NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|154293201|ref|XP_001547145|]
View 

hypothetical protein BCIN_08g00230 [Botrytis cinerea B05.10]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-444 1.36e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFAsmTPTTLRSFKsvdpnysktsanSETHPINHVEFNPhaGGTFLc 188
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT------------GHSGAVTSVAFSP--DGKLL- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 189 ISAHP--QAKLMN-RDGDIIGEFvkgdmylrdmnntKGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVI 265
Cdd:COG2319  178 ASGSDdgTVRLWDlATGKLLRTL-------------TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 266 VHKSKAsgsagrtrmTAVVWggpaQGGNNLLVSAALDGSLVMWGgngpyARPTAEIRDAHTPDTWTGGIDISPDGRMVVT 345
Cdd:COG2319  244 GHSGSV---------RSVAF----SPDGRLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 346 RGGDNLIKLWDTRKFKTpiVTVSHPSTSDVYSVTnikYSPNGANIITGSASGHLHILNSGNLKpELVTPVTPGSPLITVQ 425
Cdd:COG2319  306 GSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA---FSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVA 379

                        330
                 ....*....|....*....
gi 154293201 426 WHPKLNQIVTGSANSEVHV 444
Cdd:COG2319  380 FSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-444 1.36e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFAsmTPTTLRSFKsvdpnysktsanSETHPINHVEFNPhaGGTFLc 188
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT------------GHSGAVTSVAFSP--DGKLL- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 189 ISAHP--QAKLMN-RDGDIIGEFvkgdmylrdmnntKGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVI 265
Cdd:COG2319  178 ASGSDdgTVRLWDlATGKLLRTL-------------TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 266 VHKSKAsgsagrtrmTAVVWggpaQGGNNLLVSAALDGSLVMWGgngpyARPTAEIRDAHTPDTWTGGIDISPDGRMVVT 345
Cdd:COG2319  244 GHSGSV---------RSVAF----SPDGRLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 346 RGGDNLIKLWDTRKFKTpiVTVSHPSTSDVYSVTnikYSPNGANIITGSASGHLHILNSGNLKpELVTPVTPGSPLITVQ 425
Cdd:COG2319  306 GSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA---FSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVA 379

                        330
                 ....*....|....*....
gi 154293201 426 WHPKLNQIVTGSANSEVHV 444
Cdd:COG2319  380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-444 4.21e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 110 LKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFASMTPttLRSFKSvdpnysktsansETHPINHVEFNPHagGTFLCI 189
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKG------------HTGPVRDVAASAD--GTYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 190 SAHP-QAKLMN-RDGDIIGEFvkgdmylrdmnntKGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVIVH 267
Cdd:cd00200   69 GSSDkTIRLWDlETGECVRTL-------------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 268 kskasgsagrtrmTAVVWGGPAQGGNNLLVSAALDGSLVMWggNGPYARPTAEIrDAHTPDTWTggIDISPDGRMVVTRG 347
Cdd:cd00200  135 -------------TDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATL-TGHTGEVNS--VAFSPDGEKLLSSS 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 348 GDNLIKLWDTRKFKTPIVTVSHPStsdvySVTNIKYSPNGANIITGSASGHLHI--LNSGNLKPELvtpvtPG--SPLIT 423
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVwdLRTGECVQTL-----SGhtNSVTS 266

                        330       340
                 ....*....|....*....|.
gi 154293201 424 VQWHPKLNQIVTGSANSEVHV 444
Cdd:cd00200  267 LAWSPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-142 2.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 154293201   109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHD 142
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
109-142 3.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 154293201  109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHD 142
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-444 1.36e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFAsmTPTTLRSFKsvdpnysktsanSETHPINHVEFNPhaGGTFLc 188
Cdd:COG2319  115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT------------GHSGAVTSVAFSP--DGKLL- 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 189 ISAHP--QAKLMN-RDGDIIGEFvkgdmylrdmnntKGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVI 265
Cdd:COG2319  178 ASGSDdgTVRLWDlATGKLLRTL-------------TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 266 VHKSKAsgsagrtrmTAVVWggpaQGGNNLLVSAALDGSLVMWGgngpyARPTAEIRDAHTPDTWTGGIDISPDGRMVVT 345
Cdd:COG2319  244 GHSGSV---------RSVAF----SPDGRLLASGSADGTVRLWD-----LATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 346 RGGDNLIKLWDTRKFKTpiVTVSHPSTSDVYSVTnikYSPNGANIITGSASGHLHILNSGNLKpELVTPVTPGSPLITVQ 425
Cdd:COG2319  306 GSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVA---FSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVA 379

                        330
                 ....*....|....*....
gi 154293201 426 WHPKLNQIVTGSANSEVHV 444
Cdd:COG2319  380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-444 4.21e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 110 LKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFASMTPttLRSFKSvdpnysktsansETHPINHVEFNPHagGTFLCI 189
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL--LRTLKG------------HTGPVRDVAASAD--GTYLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 190 SAHP-QAKLMN-RDGDIIGEFvkgdmylrdmnntKGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVIVH 267
Cdd:cd00200   69 GSSDkTIRLWDlETGECVRTL-------------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 268 kskasgsagrtrmTAVVWGGPAQGGNNLLVSAALDGSLVMWggNGPYARPTAEIrDAHTPDTWTggIDISPDGRMVVTRG 347
Cdd:cd00200  135 -------------TDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATL-TGHTGEVNS--VAFSPDGEKLLSSS 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 348 GDNLIKLWDTRKFKTPIVTVSHPStsdvySVTNIKYSPNGANIITGSASGHLHI--LNSGNLKPELvtpvtPG--SPLIT 423
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRGHEN-----GVNSVAFSPDGYLLASGSEDGTIRVwdLRTGECVQTL-----SGhtNSVTS 266

                        330       340
                 ....*....|....*....|.
gi 154293201 424 VQWHPKLNQIVTGSANSEVHV 444
Cdd:cd00200  267 LAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-450 5.14e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 5.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 222 KGHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVIVHKSKasgsagrtrMTAVVWGgpaqGGNNLLVSAAL 301
Cdd:cd00200    6 KGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP---------VRDVAAS----ADGTYLASGSS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 302 DGSLVMWGGNGPyaRPTAEIRdAHTPDTWTggIDISPDGRMVVTRGGDNLIKLWDTRKFKTPIVTVSHpsTSDVYSVtni 381
Cdd:cd00200   72 DKTIRLWDLETG--ECVRTLT-GHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH--TDWVNSV--- 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154293201 382 KYSPNGANIITGSASGHLHI--LNSGNLKPELVT---PVTpgspliTVQWHPKLNQIVTGSANSEVHvLYNPNT 450
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLwdLRTGKCVATLTGhtgEVN------SVAFSPDGEKLLSSSSDGTIK-LWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-356 6.56e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFASmtpttlrsfksvdpNYSKTSANSETHPINHVEFNPHagGTFLC 188
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET--------------GKCLTTLRGHTDWVNSVAFSPD--GTFVA 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 189 ISAHpqaklmnrDGDIigefvkgdmYLRDMNNTK------GHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQK 262
Cdd:cd00200  152 SSSQ--------DGTI---------KLWDLRTGKcvatltGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLG 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 263 EVIVHKSKAsgsagrtrmTAVVWGGpaqgGNNLLVSAALDGSLVMWggNGPYARPTAEIRdAHTPDTWTggIDISPDGRM 342
Cdd:cd00200  214 TLRGHENGV---------NSVAFSP----DGYLLASGSEDGTIRVW--DLRTGECVQTLS-GHTNSVTS--LAWSPDGKR 275

                        250
                 ....*....|....
gi 154293201 343 VVTRGGDNLIKLWD 356
Cdd:cd00200  276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
223-450 4.89e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 4.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 223 GHISEITTGTWSPmDKNICVTAGTDSTLRIWDVNVRRCQKEVIVHKSKAsgsagrtrmTAVVWggpAQGGNnLLVSAALD 302
Cdd:COG2319   76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV---------RSVAF---SPDGK-TLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 303 GSLVMWGgngpyARPTAEIRDAHTPDTWTGGIDISPDGRMVVTRGGDNLIKLWDTRKFKTPIVTVSHpsTSDVYSVTnik 382
Cdd:COG2319  142 GTVRLWD-----LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH--TGAVRSVA--- 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154293201 383 YSPNGANIITGSASGHLHILNSGNLKpELVTPVTPGSPLITVQWHPKLNQIVTGSANSEVHvLYNPNT 450
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR-LWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
110-358 4.27e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 110 LKTHERAVTTTTLDPSGSRLITGSSDCTLKFHDFAsmTPTTLRSFKSvdpnysktsansETHPINHVEFNPHaGGTFLCI 189
Cdd:COG2319  200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTG------------HSGSVRSVAFSPD-GRLLASG 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 190 SAHPQAKLMNRDGdiiGEFVKgdmylrdmnNTKGHISEITTGTWSPMDKNIcVTAGTDSTLRIWDVNVRRCQKEVIVHKS 269
Cdd:COG2319  265 SADGTVRLWDLAT---GELLR---------TLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 270 KAsgsagrtrmTAVVWGgpAQGgnNLLVSAALDGSLVMWGGNGPYARPTAEirdAHTPDTWTggIDISPDGRMVVTRGGD 349
Cdd:COG2319  332 AV---------RSVAFS--PDG--KTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTS--VAFSPDGRTLASGSAD 393


                 ....*....
gi 154293201 350 NLIKLWDTR 358
Cdd:COG2319  394 GTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
271-444 1.71e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 271 ASGSAGRTRMTAVVWGGPAQGGNNLLVSAALDGSLVMWGgngpyARPTAEIRDAHTPDTWTGGIDISPDGRMVVTRGGDN 350
Cdd:COG2319   26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD-----AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154293201 351 LIKLWDTRKFKTPIVTVSHpsTSDVYSVTnikYSPNGANIITGSASGHLHILNSGNLKpELVTPVTPGSPLITVQWHPKL 430
Cdd:COG2319  101 TVRLWDLATGLLLRTLTGH--TGAVRSVA---FSPDGKTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFSPDG 174

                        170
                 ....*....|....
gi 154293201 431 NQIVTGSANSEVHV 444
Cdd:COG2319  175 KLLASGSDDGTVRL 188
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 109-142 2.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 154293201   109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHD 142
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-254 2.70e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.70e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 154293201   222 KGHISEITTGTWSPmDKNICVTAGTDSTLRIWD 254
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
109-142 3.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 154293201  109 ILKTHERAVTTTTLDPSGSRLITGSSDCTLKFHD 142
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
222-254 6.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.58e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 154293201  222 KGHISEITTGTWSPmDKNICVTAGTDSTLRIWD 254
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH