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Conserved domains on  [gi|124806693|ref|XP_001350799|]
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polyadenylation factor subunit 2, putative [Plasmodium falciparum 3D7]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-386 1.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  89 IVSLKWFNDGKRLLTGTQLSELCIWNgsYFNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVIL--SSALNLLdnY 166
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLwdLETGECV--R 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 167 AFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKCKnidTNNISCLAWNPINDIVASGNRTHTISFWDI 246
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 247 RMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYkndQIQNNKFTSnyeptyIAWNPiQNHIF 326
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVNS------VAFSP-DGYLL 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 327 SSADNKGNIKFYSTNDNKCIQTIvSAHGidnkiSSISLLDWNPLGHILTSFGDDKLLKFW 386
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTL-SGHT-----NSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-386 1.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  89 IVSLKWFNDGKRLLTGTQLSELCIWNgsYFNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVIL--SSALNLLdnY 166
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLwdLETGECV--R 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 167 AFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKCKnidTNNISCLAWNPINDIVASGNRTHTISFWDI 246
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 247 RMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYkndQIQNNKFTSnyeptyIAWNPiQNHIF 326
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVNS------VAFSP-DGYLL 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 327 SSADNKGNIKFYSTNDNKCIQTIvSAHGidnkiSSISLLDWNPLGHILTSFGDDKLLKFW 386
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTL-SGHT-----NSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
82-386 6.44e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 6.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  82 LNKSKGMIVSLKWFNDGKRLLTGTQLSELCIWNGSyfNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVILSSALN 161
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 162 LLDNYAFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKcknIDTNNISCLAWNPINDIVASGNRTHTI 241
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT---GHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 242 SFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYKNdqiqnnkftSNYEPTYIAWNPI 321
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---------HTGAVRSVAFSPD 341

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124806693 322 QNHIFSSADNkGNIKFYSTNDNKCIQTIvSAHgiDNKISSISlldWNPLGHILTSFGDDKLLKFW 386
Cdd:COG2319  342 GKTLASGSDD-GTVRLWDLATGELLRTL-TGH--TGAVTSVA---FSPDGRTLASGSADGTVRLW 399
PTZ00420 PTZ00420
coronin; Provisional
 217-292 3.21e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 217 TNNISCLAWNP-INDIVASGNRTHTISFWDIRMNK--------PIISLNSHKANVNKIKWNNNGIYLLSCSK-DSLIKLW 286
Cdd:PTZ00420  74 TSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIW 153


                 ....*.
gi 124806693 287 DIRNFK 292
Cdd:PTZ00420 154 DIENEK 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-287 1.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124806693   250 KPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWD 287
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-287 4.18e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124806693  249 NKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWD 287
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-386 1.01e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.00  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  89 IVSLKWFNDGKRLLTGTQLSELCIWNgsYFNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVIL--SSALNLLdnY 166
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLwdLETGECV--R 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 167 AFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKCKnidTNNISCLAWNPINDIVASGNRTHTISFWDI 246
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH---TDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 247 RMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYkndQIQNNKFTSnyeptyIAWNPiQNHIF 326
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL---RGHENGVNS------VAFSP-DGYLL 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 327 SSADNKGNIKFYSTNDNKCIQTIvSAHGidnkiSSISLLDWNPLGHILTSFGDDKLLKFW 386
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTL-SGHT-----NSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-386 4.97e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.68  E-value: 4.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 131 GSVSCLEWS-KNDNLFAGNSLGQIVILSSALNLLDnYAFEGLTKNVLDISLSCCNTKLAGCAD--TCnpIIWDIKTRKVI 207
Cdd:cd00200   10 GGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSdkTI--RLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 208 KDLKCkniDTNNISCLAWNPINDIVASGNRTHTISFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWD 287
Cdd:cd00200   87 RTLTG---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 288 IRNFKLLYSYK--NDQIQNnkftsnyeptyIAWNPIQNHIFSSADNkGNIKFYSTNDNKCIQTIVSaHgiDNKISSislL 365
Cdd:cd00200  164 LRTGKCVATLTghTGEVNS-----------VAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRG-H--ENGVNS---V 225

                        250       260
                 ....*....|....*....|.
gi 124806693 366 DWNPLGHILTSFGDDKLLKFW 386
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
82-386 6.44e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 6.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  82 LNKSKGMIVSLKWFNDGKRLLTGTQLSELCIWNGSyfNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVILSSALN 161
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 162 LLDNYAFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKcknIDTNNISCLAWNPINDIVASGNRTHTI 241
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT---GHSGSVRSVAFSPDGRLLASGSADGTV 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 242 SFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYKNdqiqnnkftSNYEPTYIAWNPI 321
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---------HTGAVRSVAFSPD 341

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124806693 322 QNHIFSSADNkGNIKFYSTNDNKCIQTIvSAHgiDNKISSISlldWNPLGHILTSFGDDKLLKFW 386
Cdd:COG2319  342 GKTLASGSDD-GTVRLWDLATGELLRTL-TGH--TGAVTSVA---FSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-386 8.98e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 8.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 217 TNNISCLAWNPINDIVASGNRTHTISFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYS 296
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 297 YKNDQIqnnkftsnyEPTYIAWNPiQNHIFSSADNKGNIKFYSTNDNKCIQTIvSAHGidnkiSSISLLDWNPLGHILTS 376
Cdd:cd00200   89 LTGHTS---------YVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTL-RGHT-----DWVNSVAFSPDGTFVAS 152

                        170
                 ....*....|
gi 124806693 377 FGDDKLLKFW 386
Cdd:cd00200  153 SSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
129-386 3.01e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 3.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 129 GGGSVSCLEWSKNDNLFAGNSLGQIVILSSALNLLDNYAFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIK 208
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 209 DLKcknIDTNNISCLAWNPINDIVASGNRTHTISFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDI 288
Cdd:COG2319  115 TLT---GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 289 RNFKLLYSYKNDQiqnNKFTSnyeptyIAWNPiQNHIFSSADNKGNIKFYSTNDNKCIQTIvsaHGIDNKISSISlldWN 368
Cdd:COG2319  192 ATGKLLRTLTGHT---GAVRS------VAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVA---FS 255

                        250
                 ....*....|....*...
gi 124806693 369 PLGHILTSFGDDKLLKFW 386
Cdd:COG2319  256 PDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
82-290 3.57e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 3.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693  82 LNKSKGMIVSLKWFNDGKRLLTGTQLSELCIWNGSyfNFEDMKRIPIGGGSVSCLEWSKNDNLFAGNSLGQIVILSSALN 161
Cdd:COG2319  200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 162 LLDNYAFEGLTKNVLDISLSCCNTKLAGCADTCNPIIWDIKTRKVIKDLKcknIDTNNISCLAWNPINDIVASGNRTHTI 241
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTV 354

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 124806693 242 SFWDIRMNKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRN 290
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 251-386 8.36e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 8.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 251 PIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWDIRNFKLLYSYKNDQIqnnkftsnyEPTYIAWNPIQNHIFSSAD 330
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---------PVRDVAASADGTYLASGSS 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124806693 331 NKgNIKFYSTNDNKCIQTIvsaHGIDNKISSislLDWNPLGHILTSFGDDKLLKFW 386
Cdd:cd00200   72 DK-TIRLWDLETGECVRTL---TGHTSYVSS---VAFSPDGRILSSSSRDKTIKVW 120
PTZ00420 PTZ00420
coronin; Provisional
 217-292 3.21e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 217 TNNISCLAWNP-INDIVASGNRTHTISFWDIRMNK--------PIISLNSHKANVNKIKWNNNGIYLLSCSK-DSLIKLW 286
Cdd:PTZ00420  74 TSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIW 153


                 ....*.
gi 124806693 287 DIRNFK 292
Cdd:PTZ00420 154 DIENEK 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-287 1.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 124806693   250 KPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWD 287
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
249-287 4.18e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.18e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124806693  249 NKPIISLNSHKANVNKIKWNNNGIYLLSCSKDSLIKLWD 287
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 198-346 8.87e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 8.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 198 IWDIKTRKVIKDLKCKnidTNNISCLAWNPINDIVASGNRTHTISFWDIRMNKPIISLNSHK-ANVNKIKW--NNNGIYL 274
Cdd:PTZ00421 152 VWDVERGKAVEVIKCH---SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsAKSQRCLWakRKDLIIT 228

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124806693 275 LSCSKDSL--IKLWDIRNFKLLYSYKN-DQiqnnkFTSNYEPTYiawNPIQNHIFSSADNKGNIKFYSTNDNKCI 346
Cdd:PTZ00421 229 LGCSKSQQrqIMLWDTRKMASPYSTVDlDQ-----SSALFIPFF---DEDTNLLYIGSKGEGNIRCFELMNERLT 295
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 205-386 1.96e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 40.84  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 205 KVIKDLKCKNIDTNN---------------ISCLAWNP-INDIVASGNRTHTISFWDIRMNKPIISLNSHKANVNKIKWN 268
Cdd:PLN00181 505 KKIKIFECESIIKDGrdihypvvelasrskLSGICWNSyIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS 584

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806693 269 NNGIYLL-SCSKDSLIKLWDIRnfkllysyKNDQIQNNKFTSNYEPTYIAWNPIQNHIFSSADNKgnIKFYSTNDNKC-I 346
Cdd:PLN00181 585 SADPTLLaSGSDDGSVKLWSIN--------QGVSIGTIKTKANICCVQFPSESGRSLAFGSADHK--VYYYDLRNPKLpL 654

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 124806693 347 QTIVSAHgidNKISSISLLDwnplGHILTSFGDDKLLKFW 386
Cdd:PLN00181 655 CTMIGHS---KTVSYVRFVD----SSTLVSSSTDNTLKLW 687
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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