP 554
Cdd:PRK14576 295 TGHEHMLSMVAPgvklKAVFDSTMAVIKTSGLPHYNR--GH-LGHGDGVFLGLEEVPF-VSTQAT--ETFCPGMVLSLET 368

                        250       260
                 ....*....|....*....|
gi 224013426 555 GFYDDGNYGIRIENLLEIVD 574
Cdd:PRK14576 369 PYYGIGVGSIMLEDMILITD 388
PRK14575 PRK14575
putative peptidase; Provisional
 292-572 3.40e-03

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 40.46  E-value: 3.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 292 IKPYGEVVSDIQSHLSSNSR---NKVWLD-NTRSN---YAISRVISTPSLIDAQNAVTPMKACKNPSEMEGMRRAhivdg 364
Cdd:PRK14575 116 IGPPIESVCNILKDALNDARvlnKKIAIDlNIMSNggkRVIDAVMPNVDFVDSSSIFNELRVIKSPWEIKRLRKS----- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 365 aamanfmAWLEQTIVVEGRAVSEVEID--EVLTGYRAQQPGFKEVSFPTI------AGVGPNGAIVHYRAAEGsDLLKYl 436
Cdd:PRK14575 191 -------AEITEYGITEASKLIRVGCTsaELTAAYKAAVMSKSETHFSRFhlisvgADFSPKLIPSNTKACSG-DLIKF- 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224013426 437 drtnpiliDSGGQYEYGTTDVTRTWHLGEPSEEFVDMYTRVLKGNIGVDTMIFP----ENTPGFVLDVFARKALweigKD 512
Cdd:PRK14575 262 --------DCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPgvkmKDVFDSTMEVIKKSGL----PN 329

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224013426 513 YGHG-TGHGVGAALNVHEGPHgISPRWTnkEVLKEGMVTSNEPGFYDDGNYGIRIENLLEI 572
Cdd:PRK14575 330 YNRGhLGHGNGVFLGLEESPF-VSTHAT--ESFTSGMVLSLETPYYGYNLGSIMIEDMILI 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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