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Conserved domains on  [gi|503059928|ref|WP_013294904|]
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MULTISPECIES: DNA-binding protein Alba [Methanothermobacter]

Protein Classification

DNA-binding protein Alba( domain architecture ID 10012116)

DNA-binding protein Alba binds double-stranded DNA tightly but without sequence specificity and may play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04015 PRK04015
DNA/RNA-binding protein AlbA;
1-90 2.38e-46

DNA/RNA-binding protein AlbA;


:

Pssm-ID: 235199  Cd Length: 91  Bit Score: 143.18  E-value: 2.38e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928  1 MSEENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATN 80
Cdd:PRK04015  1 MAEENVVLVGKKPVMNYVLAVLTQFNQGAKEVVIKARGRAISKAVDVAEIVRNRFLPDVEIKEIKIGTEEVTSEDGRESN 80

                        90
                ....*....|
gi 503059928 81 VSAIEIQLRK 90
Cdd:PRK04015 81 VSTIEIVLEK 90
 
Name Accession Description Interval E-value
PRK04015 PRK04015
DNA/RNA-binding protein AlbA;
1-90 2.38e-46

DNA/RNA-binding protein AlbA;


Pssm-ID: 235199  Cd Length: 91  Bit Score: 143.18  E-value: 2.38e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928  1 MSEENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATN 80
Cdd:PRK04015  1 MAEENVVLVGKKPVMNYVLAVLTQFNQGAKEVVIKARGRAISKAVDVAEIVRNRFLPDVEIKEIKIGTEEVTSEDGRESN 80

                        90
                ....*....|
gi 503059928 81 VSAIEIQLRK 90
Cdd:PRK04015 81 VSTIEIVLEK 90
TIGR00285 TIGR00285
DNA-binding protein Alba; Alba has been shown to bind DNA and affect DNA supercoiling in a ...
 4-90 7.70e-43

DNA-binding protein Alba; Alba has been shown to bind DNA and affect DNA supercoiling in a temperature dependent manner. It is regulated by acetylation (alba = acetylation lowers binding affinity) by the Sir2 protein. Alba is proposed to play a role in establishment or maintenace of chromatin architecture and thereby in transcription repression. This protein appears so far only in the Archaea, but may be universal there. There is a single member in three of the first four completed archaeal genomes, and a second copy in A. fulgidus. In Sulfolobus shibatae there is a tandem second copy that is poorly conserved and scores below the trusted cutoff; all other members of the family are conserved at greater than 50 % pairwise identity. [DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 129386  Cd Length: 87  Bit Score: 134.19  E-value: 7.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928   4 ENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATNVSA 83
Cdd:TIGR00285  1 ENVVYIGNKPVMNYVLAVLTQLNSGADEVIIKARGRAISRAVDVAEIVRNRFIPDIKIKKIKIGTEEIKSEQGREVNVST 80


                 ....*..
gi 503059928  84 IEIQLRK 90
Cdd:TIGR00285 81 IEIVLAK 87
AlbA COG1581
DNA/RNA-binding protein AlbA/Ssh10b [Transcription];
4-90 2.05e-41

DNA/RNA-binding protein AlbA/Ssh10b [Transcription];


Pssm-ID: 441189  Cd Length: 87  Bit Score: 130.72  E-value: 2.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928  4 ENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATNVSA 83
Cdd:COG1581   1 ENVVFIGKKPVMNYVLAVLTQFNNGAKEVIIKARGRAISRAVDVAEIVRKRFLGGVKIKDIKIGSEELESEDGKTRNVST 80


                ....*..
gi 503059928 84 IEIQLRK 90
Cdd:COG1581  81 IEIVLAK 87
Alba pfam01918
Alba; Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.
 5-68 8.19e-19

Alba; Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.


Pssm-ID: 426509  Cd Length: 66  Bit Score: 72.63  E-value: 8.19e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503059928   5 NVVYIG-NKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDI-QIENIDICT 68
Cdd:pfam01918  1 NVIRVSkNKPIMNYVLRALKLLNGGADEVVIKALGRAISKAVSVAEILKRRFLKGLhQINKITSSS 66
 
Name Accession Description Interval E-value
PRK04015 PRK04015
DNA/RNA-binding protein AlbA;
1-90 2.38e-46

DNA/RNA-binding protein AlbA;


Pssm-ID: 235199  Cd Length: 91  Bit Score: 143.18  E-value: 2.38e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928  1 MSEENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATN 80
Cdd:PRK04015  1 MAEENVVLVGKKPVMNYVLAVLTQFNQGAKEVVIKARGRAISKAVDVAEIVRNRFLPDVEIKEIKIGTEEVTSEDGRESN 80

                        90
                ....*....|
gi 503059928 81 VSAIEIQLRK 90
Cdd:PRK04015 81 VSTIEIVLEK 90
TIGR00285 TIGR00285
DNA-binding protein Alba; Alba has been shown to bind DNA and affect DNA supercoiling in a ...
 4-90 7.70e-43

DNA-binding protein Alba; Alba has been shown to bind DNA and affect DNA supercoiling in a temperature dependent manner. It is regulated by acetylation (alba = acetylation lowers binding affinity) by the Sir2 protein. Alba is proposed to play a role in establishment or maintenace of chromatin architecture and thereby in transcription repression. This protein appears so far only in the Archaea, but may be universal there. There is a single member in three of the first four completed archaeal genomes, and a second copy in A. fulgidus. In Sulfolobus shibatae there is a tandem second copy that is poorly conserved and scores below the trusted cutoff; all other members of the family are conserved at greater than 50 % pairwise identity. [DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 129386  Cd Length: 87  Bit Score: 134.19  E-value: 7.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928   4 ENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATNVSA 83
Cdd:TIGR00285  1 ENVVYIGNKPVMNYVLAVLTQLNSGADEVIIKARGRAISRAVDVAEIVRNRFIPDIKIKKIKIGTEEIKSEQGREVNVST 80


                 ....*..
gi 503059928  84 IEIQLRK 90
Cdd:TIGR00285 81 IEIVLAK 87
AlbA COG1581
DNA/RNA-binding protein AlbA/Ssh10b [Transcription];
4-90 2.05e-41

DNA/RNA-binding protein AlbA/Ssh10b [Transcription];


Pssm-ID: 441189  Cd Length: 87  Bit Score: 130.72  E-value: 2.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503059928  4 ENVVYIGNKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDIQIENIDICTEEIIGNEGTATNVSA 83
Cdd:COG1581   1 ENVVFIGKKPVMNYVLAVLTQFNNGAKEVIIKARGRAISRAVDVAEIVRKRFLGGVKIKDIKIGSEELESEDGKTRNVST 80


                ....*..
gi 503059928 84 IEIQLRK 90
Cdd:COG1581  81 IEIVLAK 87
Alba pfam01918
Alba; Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.
 5-68 8.19e-19

Alba; Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.


Pssm-ID: 426509  Cd Length: 66  Bit Score: 72.63  E-value: 8.19e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503059928   5 NVVYIG-NKPVMNYVLAVVTQMNGGTSEVILKARGRAISRAVDVAEIVRNRFIPDI-QIENIDICT 68
Cdd:pfam01918  1 NVIRVSkNKPIMNYVLRALKLLNGGADEVVIKALGRAISKAVSVAEILKRRFLKGLhQINKITSSS 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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