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Conserved domains on  [gi|695635261|ref|WP_032612364|]
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glycosyltransferase family 2 protein [Leclercia adecarboxylata]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 10-227 1.65e-21

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd04186:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 166  Bit Score: 88.00  E-value: 1.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  10 ISIVSHGHDDMIRE--SGILEQVKNYKDVfLVVKNNKIHSSLN---ENDSECIYFINEHfNRGFGDNNNIVFNFCKNhln 84
Cdd:cd04186    1 IIIVNYNSLEYLKAclDSLLAQTYPDFEV-IVVDNASTDGSVEllrELFPEVRLIRNGE-NLGFGAGNNQGIREAKG--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  85 mkeeDYFIVLNPDVLIDLNDVIKLCDSMRQNNEKAAtinlykddlktvydnsirhfpkfkdfflsyLGFKnktiieksav 164
Cdd:cd04186   76 ----DYVLLLNPDTVVEPGALLELLDAAEQDPDVGI------------------------------VGPK---------- 111

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695635261 165 nnkcivdwAAGSFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHKA 227
Cdd:cd04186  112 --------VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYHHG 166
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-227 1.65e-21

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 88.00  E-value: 1.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  10 ISIVSHGHDDMIRE--SGILEQVKNYKDVfLVVKNNKIHSSLN---ENDSECIYFINEHfNRGFGDNNNIVFNFCKNhln 84
Cdd:cd04186    1 IIIVNYNSLEYLKAclDSLLAQTYPDFEV-IVVDNASTDGSVEllrELFPEVRLIRNGE-NLGFGAGNNQGIREAKG--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  85 mkeeDYFIVLNPDVLIDLNDVIKLCDSMRQNNEKAAtinlykddlktvydnsirhfpkfkdfflsyLGFKnktiieksav 164
Cdd:cd04186   76 ----DYVLLLNPDTVVEPGALLELLDAAEQDPDVGI------------------------------VGPK---------- 111

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695635261 165 nnkcivdwAAGSFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHKA 227
Cdd:cd04186  112 --------VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
7-252 1.07e-16

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 75.80  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261   7 KIFISIVSHGHDDMIRES--GILEQvkNYKDVFLVVKNNkiHSS------LNENDSECIYFINEHFNRGFGDNNNIVFNF 78
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCleSLLAQ--TYPPFEVIVVDN--GSTdgtaelLAALAFPRVRVIRNPENLGFAAARNLGLRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  79 CKNhlnmkeeDYFIVLNPDVLIDlndviklcdsmrqnnekaatinlykddlktvyDNSIRHfpkfkdfflsylgfknkti 158
Cdd:COG1216   80 AGG-------DYLLFLDDDTVVE--------------------------------PDWLER------------------- 101

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261 159 ieksavnnkcIVDWAagsFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHKaQHANRSLFSKH 238
Cdd:COG1216  102 ----------LLAAA---CLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAGYRIVYVPDAVVYHL-GGASSGPLLRA 167

                        250
                 ....*....|....
gi 695635261 239 FvWHVKSIIKYCAK 252
Cdd:COG1216  168 Y-YLGRNRLLFLRK 180
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 90-219 8.41e-03

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 36.16  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261   90 YFIVLNPDVLIDLNDVIKLCDSMRQNneKAATINLykddlKTVYDNSIRHFPKFKDFFLSYLGFKNKTiiekSAVNNKCI 169
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASP--EVAIIQG-----PILPMNVGNYLEELAALFFADDHGKSIP----VRMALGRV 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 695635261  170 VDWAaGSFLAFRADHYARLGGFDESFfmYCEDIDICFRSKAEGVALVYYP 219
Cdd:pfam13632  70 LPFV-GSGAFLRRSALQEVGGWDDGS--VSEDFDFGLRLQRAGYRVRFAP 116
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-227 1.65e-21

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 88.00  E-value: 1.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  10 ISIVSHGHDDMIRE--SGILEQVKNYKDVfLVVKNNKIHSSLN---ENDSECIYFINEHfNRGFGDNNNIVFNFCKNhln 84
Cdd:cd04186    1 IIIVNYNSLEYLKAclDSLLAQTYPDFEV-IVVDNASTDGSVEllrELFPEVRLIRNGE-NLGFGAGNNQGIREAKG--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  85 mkeeDYFIVLNPDVLIDLNDVIKLCDSMRQNNEKAAtinlykddlktvydnsirhfpkfkdfflsyLGFKnktiieksav 164
Cdd:cd04186   76 ----DYVLLLNPDTVVEPGALLELLDAAEQDPDVGI------------------------------VGPK---------- 111

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695635261 165 nnkcivdwAAGSFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHKA 227
Cdd:cd04186  112 --------VSGAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYHHG 166
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
7-252 1.07e-16

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 75.80  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261   7 KIFISIVSHGHDDMIRES--GILEQvkNYKDVFLVVKNNkiHSS------LNENDSECIYFINEHFNRGFGDNNNIVFNF 78
Cdd:COG1216    4 KVSVVIPTYNRPELLRRCleSLLAQ--TYPPFEVIVVDN--GSTdgtaelLAALAFPRVRVIRNPENLGFAAARNLGLRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  79 CKNhlnmkeeDYFIVLNPDVLIDlndviklcdsmrqnnekaatinlykddlktvyDNSIRHfpkfkdfflsylgfknkti 158
Cdd:COG1216   80 AGG-------DYLLFLDDDTVVE--------------------------------PDWLER------------------- 101

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261 159 ieksavnnkcIVDWAagsFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHKaQHANRSLFSKH 238
Cdd:COG1216  102 ----------LLAAA---CLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAGYRIVYVPDAVVYHL-GGASSGPLLRA 167

                        250
                 ....*....|....
gi 695635261 239 FvWHVKSIIKYCAK 252
Cdd:COG1216  168 Y-YLGRNRLLFLRK 180
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 173-241 1.90e-06

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 47.81  E-value: 1.90e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695635261 173 AAGSFLAFRADHYARLGGFDESffMYCEDIDICFRSKAEGVALVYYPTISAVHKAQHANRSLFSKHFVW 241
Cdd:COG1215  143 ASGANLAFRREALEEVGGFDED--TLGEDLDLSLRLLRAGYRIVYVPDAVVYEEAPETLRALFRQRRRW 209
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 24-226 4.03e-04

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 40.73  E-value: 4.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  24 SGILEQVKNYK---DVFLVVKNN--KIHSSLNENDSECIYFINEHFNRGFGDNNNIVFNFCKNhlnmKEEDYFIVLNPDV 98
Cdd:cd02526   11 SKLKELLAALAeqvDKVVVVDNSsgNDIELRLRLNSEKIELIHLGENLGIAKALNIGIKAALE----NGADYVLLFDQDS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261  99 LIDLNDVIKL--CDSMRQNNEKAATI-NLYKDDlktvYDNSIRHFPKFKDFFLSYLGFKNKTIIEksavnnkciVDWAAG 175
Cdd:cd02526   87 VPPPDMVEKLlaYKILSDKNSNIGAVgPRIIDR----RTGENSPGVRKSGYKLRIQKEGEEGLKE---------VDFLIT 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695635261 176 SFLAFRADHYARLGGFDESFFMYCEDIDICFRSKAEGVALVYYPTISAVHK 226
Cdd:cd02526  154 SGSLISLEALEKVGGFDEDLFIDYVDTEWCLRARSKGYKIYVVPDAVLKHE 204
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 178-212 2.19e-03

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 38.32  E-value: 2.19e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 695635261 178 LAFRADHYARLGGFDESFFMycEDIDICFRSKAEG 212
Cdd:cd02522  141 LFIRRELFEELGGFPELPLM--EDVELVRRLRRRG 173
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 177-257 3.62e-03

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 37.98  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261 177 FLAFRADHYARLGGFDESfFMYCEDIDICFRSKAEGVALVYYPTISAVHKAQHANRSLFSKHFvWHVKSIIKYCAKTKAF 256
Cdd:cd02525  160 HGAYRREVFEKVGGFDES-LVRNEDAELNYRLRKAGYKIWLSPDIRVYYYPRSTLKKLARQYF-RYGKWRARTLRKHRKS 237


                 .
gi 695635261 257 F 257
Cdd:cd02525  238 L 238
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 90-219 8.41e-03

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 36.16  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695635261   90 YFIVLNPDVLIDLNDVIKLCDSMRQNneKAATINLykddlKTVYDNSIRHFPKFKDFFLSYLGFKNKTiiekSAVNNKCI 169
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMASP--EVAIIQG-----PILPMNVGNYLEELAALFFADDHGKSIP----VRMALGRV 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 695635261  170 VDWAaGSFLAFRADHYARLGGFDESFfmYCEDIDICFRSKAEGVALVYYP 219
Cdd:pfam13632  70 LPFV-GSGAFLRRSALQEVGGWDDGS--VSEDFDFGLRLQRAGYRVRFAP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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