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Conserved domains on  [gi|114558134|ref|XP_001145368|]
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syntaxin-binding protein 3 isoform X1 [Pan troglodytes]

Protein Classification

Sec1 family protein( domain architecture ID 10469995)

Sec1 family protein such as syntaxin-binding proteins, which participate in the regulation of synaptic vesicle docking and fusion, and vacuolar protein sorting-associated protein 33A/33B/45, which play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network

CATH:  3.40.50.1910
PubMed:  8769846|15642380
SCOP:  4002933

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
33-575 3.50e-139

Sec1 family;


:

Pssm-ID: 460020  Cd Length: 506  Bit Score: 414.03  E-value: 3.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134   33 KIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFaSKSENKYKAAYIYFTD 112
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADF-ISSRPKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  113 FCPDNLFNKIkASCSKSIRRCKEINISFIPHESQVYTLDVP--DAFYYCYSPDPgNAKGKDAIMETMADQIVTVCATLDE 190
Cdd:pfam00995  80 RLSRELLEGL-AEGDEVVKKVKEINLDFIPLESDLFSLNDPelPLYFPSYYLDL-NDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  191 NPGVRYKSkplDNASKLAQLVEKKLEDYykIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYK 270
Cdd:pfam00995 158 IPIIRYKG---PAAEMVAKKLADKLRDK--IDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNRV 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  271 YKTDG----KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKA---TEGKTSLSALTQLMKKMPHFRKQITK 343
Cdd:pfam00995 233 TLETGgkeeEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKEtrkTKGIASIADLKDFVAKLPELQEEKRK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  344 QVVHLNLAEDCMNKFK-LNIEKLCKTEQDLALGTDaegQKVKD-SMRVLLPvLLNKNHDNCDKIRAILLYIFSINGtTEE 421
Cdd:pfam00995 313 LSLHTNLAEELLKIIKkRKLDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENG-KSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  422 NLDRLIQNVkieneSDMIRNwsylgvpivpqsqqgkplrkdrsaeetfqlsrWTPFIKDIMEDAIDNRLDSKEWPYCSQC 501
Cdd:pfam00995 388 ELEDLKREL-----LQAIYG--------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPP 430
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114558134  502 PAVWNGSGAVSARQKPRANYL---EDRKNGSKLIVFVIGGITYSEMRCAYEVSQAHKsCEVIIGSTHVLTPKKLLDD 575
Cdd:pfam00995 431 DPLGADLSGSVSARSKSGASSggsRRSSFRQRVIVFVVGGVTYSEIRALRELAKKKN-KEIIIGSTSILNPNSFLES 506
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
33-575 3.50e-139

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 414.03  E-value: 3.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134   33 KIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFaSKSENKYKAAYIYFTD 112
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADF-ISSRPKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  113 FCPDNLFNKIkASCSKSIRRCKEINISFIPHESQVYTLDVP--DAFYYCYSPDPgNAKGKDAIMETMADQIVTVCATLDE 190
Cdd:pfam00995  80 RLSRELLEGL-AEGDEVVKKVKEINLDFIPLESDLFSLNDPelPLYFPSYYLDL-NDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  191 NPGVRYKSkplDNASKLAQLVEKKLEDYykIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYK 270
Cdd:pfam00995 158 IPIIRYKG---PAAEMVAKKLADKLRDK--IDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNRV 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  271 YKTDG----KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKA---TEGKTSLSALTQLMKKMPHFRKQITK 343
Cdd:pfam00995 233 TLETGgkeeEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKEtrkTKGIASIADLKDFVAKLPELQEEKRK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  344 QVVHLNLAEDCMNKFK-LNIEKLCKTEQDLALGTDaegQKVKD-SMRVLLPvLLNKNHDNCDKIRAILLYIFSINGtTEE 421
Cdd:pfam00995 313 LSLHTNLAEELLKIIKkRKLDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENG-KSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  422 NLDRLIQNVkieneSDMIRNwsylgvpivpqsqqgkplrkdrsaeetfqlsrWTPFIKDIMEDAIDNRLDSKEWPYCSQC 501
Cdd:pfam00995 388 ELEDLKREL-----LQAIYG--------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPP 430
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114558134  502 PAVWNGSGAVSARQKPRANYL---EDRKNGSKLIVFVIGGITYSEMRCAYEVSQAHKsCEVIIGSTHVLTPKKLLDD 575
Cdd:pfam00995 431 DPLGADLSGSVSARSKSGASSggsRRSSFRQRVIVFVVGGVTYSEIRALRELAKKKN-KEIIIGSTSILNPNSFLES 506
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
16-577 1.09e-69

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 235.78  E-value: 1.09e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  16 QKIKaTVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDF 95
Cdd:COG5158   10 NKIL-DEIFLVQPANIWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYFVRPTKENIDLILEDL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  96 ASKSEnkykaAYIYFTDFCPDNLFNKIKASCSKS-----IRRCKEINISFIPHESQVYTLDVPdaFYYCYSPDPGNAKGk 170
Cdd:COG5158   89 EQWDP-----FYLNYHISFLNTVTESLLELLAESgvfekILSVYEIYLDFFVLESDLFSLNLP--ESFLESSLPSTTEA- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 171 daiMETMADQIVTVCATLDENPGVRYKSKPldNASKLAQLVEKKLEDYYKID-EKSLIKGKTHSQLLIIDRGFDPVSTVL 249
Cdd:COG5158  161 ---LIKIVNGLFSLCVSLGRIPIIRYSGGK--NAEHMAKKLSDEIRNELSINfDGVVSKNPLRPILIILDRSLDPITPLL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 250 HELTFQAMAYDLLPIEN---DTYKYKTDGKEKEAILEEEDD-LWVRIRHRHIAVVLEEIPKLMKEISS--TKKATEGKTS 323
Cdd:COG5158  236 HQWTYQAMLHDLLGINNnivTIPSSSVNGPEKKFSLSDKDDpFWNDNKFLNFGEVGEKLKKLAKELKTkaQLRHKENAKS 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 324 LSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFK-LNIEKLCKTEQDLalgtdAEGQKVKDSMRVLLPVLLNKNHDNc 402
Cdd:COG5158  316 VNDIKEFVDKLPELQKRSRSLNKHLTLASELLKVVEeRYLDDFSEIEQNL-----STGNDVKSDISDLIELLESGVEED- 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 403 DKIR-AILLYIFSINGTTEENLDRLI--QNVKIENESdMIRNWSYLGVPIVPQSQQGKPLRKDRSA----EETFQLSRWT 475
Cdd:COG5158  390 DKLRlLILYSLTKDGLIKDIDELRLLriQGYGIEALN-FFQRLKELGFLTLKDSKTISLKRGDKDSlfqwFNTYSLSREH 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 476 --------------PFIKDIMEDAIDNRLDSKEWPYCSQcpavwngsGAVSARQK--PRANYLEDRkngSKLIVFVIGGI 539
Cdd:COG5158  469 qgvpdlenvysgliPLKKDIPIDLLVRRLFEPLKSSQQQ--------SLRLSRPKgrSRSNKKIPQ---QRILVFVIGGV 537
                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 114558134 540 TYSEMRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIK 577
Cdd:COG5158  538 TYEELRVLYELNESQNSVRIIYGSTEILTPAEFLDEVK 575
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
33-575 3.50e-139

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 414.03  E-value: 3.50e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134   33 KIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFaSKSENKYKAAYIYFTD 112
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADF-ISSRPKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  113 FCPDNLFNKIkASCSKSIRRCKEINISFIPHESQVYTLDVP--DAFYYCYSPDPgNAKGKDAIMETMADQIVTVCATLDE 190
Cdd:pfam00995  80 RLSRELLEGL-AEGDEVVKKVKEINLDFIPLESDLFSLNDPelPLYFPSYYLDL-NDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  191 NPGVRYKSkplDNASKLAQLVEKKLEDYykIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYK 270
Cdd:pfam00995 158 IPIIRYKG---PAAEMVAKKLADKLRDK--IDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNRV 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  271 YKTDG----KEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKA---TEGKTSLSALTQLMKKMPHFRKQITK 343
Cdd:pfam00995 233 TLETGgkeeEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKNKEtrkTKGIASIADLKDFVAKLPELQEEKRK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  344 QVVHLNLAEDCMNKFK-LNIEKLCKTEQDLALGTDaegQKVKD-SMRVLLPvLLNKNHDNCDKIRAILLYIFSINGtTEE 421
Cdd:pfam00995 313 LSLHTNLAEELLKIIKkRKLDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENG-KSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  422 NLDRLIQNVkieneSDMIRNwsylgvpivpqsqqgkplrkdrsaeetfqlsrWTPFIKDIMEDAIDNRLDSKEWPYCSQC 501
Cdd:pfam00995 388 ELEDLKREL-----LQAIYG--------------------------------YVPLLTRLVEALIKGGLLSSEFPSLKPP 430
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114558134  502 PAVWNGSGAVSARQKPRANYL---EDRKNGSKLIVFVIGGITYSEMRCAYEVSQAHKsCEVIIGSTHVLTPKKLLDD 575
Cdd:pfam00995 431 DPLGADLSGSVSARSKSGASSggsRRSSFRQRVIVFVVGGVTYSEIRALRELAKKKN-KEIIIGSTSILNPNSFLES 506
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
16-577 1.09e-69

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 235.78  E-value: 1.09e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  16 QKIKaTVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDF 95
Cdd:COG5158   10 NKIL-DEIFLVQPANIWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYFVRPTKENIDLILEDL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134  96 ASKSEnkykaAYIYFTDFCPDNLFNKIKASCSKS-----IRRCKEINISFIPHESQVYTLDVPdaFYYCYSPDPGNAKGk 170
Cdd:COG5158   89 EQWDP-----FYLNYHISFLNTVTESLLELLAESgvfekILSVYEIYLDFFVLESDLFSLNLP--ESFLESSLPSTTEA- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 171 daiMETMADQIVTVCATLDENPGVRYKSKPldNASKLAQLVEKKLEDYYKID-EKSLIKGKTHSQLLIIDRGFDPVSTVL 249
Cdd:COG5158  161 ---LIKIVNGLFSLCVSLGRIPIIRYSGGK--NAEHMAKKLSDEIRNELSINfDGVVSKNPLRPILIILDRSLDPITPLL 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 250 HELTFQAMAYDLLPIEN---DTYKYKTDGKEKEAILEEEDD-LWVRIRHRHIAVVLEEIPKLMKEISS--TKKATEGKTS 323
Cdd:COG5158  236 HQWTYQAMLHDLLGINNnivTIPSSSVNGPEKKFSLSDKDDpFWNDNKFLNFGEVGEKLKKLAKELKTkaQLRHKENAKS 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 324 LSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFK-LNIEKLCKTEQDLalgtdAEGQKVKDSMRVLLPVLLNKNHDNc 402
Cdd:COG5158  316 VNDIKEFVDKLPELQKRSRSLNKHLTLASELLKVVEeRYLDDFSEIEQNL-----STGNDVKSDISDLIELLESGVEED- 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 403 DKIR-AILLYIFSINGTTEENLDRLI--QNVKIENESdMIRNWSYLGVPIVPQSQQGKPLRKDRSA----EETFQLSRWT 475
Cdd:COG5158  390 DKLRlLILYSLTKDGLIKDIDELRLLriQGYGIEALN-FFQRLKELGFLTLKDSKTISLKRGDKDSlfqwFNTYSLSREH 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114558134 476 --------------PFIKDIMEDAIDNRLDSKEWPYCSQcpavwngsGAVSARQK--PRANYLEDRkngSKLIVFVIGGI 539
Cdd:COG5158  469 qgvpdlenvysgliPLKKDIPIDLLVRRLFEPLKSSQQQ--------SLRLSRPKgrSRSNKKIPQ---QRILVFVIGGV 537
                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 114558134 540 TYSEMRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIK 577
Cdd:COG5158  538 TYEELRVLYELNESQNSVRIIYGSTEILTPAEFLDEVK 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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