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Conserved domains on  [gi|1830856279|ref|XP_001353881|]
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insulin-like growth factor-binding protein complex acid labile subunit [Drosophila pseudoobscura]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-376 8.90e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 8.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  52 LASLQDLSDVGAENWHSLAVRNERTELALDSDTSVEYLANLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCglgelhg 131
Cdd:COG4886    34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 132 SHFAVESALQHLDASHNRLELLTKDvLGNLRKLIYANFSHNALT--GCELPHLPLLNRLDLSHNRLVNV--SFGVCPQLQ 207
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTdlPEPLGNLTNLKSLDLSNNQLTDLpeELGNLTNLK 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 208 QLLLHENRLAQLDvSAFRGLHGLLELQLSGNRLNCIAQEtFLPLNQLRVLNLSHNALDALrPSVFGAAqnfvlNLQQLDL 287
Cdd:COG4886   186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL-PELGNLT-----NLEELDL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 288 AGNHIRLLFDNQFrvLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSLEYF 367
Cdd:COG4886   258 SNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335


                  ....*....
gi 1830856279 368 EEQAFGGNT 376
Cdd:COG4886   336 TLTTLALSL 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
281-484 1.52e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 281 NLQQLDLAGNhirllfdNQFRVLPRLQALDLSRNSIASLSSgHFVGLGSLRKLYLQSNDILEIkPGAFAALANLDTLDLS 360
Cdd:COG4886    97 NLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 361 RNSLEYFEEQAFGgntLTRLRKLNLNANRLKLLhPLAFSSLPFLEYLSLGHNELRSLDVRmFAPMRHLQKLHLGHNLLEE 440
Cdd:COG4886   168 NNQLTDLPEELGN---LTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1830856279 441 IgpDVMDCLSSVMELLIDNNKLTFLVALNDtFPSLNRIAIEGNP 484
Cdd:COG4886   243 L--PELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-376 8.90e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 8.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  52 LASLQDLSDVGAENWHSLAVRNERTELALDSDTSVEYLANLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCglgelhg 131
Cdd:COG4886    34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 132 SHFAVESALQHLDASHNRLELLTKDvLGNLRKLIYANFSHNALT--GCELPHLPLLNRLDLSHNRLVNV--SFGVCPQLQ 207
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTdlPEPLGNLTNLKSLDLSNNQLTDLpeELGNLTNLK 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 208 QLLLHENRLAQLDvSAFRGLHGLLELQLSGNRLNCIAQEtFLPLNQLRVLNLSHNALDALrPSVFGAAqnfvlNLQQLDL 287
Cdd:COG4886   186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL-PELGNLT-----NLEELDL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 288 AGNHIRLLFDNQFrvLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSLEYF 367
Cdd:COG4886   258 SNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335


                  ....*....
gi 1830856279 368 EEQAFGGNT 376
Cdd:COG4886   336 TLTTLALSL 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
281-484 1.52e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 281 NLQQLDLAGNhirllfdNQFRVLPRLQALDLSRNSIASLSSgHFVGLGSLRKLYLQSNDILEIkPGAFAALANLDTLDLS 360
Cdd:COG4886    97 NLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 361 RNSLEYFEEQAFGgntLTRLRKLNLNANRLKLLhPLAFSSLPFLEYLSLGHNELRSLDVRmFAPMRHLQKLHLGHNLLEE 440
Cdd:COG4886   168 NNQLTDLPEELGN---LTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1830856279 441 IgpDVMDCLSSVMELLIDNNKLTFLVALNDtFPSLNRIAIEGNP 484
Cdd:COG4886   243 L--PELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-487 3.20e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 3.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  88 YLANLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCGL-GELHGShFAVESALQHLDASHNRLELLTKDVLGNLRKLIY 166
Cdd:PLN00113  138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLvGKIPNS-LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 167 ANFSHNALTGcELPH----LPLLNRLDLSHNRL---VNVSFGVCPQLQQLLLHENRLA-QLDVSAFrGLHGLLELQLSGN 238
Cdd:PLN00113  217 IYLGYNNLSG-EIPYeiggLTSLNHLDLVYNNLtgpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDN 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 239 RLNCIAQETFLPLNQLRVLNLSHNALDALRPsvfgAAQNFVLNLQQLDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIAS 318
Cdd:PLN00113  295 SLSGEIPELVIQLQNLEILHLFSNNFTGKIP----VALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTG 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 319 ------LSSGHFVGL------------------GSLRKLYLQSNDILEIKPGAFAAL----------------------- 351
Cdd:PLN00113  371 eipeglCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSGELPSEFTKLplvyfldisnnnlqgrinsrkwd 450

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 352 -ANLDTLDLSRNSLEYFEEQAFGGNtltRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELR--------------S 416
Cdd:PLN00113  451 mPSLQMLSLARNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgeipdelssckklvS 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 417 LDVRM----------FAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVMELLIDNNKLTFLVALNDTFPSLNRIAIEGNPWQ 486
Cdd:PLN00113  528 LDLSHnqlsgqipasFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607


                  .
gi 1830856279 487 C 487
Cdd:PLN00113  608 C 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-388 3.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 3.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 200 FGVCPQLQQLLLHENRLAQLDvsAFRGLHGLLELQLSGNRLNCIaqETFLPLNQLRVLNLSHNA------LDALRpsvfg 273
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRisvvegLENLT----- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 274 aaqnfvlNLQQLDLagnhirllfDNQfrVLPRLQALDLSRNSIASLSsghfvglGSLRKLYLQSNDILEIKPgaFAALAN 353
Cdd:cd21340    91 -------NLEELHI---------ENQ--RLPPGEKLTFDPRSLAALS-------NSLRVLNISGNNIDSLEP--LAPLRN 143

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1830856279 354 LDTLDLSRNSLEYFEEQAFGGNTLTRLRKLNLNAN 388
Cdd:cd21340   144 LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
378-438 3.19e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.19e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 378 TRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLL 438
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
204-264 1.89e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.89e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 204 PQLQQLLLHENRLAQLDVSAFRGLHGLLELQLSGNRLNCIAQETFLPLNQLRVLNLSHNAL 264
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 354-438 2.42e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 354 LDTLDLSRNSLeyfeeQAFGGNTLTRLRKL---NLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQK 430
Cdd:PLN03150  420 IDGLGLDNQGL-----RGFIPNDISKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI 494


                  ....*...
gi 1830856279 431 LHLGHNLL 438
Cdd:PLN03150  495 LNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 327-462 3.81e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 327 LGSLRKLYLQSNDILEIkpGAFAALANLDTLDLSRNSLEYFEeqafggntltrlrklNLNanrlkllhplafsSLPFLEY 406
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE---------------NLE-------------FLTNLTH 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830856279 407 LSLGHNELRSLDvrMFAPMRHLQKLHLGHNLLEEI-GpdvMDCLSSVMELLIDNNKL 462
Cdd:cd21340    51 LYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVeG---LENLTNLEELHIENQRL 102
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-376 8.90e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 8.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  52 LASLQDLSDVGAENWHSLAVRNERTELALDSDTSVEYLANLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCglgelhg 131
Cdd:COG4886    34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 132 SHFAVESALQHLDASHNRLELLTKDvLGNLRKLIYANFSHNALT--GCELPHLPLLNRLDLSHNRLVNV--SFGVCPQLQ 207
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTdlPEPLGNLTNLKSLDLSNNQLTDLpeELGNLTNLK 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 208 QLLLHENRLAQLDvSAFRGLHGLLELQLSGNRLNCIAQEtFLPLNQLRVLNLSHNALDALrPSVFGAAqnfvlNLQQLDL 287
Cdd:COG4886   186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL-PELGNLT-----NLEELDL 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 288 AGNHIRLLFDNQFrvLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSLEYF 367
Cdd:COG4886   258 SNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335


                  ....*....
gi 1830856279 368 EEQAFGGNT 376
Cdd:COG4886   336 TLTTLALSL 344
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-418 1.08e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 150 LELLTKDVLGNLRKLIYANFSHNAltgcELPHLPLLNRLDLSHNRLVN--VSFGVCPQLQQLLLHENRLAQLDvSAFRGL 227
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDLP-EPLGNL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 228 HGLLELQLSGNRLNCIAQEtFLPLNQLRVLNLSHNALDALrPSVFGAAQNfvlnLQQLDLAGNHIRLLfDNQFRVLPRLQ 307
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTN----LEELDLSGNQLTDL-PEPLANLTNLE 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 308 ALDLSRNSIASLSSghFVGLGSLRKLYLQSNDILEIKPgaFAALANLDTLDLSRNSLEYFEEQAFGGNTLTRLRKLNLNA 387
Cdd:COG4886   232 TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1830856279 388 NRLKLLHPLAFSSLPFLEYLSLGHNELRSLD 418
Cdd:COG4886   308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
137-478 6.48e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 6.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 137 ESALQHLDASHNRLELLTKDVLGNLRKLIYANFSHNALTGCELPHLPLLNRLDLSHNRlvnvSFGVCPQLQQLLLHENRL 216
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 217 AQLDVSaFRGLHGLLELQLSGNRLNCIAqETFLPLNQLRVLNLSHNALDALRPSVFGAAqnfvlNLQQLDLAGNHIRLLf 296
Cdd:COG4886   126 TDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLT-----NLKELDLSNNQITDL- 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 297 DNQFRVLPRLQALDLSRNSIASLSSGhFVGLGSLRKLYLQSNDILEIKpgAFAALANLDTLDLSRNSLEYFEEQAfggnT 376
Cdd:COG4886   198 PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA----N 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 377 LTRLRKLNLNANRLK--LLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVME 454
Cdd:COG4886   271 LTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                         330       340
                  ....*....|....*....|....
gi 1830856279 455 LLIDNNKLTFLVALNDTFPSLNRI 478
Cdd:COG4886   351 TLLLLLNLLSLLLTLLLTLGLLGL 374
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
281-484 1.52e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 281 NLQQLDLAGNhirllfdNQFRVLPRLQALDLSRNSIASLSSgHFVGLGSLRKLYLQSNDILEIkPGAFAALANLDTLDLS 360
Cdd:COG4886    97 NLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 361 RNSLEYFEEQAFGgntLTRLRKLNLNANRLKLLhPLAFSSLPFLEYLSLGHNELRSLDVRmFAPMRHLQKLHLGHNLLEE 440
Cdd:COG4886   168 NNQLTDLPEELGN---LTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTD 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1830856279 441 IgpDVMDCLSSVMELLIDNNKLTFLVALNDtFPSLNRIAIEGNP 484
Cdd:COG4886   243 L--PELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-487 3.20e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 3.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  88 YLANLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCGL-GELHGShFAVESALQHLDASHNRLELLTKDVLGNLRKLIY 166
Cdd:PLN00113  138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLvGKIPNS-LTNLTSLEFLTLASNQLVGQIPRELGQMKSLKW 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 167 ANFSHNALTGcELPH----LPLLNRLDLSHNRL---VNVSFGVCPQLQQLLLHENRLA-QLDVSAFrGLHGLLELQLSGN 238
Cdd:PLN00113  217 IYLGYNNLSG-EIPYeiggLTSLNHLDLVYNNLtgpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDN 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 239 RLNCIAQETFLPLNQLRVLNLSHNALDALRPsvfgAAQNFVLNLQQLDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIAS 318
Cdd:PLN00113  295 SLSGEIPELVIQLQNLEILHLFSNNFTGKIP----VALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTG 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 319 ------LSSGHFVGL------------------GSLRKLYLQSNDILEIKPGAFAAL----------------------- 351
Cdd:PLN00113  371 eipeglCSSGNLFKLilfsnslegeipkslgacRSLRRVRLQDNSFSGELPSEFTKLplvyfldisnnnlqgrinsrkwd 450

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 352 -ANLDTLDLSRNSLEYFEEQAFGGNtltRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELR--------------S 416
Cdd:PLN00113  451 mPSLQMLSLARNKFFGGLPDSFGSK---RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgeipdelssckklvS 527

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 417 LDVRM----------FAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVMELLIDNNKLTFLVALNDTFPSLNRIAIEGNPWQ 486
Cdd:PLN00113  528 LDLSHnqlsgqipasFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607


                  .
gi 1830856279 487 C 487
Cdd:PLN00113  608 C 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-388 3.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.27  E-value: 3.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 200 FGVCPQLQQLLLHENRLAQLDvsAFRGLHGLLELQLSGNRLNCIaqETFLPLNQLRVLNLSHNA------LDALRpsvfg 273
Cdd:cd21340    20 LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRisvvegLENLT----- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 274 aaqnfvlNLQQLDLagnhirllfDNQfrVLPRLQALDLSRNSIASLSsghfvglGSLRKLYLQSNDILEIKPgaFAALAN 353
Cdd:cd21340    91 -------NLEELHI---------ENQ--RLPPGEKLTFDPRSLAALS-------NSLRVLNISGNNIDSLEP--LAPLRN 143

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1830856279 354 LDTLDLSRNSLEYFEEQAFGGNTLTRLRKLNLNAN 388
Cdd:cd21340   144 LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
378-438 3.19e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.19e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 378 TRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLL 438
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
204-264 1.89e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.89e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 204 PQLQQLLLHENRLAQLDVSAFRGLHGLLELQLSGNRLNCIAQETFLPLNQLRVLNLSHNAL 264
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
329-390 1.89e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.89e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830856279 329 SLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSLEYFEEQAFGGntLTRLRKLNLNANRL 390
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG--LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
281-340 4.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 4.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 281 NLQQLDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDI 340
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 285-463 7.19e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 7.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 285 LDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIA-SLSSGHFVGLGSLRKLYLQSNDILEIKPGAFaaLANLDTLDLSRNS 363
Cdd:PLN00113   74 IDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 364 LEYFEEQAFGgnTLTRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLLEEIGP 443
Cdd:PLN00113  152 LSGEIPNDIG--SFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIP 229

                         170       180
                  ....*....|....*....|
gi 1830856279 444 DVMDCLSSVMELLIDNNKLT 463
Cdd:PLN00113  230 YEIGGLTSLNHLDLVYNNLT 249
LRR_8 pfam13855
Leucine rich repeat;
304-364 1.18e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.18e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 304 PRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSL 364
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 285-455 1.15e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 285 LDLAGNHIRLLFDnqFRVLPRLQALDLSRNSIASLSsghfvGLGSLRKL---YLQSNDILEIKPgaFAALANLDTLDLSR 361
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE-----NLEFLTNLthlYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 362 NSLEYFEeqafGGNTLTRLRKLNLNANRLKLLHPLAF------SSLPFLEYLSLGHNELRSLDvrMFAPMRHLQKLHLGH 435
Cdd:cd21340    78 NRISVVE----GLENLTNLEELHIENQRLPPGEKLTFdprslaALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASN 151

                         170       180
                  ....*....|....*....|
gi 1830856279 436 NLLEEIGpDVMDCLSSVMEL 455
Cdd:cd21340   152 NQISDLE-ELLDLLSSWPSL 170
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 222-463 4.43e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 222 SAFRGLHGLLELQLSGNRLNC-IAQETFLPLNQLRVLNLSHNALDALRPSvfgaaqNFVLNLQQLDLAGNHIRLLFDNQF 300
Cdd:PLN00113   87 SAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPR------GSIPNLETLDLSNNMLSGEIPNDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 301 RVLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDILEIKPGAFAALANLDTLDLSRNSLEYFEEQAFGGntLTRL 380
Cdd:PLN00113  161 GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG--LTSL 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 381 RKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVMELLIDNN 460
Cdd:PLN00113  239 NHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318


                  ...
gi 1830856279 461 KLT 463
Cdd:PLN00113  319 NFT 321
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 179-320 7.22e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 7.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 179 LPHLPLLNRLDLSHNRLVNVS-FGVCPQLQQLLLHENRLAQldVSAFRGLHGLLELQLSGNRLNCIAQETFLP------L 251
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIEnLENLVNLKKLYLGGNRISV--VEGLENLTNLEELHIENQRLPPGEKLTFDPrslaalS 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 252 NQLRVLNLSHNALDALRPsvfgaAQNFVlNLQQLDLAGNHIRLL--FDNQFRVLPRLQALDLSRNSIASLS 320
Cdd:cd21340   120 NSLRVLNISGNNIDSLEP-----LAPLR-NLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-298 8.24e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 8.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  85 SVEYLANLVELDLSAVQQLNLHTQgFSLLPNLRHLNISGCGLGELHGShFAVESALQHLDASHNRLELLtkDVLGNLRKL 164
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNL 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 165 IYANFSHNALTGC-ELPHLPLLNRLDLSHNRLVNVSFGVCPQLQQLLLHENRLAQLDVSAFRGLHGLLELQLSGNRLNCI 243
Cdd:COG4886   253 EELDLSNNQLTDLpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1830856279 244 AQETFLPLNQLRVLNLSHNALDALRPSVFGAAQNFVLNLQQLDLAGNHIRLLFDN 298
Cdd:COG4886   333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387
LRR_8 pfam13855
Leucine rich repeat;
404-462 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.40e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1830856279 404 LEYLSLGHNELRSLDVRMFAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVMELLIDNNKL 462
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
353-414 3.84e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.84e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1830856279 353 NLDTLDLSRNSLEYFEEQAFGGntLTRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNEL 414
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG--LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 181-463 8.00e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 8.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 181 HLPLLNRLDLSHNRLvnvSFGVcPQlqqlllhenrlaqldvSAFRGLHGLLELQLSGNRLNCIAQETFLPLnqLRVLNLS 260
Cdd:PLN00113   91 RLPYIQTINLSNNQL---SGPI-PD----------------DIFTTSSSLRYLNLSNNNFTGSIPRGSIPN--LETLDLS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 261 HNALDALRPSVFGaaqnFVLNLQQLDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIASLSSGHFVGLGSLRKLYLQSNDI 340
Cdd:PLN00113  149 NNMLSGEIPNDIG----SFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 341 LEIKPGAFAALANLDTLDLSRNSLEYFEEQAFGgnTLTRLRKLNLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVR 420
Cdd:PLN00113  225 SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLG--NLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE 302

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1830856279 421 MFAPMRHLQKLHLGHNLLEEIGPDVMDCLSSVMELLIDNNKLT 463
Cdd:PLN00113  303 LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS 345
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
148-319 9.13e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 9.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 148 NRLELLTKDVLGNLRKLiYANfsHNALTG-------------------CELP-HLP-LLNRLDLSHNRLVNVSFGVCPQL 206
Cdd:PRK15370  209 NELKSLPENLQGNIKTL-YAN--SNQLTSipatlpdtiqemelsinriTELPeRLPsALQSLDLFHNKISCLPENLPEEL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 207 QQLLLHENRLAQLDVsafrglH---GLLELQLSGNRLNCIAQEtfLPLNqLRVLNLSHNALDALRPSVFGAaqnfvlnLQ 283
Cdd:PRK15370  286 RYLSVYDNSIRTLPA------HlpsGITHLNVQSNSLTALPET--LPPG-LKTLEAGENALTSLPASLPPE-------LQ 349

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1830856279 284 QLDLAGNHIRLLFDNqfrVLPRLQALDLSRNSIASL 319
Cdd:PRK15370  350 VLDVSKNQITVLPET---LPPTITTLDVSRNALTNL 382
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-340 1.77e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 107 TQGFSLLPNLRHLNISGCGLGELHGShfAVESALQHlDASHNRLELLTKDVLGNLRKLiyanfshnALTGCELPHLPLLN 186
Cdd:cd00116    16 TELLPKLLCLQVLRLEGNTLGEEAAK--ALASALRP-QPSLKELCLSLNETGRIPRGL--------QSLLQGLTKGCGLQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 187 RLDLSHNRLVNVSFGV------CPQLQQLLLHENRLAQ--LDVSAfRGL----HGLLELQLSGNRLN---CIAQETFLPL 251
Cdd:cd00116    85 ELDLSDNALGPDGCGVlesllrSSSLQELKLNNNGLGDrgLRLLA-KGLkdlpPALEKLVLGRNRLEgasCEALAKALRA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 252 NQ-LRVLNLSHNAL-DALRPSVFGAAQNFVlNLQQLDLAGNHIRLLFDNQ----FRVLPRLQALDLSRNSIAS-----LS 320
Cdd:cd00116   164 NRdLKELNLANNGIgDAGIRALAEGLKANC-NLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDagaaaLA 242

                         250       260
                  ....*....|....*....|
gi 1830856279 321 SGHFVGLGSLRKLYLQSNDI 340
Cdd:cd00116   243 SALLSPNISLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
229-292 2.55e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1830856279 229 GLLELQLSGNRLNCIAQETFLPLNQLRVLNLSHNALDALRPSVFgaaQNFVlNLQQLDLAGNHI 292
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-292 2.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 2.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 140 LQHLDASHNRLElltkdVLGNLRkliyanfshnaltgcelpHLPLLNRLDLSHNRLVNVS-FGVCPQLQQLLLHENRLAQ 218
Cdd:cd21340    48 LTHLYLQNNQIE-----KIENLE------------------NLVNLKKLYLGGNRISVVEgLENLTNLEELHIENQRLPP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 219 LDVSAF--RGLHGLLE----LQLSGNRLNCIAQetFLPLNQLRVLNLSHNALDALRpSVFGAAQNFVlNLQQLDLAGNHI 292
Cdd:cd21340   105 GEKLTFdpRSLAALSNslrvLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLE-ELLDLLSSWP-SLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-175 2.99e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  87 EYLANLVELDLSAvQQLNLHTQ-------GFSLLPNLRHLNISGCGLGELHGshFAVESALQHLDASHNRLELLT--KDV 157
Cdd:cd21340    87 ENLTNLEELHIEN-QRLPPGEKltfdprsLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDL 163

                          90
                  ....*....|....*...
gi 1830856279 158 LGNLRKLIYANFSHNALT 175
Cdd:cd21340   164 LSSWPSLRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
183-240 2.00e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.00e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 183 PLLNRLDLSHNRLVNV---SFGVCPQLQQLLLHENRLAQLDVSAFRGLHGLLELQLSGNRL 240
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddgAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 248-442 3.04e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 248 FLPLNQLRVLNLSHNALDALRPSVFGAAQNfVLNLQQLDLAGN-----HIRLLFDNQFRVLPRLQALDLSRNSIASLS-- 320
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLGRNRLEGASce 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 321 --SGHFVGLGSLRKLYLQSNDILEikPG------AFAALANLDTLDLSRNSLEYFEEQAFGGntltrlrklnlnanrlkl 392
Cdd:cd00116   156 alAKALRANRDLKELNLANNGIGD--AGiralaeGLKANCNLEVLDLNNNGLTDEGASALAE------------------ 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1830856279 393 lhplAFSSLPFLEYLSLGHNELRSLDVR-----MFAPMRHLQKLHLGHNLLEEIG 442
Cdd:cd00116   216 ----TLASLKSLEVLNLGDNNLTDAGAAalasaLLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
114-174 2.71e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1830856279 114 PNLRHLNISGCGLGELHGSHFAVESALQHLDASHNRLELLTKDVLGNLRKLIYANFSHNAL 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 285-402 4.44e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 285 LDLAGNHIRLLFDNQFRVLPRLQALDLSRNSIASlssghfvglgslrklylqsndilEIkPGAFAALANLDTLDLSRNSL 364
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRG-----------------------NI-PPSLGSITSLEVLDLSYNSF 478

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1830856279 365 EYFEEQAFGgnTLTRLRKLNLNANRLKLLHPLAFSSLP 402
Cdd:PLN03150  479 NGSIPESLG--QLTSLRILNLNGNSLSGRVPAALGGRL 514
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 109-193 1.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 109 GFSLLPNLRHLNIS------GCGLGELHGSHFAVESALQHLDASHNRLELLTKdvLGNLRKLIYANFSHNALTGCE---- 178
Cdd:cd21340    85 GLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelld 162

                          90
                  ....*....|....*.
gi 1830856279 179 -LPHLPLLNRLDLSHN 193
Cdd:cd21340   163 lLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 354-438 2.42e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 354 LDTLDLSRNSLeyfeeQAFGGNTLTRLRKL---NLNANRLKLLHPLAFSSLPFLEYLSLGHNELRSLDVRMFAPMRHLQK 430
Cdd:PLN03150  420 IDGLGLDNQGL-----RGFIPNDISKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI 494


                  ....*...
gi 1830856279 431 LHLGHNLL 438
Cdd:PLN03150  495 LNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 327-462 3.81e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 327 LGSLRKLYLQSNDILEIkpGAFAALANLDTLDLSRNSLEYFEeqafggntltrlrklNLNanrlkllhplafsSLPFLEY 406
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE---------------NLE-------------FLTNLTH 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1830856279 407 LSLGHNELRSLDvrMFAPMRHLQKLHLGHNLLEEI-GpdvMDCLSSVMELLIDNNKL 462
Cdd:cd21340    51 LYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVeG---LENLTNLEELHIENQRL 102
LRR_8 pfam13855
Leucine rich repeat;
91-150 4.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279  91 NLVELDLSAVQQLNLHTQGFSLLPNLRHLNISGCGLGELHGSHFAVESALQHLDASHNRL 150
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 187-390 5.21e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 187 RLDLSHNRLVNVSFgvcPQLQQLLLHENRLAQLDVSAFRGLHGLLELQLSGNRLNCIAQETFLPLNQLRVLNLSHNALDA 266
Cdd:COG5238   118 DLRRIMAKTLEDSL---ILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGD 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 267 LRPSVFGAAQNFVLNLQQLDLAGNHIRLL----FDNQFRVLPRLQALDLSRNSIaslSSGHFVGLGSlrklYLQSNDile 342
Cdd:COG5238   195 EGIEELAEALTQNTTVTTLWLKRNPIGDEgaeiLAEALKGNKSLTTLDLSNNQI---GDEGVIALAE----ALKNNT--- 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1830856279 343 ikpgafaalaNLDTLDLSRNSLEyfEEQAFGGNTL----TRLRKLNLNANRL 390
Cdd:COG5238   265 ----------TVETLYLSGNQIG--AEGAIALAKAlqgnTTLTSLDLSVNRI 304
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 314-405 5.25e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 314 NSIASLSSGHFVGLgSLRKLYLQSNdILEIKPGAFAALANLDTLDLSrNSLEYFEEQAFGGntlTRLRKLNLNANrLKLL 393
Cdd:pfam13306  43 SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAFSN---CSLKSITIPSS-VTTI 115

                          90
                  ....*....|..
gi 1830856279 394 HPLAFSSLPFLE 405
Cdd:pfam13306 116 GSYAFSNCSNLK 127
PLN03150 PLN03150
hypothetical protein; Provisional
 100-180 6.45e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1830856279 100 VQQLNLHTQGF-SLLPN----LRHL---NISGCGL-GELHGShFAVESALQHLDASHNRLELLTKDVLGNLRKLIYANFS 170
Cdd:PLN03150  420 IDGLGLDNQGLrGFIPNdiskLRHLqsiNLSGNSIrGNIPPS-LGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                          90
                  ....*....|
gi 1830856279 171 HNALTGcELP 180
Cdd:PLN03150  499 GNSLSG-RVP 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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