NCBI Conserved Domain Search

Conserved domains on [gi|499238903|ref|WP_010936443|]

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bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase [Dehalococcoides mccartyi]

Protein Classification

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11415140)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH: 3.40.50.720|3.40.430.10

EC: 1.5.1.5|3.5.4.9

Gene Ontology: GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730

PubMed: 8485162

SCOP: 4000102

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-294

1.57e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 491.07 E-value: 1.57e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTcig 240
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRR----NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN--- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:COG0190  233 RVEDGK--LVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-294

1.57e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 491.07 E-value: 1.57e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTcig 240
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRR----NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN--- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:COG0190  233 RVEDGK--LVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284

PRK14190

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-294

3.22e-167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184560 [Multi-domain] Cd Length: 284 Bit Score: 464.87 E-value: 3.22e-167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKaKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14190   1 MMAVIIDGKEVAKEKREQLKEEVVKLK-EQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14190  80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIG 240
Cdd:PRK14190 160 HVVVVGRSNIVGKPVGQLLLNE----NATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLE 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPegkriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14190 236 NGK-----LCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAGGR 284

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-289

5.51e-89

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.

Pssm-ID: 133448 Cd Length: 168 Bit Score: 262.49 E-value: 5.51e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 116 PDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQkapgANATVTICHS 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLN----RNATVTVCHS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 196 GTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGytPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPM 275
Cdd:cd01080   77 KTKNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVP--DKSGGKLVGDVDFESAKEKASAITPVPGGVGPM 154

                        170
                 ....*....|....
gi 499238903 276 TIIMLMLNTLTAAK 289
Cdd:cd01080  155 TVAMLMKNTVEAAK 168

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

124-292

3.93e-88

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 259.71 E-value: 3.93e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  124 HPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLI 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA----NATVTVCHSKTKDLAEI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  204 TSQADILVSAMGKPKFITADMVRQGAVVIDVGTtcigyTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLN 283
Cdd:pfam02882  77 TREADIVVVAVGKPELIKADWIKPGAVVIDVGI-----NRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQN 151


                  ....*....
gi 499238903  284 TLTAAKRAA 292
Cdd:pfam02882 152 TVEAAKRQL 160

AlaDh_PNT_C

smart01002

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...

187-234

4.67e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.

Pssm-ID: 214966 [Multi-domain] Cd Length: 149 Bit Score: 39.80 E-value: 4.67e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 499238903   187 NATVTICHSGTKNLPLITSQADILVSAM-----GKPKFITADMVRQ---GAVVIDV 234
Cdd:smart01002  64 GARFTTLYSQAELLEEAVKEADLVIGAVlipgaKAPKLVTREMVKSmkpGSVIVDV 119

Name

Accession

Description

Interval

E-value

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-294

1.57e-177

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 491.07 E-value: 1.57e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAK-GITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTcig 240
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRR----NATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGIN--- 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:COG0190  233 RVEDGK--LVGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGL 284

PRK14190

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-294

3.22e-167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184560 [Multi-domain] Cd Length: 284 Bit Score: 464.87 E-value: 3.22e-167

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKaKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14190   1 MMAVIIDGKEVAKEKREQLKEEVVKLK-EQGIVPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14190  80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIG 240
Cdd:PRK14190 160 HVVVVGRSNIVGKPVGQLLLNE----NATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLE 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPegkriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14190 236 NGK-----LCGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAGGR 284

PRK14189

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

1-293

1.83e-131

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 184559 [Multi-domain] Cd Length: 285 Bit Score: 374.41 E-value: 1.83e-131

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14189   1 MTAQLIDGNALSKQLRAEAAQRAAALTAR-GHQPGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14189  80 ARIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIG 240
Cdd:PRK14189 160 HAVVIGRSNIVGKPMAMLLLQ----AGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVG---MN 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 241 YTPEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAG 293
Cdd:PRK14189 233 RDDAGK--LCGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAERAAA 283

PRK14188

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-294

9.44e-129

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184558 [Multi-domain] Cd Length: 296 Bit Score: 368.13 E-value: 9.44e-129

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14188   2 ATIIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14188  82 IARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLNA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLqkapGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGY- 241
Cdd:PRK14188 162 VVIGRSNLVGKPMAQLLL----AANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRIPAp 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 242 -TPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14188 238 eKGEGKTRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAACRAAGL 291

PRK14184

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-294

9.89e-122

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237635 [Multi-domain] Cd Length: 286 Bit Score: 349.84 E-value: 9.89e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   4 HIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLI 83
Cdd:PRK14184   2 LLLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  84 ARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVV 163
Cdd:PRK14184  82 AELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 164 IVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYTP 243
Cdd:PRK14184 162 VVGRSNIVGKPLALMLGAPGKFANATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVG---INRTD 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 499238903 244 EGkriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14184 239 DG---LVGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQSWKERVGL 286

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-288

8.19e-121

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 347.67 E-value: 8.19e-121

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIG 240
Cdd:PRK10792 161 NAVVVGASNIVGRPMSLELLL----AGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVG---IN 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499238903 241 YTPEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAA 288
Cdd:PRK10792 234 RLEDGK--LVGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQAC 279

PRK14168

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-294

2.14e-117

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237633 [Multi-domain] Cd Length: 297 Bit Score: 339.54 E-value: 2.14e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14168   1 MSAKIIKGTEIREEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLG--EPCFLPCTPHGVQELLIRSGIKIE 158
Cdd:PRK14168  81 ALIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMIGgdEVKFLPCTPAGIQEMLVRSGVETS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 159 GTHVVIVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTC 238
Cdd:PRK14168 161 GAEVVVVGRSNIVGKPIANMMTQKGPGANATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVNR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 499238903 239 IGYTPE-GKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14168 241 VGTNEStGKAILSGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKSAKFHLSL 297

PRK14191

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-289

2.10e-116

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172679 [Multi-domain] Cd Length: 285 Bit Score: 336.35 E-value: 2.10e-116

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14191   3 LLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLIK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14191  83 DLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYTPE 244
Cdd:PRK14191 163 IGASNIVGKPLAMLMLN----AGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIG---INRLND 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499238903 245 GKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14191 236 GR--LVGDVDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAE 278

PRK14174

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-294

4.43e-115

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172662 [Multi-domain] Cd Length: 295 Bit Score: 333.32 E-value: 4.43e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14174   3 IIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLG--EPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14174  83 DLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLVMGhlDKCFVSCTPYGILELLGRYNIETKGKHC 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCI--G 240
Cdd:PRK14174 163 VVVGRSNIVGKPMANLMLQKLKESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGINRIedP 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 YTPEGKRiLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14174 243 STKSGYR-LVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQSFERVNNL 295

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-293

1.64e-114

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 331.59 E-value: 1.64e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAALKEK-GITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14193  80 AVIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKAPgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIG 240
Cdd:PRK14193 160 HVVVIGRGVTVGRPIGLLLTRRSE--NATVTLCHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 241 ytpEGKriLSGDVDfEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAG 293
Cdd:PRK14193 238 ---DGK--LVGDVH-PDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAERRAG 284

PRK14167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

3-294

4.49e-114

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184549 [Multi-domain] Cd Length: 297 Bit Score: 330.97 E-value: 4.49e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALkAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14167   2 TEIIDGNAVAAQIRDDLTDAIETL-EDAGVTPGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14167  81 IDELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGYT 242
Cdd:PRK14167 161 VVVGRSDIVGKPMANLLIQKADGGNATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRVDAD 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499238903 243 PEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14167 241 TEKGYELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAASLQEGV 292

PRK14186

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-294

3.44e-110

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237636 [Multi-domain] Cd Length: 297 Bit Score: 320.86 E-value: 3.44e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14186   2 ALILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14186  82 IAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGyT 242
Cdd:PRK14186 162 VVVGRSILVGKPLALMLLA----ANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRLP-S 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499238903 243 PEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14186 237 SDGKTRLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLSWQKRHGL 288

PRK14179

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

3-290

3.19e-109

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 237634 [Multi-domain] Cd Length: 284 Bit Score: 318.23 E-value: 3.19e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14179   2 TEIIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14179  82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYT 242
Cdd:PRK14179 162 VVIGRSNIVGKPMAQLLLDK----NATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVG---MNRD 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499238903 243 PEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKR 290
Cdd:PRK14179 235 ENGK--LIGDVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAALR 280

PRK14173

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-293

1.29e-106

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184551 [Multi-domain] Cd Length: 287 Bit Score: 311.76 E-value: 1.29e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAkhgiVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14173   1 MAARELSGPPAAEAVYAELRARLAKLPF----VPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14173  77 ELIARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLqkapGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIG 240
Cdd:PRK14173 157 EVVVVGRSNIVGKPLAALLL----REDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRVG 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 241 yTPEGKRILSGDVDFEaVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAG 293
Cdd:PRK14173 233 -GNGGRDILTGDVHPE-VAEVAGALTPVPGGVGPMTVAMLMANTVIAALRRRG 283

PRK14176

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-292

3.73e-106

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184553 [Multi-domain] Cd Length: 287 Bit Score: 310.58 E-value: 3.73e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14176  10 IIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14176  90 SLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAVI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTcigyTPE 244
Cdd:PRK14176 170 VGHSNVVGKPMAAMLLNR----NATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGIT----KEE 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499238903 245 GKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAA 292
Cdd:PRK14176 242 DK--VYGDVDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEKSL 287

PRK14175

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-296

4.95e-104

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184552 [Multi-domain] Cd Length: 286 Bit Score: 304.92 E-value: 4.95e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14175   1 MVAKILDGKQIAKDYRQGLQDQVEALKEK-GFTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14175  80 NELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTtcig 240
Cdd:PRK14175 160 NAVVIGRSHIVGQPVSKLLLQ----KNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGN---- 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 499238903 241 yTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGLVK 296
Cdd:PRK14175 232 -TPDENGKLKGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLAEKMRRGIDS 286

PRK14183

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-292

5.11e-100

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184555 [Multi-domain] Cd Length: 281 Bit Score: 294.81 E-value: 5.11e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14183   3 ILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14183  83 MMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVCV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYTPE 244
Cdd:PRK14183 163 VGASNIVGKPMAALLLN----ANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIG---INRTED 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499238903 245 GKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAA 292
Cdd:PRK14183 236 GR--LVGDVDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKAAKNRA 281

PRK14185

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-291

6.98e-100

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184556 [Multi-domain] Cd Length: 293 Bit Score: 294.81 E-value: 6.98e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14185   3 LIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKVR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14185  83 ELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCI--GYT 242
Cdd:PRK14185 163 LGRSNIVGKPMAQLMMQKAYPGDCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVpdATR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 499238903 243 PEGKRiLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRA 291
Cdd:PRK14185 243 KSGFK-LTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLAGKKA 290

PRK14172

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-289

1.62e-98

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172660 [Multi-domain] Cd Length: 278 Bit Score: 290.53 E-value: 1.62e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14172   4 IINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEIE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14172  84 ELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVVV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIgytpE 244
Cdd:PRK14172 164 IGRSNIVGKPVAQLLLNE----NATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSV----N 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499238903 245 GKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14172 236 GK--ITGDVNFDKVIDKASYITPVPGGVGSLTTTLLIKNVCEALK 278

PRK14194

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-292

1.78e-97

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172682 [Multi-domain] Cd Length: 301 Bit Score: 289.05 E-value: 1.78e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14194   2 MSAKLIDGKAAAARVLAQVREDVRTLKAA-GIEPALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14194  81 ALIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIg 240
Cdd:PRK14194 161 HAVVIGRSNIVGKPMAALLLQ----AHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRI- 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 499238903 241 yTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAA 292
Cdd:PRK14194 236 -DDDGRSRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286

PLN02516

methylenetetrahydrofolate dehydrogenase (NADP+)

3-291

7.91e-97

methylenetetrahydrofolate dehydrogenase (NADP+)

Pssm-ID: 178131 [Multi-domain] Cd Length: 299 Bit Score: 287.17 E-value: 7.91e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PLN02516   9 AQIIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELISK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLG--EPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PLN02516  89 VHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKgrEPLFLPCTPKGCLELLSRSGIPIKGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIG 240
Cdd:PLN02516 169 KAVVVGRSNIVGLPVSLLLLK----ADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNAVS 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 241 --YTPEGKRILsGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRA 291
Cdd:PLN02516 245 dpSKKSGYRLV-GDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTVDGAKRV 296

PLN02616

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

2-290

2.72e-96

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 215332 [Multi-domain] Cd Length: 364 Bit Score: 288.06 E-value: 2.72e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   2 SAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLT 81
Cdd:PLN02616  72 GAKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  82 LIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCL--GEPCFLPCTPHGVQELLIRSGIKIEG 159
Cdd:PLN02616 152 FISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMrgREPLFVPCTPKGCIELLHRYNVEIKG 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 160 THVVIVGRSNLVGKPLAnILLQKapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCI 239
Cdd:PLN02616 232 KRAVVIGRSNIVGMPAA-LLLQR---EDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINPV 307

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 240 --GYTPEGKRiLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKR 290
Cdd:PLN02616 308 edASSPRGYR-LVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKR 359

PRK14166

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-289

8.91e-96

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172654 [Multi-domain] Cd Length: 282 Bit Score: 283.84 E-value: 8.91e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14166   3 LLDGKALSAKIKEELKEKNQFLKSK-GIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLG-EPCFLPCTPHGVQELLIRSGIKIEGTHVV 163
Cdd:PRK14166  82 TLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGlESGFLPCTPLGVMKLLKAYEIDLEGKDAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 164 IVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYTP 243
Cdd:PRK14166 162 IIGASNIVGRPMATMLLN----AGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVG---INRLE 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499238903 244 EGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14166 235 SGK--IVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAK 278

PRK14181

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

11-290

2.39e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172669 [Multi-domain] Cd Length: 287 Bit Score: 282.91 E-value: 2.39e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  11 IAAAIREEIRSEVTAlkakhgivPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIARLNADP 90
Cdd:PRK14181  12 ILATIKENISASSTA--------PGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHRLNNDP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  91 KISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGE-PCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSN 169
Cdd:PRK14181  84 NIHGILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKLLLGEtDGFIPCTPAGIIELLKYYEIPLHGRHVAIVGRSN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 170 LVGKPLANILLQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGYTPEGKRIL 249
Cdd:PRK14181 164 IVGKPLAALLMQKHPDTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRVPAANPKGYIL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 499238903 250 SGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKR 290
Cdd:PRK14181 244 VGDVDFNNVVPKCRAITPVPGGVGPMTVAMLMRNTWESYLR 284

PRK14169

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-292

3.48e-95

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184550 [Multi-domain] Cd Length: 282 Bit Score: 282.60 E-value: 3.48e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALkAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14169   1 ATRLDGRAVSKKILADLKQTVAKL-AQQDVTPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14169  80 VAELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGttcIGYT 242
Cdd:PRK14169 160 VIVGRSNIVGRPLAGLMVN----HDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVG---ISRG 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 499238903 243 PEGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAA 292
Cdd:PRK14169 233 ADGK--LLGDVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKRRA 280

PRK14178

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-289

2.81e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172666 [Multi-domain] Cd Length: 279 Bit Score: 279.81 E-value: 2.81e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTalkaKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14178   2 ILDGKAVSEKRLELLKEEII----ESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVI 164
Cdd:PRK14178  78 RLNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 165 VGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIgytpE 244
Cdd:PRK14178 158 VGRSIDVGRPMAALLLN----ADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQV----N 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499238903 245 GKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14178 230 GK--LCGDVDFDAVKEIAGAITPVPGGVGPMTIATLMENTFDAAK 272

PRK14192

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-293

9.09e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184561 [Multi-domain] Cd Length: 283 Bit Score: 278.65 E-value: 9.09e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14192   1 MMALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14192  81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVgttciG 240
Cdd:PRK14192 161 HAVVVGRSAILGKPMAMMLLN----ANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDA-----G 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 241 YTPEGKRILsGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAG 293
Cdd:PRK14192 232 FHPRDGGGV-GDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEKALG 283

PRK14187

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-294

5.85e-90

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172675 [Multi-domain] Cd Length: 294 Bit Score: 269.39 E-value: 5.85e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14187   2 TNIIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEP--CFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14187  82 INELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFTGQKknCLIPCTPKGCLYLIKTITRNLSGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIg 240
Cdd:PRK14187 162 DAVVIGRSNIVGKPMACLLLGE----NCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSI- 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 499238903 241 yTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGL 294
Cdd:PRK14187 237 -EEGGVKKFVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAACNQKGI 289

PRK14177

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-289

1.85e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172665 [Multi-domain] Cd Length: 284 Bit Score: 268.00 E-value: 1.85e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   1 MSAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLL 80
Cdd:PRK14177   1 MSPILLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  81 TLIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGT 160
Cdd:PRK14177  81 GVIDKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 161 HVVIVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVgttciG 240
Cdd:PRK14177 161 NAVVVGRSPILGKPMAMLLTE----MNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDA-----G 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 499238903 241 YTPEGkrilSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14177 232 YNPGN----VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFK 276

PLN02897

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

2-291

3.28e-89

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 178485 [Multi-domain] Cd Length: 345 Bit Score: 269.52 E-value: 3.28e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   2 SAHIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLT 81
Cdd:PLN02897  55 KTVVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  82 LIARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCL--GEPCFLPCTPHGVQELLIRSGIKIEG 159
Cdd:PLN02897 135 ALRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMrgREPLFVSCTPKGCVELLIRSGVEIAG 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 160 THVVIVGRSNLVGKPLAnILLQKapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCI 239
Cdd:PLN02897 215 KNAVVIGRSNIVGLPMS-LLLQR---HDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPV 290

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 240 -GYTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRA 291
Cdd:PLN02897 291 eDSSCEFGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKRI 343

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-289

5.51e-89

Pssm-ID: 133448 Cd Length: 168 Bit Score: 262.49 E-value: 5.51e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 116 PDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQkapgANATVTICHS 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLN----RNATVTVCHS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 196 GTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGytPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPM 275
Cdd:cd01080   77 KTKNLKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVP--DKSGGKLVGDVDFESAKEKASAITPVPGGVGPM 154

                        170
                 ....*....|....
gi 499238903 276 TIIMLMLNTLTAAK 289
Cdd:cd01080  155 TVAMLMKNTVEAAK 168

PRK14180

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-289

7.34e-89

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172668 [Multi-domain] Cd Length: 282 Bit Score: 266.51 E-value: 7.34e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14180   3 LIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCL-GEPCFLPCTPHGVQELLIRSGIKIEGTHVV 163
Cdd:PRK14180  83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLrDKKCLESCTPKGIMTMLREYGIKTEGAYAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 164 IVGRSNLVGKPLANILLQkapgANATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIgytp 243
Cdd:PRK14180 163 VVGASNVVGKPVSQLLLN----AKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHV---- 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 499238903 244 EGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:PRK14180 235 DGK--IVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQ 278

PRK14182

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-292

7.55e-89

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172670 [Multi-domain] Cd Length: 282 Bit Score: 266.50 E-value: 7.55e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   5 IINGTEIAAAIREEIRSEVTALKAKhGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIA 84
Cdd:PRK14182   3 LIDGKQIAAKVKGEVATEVRALAAR-GVQTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  85 RLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCF-LPCTPHGVQELLIRSGIKIEGTHVV 163
Cdd:PRK14182  82 RLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVpRPCTPAGVMRMLDEARVDPKGKRAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 164 IVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGytp 243
Cdd:PRK14182 162 VVGRSNIVGKPMAMMLLER----HATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLA--- 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 499238903 244 EGKriLSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAA 292
Cdd:PRK14182 235 DGK--LVGDVEFAAAAARASAITPVPGGVGPMTRAMLLVNTVELAKRTA 281

PRK14170

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-290

1.59e-88

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172658 [Multi-domain] Cd Length: 284 Bit Score: 265.40 E-value: 1.59e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   3 AHIINGTEIAAAIREEIRSEVTALkAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTL 82
Cdd:PRK14170   2 GEIIDGKKLAKEIQEKVTREVAEL-VKEGKKPGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  83 IARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14170  81 VEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTtcigyT 242
Cdd:PRK14170 161 VVIGRSNIVGKPVAQLLLNE----NATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGM-----D 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 499238903 243 PEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKR 290
Cdd:PRK14170 232 RDENNKLCGDVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAKR 279

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

124-292

3.93e-88

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 259.71 E-value: 3.93e-88

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  124 HPVNVGRMCLGEPCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLI 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNA----NATVTVCHSKTKDLAEI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  204 TSQADILVSAMGKPKFITADMVRQGAVVIDVGTtcigyTPEGKRILSGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLN 283
Cdd:pfam02882  77 TREADIVVVAVGKPELIKADWIKPGAVVIDVGI-----NRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQN 151


                  ....*....
gi 499238903  284 TLTAAKRAA 292
Cdd:pfam02882 152 TVEAAKRQL 160

PRK14171

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-295

9.62e-86

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172659 [Multi-domain] Cd Length: 288 Bit Score: 258.73 E-value: 9.62e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903   4 HIINGTEIAAAIREEIRSEVTALKAKHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLI 83
Cdd:PRK14171   3 NIIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903  84 ARLNADPKISGILVQVPLPVQISENLVLNAINPDKDVDGFHPVNVGRMCLG-EPCFLPCTPHGVQELLIRSGIKIEGTHV 162
Cdd:PRK14171  83 NELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGiSQGFIPCTALGCLAVIKKYEPNLTGKNV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 163 VIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMGKPKFITADMVRQGAVVIDVGTTCIGyt 242
Cdd:PRK14171 163 VIIGRSNIVGKPLSALLLKE----NCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRIS-- 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 243 peGKRILsGDVDFEAVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAKRAAGLV 295
Cdd:PRK14171 237 --GNKII-GDVDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKAFKDSLYTL 286

THF_DHG_CYH

pfam00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

6-121

3.83e-58

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

Pssm-ID: 459930 [Multi-domain] Cd Length: 115 Bit Score: 181.83 E-value: 3.83e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903    6 INGTEIAAAIREEIRSEVTALKAkHGIVPGLATVLVGDDPASHSYVDSKIKMCQNLGIYSEHHPLPQSATNEDLLTLIAR 85
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALKA-GGRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 499238903   86 LNADPKISGILVQVPLPVQISENLVLNAINPDKDVD 121
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115

NAD_bind_m-THF_DH_Cyclohyd_like

cd05212

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...

136-289

6.97e-24

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133451 Cd Length: 140 Bit Score: 94.50 E-value: 6.97e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 136 PCFLPCTPHGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLANILLQKapgaNATVTICHSGTKNLPLITSQADILVSAMG 215
Cdd:cd05212    5 PLFVSPVAKAVKELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRD----GATVYSCDWKTIQLQSKVHDADVVVVGSP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499238903 216 KPKFITADMVRQGAVVIDVGTTcigytpegkrILSGDVdfeaVKEKAFAITPVPKGVGPMTIIMLMLNTLTAAK 289
Cdd:cd05212   81 KPEKVPTEWIKPGATVINCSPT----------KLSGDD----VKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140

NAD_bind_m-THF_DH

cd01079

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...

116-285

5.33e-13

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133447 [Multi-domain] Cd Length: 197 Bit Score: 66.30 E-value: 5.33e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 116 PDKDVDGFHPVNVGRMCLGE---------PCFLPCTP---------HGVQELLIRSGIKIEGTHVVIVGRSNLVGKPLAN 177
Cdd:cd01079    1 PHKDVEGLSHKYIFNLYHNIrfldpenrkKSILPCTPlaivkilefLGIYNKILPYGNRLYGKTITIINRSEVVGRPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499238903 178 IL-----------------LQKAPGANATVTICHSGTKNLPLITSQADILVSAMGKPKF-ITADMVRQGAVVIDVgttci 239
Cdd:cd01079   81 LLandgarvysvdingiqvFTRGESIRHEKHHVTDEEAMTLDCLSQSDVVITGVPSPNYkVPTELLKDGAICINF----- 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 499238903 240 gytpegkrilSGDVDFEA-VKEKAFAITPVpkgVGPMTIIMLMLNTL 285
Cdd:cd01079  156 ----------ASIKNFEPsVKEKASIYVPS---IGKVTIAMLLRNLL 189

AlaDh_PNT_C

smart01002

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...

187-234

4.67e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.

Pssm-ID: 214966 [Multi-domain] Cd Length: 149 Bit Score: 39.80 E-value: 4.67e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 499238903   187 NATVTICHSGTKNLPLITSQADILVSAM-----GKPKFITADMVRQ---GAVVIDV 234
Cdd:smart01002  64 GARFTTLYSQAELLEEAVKEADLVIGAVlipgaKAPKLVTREMVKSmkpGSVIVDV 119

L-AlaDH

cd05305

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...

190-234

7.65e-03

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.

Pssm-ID: 240630 [Multi-domain] Cd Length: 359 Bit Score: 37.38 E-value: 7.65e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 499238903 190 VTICHSGTKNLPLITSQADILVSAM----GK-PKFITADMVRQ---GAVVIDV 234
Cdd:cd05305  215 VTTLYSNPANLEEALKEADLVIGAVlipgAKaPKLVTEEMVKTmkpGSVIVDV 267

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01