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Conserved domains on  [gi|149758041|ref|XP_001497175|]
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serine palmitoyltransferase 1 isoform X2 [Equus caballus]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 1-472 1.14e-168

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 483.86  E-value: 1.14e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822   8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  70 VPPVPK----DHPALNYniVSGPpsHSIVvNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822  82 IPPITEemrpEPPVLES--AAGP--HTII-NGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 146 LDLEDRLARFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822 157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 226 IEDqknpRKARVTRRFIVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIDLISA 305
Cdd:PLN02822 237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822 313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 386 VGESFSPALHLQLEESTGSREKDIKLLQEIVNQCM---SRSIALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAAA 462
Cdd:PLN02822 393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkedSVLVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                        490
                 ....*....|
gi 149758041 463 TIKEVAQAVL 472
Cdd:PLN02822 470 SLKRVAASVL 479
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 1.14e-168

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 483.86  E-value: 1.14e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822   8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  70 VPPVPK----DHPALNYniVSGPpsHSIVvNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822  82 IPPITEemrpEPPVLES--AAGP--HTII-NGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 146 LDLEDRLARFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822 157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 226 IEDqknpRKARVTRRFIVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIDLISA 305
Cdd:PLN02822 237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822 313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 386 VGESFSPALHLQLEESTGSREKDIKLLQEIVNQCM---SRSIALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAAA 462
Cdd:PLN02822 393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkedSVLVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                        490
                 ....*....|
gi 149758041 463 TIKEVAQAVL 472
Cdd:PLN02822 470 SLKRVAASVL 479
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 1.76e-79

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 251.89  E-value: 1.76e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  84 IVSGPPSHSIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAII 163
Cdd:COG0156   23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 164 YSYGFATIASAIPAYSKRGDIVFADRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156  103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 242 IVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGInIDDIDLISANMENSLASIGGFCCGR 321
Cdd:COG0156  171 IVTDGVFSMDGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAGS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 322 SFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKvVGESFSPALHLQLees 401
Cdd:COG0156  250 KELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIV--- 324

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149758041 402 tgsreKDIKLLQEIVNQCMSRSIALTQARYlekeekclppPS-------IRVVVTVEQTEEELERAAATIKEVAQA 470
Cdd:COG0156  325 -----GDAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 2.87e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.86  E-value: 2.87e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 178 YSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVAEGLYVNTGAICPL 257
Cdd:cd06454   81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGINIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454  152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 338 SASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKVVGESFSPALHLQLEestgsrekDIKLLQEIVN 417
Cdd:cd06454  231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGD--------DPAKAVAFSD 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 149758041 418 QCMSRSIALTQARY---LEKEEKclpppsIRVVVTVEQTEEELERAAATIKEV 467
Cdd:cd06454  302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 1.02e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 98.92  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041   98 KKCVNFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLARFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  170 TIASAIPAYSK-RGDIVFADRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  242 IVAEGLYVNTGAICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIdLISANMENSLASIG--- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLAEGPNL-LVVGSFSKAFGLAGwrv 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  316 GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKVVGeSFSPALH 395
Cdd:pfam00155 219 GYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFFL 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149758041  396 LQLeestGSREKDIKLLQEIVNQCmsrSIALTQARYLEKeekclpPPSIRVVVTVeQTEEELERAAATI 464
Cdd:pfam00155 297 LTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 1-472 1.14e-168

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 483.86  E-value: 1.14e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041   1 MATAAEQWVlvemvQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPL 69
Cdd:PLN02822   8 LVNAALERV-----TMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  70 VPPVPK----DHPALNYniVSGPpsHSIVvNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVH 145
Cdd:PLN02822  82 IPPITEemrpEPPVLES--AAGP--HTII-NGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVH 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 146 LDLEDRLARFMKTEEAIIYSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQE 225
Cdd:PLN02822 157 LDCETKIAKFLGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLT 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 226 IEDqknpRKARVTRRFIVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIDLISA 305
Cdd:PLN02822 237 AEN----KRKKKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 306 NMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGISGLKV 385
Cdd:PLN02822 313 AMGHALATEGGFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 386 VGESFSPALHLQLEESTGSREKDIKLLQEIVNQCM---SRSIALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAAA 462
Cdd:PLN02822 393 GSNTLSPIVFLHLEKSTGSAKEDLSLLEHIADRMLkedSVLVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASE 469

                        490
                 ....*....|
gi 149758041 463 TIKEVAQAVL 472
Cdd:PLN02822 470 SLKRVAASVL 479
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 101-472 1.46e-111

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 334.95  E-value: 1.46e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 101 VNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PLN03227   1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 181 RGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVAEGLYVNTGAICPLPEL 260
Cdd:PLN03227  81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 261 VKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGIN-IDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSA 339
Cdd:PLN03227 161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 340 SLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIS---------GLKVVGESFSPALHLQLEESTGSREKD-I 409
Cdd:PLN03227 241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149758041 410 KLLQEIVNQCMSRSIALTQAR-YLEKEEKCLPPPSIRVVVTVEQTEEELERAAATIKEVAQAVL 472
Cdd:PLN03227 321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAIL 384
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 1.76e-79

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 251.89  E-value: 1.76e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  84 IVSGPPSHSIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAII 163
Cdd:COG0156   23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 164 YSYGFATIASAIPAYSKRGDIVFADRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156  103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 242 IVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGInIDDIDLISANMENSLASIGGFCCGR 321
Cdd:COG0156  171 IVTDGVFSMDGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAGS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 322 SFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKvVGESFSPALHLQLees 401
Cdd:COG0156  250 KELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIV--- 324

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149758041 402 tgsreKDIKLLQEIVNQCMSRSIALTQARYlekeekclppPS-------IRVVVTVEQTEEELERAAATIKEVAQA 470
Cdd:COG0156  325 -----GDAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 2.87e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.86  E-value: 2.87e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 178 YSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVAEGLYVNTGAICPL 257
Cdd:cd06454   81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHFGINIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454  152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 338 SASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKVVGESFSPALHLQLEestgsrekDIKLLQEIVN 417
Cdd:cd06454  231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGD--------DPAKAVAFSD 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 149758041 418 QCMSRSIALTQARY---LEKEEKclpppsIRVVVTVEQTEEELERAAATIKEV 467
Cdd:cd06454  302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
PLN02483 PLN02483
serine palmitoyltransferase
 96-471 3.91e-56

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 193.83  E-value: 3.91e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  96 NGKKCVNFASFNFLGLLD-----NPRVkaaaLASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFAT 170
Cdd:PLN02483  98 KTRRCLNLGSYNYLGFAAadeycTPRV----IESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYAT 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 171 IASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQknPRKARVTRRFIV-AEGLYV 249
Cdd:PLN02483 174 NSTIIPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIViVEGIYS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 250 NTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIDLISANMENSLASIGGFCCGRSFVIDHQR 329
Cdd:PLN02483 252 MEGELCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLK 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 330 LSGQGYCFSASL-PPLLAAAAIEALNIMEE---NPGlfavlKEKCKRIHK-------ALQGIsGLKVVGESFSPALHLQL 398
Cdd:PLN02483 332 RTCPAHLYATSMsPPAVQQVISAIKVILGEdgtNRG-----AQKLAQIREnsnffrsELQKM-GFEVLGDNDSPVMPIML 405

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149758041 399 EESTG----SREkdikllqeivnqCMSRSIALTQARYlekeeKCLPP--PSIRVVVTVEQTEEELERAAATIKEVAQAV 471
Cdd:PLN02483 406 YNPAKipafSRE------------CLKQNVAVVVVGF-----PATPLllARARICISASHSREDLIKALEVISEVGDLV 467
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 84-468 5.79e-50

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 174.96  E-value: 5.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  84 IVSGPPSHSIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAII 163
Cdd:PRK05958  25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 164 YSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqeiedqknpRKARVTRRFIV 243
Cdd:PRK05958 105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 244 AEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGInIDDIDLIS-ANMENSLASIGGFCCGRS 322
Cdd:PRK05958 174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 323 FVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGISglKVVGESFSPALHLQLeest 402
Cdd:PRK05958 253 TLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPERRERLAALIARLRAGLRALG--FQLMDSQSAIQPLIV---- 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149758041 403 GSREKDIKLLQeivnQCMSRSIALTqarylekeekCLPPPS-------IRVVVTVEQTEEELERAAATIKEVA 468
Cdd:PRK05958 327 GDNERALALAA----ALQEQGFWVG----------AIRPPTvpagtsrLRITLTAAHTEADIDRLLEALAEAL 385
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 84-471 2.46e-47

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 168.07  E-value: 2.46e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  84 IVSGPPSHSIVVNGKKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAII 163
Cdd:PRK06939  28 ITSPQGADITVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDAIL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 164 YSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQeiedqknpRKARVTRRFIV 243
Cdd:PRK06939 108 YSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA--------KEAGARHKLIA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 244 AEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGInIDDIDLISANMENSLA-SIGGFCCGRS 322
Cdd:PRK06939 180 TDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGV-MDRVDIITGTLGKALGgASGGYTAGRK 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 323 FVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKalqgisGLKVVGESFSPALHLQLEEST 402
Cdd:PRK06939 259 EVIDWLRQRSRPYLFSNSLAPAIVAASIKVLELLEESDELRDRLWENARYFRE------GMTAAGFTLGPGEHPIIPVML 332

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149758041 403 GsrekDIKLLQEIVNQCMSRSIALT----------QARylekeekclpppsIRVVVTVEQTEEELERAAATIKEVAQAV 471
Cdd:PRK06939 333 G----DAKLAQEFADRLLEEGVYVIgfsfpvvpkgQAR-------------IRTQMSAAHTKEQLDRAIDAFEKVGKEL 394
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 98-343 2.24e-30

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 121.88  E-value: 2.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PRK13392  46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 178 YSKR--GDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKnprkarvtrrFIVAEGLYVNTGAIC 255
Cdd:PRK13392 126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 256 PLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGInIDDIDLISANMENSLASIGGFCCGRSFVIDHQRLSGQGY 335
Cdd:PRK13392 196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274


                 ....*...
gi 149758041 336 CFSASLPP 343
Cdd:PRK13392 275 IFTTALPP 282
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 1.02e-22

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 98.92  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041   98 KKCVNFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLARFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  170 TIASAIPAYSK-RGDIVFADRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  242 IVAEGLYVNTGAICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRGVTEHFGINIDDIdLISANMENSLASIG--- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDAVATRALLAEGPNL-LVVGSFSKAFGLAGwrv 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  316 GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGLFAVLKEKCKRIHKALQGIsGLKVVGeSFSPALH 395
Cdd:pfam00155 219 GYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFFL 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149758041  396 LQLeestGSREKDIKLLQEIVNQCmsrSIALTQARYLEKeekclpPPSIRVVVTVeQTEEELERAAATI 464
Cdd:pfam00155 297 LTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 98-459 9.50e-18

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 85.50  E-value: 9.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  98 KKCVNFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PLN02955 102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 178 YSKRGDIVFAD-------RAACF-------AIQKGLQ-ASR---SDIKLFKHNDMADLERLLKEQEIEdqknprkarvtR 239
Cdd:PLN02955 182 IGSVASLLAASgkplkneKVAIFsdalnhaSIIDGVRlAERqgnVEVFVYRHCDMYHLNSLLSSCKMK-----------R 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 240 RFIVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINiDDIDLISANMENSLASIGGF-- 317
Cdd:PLN02955 251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 318 CCGRSFVIDHQRlsGQGYCFSASLP-PLLAAAAIealnimeenpGLFAVLKEKCKRIH-----KALQGISGLKVVgesfS 391
Cdd:PLN02955 330 CSKKWKQLIQSR--GRSFIFSTAIPvPMAAAAYA----------AVVVARKEKWRRKAiwervKEFKALSGVDIS----S 393

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149758041 392 PALHLQLeestGSREKdikllqeivnqcmsrsiALTQARYLEK--------EEKCLPPPS--IRVVVTVEQTEEELER 459
Cdd:PLN02955 394 PIISLVV----GNQEK-----------------ALKASRYLLKsgfhvmaiRPPTVPPNScrLRVTLSAAHTTEDVKK 450
PRK07505 PRK07505
hypothetical protein; Provisional
 97-317 7.49e-17

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 82.33  E-value: 7.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  97 GKKCVNFASFNFLGLLDNPRVKAAALASLKKYGV-GTCGPRGFYgTFDVHLDLEDRLARFMKTEEAIIYSYGFAT----- 170
Cdd:PRK07505  45 GHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGASVLTFTSCSAAHlgilp 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 171 -IASAIPAYSKRGDIVFaDRAA--CFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEiedqknprkarvtRRFIVAEGL 247
Cdd:PRK07505 124 lLASGHLTGGVPPHMVF-DKNAhaSLNILKGICADETEVETIDHNDLDALEDICKTNK-------------TVAYVADGV 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149758041 248 YvNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRG-VTEHFGINIDDIDLISANMENSLASIGGF 317
Cdd:PRK07505 190 Y-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKAFGASGGV 259
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
84-343 2.99e-16

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 80.44  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041  84 IVSG--PPSHSIVvngkkcvnFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEA 161
Cdd:PRK07179  46 LVLGktPGPDAII--------LQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESC 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 162 IIYSYGFATIASAIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqeiedqknprkarvtRRF 241
Cdd:PRK07179 118 LLCQSGWAANVGLLQTIADPNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQI-----------------ERH 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 242 ----IVAEGLYVNTGAICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGINiDDIDLISANMENSLASIGGF 317
Cdd:PRK07179 181 gpgiIVVDSVYSTTGTIAPLADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRAGI 259

                        250       260
                 ....*....|....*....|....*.
gi 149758041 318 CCGRSFVIDHQRLSGQGYCFSASLPP 343
Cdd:PRK07179 260 ITCPRELAEYVPFVSYPAIFSSTLLP 285
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 101-294 2.43e-15

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 77.51  E-value: 2.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 101 VNFASFNFLGLLDNPRVKAAALASLKKY-------GVGTCGPRGFYGTFDVHLDLEDRLARFMKTEEAIIYSYGFATIAS 173
Cdd:PRK05937   7 IDFVTNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149758041 174 AIPAYSKRGDIVFADRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQeiedqknpRKARVTRRFIVAEGLYVNTGA 253
Cdd:PRK05937  87 LCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLESC--------RQRSFGRIFIFVCSVYSFKGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 149758041 254 ICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFG 294
Cdd:PRK05937 159 LAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGFCHSLG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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