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Conserved domains on  [gi|504679959|ref|WP_014867061|]
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glycosyltransferase family 2 protein [Methanoculleus bourgensis]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135280)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 4-192 4.77e-46

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 151.57  E-value: 4.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDryesdlfPVIEKIAKT--HGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKA 81
Cdd:cd04179    1 VVIPAYNEEENIP-------ELVERLLAVleEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  82 GFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGlMEEVASMRLFFSQSVNFMYRILLRHPIT-CV 160
Cdd:cd04179   74 GFKAARGDIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRGG-GAGMPLLRRLGSRLFNFLIRLLLGVRISdTQ 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 504679959 161 SPiFRLYKAETLKKI--EIESENFEINAEIISKY 192
Cdd:cd04179  153 SG-FRLFRREVLEALlsLLESNGFEFGLELLVGA 185
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 4-192 4.77e-46

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 151.57  E-value: 4.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDryesdlfPVIEKIAKT--HGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKA 81
Cdd:cd04179    1 VVIPAYNEEENIP-------ELVERLLAVleEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  82 GFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGlMEEVASMRLFFSQSVNFMYRILLRHPIT-CV 160
Cdd:cd04179   74 GFKAARGDIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRGG-GAGMPLLRRLGSRLFNFLIRLLLGVRISdTQ 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 504679959 161 SPiFRLYKAETLKKI--EIESENFEINAEIISKY 192
Cdd:cd04179  153 SG-FRLFRREVLEALlsLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-220 1.58e-45

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 151.01  E-value: 1.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   1 MVSIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALK 80
Cdd:COG0463    3 LVSVVIPTYNEEEYLEE-------ALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGlmeeVASMRLFFSQSVNFMYRILLRHPITCV 160
Cdd:COG0463   76 AGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREG----ESDLRRLGSRLFNLVRLLTNLPDSTSG 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959 161 spiFRLYKAETLKKIEIEsENFEINAEIIsKYLIAGYKIQEVPVelhKRRYGESKINIRR 220
Cdd:COG0463  152 ---FRLFRREVLEELGFD-EGFLEDTELL-RALRHGFRIAEVPV---RYRAGESKLNLRD 203
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-174 9.64e-30

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 109.02  E-value: 9.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    3 SIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAG 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLE-------TLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   83 FAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYL-QSGLMEEVASMRLFFSQSVNFMYRILLRHPITCVS 161
Cdd:pfam00535  74 LRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYViFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153

                         170
                  ....*....|...
gi 504679959  162 PIFRLYKAETLKK 174
Cdd:pfam00535 154 GGFALYRREALEE 166
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 2-227 3.51e-28

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 107.09  E-value: 3.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVdryeSDLFPVIEKiAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDD--VVVLNHEKNQGMGVAL 79
Cdd:PLN02726  11 YSIIVPTYNERLNI----ALIVYLIFK-ALQDVKDFEIIVVDDGSPDGTQDVVKQLQKVYGEdrILLRPRPGKLGLGTAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  80 KAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGLMEEVASMRLFFSQSVNFMYRILLRHPITC 159
Cdd:PLN02726  86 IHGLKHASGDFVVIMDADLSHHPKYLPSFIKKQRETGADIVTGTRYVKGGGVHGWDLRRKLTSRGANVLAQTLLWPGVSD 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959 160 VSPIFRLYKAETLKKI--EIESENFEINAEIISKYLIAGYKIQEVPVELHKRRYGESKINIrREVINNLK 227
Cdd:PLN02726 166 LTGSFRLYKRSALEDLvsSVVSKGYVFQMEIIVRASRKGYRIEEVPITFVDRVYGESKLGG-SEIVQYLK 234
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 2-116 2.21e-07

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 49.82  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    2 VSIIIPLYNEEENVDRYESDLFPVIEkiakthgvTFDFIFINDGSKDRTLEKINAIAARrddvvVLNHEKnqGMGVALKA 81
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRG--------DAEVIVVDGGSTDGTVEIARSLGAK-----VIHSPK--GRARQMNA 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 504679959   82 GFAKASADLLITMDADLTFRPEDIPLLLEAYARDH 116
Cdd:TIGR04283  66 GAALAKGDILLFLHADTRLPKDFLEAIRRALAKPG 100
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 4-192 4.77e-46

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 151.57  E-value: 4.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDryesdlfPVIEKIAKT--HGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKA 81
Cdd:cd04179    1 VVIPAYNEEENIP-------ELVERLLAVleEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  82 GFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGlMEEVASMRLFFSQSVNFMYRILLRHPIT-CV 160
Cdd:cd04179   74 GFKAARGDIVVTMDADLQHPPEDIPKLLEKLLEGGADVVIGSRFVRGG-GAGMPLLRRLGSRLFNFLIRLLLGVRISdTQ 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 504679959 161 SPiFRLYKAETLKKI--EIESENFEINAEIISKY 192
Cdd:cd04179  153 SG-FRLFRREVLEALlsLLESNGFEFGLELLVGA 185
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-220 1.58e-45

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 151.01  E-value: 1.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   1 MVSIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALK 80
Cdd:COG0463    3 LVSVVIPTYNEEEYLEE-------ALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGlmeeVASMRLFFSQSVNFMYRILLRHPITCV 160
Cdd:COG0463   76 AGLAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREG----ESDLRRLGSRLFNLVRLLTNLPDSTSG 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959 161 spiFRLYKAETLKKIEIEsENFEINAEIIsKYLIAGYKIQEVPVelhKRRYGESKINIRR 220
Cdd:COG0463  152 ---FRLFRREVLEELGFD-EGFLEDTELL-RALRHGFRIAEVPV---RYRAGESKLNLRD 203
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 4-228 2.87e-45

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 150.76  E-value: 2.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDryesDLFPVIEKIAKthGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAGF 83
Cdd:cd06442    1 IIIPTYNERENIP----ELIERLDAALK--GIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  84 AKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGLMEEVASMRLFFSQSVNFMYRILLRHPITCVSPI 163
Cdd:cd06442   75 KAARGDVIVVMDADLSHPPEYIPELLEAQLEGGADLVIGSRYVEGGGVEGWGLKRKLISRGANLLARLLLGRKVSDPTSG 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 504679959 164 FRLYKAETLKKI--EIESENFEINAEIISKYLIAGYKIQEVPVELHKRRYGESKINIrREVINNLKM 228
Cdd:cd06442  155 FRAYRREVLEKLidSLVSKGYKFQLELLVRARRLGYRIVEVPITFVDREHGESKLGG-KEIVEYLKG 220
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 4-205 4.02e-33

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 119.21  E-value: 4.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEenvDRYESDLFPVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARR-DDVVVLNHEKNQGMGVALKAG 82
Cdd:cd04188    1 VVIPAYNEE---KRLPPTLEEAVEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKNpALIRVLTLPKNRGKGGAVRAG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  83 FAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGS-PYLQSGLMEEVASMRLFFSQSVNFMYRILLRHPIT--- 158
Cdd:cd04188   78 MLAARGDYILFADADLATPFEELEKLEEALKTSGYDIAIGSrAHLASAAVVKRSWLRNLLGRGFNFLVRLLLGLGIKdtq 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 504679959 159 CVspiFRLYKAETLKKI--EIESENFEINAEIISKYLIAGYKIQEVPVE 205
Cdd:cd04188  158 CG---FKLFTRDAARRLfpRLHLERWAFDVELLVLARRLGYPIEEVPVR 203
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 4-122 2.56e-31

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 113.73  E-value: 2.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDRyesdLFPVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAGF 83
Cdd:cd04187    1 IVVPVYNEEENLPE----LYERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRVKVIRLSRNFGQQAALLAGL 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 504679959  84 AKASADLLITMDADLTFRPEDIPLLLEAYARDHpDCVSG 122
Cdd:cd04187   77 DHARGDAVITMDADLQDPPELIPEMLAKWEEGY-DVVYG 114
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-174 9.64e-30

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 109.02  E-value: 9.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    3 SIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAG 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLE-------TLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   83 FAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYL-QSGLMEEVASMRLFFSQSVNFMYRILLRHPITCVS 161
Cdd:pfam00535  74 LRAATGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYViFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153

                         170
                  ....*....|...
gi 504679959  162 PIFRLYKAETLKK 174
Cdd:pfam00535 154 GGFALYRREALEE 166
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 2-227 3.51e-28

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 107.09  E-value: 3.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVdryeSDLFPVIEKiAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDD--VVVLNHEKNQGMGVAL 79
Cdd:PLN02726  11 YSIIVPTYNERLNI----ALIVYLIFK-ALQDVKDFEIIVVDDGSPDGTQDVVKQLQKVYGEdrILLRPRPGKLGLGTAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  80 KAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGLMEEVASMRLFFSQSVNFMYRILLRHPITC 159
Cdd:PLN02726  86 IHGLKHASGDFVVIMDADLSHHPKYLPSFIKKQRETGADIVTGTRYVKGGGVHGWDLRRKLTSRGANVLAQTLLWPGVSD 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959 160 VSPIFRLYKAETLKKI--EIESENFEINAEIISKYLIAGYKIQEVPVELHKRRYGESKINIrREVINNLK 227
Cdd:PLN02726 166 LTGSFRLYKRSALEDLvsSVVSKGYVFQMEIIVRASRKGYRIEEVPITFVDRVYGESKLGG-SEIVQYLK 234
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-124 1.94e-18

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 79.09  E-value: 1.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAGF 83
Cdd:cd00761    1 VIIPAYNEEPYLER-------CLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 504679959  84 AKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSP 124
Cdd:cd00761   74 KAARGEYILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-120 3.80e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 81.33  E-value: 3.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVDRyesdlfpVIEKIAKTH--GVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVAL 79
Cdd:COG1215   31 VSVIIPAYNEEAVIEE-------TLRSLLAQDypKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAAL 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 504679959  80 KAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCV 120
Cdd:COG1215  104 NAGLKAARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGAS 144
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 4-175 1.40e-16

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 74.96  E-value: 1.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDD-VVVLNHEKNQGMGVALKAG 82
Cdd:cd06423    1 IIVPAYNEEAVIER-------TIESLLALDYPKLEVIVVDDGSTDDTLEILEELAALYIRrVLVVRDKENGGKAGALNAG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  83 FAKASADLLITMDADLTFRPEDIPLLLEAYARDHP-DCVSGSPYLQSG---LMEEVASMRLFFSQSVNFMYRILLRHPIT 158
Cdd:cd06423   74 LRHAKGDIVVVLDADTILEPDALKRLVVPFFADPKvGAVQGRVRVRNGsenLLTRLQAIEYLSIFRLGRRAQSALGGVLV 153

                        170
                 ....*....|....*..
gi 504679959 159 CVSPIFrLYKAETLKKI 175
Cdd:cd06423  154 LSGAFG-AFRREALREV 169
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 2-110 4.46e-14

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 70.15  E-value: 4.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVdryeSDLFPVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVV---LNheKNQGMGVA 78
Cdd:PRK10714   8 VSVVIPVYNEQESL----PELIRRTTAACESLGKEYEILLIDDGSSDNSAEMLVEAAQAPDSHIVailLN--RNYGQHSA 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 504679959  79 LKAGFAKASADLLITMDADLTFRPEDIPLLLE 110
Cdd:PRK10714  82 IMAGFSHVTGDLIITLDADLQNPPEEIPRLVA 113
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-111 1.38e-13

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 67.33  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   1 MVSIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIaaRRDDVVVLNHEKNQGMGVALK 80
Cdd:COG1216    4 KVSVVIPTYNRPELLRR-------CLESLLAQTYPPFEVIVVDNGSTDGTAELLAAL--AFPRVRVIRNPENLGFAAARN 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEA 111
Cdd:COG1216   75 LGLRAAGGDYLLFLDDDTVVEPDWLERLLAA 105
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-118 4.57e-12

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 64.68  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   1 MVSIIIPLYNEEEnvdryesDLFPVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLnHEKNQGMGVALK 80
Cdd:PRK10073   7 KLSIIIPLYNAGK-------DFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLL-HQANAGVSVARN 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPD 118
Cdd:PRK10073  79 TGLAVATGKYVAFPDADDVVYPTMYETLMTMALEDDLD 116
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-123 3.47e-11

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 61.44  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVDR---------YESDLFPVIekiakthgvtfdfiFINDGSKDRTLEKINAIAARRddVVVLNHEKN 72
Cdd:cd06439   31 VTIIIPAYNEEAVIEAklenllaldYPRDRLEII--------------VVSDGSTDGTAEIAREYADKG--VKLLRFPER 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 504679959  73 QGMGVALKAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGS 123
Cdd:cd06439   95 RGKAAALNRALALATGEIVVFTDANALLDPDALRLLVRHFADPSVGAVSGE 145
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-199 3.99e-11

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 61.09  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVDRyesdlfpVIEKIAK--THGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEK-NQgmGVA 78
Cdd:cd02525    2 VSIIIPVRNEEKYIEE-------LLESLLNqsYPKDLIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPKrIQ--SAG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  79 LKAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQ-SGLMEEVASMRL--FFSqSVNFMYRiLLRH 155
Cdd:cd02525   73 LNIGIRNSRGDIIIRVDAHAVYPKDYILELVEALKRTGADNVGGPMETIgESKFQKAIAVAQssPLG-SGGSAYR-GGAV 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 504679959 156 PITCVSPI-FRLYKAETLKKIEIESENFEINAEIISKYLI--AGYKI 199
Cdd:cd02525  151 KIGYVDTVhHGAYRREVFEKVGGFDESLVRNEDAELNYRLrkAGYKI 197
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 3-239 6.86e-10

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 58.24  E-value: 6.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   3 SIIIPLYNEEENVDRYESDLFPVIE-KIAKTHGVTFDFIFINDGSKDRTLE--------KINAIAarrdDVVVLNHEKNQ 73
Cdd:PTZ00260  73 SIVIPAYNEEDRLPKMLKETIKYLEsRSRKDPKFKYEIIIVNDGSKDKTLKvakdfwrqNINPNI----DIRLLSLLRNK 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  74 GMGVALKAGFAKASADLLITMDADLTFRPEDIPLL---LEAYARDHPDCVSGSpylQSGLME-EVASMRLFFSQSVNFMY 149
Cdd:PTZ00260 149 GKGGAVRIGMLASRGKYILMVDADGATDIDDFDKLediMLKIEQNGLGIVFGS---RNHLVDsDVVAKRKWYRNILMYGF 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959 150 RILLRhpITCVSPI------FRLYKAETLKKI----EIESENFEINAEIISKYLiaGYKIQEVPVElhkrrYGE---SKI 216
Cdd:PTZ00260 226 HFIVN--TICGTNLkdtqcgFKLFTRETARIIfpslHLERWAFDIEIVMIAQKL--NLPIAEVPVN-----WTEvegSKL 296

                        250       260
                 ....*....|....*....|...
gi 504679959 217 NIrreVINNLKMMRKIARTKYFH 239
Cdd:PTZ00260 297 NV---ISASIQMARDILLVRSFY 316
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-160 1.31e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 56.53  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDRyesdLFPVIEKIAKTHGvTFDFIFINDGSKDRTLEKINAIAARRD-DVVVLN--HEKNQGMGVALK 80
Cdd:cd04192    1 VVIAARNEAENLPR----LLQSLSALDYPKE-KFEVILVDDHSTDGTVQILEFAAAKPNfQLKILNnsRVSISGKKNALT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSG--SPYLQSGLMEEVASMRlFFSQSVNFMYRILLRHPIT 158
Cdd:cd04192   76 TAIKAAKGDWIVTTDADCVVPSNWLLTFVAFIQKEQIGLVAGpvIYFKGKSLLAKFQRLD-WLSLLGLIAGSFGLGKPFM 154


                 ..
gi 504679959 159 CV 160
Cdd:cd04192  155 CN 156
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 2-117 3.09e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 52.57  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVdryeSDLFPVIEKIAkthGVTFDFIFINDGSKDRTLEkinaiAARRDDVVVLNHEKnqGMGVALKA 81
Cdd:cd02522    1 LSIIIPTLNEAENL----PRLLASLRRLN---PLPLEIIVVDGGSTDGTVA-----IARSAGVVVISSPK--GRARQMNA 66

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 504679959  82 GFAKASADLLITMDADlTFRPEDIPLLLEAYARDHP 117
Cdd:cd02522   67 GAAAARGDWLLFLHAD-TRLPPDWDAAIIETLRADG 101
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 1-204 4.85e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 51.99  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    1 MVSIIIPLYNEEenvdryeSDLFPVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDD--VVVLNHEKNQGMGV- 77
Cdd:pfam13641   3 DVSVVVPAFNED-------SVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAARFPDvrLRVIRNARLLGPTGk 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   78 --ALKAGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVSGSPYLQSGLMEEVASMRLFFSQsvNFMYRILLRH 155
Cdd:pfam13641  76 srGLNHGFRAVKSDLVVLHDDDSVLHPGTLKKYVQYFDSPKVGAVGTPVFSLNRSTMLSALGALEFAL--RHLRMMSLRL 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 504679959  156 P--ITCVSPIFRLYKAETLKKIEIESENFEINAEIISKY--LIAGYKIQEVPV 204
Cdd:pfam13641 154 AlgVLPLSGAGSAIRREVLKELGLFDPFFLLGDDKSLGRrlRRHGWRVAYAPD 206
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 2-116 2.21e-07

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 49.82  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    2 VSIIIPLYNEEENVDRYESDLFPVIEkiakthgvTFDFIFINDGSKDRTLEKINAIAARrddvvVLNHEKnqGMGVALKA 81
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRG--------DAEVIVVDGGSTDGTVEIARSLGAK-----VIHSPK--GRARQMNA 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 504679959   82 GFAKASADLLITMDADLTFRPEDIPLLLEAYARDH 116
Cdd:TIGR04283  66 GAALAKGDILLFLHADTRLPKDFLEAIRRALAKPG 100
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 2-109 7.28e-07

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 49.15  E-value: 7.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   2 VSIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTF--DFIFINDGSKDRTLEkiNAIAA-----RRDDVVVLnHEKNQG 74
Cdd:PRK13915  33 VSVVLPALNEEETVGK-------VVDSIRPLLMEPLvdELIVIDSGSTDATAE--RAAAAgarvvSREEILPE-LPPRPG 102

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 504679959  75 MGVALKAGFAKASADLLITMDADLT-FRPEDIPLLL 109
Cdd:PRK13915 103 KGEALWRSLAATTGDIVVFVDADLInFDPMFVPGLL 138
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 3-97 1.20e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 48.43  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959    3 SIIIPLYNEEENVDRYESdlfpvIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLN-HEKNQGMGVALKA 81
Cdd:pfam10111   1 SVVIPVYNGEKTHWIQER-----ILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLQVYYPNaPDTTYSLAASRNR 75

                          90
                  ....*....|....*.
gi 504679959   82 GFAKASADLLITMDAD 97
Cdd:pfam10111  76 GTSHAIGEYISFIDGD 91
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 4-122 1.44e-06

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 47.45  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   4 IIIPLYNEEENVDR-YESDLfpviekiAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDD----VVVLNHEKNQGMGVa 78
Cdd:cd06913    1 IILPVHNGEQWLDEcLESVL-------QQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDsgviVLVGSHNSPSPKGV- 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 504679959  79 lkaGFAK------ASADLLITMDADLTFRPEDIPLLLEAyARDHPDCVSG 122
Cdd:cd06913   73 ---GYAKnqaiaqSSGRYLCFLDSDDVMMPQRIRLQYEA-ALQHPNSIIG 118
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 3-119 9.44e-06

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 44.84  E-value: 9.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   3 SIIIPLYNEEENVDRyesdlfpVIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVlnhEKNQGMGVALKAG 82
Cdd:cd06433    1 SIITPTYNQAETLEE-------TIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKYEDKITYWIS---EPDKGIYDAMNKG 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 504679959  83 FAKASADLLITMDADLTFRPEDIpLLLEAYARDHPDC 119
Cdd:cd06433   71 IALATGDIIGFLNSDDTLLPGAL-LAVVAAFAEHPEV 106
GT_2_like_f cd04182
GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; ...
 52-120 1.84e-04

GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133025 [Multi-domain]  Cd Length: 186  Bit Score: 41.01  E-value: 1.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 504679959  52 EKINAIAARRDDVVVLNHEKNQGMGVALKAGFAKASAD---LLITMdADLTF-RPEDIPLLLEAYARDHPDCV 120
Cdd:cd04182   53 DAVRAALAGLPVVVVINPDWEEGMSSSLAAGLEALPADadaVLILL-ADQPLvTAETLRALIDAFREDGAGIV 124
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 1-121 6.74e-04

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 39.96  E-value: 6.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   1 MVSIIIPLYNEEENVDRyesdlfpVIEKIAkthGVTFDFIFINDGSKDRTLEkinaIAARRDDVVVlnHEKNQGMGVALK 80
Cdd:cd02511    1 TLSVVIITKNEERNIER-------CLESVK---WAVDEIIVVDSGSTDRTVE----IAKEYGAKVY--QRWWDGFGAQRN 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 504679959  81 AGFAKASADLLITMDADLTFRPEDIPLLLEAYARDHPDCVS 121
Cdd:cd02511   65 FALELATNDWVLSLDADERLTPELADEILALLATDDYDGYY 105
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 3-103 1.01e-03

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 39.22  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959   3 SIIIPLYNEEENVDRYESdlfpvIEKIAKTHGVTFDFIFINDGSKDRTLEKINAIAARRDDVVVLNHEKNQGMGVALKAG 82
Cdd:cd04195    1 SVLMSVYIKEKPEFLREA-----LESILKQTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEG 75

                         90       100
                 ....*....|....*....|.
gi 504679959  83 FAKASADLLITMDADLTFRPE 103
Cdd:cd04195   76 LKHCTYDWVARMDTDDISLPD 96
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 18-113 8.63e-03

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 36.49  E-value: 8.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 504679959  18 YESDLFPVIEKIAKTHGVtFDFIFINDGSKDRTlekiNAIAAR--RDDVVVLNHEKNQGMGVALKAGFAKA---SADLLI 92
Cdd:cd02526    6 YNPDLSKLKELLAALAEQ-VDKVVVVDNSSGND----IELRLRlnSEKIELIHLGENLGIAKALNIGIKAAlenGADYVL 80

                         90       100
                 ....*....|....*....|.
gi 504679959  93 TMDADLTFRPEDIPLLLEAYA 113
Cdd:cd02526   81 LFDQDSVPPPDMVEKLLAYKI 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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