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Conserved domains on  [gi|154273873|ref|XP_001537788|]
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glycolipid-anchored surface protein 5 precursor [Histoplasma mississippiense (nom. inval.)]

Protein Classification

glycoside hydrolase family protein( domain architecture ID 581038)

glycoside hydrolase family protein may catalyze the hydrolysis of glycosidic bonds in complex sugars

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro super family cl23725
Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families ...
31-350 1.87e-165

Glycosyl hydrolases; A functionally diverse superfamily containing glycosyl hydrolase families 1,5,10,17,44,72, and others.


The actual alignment was detected with superfamily member pfam03198:

Pssm-ID: 474034 [Multi-domain]  Cd Length: 315  Bit Score: 469.16  E-value: 1.87e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873   31 ASKITPITVKGNVPMPSDGwyvdwailcllafwqgDKRFYIRGVDYQPGG---ASKLKDPIADAEECKSDIAKFKELGLN 107
Cdd:pfam03198   6 FAATPPIEIKGNKFFDSKN----------------GEQFYIKGVDYQPGGsseNSTLVDPLADADVCKRDIPYFKELGIN 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  108 TIRIYTVDNSQNHDECMAALADAGIYLVLDVNTPKYSINRKDPKPSYNDVYLQNVFATVDMFARYDNTLAFFSGNEVVND 187
Cdd:pfam03198  70 TIRVYAVDPSLNHDECMKALSDAGIYVILDLNTPKESINRADPAGSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEVTND 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  188 GLSSNTAPYVKAVTRDMRQYIRQQGLREVPVGYSAADVDTNRFQMAQYMNCGPDDERSDFFAFNDYSWCDPSTFEISGWN 267
Cdd:pfam03198 150 ASNTDASPYVKAAIRDMKQYISKHKYRTIPVGYSAADDADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKTSGYD 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  268 KKVELFSDYGLPLFLSEFGCNTNT-REWNEVKALYSDKMTSVYSGGLVYEYSQEPNNYGLVKL-EDGKAVPLKDFDTLKK 345
Cdd:pfam03198 230 DRTKEFENYSIPVFFSEYGCNKVTpRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIdGDDVVTTLADFNNLKS 309

                  ....*
gi 154273873  346 AFAAT 350
Cdd:pfam03198 310 EYAKI 314
 
Name Accession Description Interval E-value
Glyco_hydro_72 pfam03198
Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3) ...
31-350 1.87e-165

Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261.


Pssm-ID: 397351 [Multi-domain]  Cd Length: 315  Bit Score: 469.16  E-value: 1.87e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873   31 ASKITPITVKGNVPMPSDGwyvdwailcllafwqgDKRFYIRGVDYQPGG---ASKLKDPIADAEECKSDIAKFKELGLN 107
Cdd:pfam03198   6 FAATPPIEIKGNKFFDSKN----------------GEQFYIKGVDYQPGGsseNSTLVDPLADADVCKRDIPYFKELGIN 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  108 TIRIYTVDNSQNHDECMAALADAGIYLVLDVNTPKYSINRKDPKPSYNDVYLQNVFATVDMFARYDNTLAFFSGNEVVND 187
Cdd:pfam03198  70 TIRVYAVDPSLNHDECMKALSDAGIYVILDLNTPKESINRADPAGSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEVTND 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  188 GLSSNTAPYVKAVTRDMRQYIRQQGLREVPVGYSAADVDTNRFQMAQYMNCGPDDERSDFFAFNDYSWCDPSTFEISGWN 267
Cdd:pfam03198 150 ASNTDASPYVKAAIRDMKQYISKHKYRTIPVGYSAADDADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKTSGYD 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  268 KKVELFSDYGLPLFLSEFGCNTNT-REWNEVKALYSDKMTSVYSGGLVYEYSQEPNNYGLVKL-EDGKAVPLKDFDTLKK 345
Cdd:pfam03198 230 DRTKEFENYSIPVFFSEYGCNKVTpRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIdGDDVVTTLADFNNLKS 309

                  ....*
gi 154273873  346 AFAAT 350
Cdd:pfam03198 310 EYAKI 314
BglC COG2730
Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];
95-300 1.23e-06

Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];


Pssm-ID: 442036 [Multi-domain]  Cd Length: 295  Bit Score: 50.04  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  95 KSDIAKFKELGLNTIRI-------------YTVDNSQ-NH-DECMAALADAGIYLVLDV-NTPKYSINrkdpkpsYNDVY 158
Cdd:COG2730   29 EEDIDAIADWGFNTVRLpvswerlqdpdnpYTLDEAYlERvDEVVDWAKARGLYVILDLhHAPGYQGW-------YDAAT 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873 159 LQNVFATVDMFAR----YDNTLAFFSGNEVVNDglssnTAPYVKAVTRDMRQYIRQqglrevpvgysaadVDTNRFQMAQ 234
Cdd:COG2730  102 QERFIAFWRQLAErykdYPNVLGFELLNEPHGA-----TWADWNALAQRAIDAIRA--------------TNPDRLIIVE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873 235 YMNCGPDDERSDFFAFND----YS--------------WCDPSTFE---ISGWNKKVELFSDYGLPLFLSEFGCNTNTRE 293
Cdd:COG2730  163 GNNWGGAHNLRALDPLDDdnlvYSvhfygpfvfthqgaWFAGPTYPanlEARLDNWGDWAADNGVPVFVGEFGAYNDDPD 242

                 ....*..
gi 154273873 294 WNEVKAL 300
Cdd:COG2730  243 ASRLAWL 249
 
Name Accession Description Interval E-value
Glyco_hydro_72 pfam03198
Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3) ...
31-350 1.87e-165

Glucanosyltransferase; This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261.


Pssm-ID: 397351 [Multi-domain]  Cd Length: 315  Bit Score: 469.16  E-value: 1.87e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873   31 ASKITPITVKGNVPMPSDGwyvdwailcllafwqgDKRFYIRGVDYQPGG---ASKLKDPIADAEECKSDIAKFKELGLN 107
Cdd:pfam03198   6 FAATPPIEIKGNKFFDSKN----------------GEQFYIKGVDYQPGGsseNSTLVDPLADADVCKRDIPYFKELGIN 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  108 TIRIYTVDNSQNHDECMAALADAGIYLVLDVNTPKYSINRKDPKPSYNDVYLQNVFATVDMFARYDNTLAFFSGNEVVND 187
Cdd:pfam03198  70 TIRVYAVDPSLNHDECMKALSDAGIYVILDLNTPKESINRADPAGSYNVDYLERYFAVIDAFKNYTNVLGFFAGNEVTND 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  188 GLSSNTAPYVKAVTRDMRQYIRQQGLREVPVGYSAADVDTNRFQMAQYMNCGPDDERSDFFAFNDYSWCDPSTFEISGWN 267
Cdd:pfam03198 150 ASNTDASPYVKAAIRDMKQYISKHKYRTIPVGYSAADDADTRVQLADYFACGDDDERADFFGINMYEWCGYSSFKTSGYD 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  268 KKVELFSDYGLPLFLSEFGCNTNT-REWNEVKALYSDKMTSVYSGGLVYEYSQEPNNYGLVKL-EDGKAVPLKDFDTLKK 345
Cdd:pfam03198 230 DRTKEFENYSIPVFFSEYGCNKVTpRPFTEVSALYSSDMTSVFSGGLVYEYSEEANNYGLVSIdGDDVVTTLADFNNLKS 309

                  ....*
gi 154273873  346 AFAAT 350
Cdd:pfam03198 310 EYAKI 314
BglC COG2730
Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];
95-300 1.23e-06

Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism];


Pssm-ID: 442036 [Multi-domain]  Cd Length: 295  Bit Score: 50.04  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873  95 KSDIAKFKELGLNTIRI-------------YTVDNSQ-NH-DECMAALADAGIYLVLDV-NTPKYSINrkdpkpsYNDVY 158
Cdd:COG2730   29 EEDIDAIADWGFNTVRLpvswerlqdpdnpYTLDEAYlERvDEVVDWAKARGLYVILDLhHAPGYQGW-------YDAAT 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873 159 LQNVFATVDMFAR----YDNTLAFFSGNEVVNDglssnTAPYVKAVTRDMRQYIRQqglrevpvgysaadVDTNRFQMAQ 234
Cdd:COG2730  102 QERFIAFWRQLAErykdYPNVLGFELLNEPHGA-----TWADWNALAQRAIDAIRA--------------TNPDRLIIVE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154273873 235 YMNCGPDDERSDFFAFND----YS--------------WCDPSTFE---ISGWNKKVELFSDYGLPLFLSEFGCNTNTRE 293
Cdd:COG2730  163 GNNWGGAHNLRALDPLDDdnlvYSvhfygpfvfthqgaWFAGPTYPanlEARLDNWGDWAADNGVPVFVGEFGAYNDDPD 242

                 ....*..
gi 154273873 294 WNEVKAL 300
Cdd:COG2730  243 ASRLAWL 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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