NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|195398775|ref|XP_002057996|]
View 

probable ATP-dependent RNA helicase DHX34 [Drosophila virilis]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
144-665 6.36e-133

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 425.26  E-value: 6.36e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  144 ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE---FGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVG 220
Cdd:COG1643     9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  221 FQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAK-PELKLILMSATINV 299
Cdd:COG1643    89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALrPDLKLLVMSATLDA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  300 ELFHGYFKDegAQLLQVPGRLFPIKLRYMPPPAlelkagqatagsskrsQSARLDPApfiqVLSLIDQQYpITERGDVLI 379
Cdd:COG1643   169 ERFARLLGD--APVIESSGRTYPVEVRYRPLPA----------------DERDLEDA----VADAVREAL-AEEPGDILV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  380 FVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGKVKE 459
Cdd:COG1643   226 FLPGEREIRRTAEALRGRLPPDTE--ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARI 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  460 MSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQMVSMGLPDVRAF 539
Cdd:COG1643   304 PRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  540 PFIEPPETERIEQTILSLKQHCALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTLAAMLSVQNPLTTRAH 619
Cdd:COG1643   384 PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAG 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 195398775  620 TD--QRCERERQplESEQGDLFTLLRAYREWLQL-----KMARENTRK------WCHRL 665
Cdd:COG1643   464 SDllARLNLWRR--LREQQREFLSYLRLREWRDLarqlrRLLGEGANEepadyeAIGLL 520
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 793-896 1.23e-05

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 44.55  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   793 VSGFYPQLAIADEfnyckgGGQQFFHTQLKPFLSLHPNAHFAksyellklsdSELHAKPDYytpkqplserhqvLCYQSL 872
Cdd:pfam07717    6 AAGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLF----------NEKTFPPEW-------------VVYQEL 56

                           90       100
                   ....*....|....*....|....
gi 195398775   873 LETAKPYLMNCIRLPaAQTLLLFG 896
Cdd:pfam07717   57 VETTKVYIRTVTAIS-PEWLLLFA 79
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
144-665 6.36e-133

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 425.26  E-value: 6.36e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  144 ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE---FGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVG 220
Cdd:COG1643     9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  221 FQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAK-PELKLILMSATINV 299
Cdd:COG1643    89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALrPDLKLLVMSATLDA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  300 ELFHGYFKDegAQLLQVPGRLFPIKLRYMPPPAlelkagqatagsskrsQSARLDPApfiqVLSLIDQQYpITERGDVLI 379
Cdd:COG1643   169 ERFARLLGD--APVIESSGRTYPVEVRYRPLPA----------------DERDLEDA----VADAVREAL-AEEPGDILV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  380 FVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGKVKE 459
Cdd:COG1643   226 FLPGEREIRRTAEALRGRLPPDTE--ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARI 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  460 MSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQMVSMGLPDVRAF 539
Cdd:COG1643   304 PRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  540 PFIEPPETERIEQTILSLKQHCALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTLAAMLSVQNPLTTRAH 619
Cdd:COG1643   384 PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAG 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 195398775  620 TD--QRCERERQplESEQGDLFTLLRAYREWLQL-----KMARENTRK------WCHRL 665
Cdd:COG1643   464 SDllARLNLWRR--LREQQREFLSYLRLREWRDLarqlrRLLGEGANEepadyeAIGLL 520
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 138-731 7.76e-102

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 350.61  E-value: 7.76e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   138 LRQAQR-------ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRV 207
Cdd:TIGR01967   52 ARRQAVpeirypdNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGShglIGHTQPRRLAARTVAQRI 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   208 AHELLDDYGNKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPE 287
Cdd:TIGR01967  132 AEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   288 LKLILMSATINVELFHGYFKDegAQLLQVPGRLFPIKLRYMPppaLELKAGQatagsskrsQSARLDPAPFIQVLSLIDQ 367
Cdd:TIGR01967  212 LKIIITSATIDPERFSRHFNN--APIIEVSGRTYPVEVRYRP---LVEEQED---------DDLDQLEAILDAVDELFAE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   368 qypitERGDVLIFVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDyaPDGMRKCIVSTNIAETSLTVDG 447
Cdd:TIGR01967  278 -----GPGDILIFLPGEREIRDAAEILRKRNLRHTE--ILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPG 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   448 VRFVIDSGKVKEMSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQ 527
Cdd:TIGR01967  349 IHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQ 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   528 MVSMGLPDVRAFPFIEPPETERIEQTILSLKQHCALSVDE---KITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTL 604
Cdd:TIGR01967  429 MLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLII 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   605 AAMLSVQN----PLTTRAHTDQRCERERQPleseQGDLFTLLRAYREWLQLKMARENT--RKWCHRLGIEEQRFYEVCKL 678
Cdd:TIGR01967  509 ASALSIQDprerPMEKQQAADQAHARFKDP----RSDFLSRVNLWRHIEEQRQALSANqfRNACRKQYLNYLRVREWQDI 584

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 195398775   679 RQQFQRILESCRMAPPSDAGALNRTERARRHGELRQLKALKRRQRLEQPRQRK 731
Cdd:TIGR01967  585 YRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGARGRK 637
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 138-635 2.68e-97

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 337.80  E-value: 2.68e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  138 LRQAQR-------ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFG---YRSIACTQPRRLACVSLSKRV 207
Cdd:PRK11131   59 LREAARpeitypeNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgvKGLIGHTQPRRLAARTVANRI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  208 AHELLDDYGNKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPE 287
Cdd:PRK11131  139 AEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  288 LKLILMSATINVELFHGYFKDegAQLLQVPGRLFPIKLRYMPPpalelkagQATAGSSKRSQSArldpAPFIQVLSLIDQ 367
Cdd:PRK11131  219 LKVIITSATIDPERFSRHFNN--APIIEVSGRTYPVEVRYRPI--------VEEADDTERDQLQ----AIFDAVDELGRE 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  368 QypiteRGDVLIFVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDyaPDGMRKCIVSTNIAETSLTVDG 447
Cdd:PRK11131  285 G-----PGDILIFMSGEREIRDTADALNKLNLRHTE--ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPG 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  448 VRFVIDSGKVKEMSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQ 527
Cdd:PRK11131  356 IKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQ 435

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  528 MVSMGLPDVRAFPFIEPPETERIEQTILSLKQHCALSVDE-----KITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLL 602
Cdd:PRK11131  436 MTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVM 515

                         490       500       510
                  ....*....|....*....|....*....|...
gi 195398775  603 TLAAMLSVQNPlttrahtdqrceRERqPLESEQ 635
Cdd:PRK11131  516 IITSALSIQDP------------RER-PMDKQQ 535
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 145-316 6.08e-94

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 297.43  E-value: 6.08e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVGFQIR 224
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  225 FERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVELFHG 304
Cdd:cd17979    81 FERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSG 160

                         170
                  ....*....|..
gi 195398775  305 YFkdEGAQLLQV 316
Cdd:cd17979   161 YF--EGAPVVQV 170
DEXDc smart00487
DEAD-like helicases superfamily;
131-326 2.46e-21

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 93.33  E-value: 2.46e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    131 KFNRIKKLRQAQRALpiarfkddLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS----IACTQPRRLACVSLSKR 206
Cdd:smart00487    2 EKFGFEPLRPYQKEA--------IEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGkggrVLVLVPTRELAEQWAEE 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    207 VAHELLDDYGNKVGF------QIRFERNRTQNTHILFITEGLLLRQLAVAP-NLEQYDVLILDEIHER--NLFGDFLLGV 277
Cdd:smart00487   74 LKKLGPSLGLKVVGLyggdskREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKL 153

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|.
gi 195398775    278 tkcLLRAKPELKLILMSATI--NVELFHGYFKDEGAQLLQVPGRLFPIKLR 326
Cdd:smart00487  154 ---LKLLPKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 360-492 3.31e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.93  E-value: 3.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   360 QVLSLIDQQYPITERGDVLIFVSGVNEIDSiceairEYAKEQTQWLVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIA 439
Cdd:pfam00271    1 EKLEALLELLKKERGGKVLIFSQTKKTLEA------ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 195398775   440 ETSLTVDGVRFVIDsgkvkemsYDAsckgqrlkefWVSKSSAEQRKGRAGRTG 492
Cdd:pfam00271   75 ERGLDLPDVDLVIN--------YDL----------PWNPASYIQRIGRAGRAG 109
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 793-896 1.23e-05

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 44.55  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   793 VSGFYPQLAIADEfnyckgGGQQFFHTQLKPFLSLHPNAHFAksyellklsdSELHAKPDYytpkqplserhqvLCYQSL 872
Cdd:pfam07717    6 AAGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLF----------NEKTFPPEW-------------VVYQEL 56

                           90       100
                   ....*....|....*....|....
gi 195398775   873 LETAKPYLMNCIRLPaAQTLLLFG 896
Cdd:pfam07717   57 VETTKVYIRTVTAIS-PEWLLLFA 79
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
144-665 6.36e-133

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 425.26  E-value: 6.36e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  144 ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE---FGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVG 220
Cdd:COG1643     9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElgwGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  221 FQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAK-PELKLILMSATINV 299
Cdd:COG1643    89 YRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPALrPDLKLLVMSATLDA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  300 ELFHGYFKDegAQLLQVPGRLFPIKLRYMPPPAlelkagqatagsskrsQSARLDPApfiqVLSLIDQQYpITERGDVLI 379
Cdd:COG1643   169 ERFARLLGD--APVIESSGRTYPVEVRYRPLPA----------------DERDLEDA----VADAVREAL-AEEPGDILV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  380 FVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGKVKE 459
Cdd:COG1643   226 FLPGEREIRRTAEALRGRLPPDTE--ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARI 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  460 MSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQMVSMGLPDVRAF 539
Cdd:COG1643   304 PRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  540 PFIEPPETERIEQTILSLKQHCALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTLAAMLSVQNPLTTRAH 619
Cdd:COG1643   384 PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGAAG 463

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 195398775  620 TD--QRCERERQplESEQGDLFTLLRAYREWLQL-----KMARENTRK------WCHRL 665
Cdd:COG1643   464 SDllARLNLWRR--LREQQREFLSYLRLREWRDLarqlrRLLGEGANEepadyeAIGLL 520
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 138-731 7.76e-102

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 350.61  E-value: 7.76e-102
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   138 LRQAQR-------ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRV 207
Cdd:TIGR01967   52 ARRQAVpeirypdNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGShglIGHTQPRRLAARTVAQRI 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   208 AHELLDDYGNKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPE 287
Cdd:TIGR01967  132 AEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   288 LKLILMSATINVELFHGYFKDegAQLLQVPGRLFPIKLRYMPppaLELKAGQatagsskrsQSARLDPAPFIQVLSLIDQ 367
Cdd:TIGR01967  212 LKIIITSATIDPERFSRHFNN--APIIEVSGRTYPVEVRYRP---LVEEQED---------DDLDQLEAILDAVDELFAE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   368 qypitERGDVLIFVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDyaPDGMRKCIVSTNIAETSLTVDG 447
Cdd:TIGR01967  278 -----GPGDILIFLPGEREIRDAAEILRKRNLRHTE--ILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPG 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   448 VRFVIDSGKVKEMSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQ 527
Cdd:TIGR01967  349 IHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQ 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   528 MVSMGLPDVRAFPFIEPPETERIEQTILSLKQHCALSVDE---KITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTL 604
Cdd:TIGR01967  429 MLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLII 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   605 AAMLSVQN----PLTTRAHTDQRCERERQPleseQGDLFTLLRAYREWLQLKMARENT--RKWCHRLGIEEQRFYEVCKL 678
Cdd:TIGR01967  509 ASALSIQDprerPMEKQQAADQAHARFKDP----RSDFLSRVNLWRHIEEQRQALSANqfRNACRKQYLNYLRVREWQDI 584

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 195398775   679 RQQFQRILESCRMAPPSDAGALNRTERARRHGELRQLKALKRRQRLEQPRQRK 731
Cdd:TIGR01967  585 YRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGARGRK 637
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 138-635 2.68e-97

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 337.80  E-value: 2.68e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  138 LRQAQR-------ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFG---YRSIACTQPRRLACVSLSKRV 207
Cdd:PRK11131   59 LREAARpeitypeNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgvKGLIGHTQPRRLAARTVANRI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  208 AHELLDDYGNKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPE 287
Cdd:PRK11131  139 AEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPD 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  288 LKLILMSATINVELFHGYFKDegAQLLQVPGRLFPIKLRYMPPpalelkagQATAGSSKRSQSArldpAPFIQVLSLIDQ 367
Cdd:PRK11131  219 LKVIITSATIDPERFSRHFNN--APIIEVSGRTYPVEVRYRPI--------VEEADDTERDQLQ----AIFDAVDELGRE 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  368 QypiteRGDVLIFVSGVNEIDSICEAIREYAKEQTQwlVLPLHSGLALAEQDKVFDyaPDGMRKCIVSTNIAETSLTVDG 447
Cdd:PRK11131  285 G-----PGDILIFMSGEREIRDTADALNKLNLRHTE--ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPG 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  448 VRFVIDSGKVKEMSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQ 527
Cdd:PRK11131  356 IKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQ 435

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  528 MVSMGLPDVRAFPFIEPPETERIEQTILSLKQHCALSVDE-----KITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLL 602
Cdd:PRK11131  436 MTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVM 515

                         490       500       510
                  ....*....|....*....|....*....|...
gi 195398775  603 TLAAMLSVQNPlttrahtdqrceRERqPLESEQ 635
Cdd:PRK11131  516 IITSALSIQDP------------RER-PMDKQQ 535
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 145-316 6.08e-94

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 297.43  E-value: 6.08e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVGFQIR 224
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRHIACTQPRRIACISLAKRVAFESLNQYGSKVAYQIR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  225 FERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVELFHG 304
Cdd:cd17979    81 FERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIELFSG 160

                         170
                  ....*....|..
gi 195398775  305 YFkdEGAQLLQV 316
Cdd:cd17979   161 YF--EGAPVVQV 170
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 321-500 1.01e-68

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 227.80  E-value: 1.01e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  321 FPIKLRYMPPPALELkagqatagsskRSQSARLDPAPFIQVLSLIDQQYPITERGDVLIFVSGVNEIDSICEAIREYAK- 399
Cdd:cd18791     1 FPVEVYYLEDILELL-----------GISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLs 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  400 -EQTQWLVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGKVKEMSYDASCKGQRLKEFWVSK 478
Cdd:cd18791    70 pDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISK 149

                         170       180
                  ....*....|....*....|..
gi 195398775  479 SSAEQRKGRAGRTGPGVCFRLF 500
Cdd:cd18791   150 ASAEQRAGRAGRTRPGKCYRLY 171
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 162-306 5.37e-68

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 225.03  E-value: 5.37e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  162 RVLIVAGDTGCGKSTQVPQYLYEFGYRS-----IACTQPRRLACVSLSKRVAHELLDDYGNKVGFQIRFERNRTQNTHIL 236
Cdd:cd17917     2 QVVVIVGETGSGKTTQVPQFLLEDGLAKggkgrIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  237 FITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVELFHGYF 306
Cdd:cd17917    82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYF 151
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 145-608 5.71e-63

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 230.58  E-value: 5.71e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS--IACTQPRRLACVSLSKRVAHELLDDYGNKVGFQ 222
Cdd:PRK11664    4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINgkIIMLEPRRLAARNVAQRLAEQLGEKPGETVGYR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  223 IRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGD----FLLGVTKCLlraKPELKLILMSATIN 298
Cdd:PRK11664   84 MRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADlalaLLLDVQQGL---RDDLKLLIMSATLD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  299 VELFHGYFKDegAQLLQVPGRLFPIKLRYMPppaleLKAGQatagsskrsqsaRLDPAPFIQVLSLIDQqypitERGDVL 378
Cdd:PRK11664  161 NDRLQQLLPD--APVIVSEGRSFPVERRYQP-----LPAHQ------------RFDEAVARATAELLRQ-----ESGSLL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  379 IFVSGVNEIDSICEAIREYAKEQTqwLVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGKVK 458
Cdd:PRK11664  217 LFLPGVGEIQRVQEQLASRVASDV--LLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLER 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  459 EMSYDASCKGQRLKEFWVSKSSAEQRKGRAGRTGPGVCFRLFTQQQFDAFEPYPMPEIYRVPLDTMLLQMVSMGLPDVRA 538
Cdd:PRK11664  295 VARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQ 374

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  539 FPFIEPPETERIEQTILSLKQHCALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPevEQLLTLAAML 608
Cdd:PRK11664  375 LSWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKL 442
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 145-306 1.05e-51

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 179.47  E-value: 1.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGY---RSIACTQPRRLACVSLSKRVAHELLDDYGNKVGF 221
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFargGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  222 QIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLR-----AKPELKLILMSAT 296
Cdd:cd17978    81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRrrkeqKLSPLKVIIMSAT 160

                         170
                  ....*....|
gi 195398775  297 INVELFHGYF 306
Cdd:cd17978   161 LDADLFSEYF 170
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 145-308 1.08e-51

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 179.62  E-value: 1.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGY----RSIACTQPRRLACVSLSKRVAHELLDDYGNKVG 220
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYtkggGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  221 FQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVE 300
Cdd:cd17974    81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160


                  ....*...
gi 195398775  301 LFHGYFKD 308
Cdd:cd17974   161 KFSAFFDD 168
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 145-334 6.58e-50

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 174.85  E-value: 6.58e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS--------IACTQPRRLACVSLSKRVAHELlDDYG 216
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSpesdnpgmIGITQPRRVAAVSMAKRVAEEL-NVFG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  217 NKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGV-TKCL-LRAKPE------- 287
Cdd:cd17982    80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMlSRIVpLRAKLYlqdqtvk 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 195398775  288 -LKLILMSATINVELFhgyfkdegaqlLQVPgRLFPIklrymPPPALE 334
Cdd:cd17982   160 pLKLVIMSATLRVEDF-----------TENK-LLFPR-----PPPVIK 190
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 133-316 7.51e-50

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 174.53  E-value: 7.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  133 NRIKKLRQAQRALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGY-----RSIACTQPRRLACVSLSKRV 207
Cdd:cd17973     1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELphqpkKLVACTQPRRVAAMSVAQRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  208 AHELLDDYGNKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPE 287
Cdd:cd17973    81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160

                         170       180
                  ....*....|....*....|....*....
gi 195398775  288 LKLILMSATINVELFHGYFkdEGAQLLQV 316
Cdd:cd17973   161 LKLIVMSATLDAGKFQKYF--DNAPLLKV 187
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 141-317 1.45e-49

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 173.44  E-value: 1.45e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  141 AQR-ALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRVAHELLDDYG 216
Cdd:cd17971     1 EQReSLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSrgkIGCTQPRRVAAMSVAKRVAEEFGCCLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  217 NKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSAT 296
Cdd:cd17971    81 QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                         170       180
                  ....*....|....*....|.
gi 195398775  297 INVELFHGYFKDegAQLLQVP 317
Cdd:cd17971   161 LDAVKFSQYFYE--APIFTIP 179
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 145-306 1.53e-47

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 168.03  E-value: 1.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGY----RSIACTQPRRLACVSLSKRVAHELLDDYGNKVG 220
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWtaggRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  221 FQIRFE-RNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINV 299
Cdd:cd17980    81 YCIRFDdCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160


                  ....*..
gi 195398775  300 ELFHGYF 306
Cdd:cd17980   161 EKFRDFF 167
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 145-306 5.58e-46

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 163.02  E-value: 5.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRVAHELLDDYGNKVGF 221
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDygmIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  222 QIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVEL 301
Cdd:cd17983    81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160


                  ....*
gi 195398775  302 FHGYF 306
Cdd:cd17983   161 FADFF 165
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 145-316 9.45e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 159.54  E-value: 9.45e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRVAHELLDDYGNKVGF 221
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIrglIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  222 QIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATINVEL 301
Cdd:cd17989    81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160

                         170
                  ....*....|....*
gi 195398775  302 FHGYFKDegAQLLQV 316
Cdd:cd17989   161 FSRHFNN--APIIEV 173
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 145-306 7.77e-44

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 157.31  E-value: 7.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLY----EFGYRS---IACTQPRRLACVSLSKRVAHELLDDY-- 215
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGSscrIVCTQPRRISAISVAERVAAERAESCgl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  216 GNKVGFQIRFERNRTQN-THILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMS 294
Cdd:cd17981    81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                         170
                  ....*....|..
gi 195398775  295 ATINVELFHGYF 306
Cdd:cd17981   161 ATLNAEKFSDYF 172
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 145-308 1.27e-42

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 153.46  E-value: 1.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE---FGYRS----IACTQPRRLACVSLSKRVAHELLDDYGN 217
Cdd:cd17985     1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnslQGPPLpvanIICTQPRRISAISVAERVAQERAERVGQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  218 KVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATI 297
Cdd:cd17985    81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160

                         170
                  ....*....|.
gi 195398775  298 NVELFHGYFKD 308
Cdd:cd17985   161 NAELFSDYFNS 171
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 145-306 6.38e-42

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 151.55  E-value: 6.38e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS---IACTQPRRLACVSLSKRVAHELLDDYGNKVGF 221
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQhgmIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  222 QIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLL-----RAKPELKLILMSAT 296
Cdd:cd17984    81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLKVVVMSAT 160

                         170
                  ....*....|
gi 195398775  297 INVELFHGYF 306
Cdd:cd17984   161 LELAKLSAFF 170
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 122-306 6.37e-41

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 150.75  E-value: 6.37e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  122 IYLDFKQKEKFNR-----IKKLRQAQRALPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE-------FGYRS 189
Cdd:cd17972    31 ISMDLKNELMYQReqdhnLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDdfiqndrAAECN 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  190 IACTQPRRLACVSLSKRVAHELLDDYGNKVGFQIRFErNRTQNTH--ILFITEGLLLRQLAVApnLEQYDVLILDEIHER 267
Cdd:cd17972   111 IVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFE-SVLPRPHasILFCTVGVLLRKLEAG--IRGISHVIVDEIHER 187

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 195398775  268 NLFGDFLLGVTKCLLRAKPELKLILMSATINVELFHGYF 306
Cdd:cd17972   188 DINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 145-308 1.13e-40

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 148.02  E-value: 1.13e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE---FGYRSIAC----TQPRRLACVSLSKRVAHELLDDYGN 217
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvLRGRGARCnvviTQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  218 KVGFQIRFE-RNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSAT 296
Cdd:cd17976    81 NVGYQVRLEsRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|..
gi 195398775  297 INVELFHGYFKD 308
Cdd:cd17976   161 GDNQRLSRYFGG 172
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 145-306 4.02e-39

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 143.80  E-value: 4.02e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQY-LYEFGYRSIAC----TQPRRLACVSLSKRVAHELLDDYGNKV 219
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCnivvTQPRRIAAISIARRVSQEREWTLGSLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  220 GFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKP-ELKLILMSATIN 298
Cdd:cd17988    81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSrHVKIILMSATIS 160


                  ....*...
gi 195398775  299 VELFHGYF 306
Cdd:cd17988   161 CKEFADYF 168
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 145-306 4.76e-38

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 140.82  E-value: 4.76e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYE--------FGYRSIACTQPRRLACVSLSKRVAHELLDDYG 216
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnggtAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  217 -----NKVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLI 291
Cdd:cd17975    81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160

                         170
                  ....*....|....*
gi 195398775  292 LMSATINVELFHGYF 306
Cdd:cd17975   161 LMSATVDCEKFSSYF 175
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 145-306 3.11e-36

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 135.34  E-value: 3.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS-----IACTQPRRLACVSLSKRVAHELLDDYGNKV 219
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANgipcrIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  220 GFQIRFERNRTQNTHILFITEGLLLRQL-AVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATIN 298
Cdd:cd17987    81 GYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160


                  ....*...
gi 195398775  299 VELFHGYF 306
Cdd:cd17987   161 VNLFIRYF 168
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 145-302 7.22e-33

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 125.52  E-value: 7.22e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLY---EFGYRSIACTQPRRLACVSLSKRVAHELLDDYGNKVGF 221
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLaelWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  222 QIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRA-KPELKLILMSATINVE 300
Cdd:cd17990    81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAMSATLDGD 160


                  ..
gi 195398775  301 LF 302
Cdd:cd17990   161 GL 162
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 145-308 3.47e-31

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 120.70  E-value: 3.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQATRVLIVAGDTGCGKSTQVPQYLYEF----GYRS--IACTQPRRLACVSLSKRVAHELLDDYGNK 218
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYclsaHYQHgvVVCTQVHKQTAVWLALRVADEMDVNIGHE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  219 VGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSATIN 298
Cdd:cd17977    81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160

                         170
                  ....*....|
gi 195398775  299 VELFHGYFKD 308
Cdd:cd17977   161 SSKLLSYYGN 170
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 145-295 5.26e-27

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 108.83  E-value: 5.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  145 LPIARFKDDLRSALQA-TRVLIVAGDTGCGKSTQVPQYLYEFGYR------SIACTQPRRLACVSLSKRVAHELLDDYGN 217
Cdd:cd17986     1 LPIWAAKFTFLEQLESpSGIVLVSGEPGSGKSTQVPQWCAEFALSrgfqkgQVTVTQPHPLAARSLALRVADEMDLNLGH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195398775  218 KVGFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAKPELKLILMSA 295
Cdd:cd17986    81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTS 158
DEXDc smart00487
DEAD-like helicases superfamily;
131-326 2.46e-21

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 93.33  E-value: 2.46e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    131 KFNRIKKLRQAQRALpiarfkddLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGYRS----IACTQPRRLACVSLSKR 206
Cdd:smart00487    2 EKFGFEPLRPYQKEA--------IEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGkggrVLVLVPTRELAEQWAEE 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    207 VAHELLDDYGNKVGF------QIRFERNRTQNTHILFITEGLLLRQLAVAP-NLEQYDVLILDEIHER--NLFGDFLLGV 277
Cdd:smart00487   74 LKKLGPSLGLKVVGLyggdskREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKL 153

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|.
gi 195398775    278 tkcLLRAKPELKLILMSATI--NVELFHGYFKDEGAQLLQVPGRLFPIKLR 326
Cdd:smart00487  154 ---LKLLPKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 126-501 6.18e-21

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 98.90  E-value: 6.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  126 FKQKEKFNRIKkLRQAQralPIARFKddLRSALQATRVLIVAGDTGCGKSTQVPQYLYEFGY-----------------R 188
Cdd:PHA02653  150 LGNPEPFSKIP-LASLQ---PDVQLK--IFEAWISRKPVVLTGGTGVGKTSQVPKLLLWFNYlfggfdnldkidpnfieR 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  189 SIACTQPRrlacVSLSKRVAHELL-----DD---------YGNKvgfQIRFERNRTQNTHILFITEGLLLRqlavapNLE 254
Cdd:PHA02653  224 PIVLSLPR----VALVRLHSITLLkslgfDEidgspislkYGSI---PDELINTNPKPYGLVFSTHKLTLN------KLF 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  255 QYDVLILDEIHERNLFGDFLLGVTK---CLLRAkpelkLILMSATI--NVELFHGYFKDegAQLLQVPG-RLFPIKLRYM 328
Cdd:PHA02653  291 DYGTVIIDEVHEHDQIGDIIIAVARkhiDKIRS-----LFLMTATLedDRDRIKEFFPN--PAFVHIPGgTLFPISEVYV 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  329 PPPALELKAGQATAGSSKRSQSARLDPAPfiqvlsliDQQYpitergDVLIFVSGVNEidsiCEAIREY-AKEQTQWLVL 407
Cdd:PHA02653  364 KNKYNPKNKRAYIEEEKKNIVTALKKYTP--------PKGS------SGIVFVASVSQ----CEEYKKYlEKRLPIYDFY 425

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  408 PLHSGLALAeqDKVFDYAPDGMRKCI-VSTNIAETSLTVDGVRFVIDSGKVkemsYDASCKGQRlkEFWVSKSSAEQRKG 486
Cdd:PHA02653  426 IIHGKVPNI--DEILEKVYSSKNPSIiISTPYLESSVTIRNATHVYDTGRV----YVPEPFGGK--EMFISKSMRTQRKG 497

                         410
                  ....*....|....*
gi 195398775  487 RAGRTGPGVCFRLFT 501
Cdd:PHA02653  498 RVGRVSPGTYVYFYD 512
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 562-642 8.78e-16

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 73.46  E-value: 8.78e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    562 ALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTLAAMLSVQNPltTRAHTDQRCERERQPLESEQGDLFTL 641
Cdd:smart00847    4 ALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDP--RPKEKREDADAARRRFADPESDHLTL 81


                    .
gi 195398775    642 L 642
Cdd:smart00847   82 L 82
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 360-492 3.31e-14

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 69.93  E-value: 3.31e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   360 QVLSLIDQQYPITERGDVLIFVSGVNEIDSiceairEYAKEQTQWLVLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIA 439
Cdd:pfam00271    1 EKLEALLELLKKERGGKVLIFSQTKKTLEA------ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 195398775   440 ETSLTVDGVRFVIDsgkvkemsYDAsckgqrlkefWVSKSSAEQRKGRAGRTG 492
Cdd:pfam00271   75 ERGLDLPDVDLVIN--------YDL----------PWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
406-492 1.27e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 67.24  E-value: 1.27e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775    406 VLPLHSGLALAEQDKVFDYAPDGMRKCIVSTNIAETSLTVDGVRFVIDSGkvkemsydasckgqrlkeFWVSKSSAEQRK 485
Cdd:smart00490   14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------------------LPWSPASYIQRI 75


                    ....*..
gi 195398775    486 GRAGRTG 492
Cdd:smart00490   76 GRAGRAG 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 557-641 2.87e-12

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 64.18  E-value: 2.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   557 LKQHCALSVDEKITPLGSSLANLPVELPIGKMLLMGCVFPEVEQLLTLAAMLSVQNPLT-------------TRAHTDQR 623
Cdd:pfam04408    5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVqpnfldprsaakaARRRRRAA 84

                           90       100
                   ....*....|....*....|
gi 195398775   624 CERERQPLESEQ--GDLFTL 641
Cdd:pfam04408   85 DEKARAKFARLDleGDHLTL 104
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 142-301 4.40e-08

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 53.79  E-value: 4.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   142 QRALPIARFKDDLrsalqatrvlIVAGDTGCGKST--QVP--QYLYE-FGYRSIACTQPRRlacvSLSK---RVAHELLD 213
Cdd:pfam00270    5 AEAIPAILEGRDV----------LVQAPTGSGKTLafLLPalEALDKlDNGPQALVLAPTR----ELAEqiyEELKKLGK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   214 DYGNKV-----GFQIRFERNRTQNTHILFITEGLLLRQLAVAPNLEQYDVLILDEIHE--RNLFGDfllGVTKCLLRAKP 286
Cdd:pfam00270   71 GLGLKVasllgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGP---DLEEILRRLPK 147

                          170
                   ....*....|....*
gi 195398775   287 ELKLILMSATINVEL 301
Cdd:pfam00270  148 KRQILLLSATLPRNL 162
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 164-296 2.76e-06

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 48.17  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  164 LIVAGDTGCGKSTQVP----QYLYEFGYRsIACTQPRRlacvSLSKRVAHELLD--DYGNKVGFQIRF------ERNRTQ 231
Cdd:cd00046     4 VLITAPTGSGKTLAALlaalLLLLKKGKK-VLVLVPTK----ALALQTAERLRElfGPGIRVAVLVGGssaeerEKNKLG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195398775  232 NTHILFITEGLLLR--QLAVAPNLEQYDVLILDEIHERNLFGDFLLGVTKCLLRAK-PELKLILMSAT 296
Cdd:cd00046    79 DADIIIATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGlKNAQVILLSAT 146
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 793-896 1.23e-05

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 44.55  E-value: 1.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775   793 VSGFYPQLAIADEfnyckgGGQQFFHTQLKPFLSLHPNAHFAksyellklsdSELHAKPDYytpkqplserhqvLCYQSL 872
Cdd:pfam07717    6 AAGLYPNVARRDP------KGKGYTTLSDNQRVFIHPSSVLF----------NEKTFPPEW-------------VVYQEL 56

                           90       100
                   ....*....|....*....|....
gi 195398775   873 LETAKPYLMNCIRLPaAQTLLLFG 896
Cdd:pfam07717   57 VETTKVYIRTVTAIS-PEWLLLFA 79
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
137-439 1.07e-03

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 43.09  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  137 KLRQAQRALpIARFKDDLRSAlqATRVLIVAgDTGCGKSTqvpqylyeFGYRSIACTQPRRLACVslskrVAH--ELL-- 212
Cdd:COG1061    80 ELRPYQQEA-LEALLAALERG--GGRGLVVA-PTGTGKTV--------LALALAAELLRGKRVLV-----LVPrrELLeq 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  213 --DDYGNKVGFQIRFERNRTQNTHILFITegllLRQLAVAPNLEQ----YDVLILDEIHerNLFGDFLLGVtkclLRAKP 286
Cdd:COG1061   143 waEELRRFLGDPLAGGGKKDSDAPITVAT----YQSLARRAHLDElgdrFGLVIIDEAH--HAGAPSYRRI----LEAFP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  287 ELKLILMSAT--------INVELFHGYFKDEGAQLLQVPGRLFPIklRYMPPPAlELKAGQATAGSSKRSQSARLDPAP- 357
Cdd:COG1061   213 AAYRLGLTATpfrsdgreILLFLFDGIVYEYSLKEAIEDGYLAPP--EYYGIRV-DLTDERAEYDALSERLREALAADAe 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195398775  358 -FIQVLSLIDQQYPITERgdVLIFVSGVNEIDSICEAIREyakeqTQWLVLPLHSGLALAEQDKVFDYAPDGMRKCIVST 436
Cdd:COG1061   290 rKDKILRELLREHPDDRK--TLVFCSSVDHAEALAELLNE-----AGIRAAVVTGDTPKKEREEILEAFRDGELRILVTV 362


                  ...
gi 195398775  437 NIA 439
Cdd:COG1061   363 DVL 365
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 433-499 2.93e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 37.68  E-value: 2.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195398775  433 IVSTNIAETSLTVDGVRFVIDSGKVKemsydasckgqrlkefwvSKSSAEQRKGRAGRTG--PGVCFRL 499
Cdd:cd18785    26 LVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGGkdEGEVILF 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH