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NADP-dependent malic enzyme [Halobacterium salinarum]
Protein Classification
NADP-dependent malic enzyme ( domain architecture ID 11482649 )
NADP-dependent malic enzyme catalyzes the conversion of (S)-malate to pyruvate and carbon dioxide using NADP as a cofactor
List of domain hits
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
1-737
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1248.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD ALDYH ASDP PGK V E IST TKP TN TQRDLSLAYSPGVAAPC RA IA D DP TE A FTH T TK GN M V G V V SNG S AVLGLG D I 80
Cdd:PRK07232 1 EQ L KQA ALDYH RFPR PGK I E VTP TKP LA TQRDLSLAYSPGVAAPC LE IA K DP AD A YKY T AR GN L V A V I SNG T AVLGLG N I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 GA Q A A KPVMEGKGVLFK R FA D IDVFDIE L D QATA D ELVAT V S A M EPTFGGINLEDIKAPECF EV E RR L GDA MD V PVFHDD 160
Cdd:PRK07232 81 GA L A S KPVMEGKGVLFK K FA G IDVFDIE V D EEDP D KFIEA V A A L EPTFGGINLEDIKAPECF YI E EK L RER MD I PVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAIIS G AALLNA A E IA GK DLS D LDV V F SGAGA S AIA TAKFY V S LG VDR E H I TM CDS S GVI TED R D -- VN E F KAA F A Q 238
Cdd:PRK07232 161 QHGTAIIS A AALLNA L E LV GK KIE D VKI V V SGAGA A AIA CLNLL V A LG AKK E N I IV CDS K GVI YKG R T eg MD E W KAA Y A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PA D s GGD LA D A MA GADVF V GLS VG G IVNQA MV R SMAD D PI V FA M ANPDPEI DY E S AKA A R E D t V I M ATGRSDYPNQVNNV 318
Cdd:PRK07232 241 DT D - ART LA E A IE GADVF L GLS AA G VLTPE MV K SMAD N PI I FA L ANPDPEI TP E E AKA V R P D - A I I ATGRSDYPNQVNNV 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 319 L G FP F IFRGALDV R AT D INEEMK V AA AT A L A D LA KQD V P DEV VK AYG D Q P L Q FG S EYIIPKP L DPR VLFEV APAVA D AAM 398
Cdd:PRK07232 319 L C FP Y IFRGALDV G AT T INEEMK L AA VR A I A E LA REE V S DEV AA AYG G Q K L S FG P EYIIPKP F DPR LIVKI APAVA K AAM 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 399 ET GVA RTEL - D LVD YRE E LEA RLG K SREM M RIVIN KAK SEQQ R IALG EG GD E KMI RAA HQMHEA G I A D P V L L G DRDT I QG 477
Cdd:PRK07232 399 DS GVA TRPI a D MDA YRE K LEA FVY K TGLV M KPIFA KAK KDPK R VVFA EG EE E RVL RAA QEVVDE G L A K P I L I G RPEV I EA 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 478 TVDA L S LD FDPD V V ----- DP D EGDHSA Y ADTL Y D L RK RKG I T RNE A ES LV A RD PNYL G ST MV EA GDADA FLT GLT HH Y P 552
Cdd:PRK07232 479 RIKK L G LD LKAG V D feivn PE D DPRYEE Y WQYY Y E L LQ RKG V T PED A RR LV R RD RTVI G AM MV AR GDADA MIC GLT GR Y H 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 553 SA L K P PL QV V G TA P DTDYV A GVYM L TFQNRVV F C AD AT VN Q DP D A DV LAE V A QHT A DLA RRF NVD PRVA V LS Y SNFGS V D 632
Cdd:PRK07232 559 EH L R P VR QV I G LR P GVHTA A AMNA L LLKGGNL F I AD TY VN E DP T A EE LAE I A LMA A EEV RRF GIE PRVA L LS H SNFGS S D 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 633 NEGT RK P R R A AQQ LRE d DDI D FP VDGEM QA D T A VV E D I LQGS Y E FS D L DTA ANVL IF PNLEA G NI G Y K LL QR LGG ADA IG 712
Cdd:PRK07232 639 SPSA RK M R E A VEL LRE - RAP D LE VDGEM HG D A A LN E E I RKDL Y P FS R L KGP ANVL VM PNLEA A NI S Y N LL KE LGG GVT IG 717
730 740
....*....|....*....|....*
gi 499205643 713 P M L V GM N KPVH V L QRGDE V KD IVN L 737
Cdd:PRK07232 718 P I L L GM A KPVH I L TPSAT V RR IVN M 742
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
1-737
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1248.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD ALDYH ASDP PGK V E IST TKP TN TQRDLSLAYSPGVAAPC RA IA D DP TE A FTH T TK GN M V G V V SNG S AVLGLG D I 80
Cdd:PRK07232 1 EQ L KQA ALDYH RFPR PGK I E VTP TKP LA TQRDLSLAYSPGVAAPC LE IA K DP AD A YKY T AR GN L V A V I SNG T AVLGLG N I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 GA Q A A KPVMEGKGVLFK R FA D IDVFDIE L D QATA D ELVAT V S A M EPTFGGINLEDIKAPECF EV E RR L GDA MD V PVFHDD 160
Cdd:PRK07232 81 GA L A S KPVMEGKGVLFK K FA G IDVFDIE V D EEDP D KFIEA V A A L EPTFGGINLEDIKAPECF YI E EK L RER MD I PVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAIIS G AALLNA A E IA GK DLS D LDV V F SGAGA S AIA TAKFY V S LG VDR E H I TM CDS S GVI TED R D -- VN E F KAA F A Q 238
Cdd:PRK07232 161 QHGTAIIS A AALLNA L E LV GK KIE D VKI V V SGAGA A AIA CLNLL V A LG AKK E N I IV CDS K GVI YKG R T eg MD E W KAA Y A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PA D s GGD LA D A MA GADVF V GLS VG G IVNQA MV R SMAD D PI V FA M ANPDPEI DY E S AKA A R E D t V I M ATGRSDYPNQVNNV 318
Cdd:PRK07232 241 DT D - ART LA E A IE GADVF L GLS AA G VLTPE MV K SMAD N PI I FA L ANPDPEI TP E E AKA V R P D - A I I ATGRSDYPNQVNNV 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 319 L G FP F IFRGALDV R AT D INEEMK V AA AT A L A D LA KQD V P DEV VK AYG D Q P L Q FG S EYIIPKP L DPR VLFEV APAVA D AAM 398
Cdd:PRK07232 319 L C FP Y IFRGALDV G AT T INEEMK L AA VR A I A E LA REE V S DEV AA AYG G Q K L S FG P EYIIPKP F DPR LIVKI APAVA K AAM 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 399 ET GVA RTEL - D LVD YRE E LEA RLG K SREM M RIVIN KAK SEQQ R IALG EG GD E KMI RAA HQMHEA G I A D P V L L G DRDT I QG 477
Cdd:PRK07232 399 DS GVA TRPI a D MDA YRE K LEA FVY K TGLV M KPIFA KAK KDPK R VVFA EG EE E RVL RAA QEVVDE G L A K P I L I G RPEV I EA 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 478 TVDA L S LD FDPD V V ----- DP D EGDHSA Y ADTL Y D L RK RKG I T RNE A ES LV A RD PNYL G ST MV EA GDADA FLT GLT HH Y P 552
Cdd:PRK07232 479 RIKK L G LD LKAG V D feivn PE D DPRYEE Y WQYY Y E L LQ RKG V T PED A RR LV R RD RTVI G AM MV AR GDADA MIC GLT GR Y H 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 553 SA L K P PL QV V G TA P DTDYV A GVYM L TFQNRVV F C AD AT VN Q DP D A DV LAE V A QHT A DLA RRF NVD PRVA V LS Y SNFGS V D 632
Cdd:PRK07232 559 EH L R P VR QV I G LR P GVHTA A AMNA L LLKGGNL F I AD TY VN E DP T A EE LAE I A LMA A EEV RRF GIE PRVA L LS H SNFGS S D 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 633 NEGT RK P R R A AQQ LRE d DDI D FP VDGEM QA D T A VV E D I LQGS Y E FS D L DTA ANVL IF PNLEA G NI G Y K LL QR LGG ADA IG 712
Cdd:PRK07232 639 SPSA RK M R E A VEL LRE - RAP D LE VDGEM HG D A A LN E E I RKDL Y P FS R L KGP ANVL VM PNLEA A NI S Y N LL KE LGG GVT IG 717
730 740
....*....|....*....|....*
gi 499205643 713 P M L V GM N KPVH V L QRGDE V KD IVN L 737
Cdd:PRK07232 718 P I L L GM A KPVH I L TPSAT V RR IVN M 742
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-420
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 661.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD AL D YH ASDPP GK VEIST T K P TN TQ R DLSLAY S PGVA AP C RA IA D DP TE A FTH T T KGN M V G VV SN G S AVLGLGDI 80
Cdd:COG0281 7 ET L EQE AL E YH RIYDR GK ILVYP T V P LH TQ E DLSLAY T PGVA EA C LE IA E DP RL A YGY T A KGN L V A VV TD G T AVLGLGDI 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 G AQ A AK PVMEGK G VLFK R FA D ID V F D I E LD QATA DE L V AT V S A M EPTFGGINLEDIKAP E CFE V E R RL GDAM D V PVFHDD 160
Cdd:COG0281 87 G PL A GM PVMEGK A VLFK A FA G ID A F P I C LD TNDP DE F V EA V K A L EPTFGGINLEDIKAP N CFE I E E RL REEL D I PVFHDD 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAI ISG AALLNA AEIA GK D L S D LDV V FS GAGA SA IA T A KFY V SL G VDR E H I T M C DS S G VIT E D R - D V N EF K AA FA Q - 238
Cdd:COG0281 167 QHGTAI VVL AALLNA LKLV GK K L E D QKI V IN GAGA AG IA I A RLL V AA G LSE E N I I M V DS K G LLY E G R t D L N PY K RE FA R d 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 -- P ADSG G D LA D A MA GADVF V G L S VG G IVNQA MV R SMA DD PI V FA M ANP D PEI DY E S AKA ARED t V I M ATGRSDYPNQVN 316
Cdd:COG0281 247 tn P RGLK G T LA E A IK GADVF I G V S AP G AFTEE MV K SMA KR PI I FA L ANP T PEI TP E D AKA WGDG - A I V ATGRSDYPNQVN 325
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 317 NVL G FP F IFRGALDVRAT D I NE EMK V aaataladlakqdvpd EVVK A YG D Q -- PLQF G SE YIIP K P L DPRV LFE VA P AVA 394
Cdd:COG0281 326 NVL I FP G IFRGALDVRAT R I TD EMK L ---------------- AAAR A LA D L vd EEEL G PD YIIP S P F DPRV SPA VA A AVA 389
410 420
....*....|....*....|....*.
gi 499205643 395 D AA M E T GVAR TEL D l V DYRE E LEAR L 420
Cdd:COG0281 390 K AA I E S GVAR RPI D - E DYRE A LEAR M 414
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
161-398
8.65e-110
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 332.84
E-value: 8.65e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 Q H GTAI ISG A A LLNA AE I A GK D L S D LDV V FS GAGA SA I AT AK FY V SL GV D R EH I TMC DS S G VI T ED R D -- V N EF K AA FA Q 238
Cdd:smart00919 1 Q Q GTAI VVL A G LLNA LK I T GK K L E D QRI V VN GAGA AG I GI AK LL V AA GV K R KN I WLV DS K G LL T KG R E dn L N PY K KP FA R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PAD -- SG G D L AD A MA GADV FV G L S - V GG IVNQA MV R SMA DD PI V FA MA NP D PEI DYES A K A A R EDTV I M ATGRSDYPNQV 315
Cdd:smart00919 81 KTN er ET G T L EE A VK GADV LI G V S g P GG AFTEE MV K SMA ER PI I FA LS NP T PEI EPTA A D A Y R WTAA I V ATGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 316 NNVL G FP F IF R GALDVRA TD I NE EMK V A aataladlakqd VPDEVVK A YGDQPLQF G SE YIIP K P L D P RV LFE VA P AVA D 395
Cdd:smart00919 161 NNVL I FP G IF L GALDVRA RR I TD EMK L A ------------ AAEALAD A VPVSEEEL G PG YIIP S P F D R RV SAR VA V AVA K 228
...
gi 499205643 396 AA M 398
Cdd:smart00919 229 AA I 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
161-397
5.97e-107
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 325.38
E-value: 5.97e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAI ISG A A LLNA AEIA GK DLSDLDV V FS GAGA SA IA T A KFYVSL G VDR E H I TMC DS S GVI T E D R ------ D V NE FKA 234
Cdd:cd05311 1 QHGTAI VTL A G LLNA LKLV GK KIEEVKI V IN GAGA AG IA I A RLLLAA G AKP E N I VVV DS K GVI Y E G R eddlnp D K NE IAK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 235 AFA q P ADS GG D L AD A MA GADVF V G L S VG G I V NQA M VRS MA D DPIVFA M ANP D PEI DY E S AK A A RE D tv I M ATGRSD Y PNQ 314
Cdd:cd05311 81 ETN - P EKT GG T L KE A LK GADVF I G V S RP G V V KKE M IKK MA K DPIVFA L ANP V PEI WP E E AK E A GA D -- I V ATGRSD F PNQ 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 315 VNNVLGFP F IFRGALDVRAT D I N EEMK V AAA T A L ADLA KQD V P devvkaygdqplqf G S EYIIP K P L DPRV LFE VA P AVA 394
Cdd:cd05311 158 VNNVLGFP G IFRGALDVRAT K I T EEMK L AAA E A I ADLA EEE V L -------------- G E EYIIP T P F DPRV VPR VA T AVA 223
...
gi 499205643 395 D AA 397
Cdd:cd05311 224 K AA 226
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
427-737
2.77e-95
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 298.84
E-value: 2.77e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 427 MRIVINK AK SEQQ RI ALG EG G DE KMIR AA HQMHEA GIADP V L L GD RDT I QGTVDA L S LD F D PDVVDPD E GD -- HSA YAD T 504
Cdd:pfam01515 2 LERIFER AK KAKK RI VFP EG E DE RVLK AA QKLLQQ GIADP I L I GD EIE I KAKALG L D LD L D GIEIVDP E TS pr LEE YAD F 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 505 L Y D LRKRKG I T RNE A ESL V a RDPNY LGSTM V EA G D AD AFLT G LTHHYPSA L K P P LQ VV GT A P DTDY V AG V YMLTFQNRVV 584
Cdd:pfam01515 82 Y Y E LRKRKG M T PEI A REI V - RDPNY FAAML V KL G E AD GMVS G AVNTTADT L R P A LQ II GT K P GVKT V SS V FIMLLPDGLL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 585 F C AD AT VN QD P D A DV LAE V A QHT A DL A R RF - NVD PRVA V LSYS N FGS VDN E GTR K P R R A AQQL RE DD d I D FP VDGE M Q A D 663
Cdd:pfam01515 161 F F AD CA VN PN P T A EE LAE I A LMS A KT A K RF g IIE PRVA L LSYS T FGS GKG E DVE K V R E A TKIV RE RA - P D LV VDGE L Q F D 239
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499205643 664 T A V VE DILQGSYEF S DLDTA ANV LI FP N LEAGNIGYK LL QRLGGA D AIGP M L V G MN KPV HV L Q RG DE V K DIVN L 737
Cdd:pfam01515 240 A A L VE EVAAQKAPD S PVAGK ANV FV FP D LEAGNIGYK IA QRLGGA E AIGP I L Q G LA KPV ND L S RG AS V E DIVN T 313
pta
TIGR00651 phosphate acetyltransferase; Alternate name: phosphotransacetylase Model contains a gene from ...
441-737
1.46e-73
phosphate acetyltransferase; Alternate name: phosphotransacetylase Model contains a gene from E.coli coding for ethanolamine utilization protein (euti) and also contains similarity to malate oxidoreductases [Central intermediary metabolism, Other, Energy metabolism, Fermentation]
Pssm-ID: 273196 [Multi-domain]
Cd Length: 303
Bit Score: 241.19
E-value: 1.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 441 I ALG EG GDEKMIR AA HQMH E A GIA D PV L LG DRDT IQ GTVDA -- L S L DFDPDVVDPDEG D HSA YA DTLYD LRK R KG I T RNE 518
Cdd:TIGR00651 1 I VFP EG WEPRVLK AA ALLA E R GIA T PV V LG NPEE IQ PKAAG cn L D L GHVVIIDPDVSP D RES YA ERYVE LRK H KG M T EAQ 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 519 A ESLV a RD PN Y LGST MV EA G D AD AFLT G LT H HYPSA L K P P LQ VVG T A P DTDY V AG V YMLTFQNR V VFC AD AT VN Q DP D A D 598
Cdd:TIGR00651 81 A RKQL - RD ES Y FATM MV AL G E AD GLVS G AV H TTADT L R P A LQ IIK T L P GVKI V SS V FIMDLGEE V LVF AD CA VN P DP N A E 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 599 V LAE V A QHT A DL A RR F - NVD P R VA V LSYS NF GS VDN E GTR K P R R A AQQLR E DD d I D FPV DGE M Q A D T A V VE DILQGSYEF 677
Cdd:TIGR00651 160 Q LAE I A IQS A NS A KS F g EIE P K VA L LSYS TK GS GKG E EVE K V R E A TRIAK E KR - P D LTI DGE L Q F D A A F VE KVAEKKAPN 238
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 678 S DLDTA ANV LI FP N L E AGNIGYK LL QRLG G A D AIGP M L V G M NKPV HV L Q RG DE V K DIVN L 737
Cdd:TIGR00651 239 S PVAGS ANV FV FP D L D AGNIGYK IV QRLG D A E AIGP I L Q G L NKPV ND L S RG CS V E DIVN T 298
Name
Accession
Description
Interval
E-value
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
1-737
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1248.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD ALDYH ASDP PGK V E IST TKP TN TQRDLSLAYSPGVAAPC RA IA D DP TE A FTH T TK GN M V G V V SNG S AVLGLG D I 80
Cdd:PRK07232 1 EQ L KQA ALDYH RFPR PGK I E VTP TKP LA TQRDLSLAYSPGVAAPC LE IA K DP AD A YKY T AR GN L V A V I SNG T AVLGLG N I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 GA Q A A KPVMEGKGVLFK R FA D IDVFDIE L D QATA D ELVAT V S A M EPTFGGINLEDIKAPECF EV E RR L GDA MD V PVFHDD 160
Cdd:PRK07232 81 GA L A S KPVMEGKGVLFK K FA G IDVFDIE V D EEDP D KFIEA V A A L EPTFGGINLEDIKAPECF YI E EK L RER MD I PVFHDD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAIIS G AALLNA A E IA GK DLS D LDV V F SGAGA S AIA TAKFY V S LG VDR E H I TM CDS S GVI TED R D -- VN E F KAA F A Q 238
Cdd:PRK07232 161 QHGTAIIS A AALLNA L E LV GK KIE D VKI V V SGAGA A AIA CLNLL V A LG AKK E N I IV CDS K GVI YKG R T eg MD E W KAA Y A V 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PA D s GGD LA D A MA GADVF V GLS VG G IVNQA MV R SMAD D PI V FA M ANPDPEI DY E S AKA A R E D t V I M ATGRSDYPNQVNNV 318
Cdd:PRK07232 241 DT D - ART LA E A IE GADVF L GLS AA G VLTPE MV K SMAD N PI I FA L ANPDPEI TP E E AKA V R P D - A I I ATGRSDYPNQVNNV 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 319 L G FP F IFRGALDV R AT D INEEMK V AA AT A L A D LA KQD V P DEV VK AYG D Q P L Q FG S EYIIPKP L DPR VLFEV APAVA D AAM 398
Cdd:PRK07232 319 L C FP Y IFRGALDV G AT T INEEMK L AA VR A I A E LA REE V S DEV AA AYG G Q K L S FG P EYIIPKP F DPR LIVKI APAVA K AAM 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 399 ET GVA RTEL - D LVD YRE E LEA RLG K SREM M RIVIN KAK SEQQ R IALG EG GD E KMI RAA HQMHEA G I A D P V L L G DRDT I QG 477
Cdd:PRK07232 399 DS GVA TRPI a D MDA YRE K LEA FVY K TGLV M KPIFA KAK KDPK R VVFA EG EE E RVL RAA QEVVDE G L A K P I L I G RPEV I EA 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 478 TVDA L S LD FDPD V V ----- DP D EGDHSA Y ADTL Y D L RK RKG I T RNE A ES LV A RD PNYL G ST MV EA GDADA FLT GLT HH Y P 552
Cdd:PRK07232 479 RIKK L G LD LKAG V D feivn PE D DPRYEE Y WQYY Y E L LQ RKG V T PED A RR LV R RD RTVI G AM MV AR GDADA MIC GLT GR Y H 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 553 SA L K P PL QV V G TA P DTDYV A GVYM L TFQNRVV F C AD AT VN Q DP D A DV LAE V A QHT A DLA RRF NVD PRVA V LS Y SNFGS V D 632
Cdd:PRK07232 559 EH L R P VR QV I G LR P GVHTA A AMNA L LLKGGNL F I AD TY VN E DP T A EE LAE I A LMA A EEV RRF GIE PRVA L LS H SNFGS S D 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 633 NEGT RK P R R A AQQ LRE d DDI D FP VDGEM QA D T A VV E D I LQGS Y E FS D L DTA ANVL IF PNLEA G NI G Y K LL QR LGG ADA IG 712
Cdd:PRK07232 639 SPSA RK M R E A VEL LRE - RAP D LE VDGEM HG D A A LN E E I RKDL Y P FS R L KGP ANVL VM PNLEA A NI S Y N LL KE LGG GVT IG 717
730 740
....*....|....*....|....*
gi 499205643 713 P M L V GM N KPVH V L QRGDE V KD IVN L 737
Cdd:PRK07232 718 P I L L GM A KPVH I L TPSAT V RR IVN M 742
PRK12862
PRK12862 malic enzyme; Reviewed
1-737
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1029.06
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD ALDYH ASDP PGK V EI ST TKP TNT QRDL S LAYSPGVAAPC RA IA D DP TE A FTH T TK GN M V G VVSNG S AVLGLG D I 80
Cdd:PRK12862 9 AE L REA ALDYH RFPT PGK I EI AP TKP LAN QRDL A LAYSPGVAAPC LE IA A DP AN A ARY T SR GN L V A VVSNG T AVLGLG N I 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 G AQ A A KPVMEGK G VLFK R FA D IDVFDIELD QATA D E LV AT V S A M EPTFGGINLEDIKAPECF EV ER R L GDA M DV PVFHDD 160
Cdd:PRK12862 89 G PL A S KPVMEGK A VLFK K FA G IDVFDIELD ESDP D K LV EI V A A L EPTFGGINLEDIKAPECF YI ER E L RER M KI PVFHDD 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAII SG AALLN AAEIA GKD LS D LDV V F SGAGA S A I A TAKFY VSLGV D RE H I TMC D SS GV IT E D R -- DVNEF KA AF AQ 238
Cdd:PRK12862 169 QHGTAII VA AALLN GLKLV GKD IE D VKL V A SGAGA A A L A CLDLL VSLGV K RE N I WVT D IK GV VY E G R te LMDPW KA RY AQ 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PA D s GGD LA DAMA GADVF V GLS VG G IVNQA MV RS MA DD P IV FA M ANP D PEI DY E S A K A A R E D t V I M ATGRSDYPNQVNNV 318
Cdd:PRK12862 249 KT D - ART LA EVIE GADVF L GLS AA G VLKPE MV KK MA PR P LI FA L ANP T PEI LP E E A R A V R P D - A I I ATGRSDYPNQVNNV 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 319 L G FP F IFRGALDV R AT D INEEMK V AA AT A L A D LA KQDVP D E V VK AYG DQP L Q FG SE Y I IPKP L DPR VLFEV APAVA D AAM 398
Cdd:PRK12862 327 L C FP Y IFRGALDV G AT T INEEMK I AA VR A I A E LA REEQS D V V AA AYG GED L S FG PD Y L IPKP F DPR LILKI APAVA Q AAM 406
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 399 ET GVA RTEL - D LVD YRE E L EARLGK S REM M RI V INK AK SEQQ R IALG EG G DE KMI RAA HQMHEA G I A D P V L L G DRDT I QG 477
Cdd:PRK12862 407 DS GVA TRPI e D MDA YRE Q L NQFVYH S GLI M KP V FAA AK AAPK R VVFA EG E DE RVL RAA QVVVDE G L A K P I L I G RPAV I EA 486
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 478 TVDALS L DFD P D V VDP --- D E G D H -- SA Y A DT LYD L RK RKG I T RNE A ESL V A R DPNYL G ST MV EA G D ADA FLT G LTHH Y P 552
Cdd:PRK12862 487 RIERAG L RLR P G V DFE ivn P E D D P ry RD Y W DT YHA L MG RKG V T PEM A RRE V R R RTTLI G AM MV KR G E ADA MIC G TEGR Y E 566
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 553 SA L KPP LQV V G TA P DTDYV A GVYM L TFQN R VV F C AD AT VN Q DP D A DV LAE VAQHT A DLA RRF NVD P R VA V LS Y SNFGS V D 632
Cdd:PRK12862 567 RH L EFV LQV I G KR P GVRVY A AMSL L ILPG R TL F L AD TH VN E DP T A EE LAE ITILA A EEV RRF GIE P K VA L LS H SNFGS S D 646
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 633 NEGT RK P R R A AQQ LRE d DDI D FP VDGEM QA D T A VV E DILQGSYEF S D L DTA AN V L I FPNL E A G NI G Y K LL QRLG G - AD A I 711
Cdd:PRK12862 647 SPSA RK M R E A LEI LRE - RAP D LE VDGEM HG D A A LD E ELRDRIFPD S R L EGE AN L L V FPNL D A A NI A Y N LL KTAA G n GL A V 725
730 740
....*....|....*....|....*.
gi 499205643 712 GP M L V G MN KPVH V L QRGDE V KD IVN L 737
Cdd:PRK12862 726 GP I L L G AA KPVH I L TPSAT V RR IVN M 751
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-420
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 661.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 1 MG L DDD AL D YH ASDPP GK VEIST T K P TN TQ R DLSLAY S PGVA AP C RA IA D DP TE A FTH T T KGN M V G VV SN G S AVLGLGDI 80
Cdd:COG0281 7 ET L EQE AL E YH RIYDR GK ILVYP T V P LH TQ E DLSLAY T PGVA EA C LE IA E DP RL A YGY T A KGN L V A VV TD G T AVLGLGDI 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 81 G AQ A AK PVMEGK G VLFK R FA D ID V F D I E LD QATA DE L V AT V S A M EPTFGGINLEDIKAP E CFE V E R RL GDAM D V PVFHDD 160
Cdd:COG0281 87 G PL A GM PVMEGK A VLFK A FA G ID A F P I C LD TNDP DE F V EA V K A L EPTFGGINLEDIKAP N CFE I E E RL REEL D I PVFHDD 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAI ISG AALLNA AEIA GK D L S D LDV V FS GAGA SA IA T A KFY V SL G VDR E H I T M C DS S G VIT E D R - D V N EF K AA FA Q - 238
Cdd:COG0281 167 QHGTAI VVL AALLNA LKLV GK K L E D QKI V IN GAGA AG IA I A RLL V AA G LSE E N I I M V DS K G LLY E G R t D L N PY K RE FA R d 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 -- P ADSG G D LA D A MA GADVF V G L S VG G IVNQA MV R SMA DD PI V FA M ANP D PEI DY E S AKA ARED t V I M ATGRSDYPNQVN 316
Cdd:COG0281 247 tn P RGLK G T LA E A IK GADVF I G V S AP G AFTEE MV K SMA KR PI I FA L ANP T PEI TP E D AKA WGDG - A I V ATGRSDYPNQVN 325
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 317 NVL G FP F IFRGALDVRAT D I NE EMK V aaataladlakqdvpd EVVK A YG D Q -- PLQF G SE YIIP K P L DPRV LFE VA P AVA 394
Cdd:COG0281 326 NVL I FP G IFRGALDVRAT R I TD EMK L ---------------- AAAR A LA D L vd EEEL G PD YIIP S P F DPRV SPA VA A AVA 389
410 420
....*....|....*....|....*.
gi 499205643 395 D AA M E T GVAR TEL D l V DYRE E LEAR L 420
Cdd:COG0281 390 K AA I E S GVAR RPI D - E DYRE A LEAR M 414
PRK12861
PRK12861 malic enzyme; Reviewed
7-737
0e+00
malic enzyme; Reviewed
Pssm-ID: 183798 [Multi-domain]
Cd Length: 764
Bit Score: 650.80
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 7 ALDYH ASDP PGK VEISTT KP TN TQRDL S LAY S PGVA AP C RA IA D DP TE AF TH T TK GN M VGV VS NG S AVLGLG D IGA Q A A K 86
Cdd:PRK12861 11 ALDYH EFPT PGK ISVVAS KP LV TQRDL A LAY T PGVA SA C EE IA A DP LN AF RF T SR GN L VGV IT NG T AVLGLG N IGA L A S K 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 87 PVMEGK G VLFK R FA D IDVFDIE LDQATA D E LV ATVSAM EPTFGGINLEDIKAPECF E VER R L GDA M DV PVFHDDQHGTAI 166
Cdd:PRK12861 91 PVMEGK A VLFK K FA G IDVFDIE INETDP D K LV DIIAGL EPTFGGINLEDIKAPECF T VER K L RER M KI PVFHDDQHGTAI 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 167 ISG AA LL N AAEIA GK DLSDLD VV F SGAGA S A I A TAKFY V S LG VDR E H I TMC D SS GV ITED R D -- VNEF K AA FAQ PA D S g G 244
Cdd:PRK12861 171 TVS AA FI N GLKVV GK SIKEVK VV T SGAGA A A L A CLDLL V D LG LPV E N I WVT D IE GV VYRG R T tl MDPD K ER FAQ ET D A - R 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 245 D LA DAMA GADVF V GLS V GG IVNQA M VRS MA DD P IVF A M ANP D PEI DY E S A K A A R E D t V IM ATGRSDYPNQVNNVL G FP F I 324
Cdd:PRK12861 250 T LA EVIG GADVF L GLS A GG VLKAE M LKA MA AR P LIL A L ANP T PEI FP E L A H A T R D D - V VI ATGRSDYPNQVNNVL C FP Y I 328
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 325 FRGALDV R AT D I NE EM KV AA AT A L A D LA KQDVP D E V VK AYG DQPLQ FG SE Y I IPKP L DPR VLFEV APAVA D AAME T GVA R 404
Cdd:PRK12861 329 FRGALDV G AT T I TR EM EI AA VH A I A G LA EEEQN D V V AA AYG AYDVS FG PQ Y L IPKP F DPR LIVRI APAVA K AAME G GVA T 408
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 405 TEL - DL VD Y R E E L EARLGK S REM M RIVINK A KS ----- EQQ RI ALG EG G DE KMI RA AHQMHEAGI A D P V L L G DRDTIQGT 478
Cdd:PRK12861 409 RPI a DL DA Y V E Q L QQFVYH S GAF M KPLFAA A RQ lvrdg GKA RI VFT EG E DE RVL RA VQVIVDEKL A R P I L V G RPEVLLAR 488
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 479 VDALS L --- DFDPDV V DPD E G D HS -- A Y AD T LYD LR K R K GI TRNE A ESLVA R DPNYL G ST MV EA GDAD AFLT G LTHH Y PS 553
Cdd:PRK12861 489 IERFG L rlr LGQDVE V TNP E Y D ER fp Q Y WT T YWE LR C R D GI SKEM A RVEMR R RLTLI G AM MV RL GDAD GMIC G TVGE Y HN 568
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 554 A L KPPLQ V V G TA P DTDYV A GVYM L TFQN R V V FCA D AT VN QD PDA DVL AE VAQHT A DLARRF N VD P R VA V LS Y SNFGS VDN 633
Cdd:PRK12861 569 H L RFVDE V I G RK P GASTY A AMNI L LLDQ R T V ALV D TH VN DN PDA EQI AE FTIAA A RQMEWL N LT P K VA L LS R SNFGS GSA 648
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 634 EGTR K P RRA AQQL RE DDD i D FPV DGEM QA D T A VV E DILQGSYEF S D L DT AAN V L IF PN LE AGNI G Y K LL QRLG G AD - A I G 712
Cdd:PRK12861 649 ASGV K M RRA LEIV RE QAP - D LEA DGEM HG D C A LD E GLRARLLPM S P L KG AAN L L VC PN VD AGNI A Y N LL KTEA G SN v A V G 727
730 740
....*....|....*....|....*
gi 499205643 713 P M L V G M N K PV HV L QRGDE V KD IVN L 737
Cdd:PRK12861 728 P F L L G V N A PV NI L TSSAT V RR IVN M 752
Pta
COG0280 Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production ...
426-737
8.42e-123
Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production and conversion];
Pssm-ID: 440049 [Multi-domain]
Cd Length: 320
Bit Score: 370.17
E-value: 8.42e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 426 MM R IV I NK AK SEQQ RI ALG EG G DE KMI RAA HQMHEA G I A D P V L L G DRDT I QGTVDA -- L S L DFDPDVVDP D EGDHSA YA D 503
Cdd:COG0280 2 FF R PL I ER AK AAPK RI VFA EG E DE RVL RAA QEALDE G L A E P I L V G RPEK I EARAEE lg L D L SGFEIIDPE D SPRYEE YA E 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 504 TL Y D LRKRKG I T RN EA ES LV a RD PN Y LGST MV EA G D AD AFLT G LTHHYPSA L K P P LQ VV G TA P DTDY V AG V YMLTFQN R V 583
Cdd:COG0280 82 AY Y E LRKRKG V T PE EA RE LV - RD AA Y FAAM MV RL G E AD GLVK G AVGTTADL L R P V LQ II G LR P GVKR V SH V FLMELPD R L 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 584 V F CA D AT VN Q DP D A DV LA EV A QHT AD L AR R F NVD P R VA V LS Y S N FGS VDNEG T R K P R R A AQQL R E d DDI D FP VDGE M Q A D 663
Cdd:COG0280 161 L F IT D TA VN I DP T A EQ LA DI A INA AD T AR A F GIE P K VA L LS A S E FGS PKGPS T D K V R E A TKMA R G - QIP D LE VDGE L Q F D 239
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499205643 664 T A VVEDILQGSYEF S DLDTA ANVL I FP N LEAGNI G YKLLQRL G GA D AIGP M L V G MN KPVH V L Q RGD E V K DIVN L 737
Cdd:COG0280 240 A A LSPEAAKRKGPD S PVAGD ANVL V FP D LEAGNI L YKLLQRL A GA E AIGP I L L G LA KPVH L L S RGD S V R DIVN S 313
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
161-398
8.65e-110
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 332.84
E-value: 8.65e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 Q H GTAI ISG A A LLNA AE I A GK D L S D LDV V FS GAGA SA I AT AK FY V SL GV D R EH I TMC DS S G VI T ED R D -- V N EF K AA FA Q 238
Cdd:smart00919 1 Q Q GTAI VVL A G LLNA LK I T GK K L E D QRI V VN GAGA AG I GI AK LL V AA GV K R KN I WLV DS K G LL T KG R E dn L N PY K KP FA R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 239 PAD -- SG G D L AD A MA GADV FV G L S - V GG IVNQA MV R SMA DD PI V FA MA NP D PEI DYES A K A A R EDTV I M ATGRSDYPNQV 315
Cdd:smart00919 81 KTN er ET G T L EE A VK GADV LI G V S g P GG AFTEE MV K SMA ER PI I FA LS NP T PEI EPTA A D A Y R WTAA I V ATGRSDYPNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 316 NNVL G FP F IF R GALDVRA TD I NE EMK V A aataladlakqd VPDEVVK A YGDQPLQF G SE YIIP K P L D P RV LFE VA P AVA D 395
Cdd:smart00919 161 NNVL I FP G IF L GALDVRA RR I TD EMK L A ------------ AAEALAD A VPVSEEEL G PG YIIP S P F D R RV SAR VA V AVA K 228
...
gi 499205643 396 AA M 398
Cdd:smart00919 229 AA I 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
161-397
5.97e-107
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 325.38
E-value: 5.97e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QHGTAI ISG A A LLNA AEIA GK DLSDLDV V FS GAGA SA IA T A KFYVSL G VDR E H I TMC DS S GVI T E D R ------ D V NE FKA 234
Cdd:cd05311 1 QHGTAI VTL A G LLNA LKLV GK KIEEVKI V IN GAGA AG IA I A RLLLAA G AKP E N I VVV DS K GVI Y E G R eddlnp D K NE IAK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 235 AFA q P ADS GG D L AD A MA GADVF V G L S VG G I V NQA M VRS MA D DPIVFA M ANP D PEI DY E S AK A A RE D tv I M ATGRSD Y PNQ 314
Cdd:cd05311 81 ETN - P EKT GG T L KE A LK GADVF I G V S RP G V V KKE M IKK MA K DPIVFA L ANP V PEI WP E E AK E A GA D -- I V ATGRSD F PNQ 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 315 VNNVLGFP F IFRGALDVRAT D I N EEMK V AAA T A L ADLA KQD V P devvkaygdqplqf G S EYIIP K P L DPRV LFE VA P AVA 394
Cdd:cd05311 158 VNNVLGFP G IFRGALDVRAT K I T EEMK L AAA E A I ADLA EEE V L -------------- G E EYIIP T P F DPRV VPR VA T AVA 223
...
gi 499205643 395 D AA 397
Cdd:cd05311 224 K AA 226
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
427-737
2.77e-95
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 298.84
E-value: 2.77e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 427 MRIVINK AK SEQQ RI ALG EG G DE KMIR AA HQMHEA GIADP V L L GD RDT I QGTVDA L S LD F D PDVVDPD E GD -- HSA YAD T 504
Cdd:pfam01515 2 LERIFER AK KAKK RI VFP EG E DE RVLK AA QKLLQQ GIADP I L I GD EIE I KAKALG L D LD L D GIEIVDP E TS pr LEE YAD F 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 505 L Y D LRKRKG I T RNE A ESL V a RDPNY LGSTM V EA G D AD AFLT G LTHHYPSA L K P P LQ VV GT A P DTDY V AG V YMLTFQNRVV 584
Cdd:pfam01515 82 Y Y E LRKRKG M T PEI A REI V - RDPNY FAAML V KL G E AD GMVS G AVNTTADT L R P A LQ II GT K P GVKT V SS V FIMLLPDGLL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 585 F C AD AT VN QD P D A DV LAE V A QHT A DL A R RF - NVD PRVA V LSYS N FGS VDN E GTR K P R R A AQQL RE DD d I D FP VDGE M Q A D 663
Cdd:pfam01515 161 F F AD CA VN PN P T A EE LAE I A LMS A KT A K RF g IIE PRVA L LSYS T FGS GKG E DVE K V R E A TKIV RE RA - P D LV VDGE L Q F D 239
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 499205643 664 T A V VE DILQGSYEF S DLDTA ANV LI FP N LEAGNIGYK LL QRLGGA D AIGP M L V G MN KPV HV L Q RG DE V K DIVN L 737
Cdd:pfam01515 240 A A L VE EVAAQKAPD S PVAGK ANV FV FP D LEAGNIGYK IA QRLGGA E AIGP I L Q G LA KPV ND L S RG AS V E DIVN T 313
eutD
PRK09653 phosphotransacetylase;
425-737
8.56e-81
phosphotransacetylase;
Pssm-ID: 236609 [Multi-domain]
Cd Length: 324
Bit Score: 260.93
E-value: 8.56e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 425 EMMRIVIN KAK SEQQR I A L G EG G DE KMIR AA HQMHEA G IAD P V LLG DRDT I QGTVDA L S LD F D PDVVDPD E -- GDHSAY A 502
Cdd:PRK09653 2 DLFESLKE KAK GKKKK I V L P EG E DE RVLK AA KRLQKE G LVE P I LLG NPEE I RAKAKE L G LD L D GVEIIDP E ty PLLEEF A 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 503 DTLYD LRK R KG ITRNE AE S L va R DPNY L G STM V EA G D AD AFLT G LT H HYPSA L K P P LQ VVG T A P DTDY V AG V Y - M LTFQN 581
Cdd:PRK09653 82 EAFVE LRK G KG TEEDA AE L L -- K DPNY F G TML V KL G K AD GMVS G AI H STADT L R P A LQ IIK T K P GVKT V SS V F i M VKGDE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 582 R VV F c AD AT VN QD P D A DV LAE V A QHT A DL A RR F NV DP R VA V LS Y S NF GS VDNEGTR K PRR A AQQLR E DDD i D FPV DGE M Q 661
Cdd:PRK09653 160 R YI F - AD CA VN PN P T A EQ LAE I A INS A ET A KA F GI DP K VA M LS F S TK GS AKGPEVD K VQE A TEIAK E LAP - D LKI DGE L Q 237
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499205643 662 A D T A V V EDILQGSYEF S DLDTA ANV LI FP N LEAGNIGYK LL QRLGG AD A I GP M L V G M NKPV HV L Q RG DE V K DI V NL 737
Cdd:PRK09653 238 F D A A F V PEVAAKKAPG S PVAGK ANV FV FP S LEAGNIGYK IA QRLGG FE A V GP I L Q G L NKPV ND L S RG CS V E DI Y NL 313
pta
TIGR00651 phosphate acetyltransferase; Alternate name: phosphotransacetylase Model contains a gene from ...
441-737
1.46e-73
phosphate acetyltransferase; Alternate name: phosphotransacetylase Model contains a gene from E.coli coding for ethanolamine utilization protein (euti) and also contains similarity to malate oxidoreductases [Central intermediary metabolism, Other, Energy metabolism, Fermentation]
Pssm-ID: 273196 [Multi-domain]
Cd Length: 303
Bit Score: 241.19
E-value: 1.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 441 I ALG EG GDEKMIR AA HQMH E A GIA D PV L LG DRDT IQ GTVDA -- L S L DFDPDVVDPDEG D HSA YA DTLYD LRK R KG I T RNE 518
Cdd:TIGR00651 1 I VFP EG WEPRVLK AA ALLA E R GIA T PV V LG NPEE IQ PKAAG cn L D L GHVVIIDPDVSP D RES YA ERYVE LRK H KG M T EAQ 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 519 A ESLV a RD PN Y LGST MV EA G D AD AFLT G LT H HYPSA L K P P LQ VVG T A P DTDY V AG V YMLTFQNR V VFC AD AT VN Q DP D A D 598
Cdd:TIGR00651 81 A RKQL - RD ES Y FATM MV AL G E AD GLVS G AV H TTADT L R P A LQ IIK T L P GVKI V SS V FIMDLGEE V LVF AD CA VN P DP N A E 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 599 V LAE V A QHT A DL A RR F - NVD P R VA V LSYS NF GS VDN E GTR K P R R A AQQLR E DD d I D FPV DGE M Q A D T A V VE DILQGSYEF 677
Cdd:TIGR00651 160 Q LAE I A IQS A NS A KS F g EIE P K VA L LSYS TK GS GKG E EVE K V R E A TRIAK E KR - P D LTI DGE L Q F D A A F VE KVAEKKAPN 238
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 678 S DLDTA ANV LI FP N L E AGNIGYK LL QRLG G A D AIGP M L V G M NKPV HV L Q RG DE V K DIVN L 737
Cdd:TIGR00651 239 S PVAGS ANV FV FP D L D AGNIGYK IV QRLG D A E AIGP I L Q G L NKPV ND L S RG CS V E DIVN T 298
PRK05632
PRK05632 phosphate acetyltransferase; Reviewed
431-736
4.13e-60
phosphate acetyltransferase; Reviewed
Pssm-ID: 235537 [Multi-domain]
Cd Length: 684
Bit Score: 215.40
E-value: 4.13e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 431 INK A KSEQQ RI A L G EG GDEKMIR AA HQMH E A GIAD P VLLG DRDT I QGTVD A LSL D - FDPDVVDPDEGDHSA Y ADT L YD LR 509
Cdd:PRK05632 370 TER A RAAKK RI V L P EG DEPRTLK AA AICL E R GIAD C VLLG NPEE I RRVAA A QGV D l PAGIEIIDPSEVRER Y VAP L VE LR 449
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 510 K R KG I T RNE A ESLVA r D PN Y L G ST M VEA G DA D AFLT G LT H HYPSALK P P LQ VVG TAP DTDY V AG V YMLTFQNR V VFCA D A 589
Cdd:PRK05632 450 K H KG M T EEV A REQLE - D NV Y F G TM M LAL G EV D GLVS G AV H TTANTIR P A LQ LIK TAP GSSL V SS V FFMLLPDQ V LVYG D C 528
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 590 T VN Q DP D A DV LAE V A QHT AD L A RR F NVD PRVA V LSYS NFG S --- V D N E GT R KPR R A A QQL R E D ddid FPV DG EM Q A D T AV 666
Cdd:PRK05632 529 A VN P DP T A EQ LAE I A IQS AD S A AA F GIE PRVA M LSYS TGT S gsg A D V E KV R EAT R L A RER R P D ---- LLI DG PL Q Y D A AV 604
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499205643 667 VEDI ---- LQG S yefsdl DT A -- A N V L IFP N L EA GN IG YK LL QR LG GA DA IGPML V G MN KPV HV L Q RG DE V K DIVN 736
Cdd:PRK05632 605 DPSV arsk APN S ------ PV A gr A T V F IFP D L NT GN TT YK AV QR SA GA VS IGPML Q G LR KPV ND L S RG AL V D DIVN 674
malic
pfam00390 Malic enzyme, N-terminal domain;
16-148
3.54e-40
Malic enzyme, N-terminal domain;
Pssm-ID: 395314 [Multi-domain]
Cd Length: 182
Bit Score: 145.87
E-value: 3.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 16 P GK V E ISTT K PTN T Q -- R DL SLA Y S P G V AAP C R AI ADDPTEAF - TH T TK GN M ---------------- V G VV SN G SAV LG 76
Cdd:pfam00390 1 Q GK N E VLFY K LLS T H ie E DL PIV Y T P T V GEA C Q AI SEIYRRPR g LY T SI GN L gkikdilknwpeedvr V I VV TD G ERI LG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 77 LGD I G A q A AK P V MEGK GV L FKR FA D ID --- V FD I E LD QA T A --------------------------- DE L V AT V S A ME P 126
Cdd:pfam00390 81 LGD L G V - A GM P I MEGK LA L YTA FA G ID psr V LP I V LD VG T N nekllndplylglrhkrvrgeeydefv DE F V EA V K A LF P 159
170 180
....*....|....*....|..
gi 499205643 127 T FGGI NL ED IK AP EC FE VER R L 148
Cdd:pfam00390 160 P FGGI QF ED FG AP NA FE ILE R Y 181
PLN03129
PLN03129 NADP-dependent malic enzyme; Provisional
65-412
1.06e-28
NADP-dependent malic enzyme; Provisional
Pssm-ID: 215594 [Multi-domain]
Cd Length: 581
Bit Score: 121.56
E-value: 1.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 65 V G VV SN G SAV LGLGD I G A Q A akpv M --- E GK GV L FKRFAD ---------- IDV ----------- F D I E L D Q ATA ----- D 115
Cdd:PLN03129 174 V I VV TD G ERI LGLGD L G V Q G ---- M gip V GK LD L YTAAGG irpsavlpvc IDV gtnnekllndp F Y I G L R Q PRL tgeey D 249
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 116 ELV A - TVS A MEPTF G G --- INL ED IKAPEC F EVER R LGD am DVPV F H DD QH GTA IISG A A LL N A AEIA G K DL S D LDVV F S 191
Cdd:PLN03129 250 ELV D e FME A VKQRW G P kvl VQF ED FANKNA F RLLQ R YRT -- THLC F N DD IQ GTA AVAL A G LL A A LRAT G G DL A D QRIL F A 327
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 192 GAG ASAIAT A KFYVS ----- L G VD ---- R EH I TMC DS S G VI T ED R -- DVNE FK AA FA QPADS G GD L AD A MAGA -- D V FV G 258
Cdd:PLN03129 328 GAG EAGTGI A ELIAL amsrq T G IS eeea R KR I WLV DS K G LV T KS R kd SLQP FK KP FA HDHEP G AS L LE A VKAI kp T V LI G 407
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 259 LS - VGG IVNQAMVRS MA DD --- PI V FA MA NP -- DP E IDY E S A KAAREDTV I M A T ---------- G RSDY P N Q V NN VLG FP 322
Cdd:PLN03129 408 LS g VGG TFTKEVLEA MA SL ner PI I FA LS NP ts KA E CTA E E A YTWTGGRA I F A S gspfdpveyn G KTFH P G Q A NN AYI FP 487
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 323 F I FR GAL DVR A TDINEE M KV AAA taladlakqdvpd E VVK A Y - GDQP L QF G SE Y ---- I I PK pldpr VLFE VA P AVA DA A 397
Cdd:PLN03129 488 G I GL GAL LSG A IRVTDD M LL AAA ------------- E ALA A Q v TEEE L AK G AI Y ppfs R I RD ----- ISAH VA A AVA AK A 549
410
....*....|....*...
gi 499205643 398 M E T G V A R --- TEL DLV D Y 412
Cdd:PLN03129 550 Y E E G L A T rlp RPE DLV E Y 567
PTZ00317
PTZ00317 NADP-dependent malic enzyme; Provisional
33-418
6.96e-27
NADP-dependent malic enzyme; Provisional
Pssm-ID: 240357 [Multi-domain]
Cd Length: 559
Bit Score: 115.88
E-value: 6.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 33 L SLA Y S P G V AAP C RAIADDPTEA ---- FTHTT KG NM ------------- V G V VSN GS AV LGLGD I GA QAA k PVME GK GV L 95
Cdd:PTZ00317 102 L PII Y T P T V GEA C QNYSNLFQRD rgly LSRAH KG KI reilknwpydnvd V I V ITD GS RI LGLGD L GA NGM - GISI GK LS L 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 96 FKRFAD I D --- V FDIE LD QA T --------------------------- A DE LVAT VS AME P T f GGINL ED IKAPE CF EVE 145
Cdd:PTZ00317 181 YVAGGG I N psr V LPVV LD VG T nnekllndplylglrekrldddeyyel L DE FMEA VS SRW P N - AVVQF ED FSNNH CF DLL 259
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 146 R R LGDA md VPV F H DD QH GT AIISG A AL LNA AEIA G KDLSDLDV VF S GAG AS AI AT A KFYVS L ---- GV D RE H ---- ITMC 217
Cdd:PTZ00317 260 E R YQNK -- YRC F N DD IQ GT GAVIA A GF LNA LKLS G VPPEEQRI VF F GAG SA AI GV A NNIAD L aaey GV T RE E alks FYLV 337
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 218 DS S G VI T ED R D -- VNEF K AA FA Q ---- PA DS GG - D L A D AMAGA -- DVFV GLS - VGG IVNQAM V RS MA DD --- PI V F AMA N 284
Cdd:PTZ00317 338 DS K G LV T TT R G dk LAKH K VP FA R tdis AE DS SL k T L E D VVRFV kp TALL GLS g VGG VFTEEV V KT MA SN ver PI I F PLS N 417
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 285 P -- DP E IDY E S A KAAREDTV I M A T G ---------- RSDY P N Q V NN VLG FP FIFR G ALDVRATD I NE EM KV AAA TA LA D L a 352
Cdd:PTZ00317 418 P ts KA E CTA E D A YKWTNGRA I V A S G spfppvtlng KTIQ P S Q G NN LYV FP GVGL G CAIAQPSY I PD EM LI AAA AS LA T L - 496
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 499205643 353 kqd V PD E VVK aygdqplqfg SEYII P k PL DP -- RVLFEV A PA V ADA A M E T G V A RTEL d L V D Y R E EL E A 418
Cdd:PTZ00317 497 --- V SE E DLR ---------- EGKLY P - PL ED ir EISAHI A VD V IEE A Q E M G I A KNKD - L P D N R D EL L A 549
NAD_bind_1_malic_enz
cd05312 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the ...
163-419
1.47e-26
NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists of eukaryotic and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133454
Cd Length: 279
Bit Score: 109.95
E-value: 1.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 163 GTA IISG A A LL N A AE I A GK D LSD LDVV F S GAG ASA I AT A K ---- FY V SL G VD ---- R EH I TMC DS S G VI T E DR - D VNE FK 233
Cdd:cd05312 3 GTA AVAL A G LL A A LR I T GK P LSD QRIL F L GAG SAG I GI A D livs AM V RE G LS eeea R KK I WLV DS K G LL T K DR k D LTP FK 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 234 AA FA QPADSGG -- D L ADAM -- AGAD V FV GLS - VGG IVNQAM VR S MA --- DD PI V FA MA NP DP -- E IDY E S A KAAREDTVI 303
Cdd:cd05312 83 KP FA RKDEEKE gk S L LEVV ka VKPT V LI GLS g VGG AFTEEV VR A MA ksn ER PI I FA LS NP TS ka E CTA E D A YKWTDGRAL 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 304 M A T G ---------- RSDY P N Q V NN VLG FP F I FR GA LDVR A TD I NE EM kvaa AT A L A DLAKQD V P DE VVKA ygdqplqf G S 373
Cdd:cd05312 163 F A S G spfppveyng KTYV P G Q G NN AYI FP G I GL GA ILSG A RH I TD EM ---- FL A A A EALASL V T DE ELAR -------- G R 230
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 499205643 374 E Y ii P k PL DP -- RVLFEV A P AVA DA A M E T G V A RTELDLV D YR E ELEAR 419
Cdd:cd05312 231 L Y -- P - PL SN ir EISAQI A V AVA KY A Y E E G L A TRYPPPE D LE E YVKSQ 275
NAD_bind_malic_enz
cd00762 NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid ...
161-340
2.49e-26
NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133442
Cd Length: 254
Bit Score: 108.84
E-value: 2.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 161 QH GTA IISG A A LL N A AEIAG K DL S DLD V V F S GAGA S A IAT A KFY V S L G V DR -------- EH I TMC D SS G VITED R ---- D 228
Cdd:cd00762 1 IQ GTA SVAV A G LL A A LKVTK K KI S EHK V L F N GAGA A A LGI A NLI V * L * V KE giskeeac KR I W*V D RK G LLVKN R ketc P 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 229 VNEFK A A FA Q P ADSG GDL A DA M -- A GA D VFV G L S - VGG IVNQAMV R SM A --- DD P IV FA MA NP DP -- E IDY E S A KA A R E D 300
Cdd:cd00762 81 NEYHL A R FA N P ERES GDL E DA V ea A KP D FLI G V S r VGG AFTPEVI R A* A ein ER P VI FA LS NP TS ka E CTA E E A YT A T E G 160
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 499205643 301 TV I M A T G RSD ---------- Y P N Q V NN VLG FP FIFR G ALDV R ATD I NEEM 340
Cdd:cd00762 161 RA I F A S G SPF hpvelnggty K P G Q G NN LYI FP GVAL G VILC R IRH I TDDV 210
PRK13529
PRK13529 oxaloacetate-decarboxylating malate dehydrogenase;
67-427
2.62e-24
oxaloacetate-decarboxylating malate dehydrogenase;
Pssm-ID: 237414 [Multi-domain]
Cd Length: 563
Bit Score: 107.91
E-value: 2.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 67 VV SN G SAV LG L GD I G AQA - AK P V me GK GV L FKRFAD ID --- VFDIE LD QA T A ----------------------- DE L V A 119
Cdd:PRK13529 151 VV TD G ERI LG I GD Q G IGG m GI P I -- GK LS L YTACGG ID par TLPVV LD VG T N neqllndplylgwrhprirgeey DE F V D 228
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 120 T - V S A MEPT F GG -- INL ED IKAPECFEVER R LG D am DVPV F H DD QH GT AIISG A A LL N A AE I A G KD LSD LDV VF S GAG AS 196
Cdd:PRK13529 229 E f V Q A VKRR F PN al LQF ED FAQKNARRILE R YR D -- EICT F N DD IQ GT GAVTL A G LL A A LK I T G EP LSD QRI VF L GAG SA 306
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 197 AIAT A KFY V SLG V D -------- R EHIT M C D SS G VI T E D R - D VNE F KAAF A QPADS --------- GGD L ADAM -- AGAD V F 256
Cdd:PRK13529 307 GCGI A DQI V AAM V R eglseeea R KRFF M V D RQ G LL T D D M p D LLD F QKPY A RKREE ladwdtegd VIS L LEVV rn VKPT V L 386
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 257 V G L S - VG G IVNQAM V RS MA --- DD PI V F AMA NP D peidy ES A K A AR ED T ------- VIM ATG ---------- RSDYPN Q V 315
Cdd:PRK13529 387 I G V S g QP G AFTEEI V KE MA ahc ER PI I F PLS NP T ----- SR A E A TP ED L iawtdgr ALV ATG spfapveyng KTYPIG Q C 461
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 316 NN VLG FP FIFR G ALDVR A TDINEE M KV aaataladlakqdvpd EVVK A YG D Q -- PLQF G SEYII P k P LDP -- R V LFEV A P 391
Cdd:PRK13529 462 NN AYI FP GLGL G VIASG A RRVTDG M LM ---------------- AAAH A LA D C vp LAKP G EGALL P - P VED ir E V SRAI A I 524
410 420 430
....*....|....*....|....*....|....*.
gi 499205643 392 AVA D AA M E T G V AR TEL D lvdyr E E LE ARL gks REM M 427
Cdd:PRK13529 525 AVA K AA I E E G L AR ETS D ----- E D LE QAI --- EDN M 552
Malic_M
pfam03949 Malic enzyme, NAD binding domain;
163-340
7.89e-24
Malic enzyme, NAD binding domain;
Pssm-ID: 427608 [Multi-domain]
Cd Length: 257
Bit Score: 101.50
E-value: 7.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 163 GTA IISG A A LL N A AE I A GK D LS DLDV VF S GAG ASA I AT A KF ---- Y V SL G VDR E ---- H I T M C D SS G VI T E DR - D VNE F K 233
Cdd:pfam03949 3 GTA AVAL A G LL A A LK I T GK P LS EQRI VF F GAG SAG I GI A DQ irda M V RE G LSE E eark R I W M V D RQ G LL T D DR e D LTD F Q 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 234 AA FA QPADS ------ G GD L ADAM -- AGAD V FV G L S - V G G IVNQAM VR S MA --- DD PI V F AMA NP DP -- E IDY E S A KAARE 299
Cdd:pfam03949 83 KP FA RKRAE lkgwgd G IT L LEVV rk VKPT V LI G A S g V P G AFTEEI VR A MA aht ER PI I F PLS NP TS ka E ATP E D A YKWTD 162
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 499205643 300 DTVIM ATG ---------- RSDYPN Q V NN VLG FP FIFR GA LDV RA TD I NE EM 340
Cdd:pfam03949 163 GRALF ATG spfppveyng KTYHIG Q G NN AYI FP GLGL GA IVS RA RR I TD EM 213
PRK05805
PRK05805 phosphate butyryltransferase; Validated
426-729
1.78e-08
phosphate butyryltransferase; Validated
Pssm-ID: 180267
Cd Length: 301
Bit Score: 56.64
E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 426 M MRI --- VIN KAK S - EQQR I ALGEGG DE KMIR A AHQMH E A GIA DPV L L GD RDT I Q gtvdalsldfdpdvvdpdegdhs AY 501
Cdd:PRK05805 1 M IKS fde ILS KAK E q PPKT I SVAVAQ DE PVLE A VKEAK E L GIA NAI L V GD KEK I K ----------------------- EI 57
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 502 A dtlydlrkr K G I TRNEAESLVARDPNYLGST ----- M V EA G D AD AFLT GL TH h YPSA L KPP L - QVV G -- T APDTDY VA g 573
Cdd:PRK05805 58 A --------- K E I DMDLEDFEIIDEKDNRKAA lkave L V SS G K AD MVMK GL VD - TANF L RAV L n KEI G lr T GKTMSH VA - 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 574 V YMLTFQN R VV F CA DA TV N QD PD ADVLAEVAQHTADL A RRFNVD - P R VA VL sysnf GS V DNEGTRK P R ---- RAAQQLRE 648
Cdd:PRK05805 127 V FEVPKYD R LL F LT DA AF N IA PD LKEKIDIINNAVTV A HAIGIE n P K VA PI ----- CA V EVVNPKM P A tlda ALLSKMSD 201
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 649 DDD I - DFP VDG EMQA D T A VV E DILQGSYEFSDLDTA A NV L IF PN L EAGN IG YK L L QRLGGA d AI G PM LVG MNK PV HVLQ R 727
Cdd:PRK05805 202 RGQ I k GCI VDG PLAL D N A LS E EAAKHKGIDGPVAGN A DI L LV PN I EAGN VM YK T L TYFADC - KN G GL LVG TSA PV VLTS R 280
..
gi 499205643 728 G D 729
Cdd:PRK05805 281 A D 282
PRK07742
PRK07742 phosphate butyryltransferase; Validated
428-729
1.43e-07
phosphate butyryltransferase; Validated
Pssm-ID: 236086
Cd Length: 299
Bit Score: 53.94
E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 428 RIVINK A KSEQQRI A LGEGG DE KM I R A AHQMH E AGI A DPV L L G DRDT I Q gtvdalsldfdpdvvdpdegdhsayadtly D 507
Cdd:PRK07742 5 HLIDQA A GQPKKTV A VAVAE DE EV I E A VAKAI E LQL A RFR L Y G NQEK I M ------------------------------ G 54
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 508 LRKRK G ITRN E AESLVARDPN ---- Y L GSTM V EA G D AD AFLT G lth HY P S A -- LK PP L QV --- VGTAPDTDY VA g V YMLT 578
Cdd:PRK07742 55 MLQEH G LQTS E HIEIIHAQSS aeaa E L AVKA V RN G E AD VLMK G --- NV P T A ni LK AV L NK ewg LRKGSVLSH VA - V FEVP 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 579 FQN R VV F CA DA TV N QD PD ADVL A EVA Q HTADL AR RFNV D - P R VA V L SYSNFGSVDNEG T RKPRRAA Q QL R EDDDIDFP VD 657
Cdd:PRK07742 131 NYD R LI F VT DA AM N IA PD LEQK A AII Q NAVEV AR AIGI D l P K VA P L AAVEVVNPAMQA T IDAAALT Q MN R RGQIKNCV VD 210
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 499205643 658 G EMQA D T AV VEDILQGSYEF SD LDTA A NV L IF P NL EAGN IG YK L L QRLGG A D a I G P M LV G MNK P VHVLQ R G D 729
Cdd:PRK07742 211 G PLAL D N AV SQIAAEHKGIV SD VAGK A DI L LV P TI EAGN VL YK S L VYFAD A K - V G A M IA G AKA P IVLTS R A D 281
PRK11890
PRK11890 phosphate acetyltransferase; Provisional
585-731
2.83e-05
phosphate acetyltransferase; Provisional
Pssm-ID: 183361
Cd Length: 312
Bit Score: 46.91
E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 585 FCA DA T VN QD P DADVL A EVA Q HTA DLA RRFNV D - PRVA V LS ysnfg S V DNEGTRK P R -------- RA A QQLREDDD I dfp 655
Cdd:PRK11890 143 IIT DA A VN IA P TLEDK A DIV Q NAI DLA HALGF D e PRVA I LS ----- A V ETVNPKI P S tldaaalc KM A DRGQITGA I --- 214
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 499205643 656 V DG EMQA D T A VVEDILQGSYEF S DLDTA A NV L IF P N LEAGN IGY K L L QR L G GADA I G PM L v G MNK P VHVLQ R G D E V 731
Cdd:PRK11890 215 L DG PLAF D N A ISPEAARIKGIV S PVAGD A DI L VV P D LEAGN MLA K Q L TF L A GADA A G IV L - G ARV P IILTS R A D S V 289
PRK08190
PRK08190 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
448-732
5.68e-04
bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated
Pssm-ID: 236180 [Multi-domain]
Cd Length: 466
Bit Score: 42.94
E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 448 D EKMI R A A HQMH EAG IAD PVL L G DRDT I QGTVDALS LD FDPDVVDPDEGD H S A yadtlydlrkrkgitrne A ESL VA rdp 527
Cdd:PRK08190 186 D AESL R G A LEAA EAG LIE PVL V G PEAK I RAAAEEAG LD LSGVRIVDVPHS H A A ------------------ A ARA VA --- 244
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 528 nylgst MVE AG DAD A FLT G l TH H YPSA L KPPLQVVGTAPDTDYVAG V YMLTFQN -- R VVFCA DA TV N QD P DADVLAEVA Q 605
Cdd:PRK08190 245 ------ LAR AG EVE A LMK G - SL H TDEL L SAVVARDSGLRTERRISH V FAMDVPT yp R PLLIT DA AI N IA P TLEDKRDIV Q 317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499205643 606 HTA DLA RRFN V D - P R VA V LS ysnfg S V DNEGTRK P RR -- AA Q -------- Q LR ed DD I dfp VDG EMQA D T A VVEDILQGS 674
Cdd:PRK08190 318 NAI DLA HALG V E e P K VA I LS ----- A V ETVNPKM P ST ld AA A lckmadrg Q IT -- GG I --- VDG PLAF D N A ISAEAARTK 387
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 499205643 675 YEF S DLDTA A NV L IF P N LEAGN IGY K L L QR L G GADA I G p MLV G MNK P VHVLQ R G D EVK 732
Cdd:PRK08190 388 GIV S PVAGQ A DI L VV P D LEAGN MLA K Q L TY L A GADA A G - IVL G ARV P IILTS R A D SLR 444
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
