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Conserved domains on  [gi|149738240|ref|XP_001500176|]
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dolichyldiphosphatase 1 [Equus caballus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130181)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to dolichyldiphosphatase, a membrane-associated protein located in the endoplasmic reticulum that hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016791|GO:0016311|GO:0008610
PubMed:  12447906|9260289
SCOP:  4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 9.48e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


:

Pssm-ID: 239477  Cd Length: 159  Bit Score: 213.29  E-value: 9.48e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  16 VSLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCgGPHMAVGT 95
Cdd:cd03382    1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLM 175
Cdd:cd03382   80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                 ....*
gi 149738240 176 AIAWF 180
Cdd:cd03382  155 GILWF 159
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 9.48e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 213.29  E-value: 9.48e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  16 VSLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCgGPHMAVGT 95
Cdd:cd03382    1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLM 175
Cdd:cd03382   80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                 ....*
gi 149738240 176 AIAWF 180
Cdd:cd03382  155 GILWF 159
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 61-184 2.96e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.06  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240   61 SFLGGLALNEGVNWLIKHVIQEPRP-----CGGPHMAVGT----KYGMPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFL 131
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPfflllEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLL----------RRL 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 149738240  132 DLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAWFVFTQ 184
Cdd:pfam01569  71 RKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
65-180 1.47e-11

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 59.67  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240    65 GLALNEGVNWLIKHVIQEPRP---------CGGPHMAV-GTKYGMPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldll 134
Cdd:smart00014   3 LAVVSQLFNGVIKNYFGRPRPfflsigdacCTPNFLLTlEAGYSFPSGHTAFAFAFALFLLLYLPARAG----------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 149738240   135 wRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAWF 180
Cdd:smart00014  72 -RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-184 1.04e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 47.73  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240   9 LPASWRPVSLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCGG 88
Cdd:COG0671   25 LALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  89 PHMAV----GTKYGMPSSHSqfMWFFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQ 164
Cdd:COG0671  105 PDLELllgtAGGYSFPSGHA--AAAFALALVLAL--------------LLPRRWLAALLLALALLVGLSRVYLGVHYPSD 168

                        170       180
                 ....*....|....*....|
gi 149738240 165 VLYGGIAGSLMAIAWFVFTQ 184
Cdd:COG0671  169 VLAGALLGLAIALLLLALLR 188
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 76-202 9.52e-03

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 36.64  E-value: 9.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  76 IKHVIQEPRPCGGP-HMAVGTK--------YGMPSSHSQFMWFFSVYsfLFLYLRMHQTN-NARfldlLWRHVLSLGLLT 145
Cdd:PLN02525  54 IKDVVSAPRPSCPPvRRVTATKdeeenameYGLPSSHTLNTVCLSGY--LLHYVLSYLQNvDAS----VIFAGLALFCLL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149738240 146 AAfLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAW---------FVFTQEVLTPLFPRIA-----AWPISEF 202
Cdd:PLN02525 128 VA-LVGFGRLYLGMHSPIDIIAGLAIGLVILAFWltvdeyvdaFITSGQNVTPFWAALSflllfAYPTPEF 197
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 9.48e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 213.29  E-value: 9.48e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  16 VSLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCgGPHMAVGT 95
Cdd:cd03382    1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLM 175
Cdd:cd03382   80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                 ....*
gi 149738240 176 AIAWF 180
Cdd:cd03382  155 GILWF 159
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 55-180 1.02e-15

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 70.95  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  55 RELHTISFLGGLALNEGVNWLIKHVIQEPRP--------CGGPHMAVGTKYGMPSSHSQFMWFFSVYSFLFLYLRmhqtn 126
Cdd:cd01610    1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPyfllrcgpDGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPRR----- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 149738240 127 narfldlLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAWF 180
Cdd:cd01610   76 -------LLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 61-184 2.96e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.06  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240   61 SFLGGLALNEGVNWLIKHVIQEPRP-----CGGPHMAVGT----KYGMPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFL 131
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPfflllEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLL----------RRL 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 149738240  132 DLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAWFVFTQ 184
Cdd:pfam01569  71 RKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
65-180 1.47e-11

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 59.67  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240    65 GLALNEGVNWLIKHVIQEPRP---------CGGPHMAV-GTKYGMPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldll 134
Cdd:smart00014   3 LAVVSQLFNGVIKNYFGRPRPfflsigdacCTPNFLLTlEAGYSFPSGHTAFAFAFALFLLLYLPARAG----------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 149738240   135 wRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAWF 180
Cdd:smart00014  72 -RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 59-177 5.62e-11

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 58.80  E-value: 5.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  59 TISFLGGLALNEGVNWLIKHVIQEPRP--------------CGGPHMAVGTKYGM--------------PSSHSQFmwff 110
Cdd:cd03384    6 VGVFLFGLFATQLLTDLGKYVTGRLRPhfldvckpnytdltCSLDHQYIADCTCCtgdpdlirearlsfPSGHASL---- 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149738240 111 SVYSFLFLYLRMHQTNNARFLDLLwRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMAI 177
Cdd:cd03384   82 SMYAAVFLALYLQARLKLRGSRLL-RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIAL 147
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 41-187 8.30e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 59.16  E-value: 8.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  41 VFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCGGPHMAVGTkYGMPSSHSqfMWFFSVYSFLFLYL 120
Cdd:cd03392   46 IIVLLLALLLLLKRRRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPEGG-YSFPSGHA--MGATVLYGFLAYLL 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149738240 121 RMHQTNNArfldllWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLyggiAGSLMAIAWFVFTQEVL 187
Cdd:cd03392  123 ARRLPRRR------VRILLLILAAILILLVGLSRLYLGVHYPSDVL----AGWLLGLAWLALLILLY 179
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 32-180 6.75e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 51.07  E-value: 6.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  32 LLAYLSLSPVFVIVGFvTLIIFKRELHTISFLGGLALNEGVNWLI----KHVIQEPRP-----C--GGPHMAVGTKYG-- 98
Cdd:cd03390   18 LVIISVGIPLLVIILI-SLFFRRSLWDLHTSLLGLLLSVSLNGVItnvlKNYAGRPRPdflarCfpDGGTPSDTLVGIdi 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  99 ---------------MPSSHSQFMwfFSVYSFLFLYL--RMHQTNNARFLdllWRHVLSLGLLTAAFLVSYSRVYLLYHT 161
Cdd:cd03390   97 cctgdpgvlkegrksFPSGHSSFA--FAGLGFLSLYLagKLHIFDPRGSS---WRLLLALLPLLLAILVAVSRTRDYRHH 171

                        170
                 ....*....|....*....
gi 149738240 162 WSQVLYGGIAGSLMAIAWF 180
Cdd:cd03390  172 FSDVIAGSLIGLIIAYLSY 190
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 73-184 5.70e-07

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 48.03  E-value: 5.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  73 NWLIKHVIQEPRPC---GGPHMAV----GTKYGMPSSHSQFMwfFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLT 145
Cdd:cd03395   73 SGFLKPLVARLRPCnalDGVRLVVlgdqGGSYSFASSHAANS--FALALFIWL--------------FFRRGLFSPVLLL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 149738240 146 AAFLVSYSRVYLLYHTWSQVLYGGIAGSLMA-IAWFVFTQ 184
Cdd:cd03395  137 WALLVGYSRVYVGVHYPGDVIAGALIGIISGlLFYLLFSW 176
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-184 1.04e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 47.73  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240   9 LPASWRPVSLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKHVIQEPRPCGG 88
Cdd:COG0671   25 LALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  89 PHMAV----GTKYGMPSSHSqfMWFFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLTAAFLVSYSRVYLLYHTWSQ 164
Cdd:COG0671  105 PDLELllgtAGGYSFPSGHA--AAAFALALVLAL--------------LLPRRWLAALLLALALLVGLSRVYLGVHYPSD 168

                        170       180
                 ....*....|....*....|
gi 149738240 165 VLYGGIAGSLMAIAWFVFTQ 184
Cdd:COG0671  169 VLAGALLGLAIALLLLALLR 188
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 65-176 1.13e-05

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 43.09  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  65 GLALNEGVNWLIKHVIQEPRPCGGPhmavGTKYGMPSSHSQfmWFFSVYSFLflylrmhqtnnARFLDLLWrhvLSLGLL 144
Cdd:cd03394   11 AAALTAAVTEGLKFAVGRARPDGSN----NGYRSFPSGHTA--SAFAAATFL-----------QYRYGWRW---YGIPAY 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 149738240 145 TAAFLVSYSRVYLLYHTWSQVLYGGIAGSLMA 176
Cdd:cd03394   71 ALASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 98-183 8.21e-03

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 35.00  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  98 GMPSSHSQFMwfFSVYSFLFLylrmhQTNNarfldllwrHVLSLGLLTAAFLVSYSRVYLLYHTWSQVLYGGIAGSLmaI 177
Cdd:cd03383   40 GMPSGHAAIA--FSIATAISL-----ITNN---------PIISILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGAL--I 101


                 ....*.
gi 149738240 178 AWFVFT 183
Cdd:cd03383  102 TLLIFK 107
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 76-202 9.52e-03

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 36.64  E-value: 9.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149738240  76 IKHVIQEPRPCGGP-HMAVGTK--------YGMPSSHSQFMWFFSVYsfLFLYLRMHQTN-NARfldlLWRHVLSLGLLT 145
Cdd:PLN02525  54 IKDVVSAPRPSCPPvRRVTATKdeeenameYGLPSSHTLNTVCLSGY--LLHYVLSYLQNvDAS----VIFAGLALFCLL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149738240 146 AAfLVSYSRVYLLYHTWSQVLYGGIAGSLMAIAW---------FVFTQEVLTPLFPRIA-----AWPISEF 202
Cdd:PLN02525 128 VA-LVGFGRLYLGMHSPIDIIAGLAIGLVILAFWltvdeyvdaFITSGQNVTPFWAALSflllfAYPTPEF 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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