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Conserved domains on  [gi|499206120|ref|WP_010903660|]
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MULTISPECIES: tyrosine--tRNA ligase [Halobacterium]

Protein Classification

tyrosine--tRNA ligase( domain architecture ID 10013090)

tyrosine--tRNA ligase catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 1-326 3.60e-162

tyrosyl-tRNA synthetase; Validated


:

Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 455.09  E-value: 3.60e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   1 MNAYERITRNTAEVVTEEEVRELAEDPEGKRVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSF 80
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLNDKGDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  81 EEIRATADQMKAQFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQRAMAEI-QSGETPKVSHVVYPLMQA 159
Cdd:PRK08560  82 EEIRKVAEYNKKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMgRRMEEPDVSKLVYPLMQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 160 LDIEYLDLDLAIGGMDQRKVHMLAREELPSVGYEKRPVLHTPIIGDLGSGDGKMSSSE-GVTISMEDSTADIEEKVTGAF 238
Cdd:PRK08560 162 ADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGGIKMSKSKpGSAIFVHDSPEEIRRKIKKAY 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 239 CPQtRDPEGetvNPVLELFQYHVFPRFDEVVVQRPDEYGGDLVYESYEDLADDLESGELHPADAKGALAAALDELIEPGR 318
Cdd:PRK08560 242 CPP-GEVEG---NPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPVR 317


                 ....*...
gi 499206120 319 QRLREIRG 326
Cdd:PRK08560 318 EYLEEGPE 325
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 1-326 3.60e-162

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 455.09  E-value: 3.60e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   1 MNAYERITRNTAEVVTEEEVRELAEDPEGKRVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSF 80
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLNDKGDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  81 EEIRATADQMKAQFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQRAMAEI-QSGETPKVSHVVYPLMQA 159
Cdd:PRK08560  82 EEIRKVAEYNKKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMgRRMEEPDVSKLVYPLMQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 160 LDIEYLDLDLAIGGMDQRKVHMLAREELPSVGYEKRPVLHTPIIGDLGSGDGKMSSSE-GVTISMEDSTADIEEKVTGAF 238
Cdd:PRK08560 162 ADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGGIKMSKSKpGSAIFVHDSPEEIRRKIKKAY 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 239 CPQtRDPEGetvNPVLELFQYHVFPRFDEVVVQRPDEYGGDLVYESYEDLADDLESGELHPADAKGALAAALDELIEPGR 318
Cdd:PRK08560 242 CPP-GEVEG---NPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPVR 317


                 ....*...
gi 499206120 319 QRLREIRG 326
Cdd:PRK08560 318 EYLEEGPE 325
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 30-297 4.01e-80

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 244.82  E-value: 4.01e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  30 KRVYVGYEPSG-VLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDK---------GSFEEIRATADQMKAQFLAYGL 99
Cdd:cd00805    1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPsgkseerklLDLELIRENAKYYKKQLKAILD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 100 --DEDQTEFVLGSSFQLDeDYELDLHAMQVETSLKRAQRAMAEI---QSGETPKVSHVVYPLMQALDIEYLDLDLAIGGM 174
Cdd:cd00805   81 fiPPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKvrlEEEEGISFSEFIYPLLQAYDFVYLDVDLQLGGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 175 DQRKVHMLAREELPSVGYEKRPVLHTPIIGDLGSgdGKMSSSEG--VTISMEDSTADIEEKVTGAFCPqtrdpegetvnP 252
Cdd:cd00805  160 DQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDG--GKMSKSEGnaIWDPVLDSPYDVYQKIRNAFDP-----------D 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499206120 253 VLELFQYHVFPRfdevvvqrpdeyggdlvYESYEDLADDLESGEL 297
Cdd:cd00805  227 VLEFLKLFTFLD-----------------YEEIEELEEEHAEGPL 254
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 1-299 8.48e-61

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 198.78  E-value: 8.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120    1 MNAYERITRNTAEVVTEEEVRELAEDPEGK-RVYVGYEPSGV-LHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKG 78
Cdd:TIGR00234   2 NNILLLLTKRGLEVQTPEEEKDLLKLLERPlKLYLGFDPTAPsLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDPT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   79 SFEEIR--ATADQMKA------QFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQRAMAEIQS-GETPKV 149
Cdd:TIGR00234  82 GKSEVRkiLTREEVQEnaenikKQIARFLDFEKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRfEENISL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  150 SHVVYPLMQALDIEYLDLDLAIGGMDQ----RKVHMLAREELPSVGYEKRPVLHTPIIGDL--GSGDGKMSSSEGVT--- 220
Cdd:TIGR00234 162 HEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPADGEKmgKSLGGAVSLDEGKYdfy 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  221 ISMEDSTADIEEKVTGAFCPQTRDPEGETV------------NPVLELFQYHVFPRF------------------DEVVV 270
Cdd:TIGR00234 242 QKVINTPDELVKKYLKLFTFLGLEEIEQLVelkgpnprevkeNLALEITKYVHGPEAalaaeeiseaifsgglnpDEVPI 321

                         330       340
                  ....*....|....*....|....*....
gi 499206120  271 QRPDEYGGDLVYESYEDLADDLESGELHP 299
Cdd:TIGR00234 322 FRPEKFGGPITLADLLVLSGLFPSKSEAR 350
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
31-299 3.72e-39

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 139.72  E-value: 3.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   31 RVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSFEE------IRATADQMKAQfLAYGLDEDQT 104
Cdd:pfam00579   7 RVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPErkllsrETVLENAIKAQ-LACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  105 EFVLGSSFQLDEDYELDLHAMQVETSLKRAQRA---MAEIQSGETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHM 181
Cdd:pfam00579  86 EIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFkdvKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  182 LAREELPSVGYEKRPV---LHTPIIGDLgSGDGKMSSSEG-VTISMEDSTADIEEKVTGAFCpqtrDPEGEtvNPVLELF 257
Cdd:pfam00579 166 LGRDLARRFNKKIFKKpvgLTNPLLTGL-DGGKKMSKSAGnSAIFLDDDPESVYKKIQKAYT----DPDRE--VRKDLKL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 499206120  258 QYHVFPrfdeVVVQRPDEYGGDLVYESYEDLADDLESGELHP 299
Cdd:pfam00579 239 FTFLSN----EEIEILEAELGKSPYREAEELLAREVTGLVHG 276
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 27-258 9.83e-13

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 67.77  E-value: 9.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  27 PEGKRVYVGYEPSGVLHLGHLLTA--NKLmDLQDAgMEVVVLLADVHAyLNDKGSFEEIRATADQMKAQFLAYGLDEDQT 104
Cdd:COG0180    1 MSKKRVLSGIQPTGRLHLGNYLGAlkNWV-ELQDE-YECFFFIADLHA-LTTPQDPEELRENTREVAADYLAAGLDPEKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 105 EFVLGSsfQLDEDYELDLHAMQVeTSLKRAQRA-----MAEIQSGETPKVSHVVYPLMQALDIeyldldLAIG------G 173
Cdd:COG0180   78 TIFVQS--DVPEHAELAWLLSCL-TPLGELERMpqfkdKSAKNGKENVNAGLLTYPVLMAADI------LLYKadlvpvG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 174 MDQ-----------RKVHMLAREELPsvgyEKRPVL--HTPIIGDLgSGDGKMSSSEGVTISMEDSTADIEEKVTGAF-- 238
Cdd:COG0180  149 EDQkqhleltrdiaRRFNHRYGEVFP----EPEALIpeEGARIPGL-DGRKKMSKSYGNTINLLDDPKEIRKKIKSAVtd 223

                        250       260
                 ....*....|....*....|..
gi 499206120 239 -CPQTRDPEGET-VNPVLELFQ 258
Cdd:COG0180  224 sERLRYDDPGKPeVCNLFTIYS 245
 
Name Accession Description Interval E-value
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 1-326 3.60e-162

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 455.09  E-value: 3.60e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   1 MNAYERITRNTAEVVTEEEVRELAEDPEGKRVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSF 80
Cdd:PRK08560   2 EERLELITRNTEEVVTEEELRELLESKEEPKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLNDKGDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  81 EEIRATADQMKAQFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQRAMAEI-QSGETPKVSHVVYPLMQA 159
Cdd:PRK08560  82 EEIRKVAEYNKKVFEALGLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMgRRMEEPDVSKLVYPLMQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 160 LDIEYLDLDLAIGGMDQRKVHMLAREELPSVGYEKRPVLHTPIIGDLGSGDGKMSSSE-GVTISMEDSTADIEEKVTGAF 238
Cdd:PRK08560 162 ADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGGIKMSKSKpGSAIFVHDSPEEIRRKIKKAY 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 239 CPQtRDPEGetvNPVLELFQYHVFPRFDEVVVQRPDEYGGDLVYESYEDLADDLESGELHPADAKGALAAALDELIEPGR 318
Cdd:PRK08560 242 CPP-GEVEG---NPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPVR 317


                 ....*...
gi 499206120 319 QRLREIRG 326
Cdd:PRK08560 318 EYLEEGPE 325
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 30-297 4.01e-80

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 244.82  E-value: 4.01e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  30 KRVYVGYEPSG-VLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDK---------GSFEEIRATADQMKAQFLAYGL 99
Cdd:cd00805    1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPsgkseerklLDLELIRENAKYYKKQLKAILD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 100 --DEDQTEFVLGSSFQLDeDYELDLHAMQVETSLKRAQRAMAEI---QSGETPKVSHVVYPLMQALDIEYLDLDLAIGGM 174
Cdd:cd00805   81 fiPPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKvrlEEEEGISFSEFIYPLLQAYDFVYLDVDLQLGGS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 175 DQRKVHMLAREELPSVGYEKRPVLHTPIIGDLGSgdGKMSSSEG--VTISMEDSTADIEEKVTGAFCPqtrdpegetvnP 252
Cdd:cd00805  160 DQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDG--GKMSKSEGnaIWDPVLDSPYDVYQKIRNAFDP-----------D 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 499206120 253 VLELFQYHVFPRfdevvvqrpdeyggdlvYESYEDLADDLESGEL 297
Cdd:cd00805  227 VLEFLKLFTFLD-----------------YEEIEELEEEHAEGPL 254
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 1-299 8.48e-61

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 198.78  E-value: 8.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120    1 MNAYERITRNTAEVVTEEEVRELAEDPEGK-RVYVGYEPSGV-LHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKG 78
Cdd:TIGR00234   2 NNILLLLTKRGLEVQTPEEEKDLLKLLERPlKLYLGFDPTAPsLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDPT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   79 SFEEIR--ATADQMKA------QFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQRAMAEIQS-GETPKV 149
Cdd:TIGR00234  82 GKSEVRkiLTREEVQEnaenikKQIARFLDFEKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRfEENISL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  150 SHVVYPLMQALDIEYLDLDLAIGGMDQ----RKVHMLAREELPSVGYEKRPVLHTPIIGDL--GSGDGKMSSSEGVT--- 220
Cdd:TIGR00234 162 HEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPADGEKmgKSLGGAVSLDEGKYdfy 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  221 ISMEDSTADIEEKVTGAFCPQTRDPEGETV------------NPVLELFQYHVFPRF------------------DEVVV 270
Cdd:TIGR00234 242 QKVINTPDELVKKYLKLFTFLGLEEIEQLVelkgpnprevkeNLALEITKYVHGPEAalaaeeiseaifsgglnpDEVPI 321

                         330       340
                  ....*....|....*....|....*....
gi 499206120  271 QRPDEYGGDLVYESYEDLADDLESGELHP 299
Cdd:TIGR00234 322 FRPEKFGGPITLADLLVLSGLFPSKSEAR 350
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 33-318 2.55e-55

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 184.51  E-value: 2.55e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  33 YVGYEPSGVLHLGH-LLTANKLMDLQDAGMEVVVLLADVHAYLNDK--GSFEEIRATADQMKAQFLAYGLDEDQTEFVLG 109
Cdd:PTZ00126  70 YDGFEPSGRMHIAQgILKAINVNKLTKAGCVFVFWVADWFALLNNKmgGDLEKIRKVGEYFIEVWKAAGMDMDNVRFLWA 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 110 SSF--QLDEDYELdlHAMQVE-----TSLKRAQRAMAEIQSGETPkVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHML 182
Cdd:PTZ00126 150 SEEinKNPNDYWL--RVMDIArsfniTRIKRCSQIMGRSEGDEQP-CAQILYPCMQCADIFYLKADICQLGMDQRKVNML 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 183 AREELPSVGYEKRPVL--HTPIIGdLGSGDGKMS-SSEGVTISMEDSTADIEEKVTGAFCPqtrdPEGETVNPVLELFQY 259
Cdd:PTZ00126 227 AREYCDKKKIKKKPIIlsHHMLPG-LLEGQEKMSkSDPNSAIFMEDSEEDVNRKIKKAYCP----PGVIEGNPILAYFKS 301

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499206120 260 HVFPRFDEVVVQRPDEYGGDLVYESYEDLADDLESGELHPADAKGALAAALDELIEPGR 318
Cdd:PTZ00126 302 IVFPAFNSFTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDLKPALAKYLNLMLQPVR 360
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
31-299 3.72e-39

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 139.72  E-value: 3.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   31 RVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSFEE------IRATADQMKAQfLAYGLDEDQT 104
Cdd:pfam00579   7 RVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIGDPSKSPErkllsrETVLENAIKAQ-LACGLDPEKA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  105 EFVLGSSFQLDEDYELDLHAMQVETSLKRAQRA---MAEIQSGETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHM 181
Cdd:pfam00579  86 EIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFkdvKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNIE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  182 LAREELPSVGYEKRPV---LHTPIIGDLgSGDGKMSSSEG-VTISMEDSTADIEEKVTGAFCpqtrDPEGEtvNPVLELF 257
Cdd:pfam00579 166 LGRDLARRFNKKIFKKpvgLTNPLLTGL-DGGKKMSKSAGnSAIFLDDDPESVYKKIQKAYT----DPDRE--VRKDLKL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 499206120  258 QYHVFPrfdeVVVQRPDEYGGDLVYESYEDLADDLESGELHP 299
Cdd:pfam00579 239 FTFLSN----EEIEILEAELGKSPYREAEELLAREVTGLVHG 276
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 31-319 7.22e-31

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 122.70  E-value: 7.22e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  31 RVYVGYEPSGVLHLGH-LLTANKLMDLQDAGMEVVVLLADVHAYLNDK--GSFEEIRATADQMKAQFLAYGLDEDQTEFv 107
Cdd:PTZ00348  34 RCYDGFEPSGRMHIAQgIFKAVNVNKCTQAGCEFVFWVADWFALMNDKvgGELEKIRIVGRYLIEVWKAAGMDMDKVLF- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 108 LGSSFQLDEDYE------LDLHAMQVETSLKRAQRAMAEiQSGeTPKVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHM 181
Cdd:PTZ00348 113 LWSSEEITNHANtywrtvLDIGRQNTIARIKKCCTIMGK-TEG-TLTAAQVLYPLMQCADIFFLKADICQLGLDQRKVNM 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 182 LAREELPSVGYEKRPV-LHTPIIGDLGSGDGKMSSSE-GVTISMEDSTADIEEKVTGAFCPQTRDPEGETV--------- 250
Cdd:PTZ00348 191 LAREYCDLIGRKLKPViLSHHMLAGLKQGQAKMSKSDpDSAIFMEDTEEDVARKIRQAYCPRVKQSASEITddgapvatd 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 499206120 251 --NPVLELFQYHVFPRFDEVVVQRPDEyggdlvYESYEDLADDLESGELHPADAKGALAAALDELIEPGRQ 319
Cdd:PTZ00348 271 drNPVLDYFQCVVYARPGAVATIDGTT------YATYEDLEQAFVSDEVSEEALKSCLIDEVNALLEPVRQ 335
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 31-292 2.26e-28

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 110.75  E-value: 2.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  31 RVYVGYEPSGVLHLGHLLTANK-LMDLQDAGMEVVVLLADVHAYLNDKGSFEEIRATADQMKAQFLAYGLDEDQTEFVLG 109
Cdd:cd00806    1 RVLSGIQPSGSLHLGHYLGAFRfWVWLQEAGYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 110 SsfQLDEDYELDLhAMQVETSLKRAQRAM---AEIQSGETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQrKVHM-LARE 185
Cdd:cd00806   81 S--DVPEHYELAW-LLSCVVTFGELERMTgfkDKSAQGESVNIGLLTYPVLQAADILLYKACLVPVGIDQ-DPHLeLTRD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 186 ELPSVGYEKRPVLHTP--IIG------DLGSGDGKMSSSEG-VTISMEDSTADIEEKV----TGAFCPQTRDPEGETVNP 252
Cdd:cd00806  157 IARRFNKLYGEIFPKPaaLLSkgaflpGLQGPSKKMSKSDPnNAIFLTDSPKEIKKKImkaaTDGGRTEHRRDGGGPGVS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 499206120 253 VLeLFQYHVFPRFDEVVVQRPDEY--GGDLVYESYEDLADDL 292
Cdd:cd00806  237 NL-VEIYSAFFNDDDEELEEIDEYrsGGLGYGECKKLLAEAI 277
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 28-260 3.36e-19

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 86.62  E-value: 3.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120   28 EGKRVYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSFEEIRATADQMKAQFLAYGLDEDQTEFV 107
Cdd:TIGR00233   1 KKFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDALRKAREELAADYLAVGLDPEKTFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  108 LGSsfQLDEDYELDLhAMQVETSLKRAQRAMA--EIQSGETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQrKVHM-LAR 184
Cdd:TIGR00233  81 LQS--DYPEHYELAW-LLSCQVTFGELKRMTQfkDKSQAENVPIGLLSYPVLQAADILLYQADLVPVGIDQ-DQHLeLTR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  185 E------ELPSVGYEKRPVLHTPIIGDL-GSGDGKMSSS-EGVTISMEDSTADIEEKVTGAfcpqTRDPEGET------- 249
Cdd:TIGR00233 157 DlaerfnKKFKNFFPKPESLISKFFPRLmGLSGKKMSKSdPNSAIFLTDTPKQIKKKIRKA----ATDGGRVTlfehrek 232

                         250
                  ....*....|....*.
gi 499206120  250 -----VNPVLELFQYH 260
Cdd:TIGR00233 233 pgvpnLLVIYQYLSFF 248
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 32-280 7.20e-16

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 77.21  E-value: 7.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  32 VYVGYEPSGVLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKGSFEEIRATADQMKAQFLAYGLDEDQTEFVLGSS 111
Cdd:PRK12285  69 VYTGFMPSGPMHIGHKMVFDELKWHQEFGANVYIPIADDEAYAARGLSWEETREWAYEYILDLIALGFDPDKTEIYFQSE 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 112 FQldedyelDLHAMQVETSlKRAQraMAEIQ-----SGETpKVSHVVYPLMQALDIEYLDLD------LAIGGMDQRKvH 180
Cdd:PRK12285 149 NI-------KVYDLAFELA-KKVN--FSELKaiygfTGET-NIGHIFYPATQAADILHPQLEegpkptLVPVGIDQDP-H 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 181 M-LAREELPSV--GYEKRP---VLHTPIIGDLGsgdGKMSSSE-GVTISMEDSTADIEEKVTGAF---CP----QTR--- 243
Cdd:PRK12285 217 IrLTRDIAERLhgGYGFIKpssTYHKFMPGLTG---GKMSSSKpESAIYLTDDPETVKKKIMKALtggRAtleeQRKlgg 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 499206120 244 DPEgetVNPVLELFQYHVFPRfDEVVVQRPDEY-GGDL 280
Cdd:PRK12285 294 EPD---ECVVYELLLYHLEED-DKELKEIYEECrSGEL 327
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 30-257 5.81e-13

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 68.34  E-value: 5.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  30 KRVYVGYEPSGVLHLGHLLTANK-LMDLQDAGmEVVVLLADVHAYLNDKGSFEEIRATADQMKAQFLAYGLDEDQTEFVL 108
Cdd:PRK12282   3 PIILTGDRPTGKLHLGHYVGSLKnRVALQNEH-EQFVLIADQQALTDNAKNPEKIRRNILEVALDYLAVGIDPAKSTIFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 109 GSsfQLDEDYELDLHAMQVeTSLKRAQR---AMAEIQS---GETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHML 182
Cdd:PRK12282  82 QS--QIPELAELTMYYMNL-VTVARLERnptVKTEIAQkgfGRSIPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 183 AREELPSVGYE-KRPVLHTP--IIGDLG-----SGDGKMSSSEGVTISMEDSTADIEEKVTGAFCPQTR----DP---EG 247
Cdd:PRK12282 159 TREIVRRFNSLyGTDVLVEPeaLLPEAGrlpglDGKAKMSKSLGNAIYLSDDADTIKKKVMSMYTDPNHirveDPgkvEG 238

                        250
                 ....*....|
gi 499206120 248 ETVNPVLELF 257
Cdd:PRK12282 239 NVVFTYLDAF 248
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 27-258 9.83e-13

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 67.77  E-value: 9.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  27 PEGKRVYVGYEPSGVLHLGHLLTA--NKLmDLQDAgMEVVVLLADVHAyLNDKGSFEEIRATADQMKAQFLAYGLDEDQT 104
Cdd:COG0180    1 MSKKRVLSGIQPTGRLHLGNYLGAlkNWV-ELQDE-YECFFFIADLHA-LTTPQDPEELRENTREVAADYLAAGLDPEKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 105 EFVLGSsfQLDEDYELDLHAMQVeTSLKRAQRA-----MAEIQSGETPKVSHVVYPLMQALDIeyldldLAIG------G 173
Cdd:COG0180   78 TIFVQS--DVPEHAELAWLLSCL-TPLGELERMpqfkdKSAKNGKENVNAGLLTYPVLMAADI------LLYKadlvpvG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 174 MDQ-----------RKVHMLAREELPsvgyEKRPVL--HTPIIGDLgSGDGKMSSSEGVTISMEDSTADIEEKVTGAF-- 238
Cdd:COG0180  149 EDQkqhleltrdiaRRFNHRYGEVFP----EPEALIpeEGARIPGL-DGRKKMSKSYGNTINLLDDPKEIRKKIKSAVtd 223

                        250       260
                 ....*....|....*....|..
gi 499206120 239 -CPQTRDPEGET-VNPVLELFQ 258
Cdd:COG0180  224 sERLRYDDPGKPeVCNLFTIYS 245
PRK13354 PRK13354
tyrosyl-tRNA synthetase; Provisional
 32-226 4.06e-10

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 237360 [Multi-domain]  Cd Length: 410  Bit Score: 60.30  E-value: 4.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  32 VYVGYEPSG-VLHLGHLLTANKLMDLQDAGMEVVVLLADVHAYLNDKG---------SFEEIRATADQMKAQFLAYgLDE 101
Cdd:PRK13354  36 LYLGFDPTApSLHIGHLVPLMKLKRFQDAGHRPVILIGGFTGKIGDPSgkskerkllTDEQVQHNAKTYTEQIFKL-FDF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 102 DQTEFVLGS------SFqldEDYELDLHA-MQVETSLKR---AQRamaeIQSGETPKVSHVVYPLMQALDIEYL----DL 167
Cdd:PRK13354 115 EKTEIVNNSdwlsklNL---IDFLRDYGKhFTVNRMLERddvKSR----LEREQGISFTEFFYPLLQAYDFVHLnrkeDV 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 499206120 168 DLAIGGMDQRKVHMLAREELPSVGYEKRPVLHTPIIgdLGSGDGKMSSSEGVTISMEDS 226
Cdd:PRK13354 188 DLQIGGTDQWGNILMGRDLQRKLEGEEQFGLTMPLL--EGADGTKMGKSAGGAIWLDPE 244
PTZ00348 PTZ00348
tyrosyl-tRNA synthetase; Provisional
 62-299 1.65e-09

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 173541 [Multi-domain]  Cd Length: 682  Bit Score: 58.76  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  62 EVVVLLADVHAYLNDKGSFEE--IRATADQMKAQFLAYGLDED-----QTEFVLGSSfqldEDYELDLHAMQVETSLKRA 134
Cdd:PTZ00348 409 TVTLVLPDWSAVASDEITGEEkdISAALEVNCALLKAYGLPSEvkivrENEVILGNP----NDFWVSVIGIARKNLLSHV 484

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 135 QramaEIQSGETPKVSHVVYPLMQALDIEYLDLDLAIGGMDQRKVHMLARE-------ELPSVGyEKRPVLHTP--IIGD 205
Cdd:PTZ00348 485 E----ELYGGELRNAGQVIAALMRVATALMLSASHVISTSLDGGINEFAREytkgrieCIQALE-GRVPALHRPgaAPAV 559

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 206 LGSGDgkmsssegvTISMEDSTADIEEKVTGAFCPQTrdpegETVNPVLELFQyHVFPRFDEVVVQRPDEYGGDLVYESY 285
Cdd:PTZ00348 560 LGADD---------VLYLDDNDMDIRRKIKKAYSAPN-----EEANPVISVAQ-HLLAQQGALSIERGEANGGNVAYNTP 624

                        250
                 ....*....|....
gi 499206120 286 EDLADDLESGELHP 299
Cdd:PTZ00348 625 EALVADCGSGALHP 638
TyrS COG0162
Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA ...
 31-218 2.37e-06

Tyrosyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tyrosyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439932 [Multi-domain]  Cd Length: 409  Bit Score: 48.88  E-value: 2.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  31 RVYVGYEPSGV-LHLGHLLTANKLMDLQDAGMEVVVLLADVHAY------------LNDKgsfEEIRATADQMKAQFLAY 97
Cdd:COG0162   31 TIYLGFDPTAPsLHLGHLVPLMKLRRFQDLGHRPIALIGGFTGMigdpsgkseerkLLTE---EQVAENAETIKEQVFKF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  98 gLD--EDQTEFV-----------------LGSSFQLD-----EDYELDLHAmqvETSLkraqrAMAEIqsgetpkvshvV 153
Cdd:COG0162  108 -LDfdDNKAEIVnnsdwlgklsfidflrdLGKHFTVNrmlerDDVKKRLES---GQGI-----SFTEF-----------S 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 499206120 154 YPLMQALDIEYL----DLDLAIGGMDQ-------RKvhmLAREelpsvgYEKRPV--LHTPIIgdLGSgDG-KMSSSEG 218
Cdd:COG0162  168 YPLLQGYDFVELyrryGCDLQLGGSDQwgnilagRE---LQRR------YGGEPQfgLTMPLL--TGA-DGtKMGKSEG 234
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 30-247 5.82e-06

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 47.39  E-value: 5.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120  30 KRVYVGYEPSGVLHLGHLLTANKLM-DLQDaGMEVVVLLADVHA--YLNDKgsfEEIRATADQMKAQFLAYGLDEDQTEF 106
Cdd:PRK00927   2 KRVLSGIQPTGKLHLGNYLGAIKNWvELQD-EYECFFCIADLHAltVPQDP---EELRENTRELAADYLACGIDPEKSTI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 107 VLGSsfQLDEDYELDLhAMQVETSLKRAQRA-----MAEIQsGETPKVSHVVYPLMQALDIeyldldLAIG------GMD 175
Cdd:PRK00927  78 FVQS--HVPEHAELAW-ILNCITPLGELERMtqfkdKSAKQ-KENVSAGLFTYPVLMAADI------LLYKadlvpvGED 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499206120 176 QrKVHM-LARE-------------ELPSVGYEKrpvlHTPIIGDLGSGDGKMSSSEGV---TISMEDSTADIEEKVTGAF 238
Cdd:PRK00927 148 Q-KQHLeLTRDiarrfnnlygevfPVPEPLIPK----VGARVMGLDGPTKKMSKSDPNdnnTINLLDDPKTIAKKIKKAV 222


                 ....*....
gi 499206120 239 cpqTrDPEG 247
Cdd:PRK00927 223 ---T-DSER 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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