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Conserved domains on  [gi|1810726184|ref|XP_001960487|]
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serine-threonine kinase receptor-associated protein [Drosophila ananassae]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-310 1.37e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  16 GQLGINCEGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTA 95
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  96 RIWCAITGDELVKFTLPE-AVTCVDLNEKSTCMVAGclGVDPVINLFDLNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLL 174
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASG--SADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 175 TSSYDRTVRMWDCVSGLETHsiVLPHHAK---SLELHADND-IVTIAYGNSIIFVDTNNFEILSQ-RRMDFKVTGATLHP 249
Cdd:COG2319   263 SGSADGTVRLWDLATGELLR--TLTGHSGgvnSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 340

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810726184 250 KKESFVCITGDGRLNKYDYVTDALLDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLWQ 310
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-310 1.37e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  16 GQLGINCEGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTA 95
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  96 RIWCAITGDELVKFTLPE-AVTCVDLNEKSTCMVAGclGVDPVINLFDLNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLL 174
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASG--SADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 175 TSSYDRTVRMWDCVSGLETHsiVLPHHAK---SLELHADND-IVTIAYGNSIIFVDTNNFEILSQ-RRMDFKVTGATLHP 249
Cdd:COG2319   263 SGSADGTVRLWDLATGELLR--TLTGHSGgvnSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 340

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810726184 250 KKESFVCITGDGRLNKYDYVTDALLDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLWQ 310
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-310 5.05e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 5.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  23 EGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTARIWCAIT 102
Cdd:cd00200     6 KGHTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 103 GDELVKFTL-PEAVTCVDLNEKSTCMVAGclGVDPVINLFDLNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRT 181
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 182 VRMWDCVSGLETHsiVLPHHAK---SLELHADN-DIVTIAYGNSIIFVDTNNFEILSQ-RRMDFKVTGATLHPKKESFVC 256
Cdd:cd00200   159 IKLWDLRTGKCVA--TLTGHTGevnSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1810726184 257 ITGDGRLNKYDYVTDALLDSFYAHKgEPICCVRYSPDGEVYASSSCSGEMMLWQ 310
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 25-186 4.78e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  25 HTMAVEQLGFSK---ICESGYY---LASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLND-EATMMASGSADRTARI 97
Cdd:PLN00181  523 HYPVVELASRSKlsgICWNSYIksqVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKL 602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  98 WCAITGDELVKFTLPEAVTCVDL-NEKSTCMVAGclGVDPVINLFDLNGADWkPLLSLKGHSRGVRDAIFCRNDfSLLTS 176
Cdd:PLN00181  603 WSINQGVSIGTIKTKANICCVQFpSESGRSLAFG--SADHKVYYYDLRNPKL-PLCTMIGHSKTVSYVRFVDSS-TLVSS 678

                         170
                  ....*....|
gi 1810726184 177 SYDRTVRMWD 186
Cdd:PLN00181  679 STDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-186 5.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1810726184  147 DWKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRTVRMWD 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
64-98 7.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 7.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1810726184  64 VGTLTGHEAGVWSVTLNDEATMMASGSADRTARIW 98
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-310 1.37e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 1.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  16 GQLGINCEGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTA 95
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  96 RIWCAITGDELVKFTLPE-AVTCVDLNEKSTCMVAGclGVDPVINLFDLNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLL 174
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTgAVRSVAFSPDGKLLASG--SADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 175 TSSYDRTVRMWDCVSGLETHsiVLPHHAK---SLELHADND-IVTIAYGNSIIFVDTNNFEILSQ-RRMDFKVTGATLHP 249
Cdd:COG2319   263 SGSADGTVRLWDLATGELLR--TLTGHSGgvnSVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 340

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1810726184 250 KKESFVCITGDGRLNKYDYVTDALLDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLWQ 310
Cdd:COG2319   341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
16-309 3.46e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 3.46e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  16 GQLGINCEGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTA 95
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFS---PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  96 RIWCAITGDELVKFTLPE-AVTCVDLNEKSTCMVAGclGVDPVINLFDLngADWKPLLSLKGHSRGVRDAIFCRNDFSLL 174
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSgAVTSVAFSPDGKLLASG--SDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 175 TSSYDRTVRMWDCVSGLETHsiVLPHHAK---SLELHADND-IVTIAYGNSIIFVDTNNFEILSQRRMDF-KVTGATLHP 249
Cdd:COG2319   221 SGSADGTVRLWDLATGKLLR--TLTGHSGsvrSVAFSPDGRlLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSP 298

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 250 KKESFVCITGDGRLNKYDYVTDALLDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLW 309
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-310 5.05e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 5.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  23 EGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTARIWCAIT 102
Cdd:cd00200     6 KGHTGGVTCVAFS---PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 103 GDELVKFTL-PEAVTCVDLNEKSTCMVAGclGVDPVINLFDLNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRT 181
Cdd:cd00200    83 GECVRTLTGhTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETG--KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 182 VRMWDCVSGLETHsiVLPHHAK---SLELHADN-DIVTIAYGNSIIFVDTNNFEILSQ-RRMDFKVTGATLHPKKESFVC 256
Cdd:cd00200   159 IKLWDLRTGKCVA--TLTGHTGevnSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1810726184 257 ITGDGRLNKYDYVTDALLDSFYAHKgEPICCVRYSPDGEVYASSSCSGEMMLWQ 310
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHT-NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-310 1.10e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 1.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  64 VGTLTGHEAGVWSVTLNDEATMMASGSADRTARIWCAITGDELVKFTLPE-AVTCVDLNEKSTCMVAGclGVDPVINLFD 142
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTgPVRDVAASADGTYLASG--SSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 143 LNGAdwKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRTVRMWDCVSGleTHSIVLPHH---AKSLELHADNDIVTIAYG 219
Cdd:cd00200    80 LETG--ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHtdwVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 220 NSIIFV-DTNNFEILsQRRMDFK--VTGATLHPKKESFVCITGDGRLNKYDYVTDALLDSFYAHKgEPICCVRYSPDGEV 296
Cdd:cd00200   156 DGTIKLwDLRTGKCV-ATLTGHTgeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE-NGVNSVAFSPDGYL 233

                         250
                  ....*....|....
gi 1810726184 297 YASSSCSGEMMLWQ 310
Cdd:cd00200   234 LASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
40-309 8.98e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 8.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  40 SGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTARIWCAITGDELVKFT-LPEAVTCV 118
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 119 DLNEKSTCMVAGclGVDPVINLFDLngADWKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRTVRMWDCVSGLETHsiVL 198
Cdd:COG2319   127 AFSPDGKTLASG--SADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--TL 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 199 PHHAK---SLELHADND-IVTIAYGNSIIFVDTNNFEILSQRRM-DFKVTGATLHPKKESFVCITGDGRLNKYDYVTDAL 273
Cdd:COG2319   201 TGHTGavrSVAFSPDGKlLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1810726184 274 LDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLW 309
Cdd:COG2319   281 LRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-186 1.60e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  16 GQLGINCEGHTMAVEQLGFSKiceSGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTA 95
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSP---DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  96 RIWCAITGDELVKFTL-PEAVTCVDLNEKSTCMVAGclGVDPVINLFDLNgaDWKPLLSLKGHSRGVRDAIFCRNDFSLL 174
Cdd:cd00200   202 KLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASG--SEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         170
                  ....*....|..
gi 1810726184 175 TSSYDRTVRMWD 186
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-98 2.72e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 2.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  11 YKMSCGQLGINCEGHTMAVEQLGFSkicESGYYLASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLNDEATMMASGS 90
Cdd:cd00200   204 WDLSTGKCLGTLRGHENGVNSVAFS---PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                  ....*...
gi 1810726184  91 ADRTARIW 98
Cdd:cd00200   281 ADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 25-186 4.78e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  25 HTMAVEQLGFSK---ICESGYY---LASAGLDKLVVLRHGDTGDWVGTLTGHEAGVWSVTLND-EATMMASGSADRTARI 97
Cdd:PLN00181  523 HYPVVELASRSKlsgICWNSYIksqVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKL 602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  98 WCAITGDELVKFTLPEAVTCVDL-NEKSTCMVAGclGVDPVINLFDLNGADWkPLLSLKGHSRGVRDAIFCRNDfSLLTS 176
Cdd:PLN00181  603 WSINQGVSIGTIKTKANICCVQFpSESGRSLAFG--SADHKVYYYDLRNPKL-PLCTMIGHSKTVSYVRFVDSS-TLVSS 678

                         170
                  ....*....|
gi 1810726184 177 SYDRTVRMWD 186
Cdd:PLN00181  679 STDNTLKLWD 688
WD40 COG2319
WD40 repeat [General function prediction only];
87-315 1.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184  87 ASGSADRTARIWCAITGDELVKFT-LPEAVTCVDLNEKSTCMVAGCLGVDPVInlfdLNGADWKPLLSLKGHSRGVRDAI 165
Cdd:COG2319    10 AAASADLALALLAAALGALLLLLLgLAAAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATLLGHTAAVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 166 FCRNDFSLLTSSYDRTVRMWDCVSGLETHSivlphhaksLELHADNdivtiaygnsiifvdtnnfeilsqrrmdfkVTGA 245
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRT---------LTGHTGA------------------------------VRSV 126

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1810726184 246 TLHPKKESFVCITGDGRLNKYDYVTDALLDSFYAHKGePICCVRYSPDGEVYASSSCSGEMMLWQQTVGK 315
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 147-186 5.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1810726184  147 DWKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRTVRMWD 186
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
64-98 7.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 7.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1810726184  64 VGTLTGHEAGVWSVTLNDEATMMASGSADRTARIW 98
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-98 8.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 8.17e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1810726184   60 TGDWVGTLTGHEAGVWSVTLNDEATMMASGSADRTARIW 98
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
148-186 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1810726184 148 WKPLLSLKGHSRGVRDAIFCRNDFSLLTSSYDRTVRMWD 186
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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