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Conserved domains on  [gi|496036502|ref|WP_008761009|]
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MULTISPECIES: glucosamine-6-phosphate deaminase [Bacteroides]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10011441)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-260 5.64e-169

glucosamine-6-phosphate deaminase; Provisional


:

Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 467.38  E-value: 5.64e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|
gi 496036502 241 DAATEELKVGTYRYFKDIEA 260
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEA 260
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-260 5.64e-169

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 467.38  E-value: 5.64e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|
gi 496036502 241 DAATEELKVGTYRYFKDIEA 260
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEA 260
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 4.89e-162

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 449.65  E-value: 4.89e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502    1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 496036502  241 DAATEELKVGTYRYFKDIE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 1.03e-135

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 382.22  E-value: 1.03e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  10 QSVSQWAAHYVAAKIKAAnptpeKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKEHPESYYSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  90 WNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQKTLTTDTIIA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496036502 170 NSRFFDNDiNKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCDDAATEEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.31e-122

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 349.46  E-value: 1.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAA---NPtpekPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGL 77
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEAiaeKG----RAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  78 PKEHPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRT 157
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 158 -RQKTLTTDTIIANSRFFDNdINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGI 236
Cdd:COG0363  158 dRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|..
gi 496036502 237 IVCDDAATEELK 248
Cdd:COG0363  237 WFLDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.58e-21

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 89.60  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502    7 PDYQSVSQWAAHYVAAKIKAANPTPEkPFVLGCPTGSSPLGMYKALIDlnKKGIVSFQNVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERG-RFTLALSGGSTPKPLYELLAA--APARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   86 YSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGG------IDLFMGGIGPDGHIA--FnePGS-SLTSR 156
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF--PGSpALEET 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  157 TRQKTLTTDtiiansrffdndinkVPKTA---LTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQM 223
Cdd:pfam01182 154 DRLVVAVTD---------------SPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-260 5.64e-169

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 467.38  E-value: 5.64e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|
gi 496036502 241 DAATEELKVGTYRYFKDIEA 260
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEA 260
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 4.89e-162

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 449.65  E-value: 4.89e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502    1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 496036502  241 DAATEELKVGTYRYFKDIE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 4.18e-147

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 411.84  E-value: 4.18e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 161 TLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 496036502 241 DAATEELKVGTYR 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 1.03e-135

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 382.22  E-value: 1.03e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  10 QSVSQWAAHYVAAKIKAAnptpeKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKEHPESYYSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  90 WNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQKTLTTDTIIA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496036502 170 NSRFFDNDiNKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCDDAATEEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.31e-122

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 349.46  E-value: 1.31e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIKAA---NPtpekPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGL 77
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEAiaeKG----RAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  78 PKEHPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRT 157
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 158 -RQKTLTTDTIIANSRFFDNdINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGI 236
Cdd:COG0363  158 dRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|..
gi 496036502 237 IVCDDAATEELK 248
Cdd:COG0363  237 WFLDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 4-247 8.97e-77

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 245.32  E-value: 8.97e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   4 IIQPDYQSVSQWAAHYVAAKIK---AANptpeKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK02122  31 DIFESSEEASRAVAQEIATLIRerqAEG----KPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAP--DLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTR 158
Cdd:PRK02122 107 SLQSYHRFMKENLFDHVDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTR 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 159 QKTLTTDTIIANSRFFdNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIV 238
Cdd:PRK02122 187 LVTLDHITRRDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFV 265


                 ....*....
gi 496036502 239 CDDAATEEL 247
Cdd:PRK02122 266 LDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 14-239 4.63e-41

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 139.41  E-value: 4.63e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  14 QWAAHYVAAKIKAAnPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGivSFQNVVTFNMDEYVGLPKeHPESYYSFMWNNF 93
Cdd:cd00458    2 KEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPLD-SDQSNFRQAKLLA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  94 FSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGpdghiafnepgssltsrtrqktlttdtiiansrf 173
Cdd:cd00458   78 FEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG---------------------------------- 123

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 496036502 174 fdndinkvpktaltvgvgtvLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVC 239
Cdd:cd00458  124 --------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-241 1.00e-37

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 132.65  E-value: 1.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIkaanpTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK09762   1 QTLQQVENYTALSERASEYLLAVI-----RSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILNGNAPDlDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSS-------- 152
Cdd:PRK09762  76 MPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESlqpachis 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 153 -LTSRTRQKTLttdtiIANSrffdndiNKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQM 231
Cdd:PRK09762 155 qLDARTQQHEM-----LKTA-------GRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWL 222

                        250
                 ....*....|
gi 496036502 232 HEKGIIVCDD 241
Cdd:PRK09762 223 HSNFICLIDR 232
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 1.63e-36

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 129.87  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   1 MRLIIQPDYQSVSQWAAHYVAAKIkaanpTPEKPFVLGCPTGSSPLGMYKALIDLnKKGIVSFQNVVTFNMDEYVGLPKE 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITL-VKGKAWYDNVHYYNFDEIPFRGKE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  81 HPESYYSFMWNNFFSHIDIKKENTNILN-GNApdldaecARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPG-SSLTSRTR 158
Cdd:PRK12358  75 GEGVTITNLRNLFFTPAGIKEENIHKLTiDNY-------REHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 159 QKTLTTDT--IIANSRFfDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGI 236
Cdd:PRK12358 148 EVPIQGEMvdIVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLT 226

                        250
                 ....*....|.
gi 496036502 237 IVCDDAATEEL 247
Cdd:PRK12358 227 VILDEAAAAEL 237
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.58e-21

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 89.60  E-value: 1.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502    7 PDYQSVSQWAAHYVAAKIKAANPTPEkPFVLGCPTGSSPLGMYKALIDlnKKGIVSFQNVVTFNMDE-YVglPKEHPESY 85
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERG-RFTLALSGGSTPKPLYELLAA--APARLDWSRVHVFWGDErCV--PPDDPDSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   86 YSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGG------IDLFMGGIGPDGHIA--FnePGS-SLTSR 156
Cdd:pfam01182  76 YGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF--PGSpALEET 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  157 TRQKTLTTDtiiansrffdndinkVPKTA---LTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQM 223
Cdd:pfam01182 154 DRLVVAVTD---------------SPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-230 8.92e-20

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 84.92  E-value: 8.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  10 QSVSQWAAHYVAAKIKAAnPTPEKPFVLGCPTGSSPLGMYKALIDLNKkgiVSFQNVVTFNMDE-YVglPKEHPESYYSF 88
Cdd:cd01400    1 EALAEALADRIAEALAAA-IAKRGRFSLALSGGSTPKPLYELLAAAPA---LDWSKVHVFLGDErCV--PPDDPDSNYRL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  89 MWNNFFSHIDIKKENTNILNGNApDLDAECARYEEKIKSYGG----IDLFMGGIGPDGHIA--FnePGSSLTSRTrqktl 162
Cdd:cd01400   75 AREALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--PGHPALLEE----- 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 496036502 163 TTDTIIANsrffdNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQ 230
Cdd:cd01400  147 TDRLVVAV-----TDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVL 209
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 7-247 3.60e-12

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 64.32  E-value: 3.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502    7 PDYQSVSQWAAHYVAAKIKAANPTPEKpFVLGCPTGSSPLGMYKAL----IDLNKKGIvsfqnvvtFNMDE-YVglPKEH 81
Cdd:TIGR01198   3 SNSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALaaqpLDWSRIHL--------FLGDErYV--PLDH 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502   82 PESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSY------GGIDLFMGGIGPDGHIAfnepgsSLTS 155
Cdd:TIGR01198  72 ADSNTGLAREALLDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTA------SLFP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  156 RTRQKTLTTDTIIansrfFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQM-WTISALQMHEK 234
Cdd:TIGR01198 146 HTPALQETERLVT-----VLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYpLPAAGVLHSGK 220

                         250
                  ....*....|...
gi 496036502  235 GIIVCDDAATEEL 247
Cdd:TIGR01198 221 TLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 41-217 4.57e-06

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 46.78  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502  41 TGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVgLPKEHPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAeCAR 120
Cdd:PLN02360  49 SGGSLISFMGKLCEAPYNKTVDWAKWYIFWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEA-ATD 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 496036502 121 YEEKIKSYGGI--------------DLFMGGIGPDGHIAFNEPG-SSLTSRTRQKTLTTDTiiansrffdndiNKVPKTA 185
Cdd:PLN02360 127 YEFAIRQLVKTrtigvsdisdcpkfDLILLGMGSDGHVASLFPNhPALEEKDDWVTFITDS------------PKPPPER 194

                        170       180       190
                 ....*....|....*....|....*....|..
gi 496036502 186 LTVGVGTVLSAKEVMIIVNGHNKARALYHAVE 217
Cdd:PLN02360 195 ITFTLPVINSASNVAVVATGESKANAVHLAID 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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