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Conserved domains on  [gi|194748833|ref|XP_001956846|]
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N-acetylgalactosamine kinase [Drosophila ananassae]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 35-491 1.07e-122

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 367.88  E-value: 1.07e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  35 RVQKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDSSQLQLRNIEEaKFQG--YDA 112
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 113 ------DLKTFRielpksggpaWYNYFLCGIKGVQEQLASKW----SPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATA 182
Cdd:PLN02521 110 dpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGvdvgPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIM 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 183 HVQGMQLDRRELASISAKCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA--A 260
Cdd:PLN02521 180 AALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvtA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 261 SSDYNERVVECRLATRWLA------------KVKGLINWQDFVrfidLEEACQMDNETFEKLIRDNLTKKVYTRADICKe 328
Cdd:PLN02521 259 ATNYNNRVVECRLAAIVLAvklgmsaeeaisKVKTLSDVEGLC----VSFAGSHGSSDPAVAVKELLHEGPYTAEEIEE- 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 329 lgITEQELETKFLSANT-----RHMEQFKLQQRALHVIQESGRVAKFRKICEelSSTPNEKDASKLGLLMRQSHESLREL 403
Cdd:PLN02521 334 --ILGESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVS--SSLSEEEKLKKLGDLMNESHYSCSVL 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 404 YECSHPDVERLIAI---SNALdvSARVTGAGWGGCIVAMCDSvETADEYIKALKREYYAKLPAHllERHQPNDFNEVVFA 480
Cdd:PLN02521 410 YECSCPELEELVKVcrdNGAL--GARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFA 484

                        490
                 ....*....|.
gi 194748833 481 TLPGNGAELYT 491
Cdd:PLN02521 485 SKPSSGAAILK 495
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 35-491 1.07e-122

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 367.88  E-value: 1.07e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  35 RVQKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDSSQLQLRNIEEaKFQG--YDA 112
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 113 ------DLKTFRielpksggpaWYNYFLCGIKGVQEQLASKW----SPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATA 182
Cdd:PLN02521 110 dpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGvdvgPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIM 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 183 HVQGMQLDRRELASISAKCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA--A 260
Cdd:PLN02521 180 AALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvtA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 261 SSDYNERVVECRLATRWLA------------KVKGLINWQDFVrfidLEEACQMDNETFEKLIRDNLTKKVYTRADICKe 328
Cdd:PLN02521 259 ATNYNNRVVECRLAAIVLAvklgmsaeeaisKVKTLSDVEGLC----VSFAGSHGSSDPAVAVKELLHEGPYTAEEIEE- 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 329 lgITEQELETKFLSANT-----RHMEQFKLQQRALHVIQESGRVAKFRKICEelSSTPNEKDASKLGLLMRQSHESLREL 403
Cdd:PLN02521 334 --ILGESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVS--SSLSEEEKLKKLGDLMNESHYSCSVL 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 404 YECSHPDVERLIAI---SNALdvSARVTGAGWGGCIVAMCDSvETADEYIKALKREYYAKLPAHllERHQPNDFNEVVFA 480
Cdd:PLN02521 410 YECSCPELEELVKVcrdNGAL--GARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFA 484

                        490
                 ....*....|.
gi 194748833 481 TLPGNGAELYT 491
Cdd:PLN02521 485 SKPSSGAAILK 495
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
35-460 3.14e-71

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 231.20  E-value: 3.14e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  35 RVQKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDsSQLQLRNIeeakfqGYDaDL 114
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDD-RKVRVYSA------DFD-EE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 115 KTFRI-ELPKSGGPAWYNYflcgIKGVQEQLASKWSPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRR 192
Cdd:COG0153   73 VEFDLdDLEPGEEDGWANY----VRGVAWALQERGYKLgGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 193 ELASISAKCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLP-AGKCFVVANSLAqKNKAASSDYNERVVE 270
Cdd:COG0153  149 ELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPlEGYALVIVDTNV-KHSLADSEYNERRAE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 271 CRLAtrwlakvkglinwqdfVRFIDLeeacqmdnetfeKLIRDnltkkvytradickelgITEQELEtkflsANTRHMEQ 350
Cdd:COG0153  227 CEAA----------------AAILGV------------KSLRD-----------------VTLEDLE-----AARARLGD 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 351 FKLQQRALHVIQESGRVAKFrkiCEELSstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNALD--VSARVT 428
Cdd:COG0153  257 EVLRRRARHVVTENQRVLEA---VEALR----AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAgvLGARMT 329

                        410       420       430
                 ....*....|....*....|....*....|..
gi 194748833 429 GAGWGGCIVAMCDsVETADEYIKALKREYYAK 460
Cdd:COG0153  330 GGGFGGCTIALVP-KDAVDEFIEAVAEAYAEK 360
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 37-460 1.21e-62

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 208.91  E-value: 1.21e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833   37 QKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDssqlQLRNIEEAKFQGYDADLKt 116
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDD----KNVRIYLANADNKFAERS- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  117 FRIELPKSGGPAWYNYFLCGIKGVQEQLASkwSPIGMRIAVDGNVPLAAGLsssSAMVSSAVLATAHVQGM---QLDRRE 193
Cdd:TIGR00131  77 LDLPLDGSEVSDWANYFKGVLHVAQERFNS--FPLGADIVCSGNVPTGSGL---SSSAAFECAVGAVLQNMghlPLDSKQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  194 LA-SISAKCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLP-AGKCFVVANSLAQKNKAASSdYNERVVEC 271
Cdd:TIGR00131 152 ILlRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQEC 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  272 RLATRWLAKvKGLINWQDFVrfidleeacqmdNETFEKLIrdnltkkvytrADICKELGITEqeletkflsantrhmeqf 351
Cdd:TIGR00131 230 TTAANFLAA-TDKGALRDFM------------NEYFARYI-----------ARLTKMLPLVE------------------ 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  352 klqQRALHVIQESGRVAKFRKICEelsstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNALDVS--ARVTG 429
Cdd:TIGR00131 268 ---ERAKHVVSENLRVLKAVKAMK-------DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSggSRMTG 337

                         410       420       430
                  ....*....|....*....|....*....|.
gi 194748833  430 AGWGGCIVAMCDSvETADEYIKALKREYYAK 460
Cdd:TIGR00131 338 AGFGGCTVHLVPN-ENVDKVRQAVADKYPKK 367
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 41-90 9.63e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.89  E-value: 9.63e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 194748833   41 AFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAK 90
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 35-491 1.07e-122

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 367.88  E-value: 1.07e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  35 RVQKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDSSQLQLRNIEEaKFQG--YDA 112
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVND-KYTTctFPA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 113 ------DLKTFRielpksggpaWYNYFLCGIKGVQEQLASKW----SPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATA 182
Cdd:PLN02521 110 dpdqevDLANHK----------WGNYFICGYKGVFEFLKSKGvdvgPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIM 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 183 HVQGMQLDRRELASISAKCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLPAGKCFVVANSLAQKNKA--A 260
Cdd:PLN02521 180 AALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLPAGGTFVIANSLAESNKAvtA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 261 SSDYNERVVECRLATRWLA------------KVKGLINWQDFVrfidLEEACQMDNETFEKLIRDNLTKKVYTRADICKe 328
Cdd:PLN02521 259 ATNYNNRVVECRLAAIVLAvklgmsaeeaisKVKTLSDVEGLC----VSFAGSHGSSDPAVAVKELLHEGPYTAEEIEE- 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 329 lgITEQELETKFLSANT-----RHMEQFKLQQRALHVIQESGRVAKFRKICEelSSTPNEKDASKLGLLMRQSHESLREL 403
Cdd:PLN02521 334 --ILGESLTSIFKNSPTslavlKAAKHFKLHQRAVHVYSEAKRVHAFRDTVS--SSLSEEEKLKKLGDLMNESHYSCSVL 409

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 404 YECSHPDVERLIAI---SNALdvSARVTGAGWGGCIVAMCDSvETADEYIKALKREYYAKLPAHllERHQPNDFNEVVFA 480
Cdd:PLN02521 410 YECSCPELEELVKVcrdNGAL--GARLTGAGWGGCAVALVKE-AIVPQFILALKEKFYKSRIEK--GVIKEEDLGLYVFA 484

                        490
                 ....*....|.
gi 194748833 481 TLPGNGAELYT 491
Cdd:PLN02521 485 SKPSSGAAILK 495
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
35-460 3.14e-71

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 231.20  E-value: 3.14e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  35 RVQKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDsSQLQLRNIeeakfqGYDaDL 114
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDD-RKVRVYSA------DFD-EE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 115 KTFRI-ELPKSGGPAWYNYflcgIKGVQEQLASKWSPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRR 192
Cdd:COG0153   73 VEFDLdDLEPGEEDGWANY----VRGVAWALQERGYKLgGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 193 ELASISAKCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHPkLKGTPVTLP-AGKCFVVANSLAqKNKAASSDYNERVVE 270
Cdd:COG0153  149 ELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPlEGYALVIVDTNV-KHSLADSEYNERRAE 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 271 CRLAtrwlakvkglinwqdfVRFIDLeeacqmdnetfeKLIRDnltkkvytradickelgITEQELEtkflsANTRHMEQ 350
Cdd:COG0153  227 CEAA----------------AAILGV------------KSLRD-----------------VTLEDLE-----AARARLGD 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 351 FKLQQRALHVIQESGRVAKFrkiCEELSstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNALD--VSARVT 428
Cdd:COG0153  257 EVLRRRARHVVTENQRVLEA---VEALR----AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEAgvLGARMT 329

                        410       420       430
                 ....*....|....*....|....*....|..
gi 194748833 429 GAGWGGCIVAMCDsVETADEYIKALKREYYAK 460
Cdd:COG0153  330 GGGFGGCTIALVP-KDAVDEFIEAVAEAYAEK 360
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 37-460 1.21e-62

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 208.91  E-value: 1.21e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833   37 QKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDssqlQLRNIEEAKFQGYDADLKt 116
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDD----KNVRIYLANADNKFAERS- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  117 FRIELPKSGGPAWYNYFLCGIKGVQEQLASkwSPIGMRIAVDGNVPLAAGLsssSAMVSSAVLATAHVQGM---QLDRRE 193
Cdd:TIGR00131  77 LDLPLDGSEVSDWANYFKGVLHVAQERFNS--FPLGADIVCSGNVPTGSGL---SSSAAFECAVGAVLQNMghlPLDSKQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  194 LA-SISAKCEQYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLP-AGKCFVVANSLAQKNKAASSdYNERVVEC 271
Cdd:TIGR00131 152 ILlRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPqLGIAFVIANTNVKRTLAPSN-YNTRRQEC 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  272 RLATRWLAKvKGLINWQDFVrfidleeacqmdNETFEKLIrdnltkkvytrADICKELGITEqeletkflsantrhmeqf 351
Cdd:TIGR00131 230 TTAANFLAA-TDKGALRDFM------------NEYFARYI-----------ARLTKMLPLVE------------------ 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  352 klqQRALHVIQESGRVAKFRKICEelsstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNALDVS--ARVTG 429
Cdd:TIGR00131 268 ---ERAKHVVSENLRVLKAVKAMK-------DNDFKQFGALMNESHASCDDDYECTCPEIDELVCSAALVNGSggSRMTG 337

                         410       420       430
                  ....*....|....*....|....*....|.
gi 194748833  430 AGWGGCIVAMCDSvETADEYIKALKREYYAK 460
Cdd:TIGR00131 338 AGFGGCTVHLVPN-ENVDKVRQAVADKYPKK 367
PRK05101 PRK05101
galactokinase; Provisional
 37-460 2.33e-39

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 146.61  E-value: 2.33e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  37 QKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDSsqlQLRNIEeakfQGYDADLKT 116
Cdd:PRK05101   5 QKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDR---IVRVIA----ADYDNQQDE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 117 FRIELPKSGGP--AWYNYflcgIKGVQEQLASKWSPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRRE 193
Cdd:PRK05101  78 FSLDAPIVPHPeqQWANY----VRGVVKHLQERNPDFgGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 194 LASISAKCE-QYIGTHSGGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVVANSlAQKNKAASSDYNERVVECR 272
Cdd:PRK05101 154 IALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCR-SLETKAVPMPEGVAVVIINS-NVKRGLVDSEYNTRRQQCE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 273 LATRWLAkVKGLinwqdfvRFIDLEEacqmdnetFEKlIRDNLTKKVYtradickelgiteqeletkflsantrhmeqfk 352
Cdd:PRK05101 232 TAARFFG-VKAL-------RDVTLEQ--------FNA-VAAELDPVVA-------------------------------- 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 353 lqQRALHVIQESGRVakfrkicEELSSTPNEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNAL---DVSARVTG 429
Cdd:PRK05101 263 --KRARHVITENART-------LEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKAVigdQGGVRMTG 333

                        410       420       430
                 ....*....|....*....|....*....|.
gi 194748833 430 AGWGGCIVAMCDSvETADEYIKALKREYYAK 460
Cdd:PRK05101 334 GGFGGCIVALVPE-ELVEAVRQAVAEQYEAK 363
PRK03817 PRK03817
galactokinase; Provisional
 55-462 4.23e-38

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 142.44  E-value: 4.23e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  55 VRVPGRVNIIGEHVDYC-GYsVLPMAVSQSIFLAVAKnpdSSQLQL--RNIEEAKFQGYDadlktfriELPKSGgpAWYN 131
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEK---SEKFIFysENFNEEKTFELD--------KLEKLN--SWAD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 132 YflcgIKGVQEQL-ASKWSPIGMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRRELASISAKCE-QYIGTHS 209
Cdd:PRK03817  69 Y----IKGVIWVLeKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAEnEFVGVPC 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 210 GGMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVVANSlAQKNKAASSDYNERVVECRLATRWLAKvkglinwqd 289
Cdd:PRK03817 145 GIMDQFAVAFGKKDHAIFLDTM-TLEYEYVPFPEDYEILVFDT-GVKRELASSEYNERRQECEEALKILGK--------- 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 290 fvrfidleeacqmdnETFeklirdnltkkvytradicKElgITEQELEtkflsantrHMEQFkLQQRALHVIQESGRVAK 369
Cdd:PRK03817 214 ---------------KSS-------------------KE--VTEEDLS---------KLPPL-LRKRAGYVLRENERVLK 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 370 FRKICEelsstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISNALDV-SARVTGAGWGGCIVAMCDSvETADE 448
Cdd:PRK03817 248 VRDALK-------EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAyGARLTGAGFGGSAIALVDK-GKFES 319

                        410
                 ....*....|....
gi 194748833 449 YIKALKREYYAKLP 462
Cdd:PRK03817 320 IGEELLEEYKKRFG 333
PRK05322 PRK05322
galactokinase; Provisional
 37-457 7.15e-38

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 142.69  E-value: 7.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  37 QKLNAFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDsSQLQLR--NIEEAKFQGYDADL 114
Cdd:PRK05322   4 EELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDD-KKVRLYsaNFEDLGIIEFDLDD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 115 KTFRielpKSGGpaWYNYFlcgiKGVQEQLASKWSPI--GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRR 192
Cdd:PRK05322  83 LSFD----KEDD--WANYP----KGVLKFLQEAGYKIdhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 193 ELASISAKCE-QYIGTHSGGMDQ-AIAyLGRVGCA-----HHIEFhpklKGTPVTLpAGKCFVVANSlaqkNKA---ASS 262
Cdd:PRK05322 153 ELVKLGQKTEnEFIGVNSGIMDQfAIG-MGKKDHAilldcNTLEY----EYVPLDL-GDYVIVIMNT----NKRrelADS 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 263 DYNERVVECRLATRWLAKVkglinwqdfvrfIDLEEACQMDNETFEK---LIRDNltkkvytradickelgiteqeletk 339
Cdd:PRK05322 223 KYNERRAECEKALEELQKK------------LDIKSLGELTEEEFDEysyLIKDE------------------------- 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 340 flsantrhmeqfKLQQRALHVIQESGRVAKFRKICEelsstpnEKDASKLGLLMRQSHESLRELYECSHPDVERLIAISN 419
Cdd:PRK05322 266 ------------TLLKRARHAVTENQRTLKAVKALK-------AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAW 326

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 194748833 420 ALD--VSARVTGAGWGGCIVAMCDSVEtADEYIKALKREY 457
Cdd:PRK05322 327 KQEgvLGARMTGAGFGGCAIAIVKKDK-VEAFKENVGKAY 365
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 41-90 9.63e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.89  E-value: 9.63e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 194748833   41 AFFVKQFGVEPEFIVRVPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAK 90
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK00555 PRK00555
galactokinase; Provisional
 58-456 6.97e-21

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 94.16  E-value: 6.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  58 PGRVNIIGEHVDY-CGYSvLPMAVSQSiflAVAK-NPDSSQ-LQLRNIEEakfqgyDADLktfRIELPKSGG--PAWYNY 132
Cdd:PRK00555   8 PGRINLIGEHTDYnLGFA-LPIALPQR---TVVTfTPEHTDaITASSDRA------DGSA---RIPLDTTPGqvTGWAAY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 133 flcgIKGVQEQLASKWSPI-GMRIAVDGNVPLAAGLSSSSAMVSSAVLATAHVQGMQLDRRELASISAKCE-QYIGTHSG 210
Cdd:PRK00555  75 ----AAGVIWALRGAGHPVpGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAEnEYVGAPTG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 211 GMDQAIAYLGRVGCAHHIEFHpKLKGTPVTLPAGKCFVV---ANSLAqKNKAASSDYNERVVECRLATRWLAkVKGLINW 287
Cdd:PRK00555 151 LLDQLAALFGAPKTALLIDFR-DLTVRPVAFDPDAAGVVlllMDSRA-RHRHAGGEYAARRASCERAAADLG-VSSLRAV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 288 QDfvRFIDLEEAcqmdnetfeklIRDNLTKKvytradickelgiteqeletkflsantrhmeqfklqqRALHVIQESGRV 367
Cdd:PRK00555 228 QD--RGLAALGA-----------IADPIDAR-------------------------------------RARHVLTENQRV 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 368 AKFrkiceelSSTPNEKDASKLGLLMRQSHESLRELYECSHPDVErLIAIS--NALDVSARVTGAGWGGCIVAMCdSVET 445
Cdd:PRK00555 258 LDF-------AAALADSDFTAAGQLLTASHASMRDDFEITTERID-LIADSavRAGALGARMTGGGFGGCVIALV-PADR 328

                        410
                 ....*....|.
gi 194748833 446 ADEYIKALKRE 456
Cdd:PRK00555 329 AEDVADTVRRA 339
PLN02865 PLN02865
galactokinase
 55-489 3.08e-16

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 80.62  E-value: 3.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  55 VRV---PGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKNPDSsQLQLRNieeAKFQG---YDADLKTFRIELPKSGGPA 128
Cdd:PLN02865  30 VRVvvsPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDP-EVLLRS---AQFEGevrFRVDEIQHPIANVSSDSKE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 129 ---WYNYflcgIKGVQEQLASKWSPI--GMRIAVDGNVPL---------AAGLSSSSAMVSSAVLATAHVQGMQLDRRel 194
Cdd:PLN02865 106 esnWGDY----ARGAVYALQSRGHALsqGITGYISGSEGLdssglsssaAVGVAYLLALENANNLTVSPEDNIELDRL-- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 195 asISAKceqYIGTHSGGMDQAIAYLGRVGCAHHI---EFHPKLKGTPVTLPAG-KCF--VVANSLAQKNKAASSDYNERV 268
Cdd:PLN02865 180 --IENE---YLGLRNGILDQSAILLSRYGCLTFMdckTLDHKLVSLQFQQPGGeKPFkiLLAFSGLRHALTNKPGYNLRV 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 269 VECRLATRWLAKVKGlinwqdfvrfidleeacqmdNETFEKLIRdNLTKKVYTRadickelgiteqeletkflsanTRHM 348
Cdd:PLN02865 255 SECQEAARFLLEASG--------------------NDELEPLLC-NVEPEVYEA----------------------HKCK 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 349 EQFKLQQRALHVIQESGRVAKFRKICEelsstpnEKDASKLGLLMRQSHESLRELYECSHPDVERL--IAISNALDVSAR 426
Cdd:PLN02865 292 LEAVLARRAEHYFSENMRVIKGVEAWA-------SGNLEEFGKLISASGLSSIENYECGCEPLIQLyeILLKAPGVYGAR 364

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194748833 427 VTGAGWGGCIVAMCDSvETADEYIKALKREYYAKLPAHL--LERHQPndfnevVFATLPGNGAEL 489
Cdd:PLN02865 365 FSGAGFRGCCVAFVDA-EMAEEAASFVRDEYEKAQPELAsnINGDKP------VLICEAGDCARV 422
PTZ00290 PTZ00290
galactokinase; Provisional
 28-460 2.22e-15

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 78.33  E-value: 2.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  28 PDSKIYDRVQKLNAFFVKQFGVEPEFIVR------VPGRVNIIGEHVDYCGYSVLPMAVSQSIFLAVAKnpdssqlqLRN 101
Cdd:PTZ00290   7 SDERLDSTLSTLKPIFLETFKVENDADVEwllftfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGR--------VKH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 102 IEEAKFQGYDADLKTFriELPKSGG----PAWYNYflcgikgVQEQLASKWSPIGMRI----------AVDGNVPLAAGL 167
Cdd:PTZ00290  79 FCDHKLRFATETDEHF--VLDHLGGakhnKAWTTF-------VRGAATLRLNRLGVAIdapslqgvcmVVHGTLPMGAGM 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 168 SSSSA-----MVSSAVLATAHVQGMQL---------------DRRELASISAKCE-QYIGTHSGGMDQAIAYLGRVG--- 223
Cdd:PTZ00290 150 SASASfgvalLNAINTVVTRRYKGCPTspgrrysilppmskeELIELAKQARRIEtEFCGVNVGIMDQFISAFAEEDkfm 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 224 ---CAH-HIEFHPKlkgTPVtLPAGKCFVVANSLAQKN--KAASSDYNErvvecrlatrwlakvkglinwqdfVRfIDLE 297
Cdd:PTZ00290 230 fldCKSlTFESHDM---TPL-LGDGACFLLIDSMIKHDllGGTAGMYNT------------------------VR-SDQE 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 298 EACQMDNE--------TFEKLIRDnlTKKVYTRADIckelgiteqeleTKFLSANTRHME--QFklqQRALHVIQESGRV 367
Cdd:PTZ00290 281 GAQKKIGKhryrgkpfTFSDLVRN--PKKYTFDGDV------------VAFMESCKPLMTpgEF---ERGTYNIMEQIRT 343

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 368 AKFRKICEELSSTPNEKDASKLGLLMRQSHESLRELYECSHPDVERLI-AISNALDVS-ARVTGAGWGGCIVAMCDSvET 445
Cdd:PTZ00290 344 LEFIKLNDPELPLSREERFRKAGEILNAGHQGMRDLMKITTPELDFIHeLINEEKGVAgGRMMGGGFGGCIILLLKK-NA 422

                        490
                 ....*....|....*
gi 194748833 446 ADEYIKALKREYYAK 460
Cdd:PTZ00290 423 VDRVVAHVREKFKAR 437
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 57-440 1.10e-11

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 65.25  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  57 VPGRVNIIGEH-VDYcGYSVLPMAVSQSIFLAVAKNPDSsQLQLrnieeakfqgyDADLKTFRIELPKSGGPAWyNYFLC 135
Cdd:COG1577    1 APGKLILFGEHaVVY-GQPAIAVAVDRRATVTVEPSDDD-KLRI-----------ESPDLGGTLDLDPLADAAL-RYIKA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 136 GIKGVQEQLasKWSPIGMRIAVDGNVPLAAGL-----------SsssamvssavlATAHVQGMQLDRRELASISAKCEQY 204
Cdd:COG1577   67 AIEAALEYL--GLPLKGFDIEIDSEIPRKRGLgssaavavaviR-----------ALAAFYGVELSKEELFKLALEAEKI 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 205 IGTHSGGMDQAIAYLGrvGCahhIEFHPKLKGTPVTLPAGKCFVVANSlaqKNKAASSDYNERVvecrlatrwlakvkgl 284
Cdd:COG1577  134 VHGNPSGLDTAASTYG--GP---IYYQRGDRAEPLELPKNLPLVVGDT---GVPASTKELVAKV---------------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833 285 inwqdfvrfidleeacqmdnetfekliRDNLTKKVYTRADICKELG-ITEQeletkflsantrhmeqfklqqrALHVIQe 363
Cdd:COG1577  190 ---------------------------RKLKERNPELYEAFLEEIGdLVEE----------------------AIEALE- 219

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194748833 364 sgrvakfrkiceelsstpnEKDASKLGLLMRQSHESLRELYeCSHPDVERLIAISNALDV-SARVTGAGWGGCIVAMC 440
Cdd:COG1577  220 -------------------EGDLEALGELMNENHGLLRALG-VSTPELDRLVEAARKAGAlGAKLTGAGGGGCVIALA 277
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 383-459 1.80e-11

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 60.18  E-value: 1.80e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194748833  383 EKDASKLGLLMRQSHESLREL--YECSHPDVERLIAISNALDVSARVTGAGWGGCIVAMCDSVETADEYIKALKREYYA 459
Cdd:pfam08544   7 RGDLEELGKLLTESAESLEPLlvVGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVARALREAGKK 85
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 346-438 1.03e-07

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 53.06  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194748833  346 RHMEQFKLQQRALHVIQESGR-------VAKFRKICE--------------ELSSTP----NEKDASKLGLLMRQSHESL 400
Cdd:TIGR00549 155 EGEFTKLISLDGYFVIADTGVsgstkeaVARVRQLLErfpelidsimdaigELTLEAkaalQDGDVESLGELMNINQGLL 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 194748833  401 RELyECSHPDVERLIAIS---NALdvSARVTGAGWGGCIVA 438
Cdd:TIGR00549 235 KAL-GVSHPKLDQLVEIArkaGAL--GAKLTGAGGGGCMIA 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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