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Conserved domains on  [gi|170086135|ref|XP_001874291|]
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uncharacterized protein LACBIDRAFT_379903 [Laccaria bicolor S238N-H82]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-424 4.34e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 106 LKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGMDMRCkpfntwepSGTYHIH---DLKFSNDGTKFLVISGTCQAK 182
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR--------TLKGHTGpvrDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 183 LFDRDGEEQTTYIKgdpyirdmkntaGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGART 262
Cdd:cd00200   77 LWDLETGECVRTLT------------GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL-------RGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 263 KVTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGaHAKGTEtgSLVFSVDGRTILTRGGDDTVKLWDLRSFKk 342
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KCVATLTG-HTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDLSTGK- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 343 platrsEVATLYPNTNAI----FSPDDKFVLTGAgasakgGQGALLFMEKDNLEIVKTLAVDATPVKVV-WHSKINQIVT 417
Cdd:cd00200  211 ------CLGTLRGHENGVnsvaFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLaWSPDGKRLAS 278


                 ....*..
gi 170086135 418 GLSNGTI 424
Cdd:cd00200  279 GSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-424 4.34e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 106 LKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGMDMRCkpfntwepSGTYHIH---DLKFSNDGTKFLVISGTCQAK 182
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR--------TLKGHTGpvrDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 183 LFDRDGEEQTTYIKgdpyirdmkntaGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGART 262
Cdd:cd00200   77 LWDLETGECVRTLT------------GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL-------RGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 263 KVTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGaHAKGTEtgSLVFSVDGRTILTRGGDDTVKLWDLRSFKk 342
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KCVATLTG-HTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDLSTGK- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 343 platrsEVATLYPNTNAI----FSPDDKFVLTGAgasakgGQGALLFMEKDNLEIVKTLAVDATPVKVV-WHSKINQIVT 417
Cdd:cd00200  211 ------CLGTLRGHENGVnsvaFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLaWSPDGKRLAS 278


                 ....*..
gi 170086135 418 GLSNGTI 424
Cdd:cd00200  279 GSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
106-424 5.03e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 5.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 106 LKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGmdmrCKPFNTWEpSGTYHIHDLKFSNDGTKFLVISGTCQAKLFD 185
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 186 -RDGEEQTTYikgdpyirdmkntAGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGARTKV 264
Cdd:COG2319  191 lATGKLLRTL-------------TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL-------TGHSGSV 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 265 TACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGAHAKGTetgSLVFSVDGRTILTRGGDDTVKLWDlrsfkkpL 344
Cdd:COG2319  250 RSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVN---SVAFSPDGKLLASGSDDGTVRLWD-------L 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 345 ATRSEVATLYPNTNAI----FSPDDKFVLTGagasakGGQGALLFMEKDNLEIVKTLAVDATPVK-VVWHSKINQIVTGL 419
Cdd:COG2319  318 ATGKLLRTLTGHTGAVrsvaFSPDGKTLASG------SDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGS 391


                 ....*
gi 170086135 420 SNGTI 424
Cdd:COG2319  392 ADGTV 396
PTZ00420 PTZ00420
coronin; Provisional
 209-348 9.70e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.57  E-value: 9.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 209 GHVGELTSCAWHPRDPKLFMTASADSTIRIWDVENKRKQKTVIVVKskergartKVTACGYSSDGKLIGGACLDGALHIW 288
Cdd:PTZ00420 123 GHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPK--------KLSSLKWNIKGNLLSGTCVGKHMHII 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170086135 289 QTSSNFVRPNMTIegaHAKGTETGSLV---FSVDGRTILTRGGDDT----VKLWDLRSFKKPLATRS 348
Cdd:PTZ00420 195 DPRKQEIASSFHI---HDGGKNTKNIWidgLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-240 6.15e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.15e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 170086135   209 GHVGELTSCAWHPrDPKLFMTASADSTIRIWD 240
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
209-240 1.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.68e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 170086135  209 GHVGELTSCAWHPrDPKLFMTASADSTIRIWD 240
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-424 4.34e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 136.31  E-value: 4.34e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 106 LKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGMDMRCkpfntwepSGTYHIH---DLKFSNDGTKFLVISGTCQAK 182
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR--------TLKGHTGpvrDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 183 LFDRDGEEQTTYIKgdpyirdmkntaGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGART 262
Cdd:cd00200   77 LWDLETGECVRTLT------------GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL-------RGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 263 KVTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGaHAKGTEtgSLVFSVDGRTILTRGGDDTVKLWDLRSFKk 342
Cdd:cd00200  137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KCVATLTG-HTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDLSTGK- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 343 platrsEVATLYPNTNAI----FSPDDKFVLTGAgasakgGQGALLFMEKDNLEIVKTLAVDATPVKVV-WHSKINQIVT 417
Cdd:cd00200  211 ------CLGTLRGHENGVnsvaFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLaWSPDGKRLAS 278


                 ....*..
gi 170086135 418 GLSNGTI 424
Cdd:cd00200  279 GSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
106-424 5.03e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 5.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 106 LKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGmdmrCKPFNTWEpSGTYHIHDLKFSNDGTKFLVISGTCQAKLFD 185
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 186 -RDGEEQTTYikgdpyirdmkntAGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGARTKV 264
Cdd:COG2319  191 lATGKLLRTL-------------TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL-------TGHSGSV 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 265 TACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGAHAKGTetgSLVFSVDGRTILTRGGDDTVKLWDlrsfkkpL 344
Cdd:COG2319  250 RSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVN---SVAFSPDGKLLASGSDDGTVRLWD-------L 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 345 ATRSEVATLYPNTNAI----FSPDDKFVLTGagasakGGQGALLFMEKDNLEIVKTLAVDATPVK-VVWHSKINQIVTGL 419
Cdd:COG2319  318 ATGKLLRTLTGHTGAVrsvaFSPDGKTLASG------SDDGTVRLWDLATGELLRTLTGHTGAVTsVAFSPDGRTLASGS 391


                 ....*
gi 170086135 420 SNGTI 424
Cdd:COG2319  392 ADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
105-373 1.94e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 105 SLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGmdmrCKPFNTWEPSgTYHIHDLKFSNDGTKFLVISGTCQAKLF 184
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGH-TGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 185 D-RDGEEQTTYikgdpyirdmkntAGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGARTK 263
Cdd:COG2319  232 DlATGKLLRTL-------------TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL-------TGHSGG 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 264 VTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGAHAKGTetgSLVFSVDGRTILTRGGDDTVKLWDlrsfkkp 343
Cdd:COG2319  291 VNSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVR---SVAFSPDGKTLASGSDDGTVRLWD------- 358

                        250       260       270
                 ....*....|....*....|....*....|....
gi 170086135 344 LATRSEVATLYPNTNAI----FSPDDKFVLTGAG 373
Cdd:COG2319  359 LATGELLRTLTGHTGAVtsvaFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
101-426 9.00e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 9.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 101 THEISLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGmdmrcKPFNTWEPSGTYHIHDLKFSNDGTKFLVISGTCQ 180
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 181 AKLFD-RDGEEQTTYikgdpyirdmkntAGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRG 259
Cdd:COG2319  144 VRLWDlATGKLLRTL-------------TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 260 ARTKVTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGaHAKGTEtgSLVFSVDGRTILTRGGDDTVKLWDlrs 339
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTG-HSGSVR--SVAFSPDGRLLASGSADGTVRLWD--- 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 340 fkkpLATRSEVATLYPNTNAI----FSPDDKFVLTGagasakGGQGALLFMEKDNLEIVKTLAVDATPVK-VVWHSKINQ 414
Cdd:COG2319  275 ----LATGELLRTLTGHSGGVnsvaFSPDGKLLASG------SDDGTVRLWDLATGKLLRTLTGHTGAVRsVAFSPDGKT 344

                        330
                 ....*....|..
gi 170086135 415 IVTGLSNGTIVV 426
Cdd:COG2319  345 LASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
105-339 3.03e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 3.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 105 SLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDFGGmdmrCKPFNTWEPSGTYhIHDLKFSNDGTKFLVISGTCQAKLF 184
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT----GKLLRTLTGHSGS-VRSVAFSPDGRLLASGSADGTVRLW 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 185 DRDGEEQTTYIKGdpyirdmkntagHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGARTKV 264
Cdd:COG2319  274 DLATGELLRTLTG------------HSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGAV 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 170086135 265 TACGYSSDGKLIGGACLDGALHIWQTSSNFVRPnmTIEGaHAKGTEtgSLVFSVDGRTILTRGGDDTVKLWDLRS 339
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLR--TLTG-HTGAVT--SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-336 1.67e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.79  E-value: 1.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135  94 DISQFPITHEisLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWDF--GGMDMRCKPFNTWepsgtyhIHDLKFSNDGTk 171
Cdd:cd00200   79 DLETGECVRT--LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVetGKCLTTLRGHTDW-------VNSVAFSPDGT- 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 172 FLVISGT-CQAKLFD-RDGEEQTTYikgdpyirdmkntAGHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKT 249
Cdd:cd00200  149 FVASSSQdGTIKLWDlRTGKCVATL-------------TGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 250 VivvkskeRGARTKVTACGYSSDGKLIGGACLDGALHIWQTSSNfvRPNMTIEGaHAKGTetGSLVFSVDGRTILTRGGD 329
Cdd:cd00200  215 L-------RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSG-HTNSV--TSLAWSPDGKRLASGSAD 282


                 ....*..
gi 170086135 330 DTVKLWD 336
Cdd:cd00200  283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
209-450 1.59e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 209 GHVGELTSCAWHPrDPKLFMTASADSTIRIWDVENKRKQKTVivvkskeRGARTKVTACGYSSDGKLIGGACLDGALHIW 288
Cdd:COG2319   76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL-------TGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 289 QTSSNFVRPnmTIEGAHAKGTetgSLVFSVDGRTILTRGGDDTVKLWDlrsfkkpLATRSEVATLYPNTNAI----FSPD 364
Cdd:COG2319  148 DLATGKLLR--TLTGHSGAVT---SVAFSPDGKLLASGSDDGTVRLWD-------LATGKLLRTLTGHTGAVrsvaFSPD 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 365 DKFVltgagASAKGGQGALLFmEKDNLEIVKTLAVDATPVK-VVWHSKINQIVTGLSNGTiVVLYSPETslnGAKLLLSK 443
Cdd:COG2319  216 GKLL-----ASGSADGTVRLW-DLATGKLLRTLTGHSGSVRsVAFSPDGRLLASGSADGT-VRLWDLAT---GELLRTLT 285


                 ....*..
gi 170086135 444 GPPRKVT 450
Cdd:COG2319  286 GHSGGVN 292
PTZ00420 PTZ00420
coronin; Provisional
 209-348 9.70e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.57  E-value: 9.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 209 GHVGELTSCAWHPRDPKLFMTASADSTIRIWDVENKRKQKTVIVVKskergartKVTACGYSSDGKLIGGACLDGALHIW 288
Cdd:PTZ00420 123 GHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPK--------KLSSLKWNIKGNLLSGTCVGKHMHII 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170086135 289 QTSSNFVRPNMTIegaHAKGTETGSLV---FSVDGRTILTRGGDDT----VKLWDLRSFKKPLATRS 348
Cdd:PTZ00420 195 DPRKQEIASSFHI---HDGGKNTKNIWidgLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-240 6.15e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.15e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 170086135   209 GHVGELTSCAWHPrDPKLFMTASADSTIRIWD 240
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
147-403 9.41e-06

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 48.10  E-value: 9.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 147 KPFNTWEPSGTYHIHDLKFSNDgTKFLVISGTCQAKLFDRDgeeqttYIKGDPYIRDMKNTagHVGEL----TSCAWHPR 222
Cdd:COG5170  162 KPCRVYANAHPYHINSISFNSD-KETLLSADDLRINLWNLE------IIDGSFNIVDIKPH--NMEELteviTSAEFHPE 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 223 DPKLFMTASADSTIRIWDVenkRKQKTVIVVKSKErgartkvtacgyssdgkliggacldgALHIWQTSSNFvrpnmtIE 302
Cdd:COG5170  233 MCNVFMYSSSKGEIKLNDL---RQSALCDNSKKLF--------------------------ELTIDGVDVDF------FE 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 303 GAHAKGTEtgsLVFSVDGRTILTRGGDdTVKLWDLRSFKKPLAT-------RSEVATLYPNtNAIF-------SPDDKFV 368
Cdd:COG5170  278 EIVSSISD---FKFSDNGRYILSRDYL-TVKIWDVNMAKNPIKTipmhcdlMDELNDVYEN-DAIFdkfeisfSGDDKHV 352

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 170086135 369 LTGAGASAKGGQGALLFMEKDNLeIVKTLAVDATP 403
Cdd:COG5170  353 LSGSYSNNFGIYPTDSSGFKDVG-HVVNLADGSAE 386
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-138 1.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.63e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 170086135   105 SLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWD 138
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
209-240 1.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.68e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 170086135  209 GHVGELTSCAWHPrDPKLFMTASADSTIRIWD 240
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
105-138 5.80e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.80e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 170086135  105 SLKDHTKVVSALSLDPSGARIVSGSHDYDCKLWD 138
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 187-427 1.73e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 187 DGEEQTTYIKGDPYIRDMKNtagHVGELTSCAWHPRDPKLFMTASADSTIRIWDVENKRKQKTVivvkskergaRTKVTA 266
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKE---HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTI----------KTKANI 620

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 267 CGY---SSDGKLIGGACLDGALHIWQTSsNFVRPNMTIEGAHakgtETGSLVFSVDGRTILTRGGDDTVKLWDLrSFKKP 343
Cdd:PLN00181 621 CCVqfpSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHS----KTVSYVRFVDSSTLVSSSTDNTLKLWDL-SMSIS 694

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 344 LATRSEVATLYPNTNAI----FSPDDKFVLTGAGASA-----KGGQGALLFMEKDNLEIVKTLAVDATP---VKVVWHSK 411
Cdd:PLN00181 695 GINETPLHSFMGHTNVKnfvgLSVSDGYIATGSETNEvfvyhKAFPMPVLSYKFKTIDPVSGLEVDDASqfiSSVCWRGQ 774

                        250
                 ....*....|....*.
gi 170086135 412 INQIVTGLSNGTIVVL 427
Cdd:PLN00181 775 SSTLVAANSTGNIKIL 790
PTZ00421 PTZ00421
coronin; Provisional
 209-346 3.04e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170086135 209 GHVGELTSCAWHPRDPKLFMTASADSTIRIWDVEnkrKQKTVIVVKSKErgarTKVTACGYSSDGKLIGGACLDGALHIW 288
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE---RGKAVEVIKCHS----DQITSLEWNLDGSLLCTTSKDKKLNII 195

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 170086135 289 QTSSNFVrpnMTIEGAHAkGTETGSLVFSVDGRTILTRGGDDT----VKLWDLRSFKKPLAT 346
Cdd:PTZ00421 196 DPRDGTI---VSSVEAHA-SAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMASPYST 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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