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Conserved domains on  [gi|493780934|ref|WP_006729340|]
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glycosyltransferase family A protein [Lactobacillus iners]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-189 2.17e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 120.58  E-value: 2.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   5 PQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHV 83
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  84 DTPYFTFHDGDDWVDPDYTDFFINSFKRYPHVslISCGYWIDKEKQKKSRSIDPKResghltkkeayFKIANVSTSPVKG 163
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPAD--LVYGSRLIREGESDLRRLGSRL-----------FNLVRLLTNLPDS 148

                        170       180
                 ....*....|....*....|....*...
gi 493780934 164 YTWNKCYRLDVVRKHNIK--FMGDIAFM 189
Cdd:COG0463  149 TSGFRLFRREVLEELGFDegFLEDTELL 176
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-189 2.17e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 120.58  E-value: 2.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   5 PQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHV 83
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  84 DTPYFTFHDGDDWVDPDYTDFFINSFKRYPHVslISCGYWIDKEKQKKSRSIDPKResghltkkeayFKIANVSTSPVKG 163
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPAD--LVYGSRLIREGESDLRRLGSRL-----------FNLVRLLTNLPDS 148

                        170       180
                 ....*....|....*....|....*...
gi 493780934 164 YTWNKCYRLDVVRKHNIK--FMGDIAFM 189
Cdd:COG0463  149 TSGFRLFRREVLEELGFDegFLEDTELL 176
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 9-143 3.09e-33

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 118.76  E-value: 3.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKF-LYFKLINKANEGVAAARNVALAHVDTPY 87
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDpRVIRVINEENQGLAAARNAGLKAARGEY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493780934  88 FTFHDGDDWVDPDYTDFFINSFKRYPHVSLISC--GYWIDKEKQKKSRSIDPKRESGH 143
Cdd:cd00761   81 ILFLDADDLLLPDWLERLVAELLADPEADAVGGpgNLLFRRELLEEIGGFDEALLSGE 138
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-265 1.48e-29

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 113.60  E-value: 1.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   1 MLDLPQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLINKANEGVAAARNVAL 80
Cdd:PRK10073   2 MNSTPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  81 AHVDTPYFTFHDGDDWVDPDYTDFFINsFKRYPHVSLISC-GYWIdKEKQKKSRSIDPK---RESGHLTKKEaYFKIAnV 156
Cdd:PRK10073  82 AVATGKYVAFPDADDVVYPTMYETLMT-MALEDDLDVAQCnADWC-FRDTGETWQSIPSdrlRSTGVLSGPD-WLRMA-L 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934 157 STSPVKGYTWNKCYRLDVVRKHNIKFM-----GDIAFMEDEVFNIEYVSlsdgvyFTSKPYYHYWQRPDSLIHVT-SGLK 230
Cdd:PRK10073 158 SSRRWTHVVWLGVYRRDFIVKNNIKFEpglhhQDIPWTTEVMFNALRVR------YTEQSLYKYYLHDTSVSRLPrQGNK 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 493780934 231 yipdNVRaTYRVWHKILKSLrhekKKIRRKMPNKI 265
Cdd:PRK10073 232 ----NLN-YQRHYIKITRML----EKLNRRYADKI 257
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 8-101 1.77e-28

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 106.71  E-value: 1.77e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    8 TVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHVDTP 86
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIrLPENRGKAGARNAGLRAATGD 80

                          90
                  ....*....|....*
gi 493780934   87 YFTFHDGDDWVDPDY 101
Cdd:pfam00535  81 YIAFLDADDEVPPDW 95
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 6-100 3.61e-05

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 43.83  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    6 QLTVIMPVYNVEKYIGRALEaLLNQKNRNFKLLIVnDGSKDKtrqIAESYSDKFLYFKLIN-------KANEGVAAARNV 78
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLR-YYSDFGCDYRIIIA-DSSDEK---FNENNLKVFKNYSNPNitylhypDLGVPFYEKLLD 75

                          90       100
                  ....*....|....*....|..
gi 493780934   79 ALAHVDTPYFTFHDGDDWVDPD 100
Cdd:TIGR04440  76 ALEQVETPYVVICADDDFIIPS 97
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-189 2.17e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 120.58  E-value: 2.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   5 PQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHV 83
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  84 DTPYFTFHDGDDWVDPDYTDFFINSFKRYPHVslISCGYWIDKEKQKKSRSIDPKResghltkkeayFKIANVSTSPVKG 163
Cdd:COG0463   82 RGDYIAFLDADDQLDPEKLEELVAALEEGPAD--LVYGSRLIREGESDLRRLGSRL-----------FNLVRLLTNLPDS 148

                        170       180
                 ....*....|....*....|....*...
gi 493780934 164 YTWNKCYRLDVVRKHNIK--FMGDIAFM 189
Cdd:COG0463  149 TSGFRLFRREVLEELGFDegFLEDTELL 176
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 9-143 3.09e-33

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 118.76  E-value: 3.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKF-LYFKLINKANEGVAAARNVALAHVDTPY 87
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDpRVIRVINEENQGLAAARNAGLKAARGEY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493780934  88 FTFHDGDDWVDPDYTDFFINSFKRYPHVSLISC--GYWIDKEKQKKSRSIDPKRESGH 143
Cdd:cd00761   81 ILFLDADDLLLPDWLERLVAELLADPEADAVGGpgNLLFRRELLEEIGGFDEALLSGE 138
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-265 1.48e-29

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 113.60  E-value: 1.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   1 MLDLPQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLINKANEGVAAARNVAL 80
Cdd:PRK10073   2 MNSTPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  81 AHVDTPYFTFHDGDDWVDPDYTDFFINsFKRYPHVSLISC-GYWIdKEKQKKSRSIDPK---RESGHLTKKEaYFKIAnV 156
Cdd:PRK10073  82 AVATGKYVAFPDADDVVYPTMYETLMT-MALEDDLDVAQCnADWC-FRDTGETWQSIPSdrlRSTGVLSGPD-WLRMA-L 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934 157 STSPVKGYTWNKCYRLDVVRKHNIKFM-----GDIAFMEDEVFNIEYVSlsdgvyFTSKPYYHYWQRPDSLIHVT-SGLK 230
Cdd:PRK10073 158 SSRRWTHVVWLGVYRRDFIVKNNIKFEpglhhQDIPWTTEVMFNALRVR------YTEQSLYKYYLHDTSVSRLPrQGNK 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 493780934 231 yipdNVRaTYRVWHKILKSLrhekKKIRRKMPNKI 265
Cdd:PRK10073 232 ----NLN-YQRHYIKITRML----EKLNRRYADKI 257
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 8-101 1.77e-28

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 106.71  E-value: 1.77e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    8 TVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHVDTP 86
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIrLPENRGKAGARNAGLRAATGD 80

                          90
                  ....*....|....*
gi 493780934   87 YFTFHDGDDWVDPDY 101
Cdd:pfam00535  81 YIAFLDADDEVPPDW 95
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-127 3.72e-27

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 106.75  E-value: 3.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   3 DLPQLTVIMPVYNVEKYIGRALEALLNQK--NRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVA 79
Cdd:COG1215   27 DLPRVSVIIPAYNEEAVIEETLRSLLAQDypKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIeRPENGGKAAALNAG 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 493780934  80 LAHVDTPYFTFHDGDDWVDPDYTDFFINSFKRyPHVSLISCGYWIDKE 127
Cdd:COG1215  107 LKAARGDIVVFLDADTVLDPDWLRRLVAAFAD-PGVGASGANLAFRRE 153
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
5-101 2.32e-21

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 88.90  E-value: 2.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   5 PQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYsdKFLYFKLI-NKANEGVAAARNVALAHV 83
Cdd:COG1216    3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAAL--AFPRVRVIrNPENLGFAAARNLGLRAA 80

                         90
                 ....*....|....*...
gi 493780934  84 DTPYFTFHDGDDWVDPDY 101
Cdd:COG1216   81 GGDYLLFLDDDTVVEPDW 98
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 9-101 8.56e-18

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 78.81  E-value: 8.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI--NKANEGVAAARNVALAHVDTP 86
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELAALYIRRVLVvrDKENGGKAGALNAGLRHAKGD 80

                         90
                 ....*....|....*
gi 493780934  87 YFTFHDGDDWVDPDY 101
Cdd:cd06423   81 IVVVLDADTILEPDA 95
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 8-101 9.95e-18

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 79.97  E-value: 9.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   8 TVIMPVYNVEKYIGRALEALLNQ--KNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLINKANEGVAAARNVALAHVDT 85
Cdd:cd02525    3 SIIIPVRNEEKYIEELLESLLNQsyPKDLIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPKRIQSAGLNIGIRNSRG 82

                         90
                 ....*....|....*.
gi 493780934  86 PYFTFHDGDDWVDPDY 101
Cdd:cd02525   83 DIIIRVDAHAVYPKDY 98
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-217 4.74e-17

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 77.29  E-value: 4.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   8 TVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDK--FLYFKLINKANEGVAAARNVALAHVDT 85
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKdpFIIILIRNGKNLGVARNFESLLQAADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934  86 PYFTFHDGDD-WvDPDYTDFFINSFKRYPHVSLISCGYWIdkekqkksrsIDPKRESGHLTKKEAY-------FKIANVS 157
Cdd:cd04196   81 DYVFFCDQDDiW-LPDKLERLLKAFLKDDKPLLVYSDLEL----------VDENGNPIGESFFEYQkikpgtsFNNLLFQ 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493780934 158 tSPVKGYT--WNKCYRLDVvrkhnIKFMGDIAFMEDEVFNIeYVSLSDGVYFTSKPYYHYWQ 217
Cdd:cd04196  150 -NVVTGCTmaFNRELLELA-----LPFPDADVIMHDWWLAL-LASAFGKVVFLDEPLILYRQ 204
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 4-100 1.59e-15

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 73.77  E-value: 1.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   4 LPQLTVIMPVYNVEKYIGRALEALLNQKNRNFKL--LIVNDGSKDKTRQIAESYSDKFLyFKLINKANEGVAAARNVALA 81
Cdd:cd06439   28 LPTVTIIIPAYNEEAVIEAKLENLLALDYPRDRLeiIVVSDGSTDGTAEIAREYADKGV-KLLRFPERRGKAAALNRALA 106

                         90
                 ....*....|....*....
gi 493780934  82 HVDTPYFTFHDGDDWVDPD 100
Cdd:cd06439  107 LATGEIVVFTDANALLDPD 125
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 8-144 1.71e-14

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 70.27  E-value: 1.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   8 TVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFklINKANEGVAAARNVALAHVDTPY 87
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKYEDKITYW--ISEPDKGIYDAMNKGIALATGDI 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 493780934  88 FTFHDGDDWVDPDYTDFFINSFKRYPHVSLISCG-YWIDKEKQKKSRSIDPKRESGHL 144
Cdd:cd06433   79 IGFLNSDDTLLPGALLAVVAAFAEHPEVDVVYGDvLLVDENGRVIGRRRPPPFLDKFL 136
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 9-100 2.17e-14

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 69.13  E-value: 2.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYfkLINKANEGVAAARNVALAHVDTPYF 88
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELFPEVRL--IRNGENLGFGAGNNQGIREAKGDYV 78

                         90
                 ....*....|..
gi 493780934  89 TFHDGDDWVDPD 100
Cdd:cd04186   79 LLLNPDTVVEPG 90
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 9-101 1.15e-12

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 64.90  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLN--QKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALAHVDT 85
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvlEEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIrLSRNFGKGAAVRAGFKAARG 80

                         90
                 ....*....|....*.
gi 493780934  86 PYFTFHDGDDWVDPDY 101
Cdd:cd04179   81 DIVVTMDADLQHPPED 96
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 9-120 1.61e-12

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 65.17  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRN-FKLLIVNDGSKDKTRQIAESYSDKFLYFKLI-------NKANEGVAAARNVAL 80
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFEGtLELSVFNDASTDKSAEIIEKWRKKLEDSGVIvlvgshnSPSPKGVGYAKNQAI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 493780934  81 AHVDTPYFTFHDGDDWVDPDYTDFFINSFKRYPHvSLISC 120
Cdd:cd06913   81 AQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHPN-SIIGC 119
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 7-126 2.53e-12

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 64.62  E-value: 2.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   7 LTVIMPVYNVEKYIGRALEALLNQKNRnfkLLIVNDGSKDKTRQIAESYSDKFLYFKlinkaNEGVAAARNVALAHVDTP 86
Cdd:cd02511    2 LSVVIITKNEERNIERCLESVKWAVDE---IIVVDSGSTDRTVEIAKEYGAKVYQRW-----WDGFGAQRNFALELATND 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 493780934  87 YFTFHDGDDWVDP-------------DYTDFFINSFKRYPHVSLISCGYWIDK 126
Cdd:cd02511   74 WVLSLDADERLTPeladeilallatdDYDGYYVPRRNFFLGRWIRHGGWYPDR 126
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 9-94 2.62e-10

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 58.73  E-value: 2.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEA----LLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKF-LYFKLI-NKANEGVAAARNVALAH 82
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEaveyLEERPSFSYEIIVVDDGSKDGTAEVARKLARKNpALIRVLtLPKNRGKGGAVRAGMLA 80

                         90
                 ....*....|..
gi 493780934  83 VDTPYFTFHDGD 94
Cdd:cd04188   81 ARGDYILFADAD 92
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 5-100 3.52e-10

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 57.98  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   5 PQLTVIMPVYNV-EKYIGRALEALLNQKNRNFKLLIVNDGS-KDKTRQIAESYSDKFLYFKLI-NKANEGVAAARNVALA 81
Cdd:cd04184    1 PLISIVMPVYNTpEKYLREAIESVRAQTYPNWELCIADDAStDPEVKRVLKKYAAQDPRIKVVfREENGGISAATNSALE 80

                         90
                 ....*....|....*....
gi 493780934  82 HVDTPYFTFHDGDDWVDPD 100
Cdd:cd04184   81 LATGEFVALLDHDDELAPH 99
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 9-112 4.95e-10

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 57.20  E-value: 4.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLY-FKLINKANEG--VAAARNVALAHVDT 85
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFPIpIKHVWQEDEGfrKAKIRNKAIAAAKG 80

                         90       100
                 ....*....|....*....|....*..
gi 493780934  86 PYFTFHDGDDWVDPDytdfFINSFKRY 112
Cdd:cd06420   81 DYLIFIDGDCIPHPD----FIADHIEL 103
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 5-101 1.63e-08

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 53.53  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    5 PQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKT----RQIAESYSDKFLyfKLINKANE----GVAAAR 76
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETldvaEEIAARFPDVRL--RVIRNARLlgptGKSRGL 79

                          90       100
                  ....*....|....*....|....*
gi 493780934   77 NVALAHVDTPYFTFHDGDDWVDPDY 101
Cdd:pfam13641  80 NHGFRAVKSDLVVLHDDDSVLHPGT 104
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 7-76 2.45e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 52.96  E-value: 2.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493780934   7 LTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESysdkfLYFKLINKA-------NEGVAAAR 76
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGTVAIARS-----AGVVVISSPkgrarqmNAGAAAAR 72
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 8-100 1.32e-07

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 51.51  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    8 TVIMPVYNVEK--YIGRALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFL--YFKLINKANEGVAAARNVALAHV 83
Cdd:pfam10111   1 SVVIPVYNGEKthWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLqvYYPNAPDTTYSLAASRNRGTSHA 80

                          90
                  ....*....|....*..
gi 493780934   84 DTPYFTFHDGDDWVDPD 100
Cdd:pfam10111  81 IGEYISFIDGDCLWSPD 97
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 9-65 2.84e-07

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 49.40  E-value: 2.84e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIG---RALEALLNQKNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLI 65
Cdd:cd04187    1 IVVPVYNEEENLPelyERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRVKVI 60
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
1-106 8.74e-07

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 49.22  E-value: 8.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   1 MLDLPQLTVIMPVYNVEKYIGRALEALLNQKNRNFKLLIVNDGSK--DKTRQIAESYSDKFLYFkLINKANEGVAAARNV 78
Cdd:PRK10018   1 MKDNPLISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTswEQLQQYVTALNDPRITY-IHNDINSGACAVRNQ 79

                         90       100
                 ....*....|....*....|....*...
gi 493780934  79 ALAHVDTPYFTFHDGDDWVDPDYTDFFI 106
Cdd:PRK10018  80 AIMLAQGEYITGIDDDDEWTPNRLSVFL 107
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 6-66 4.00e-06

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 47.07  E-value: 4.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493780934   6 QLTVIMPVYNVEKYIGRALEAL---LNQKNR-----NFKLLIVNDGSKDKTRQIAESYSdKFLYFKLIN 66
Cdd:PTZ00260  71 DLSIVIPAYNEEDRLPKMLKETikyLESRSRkdpkfKYEIIIVNDGSKDKTLKVAKDFW-RQNINPNID 138
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 9-109 1.40e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 44.97  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQK--NRNFKLLIVNDGSKDKTRQIAESYSDKFLYF-KLIN---KANEGVAAARNVALAH 82
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDypKEKFEVILVDDHSTDGTVQILEFAAAKPNFQlKILNnsrVSISGKKNALTTAIKA 80

                         90       100
                 ....*....|....*....|....*..
gi 493780934  83 VDTPYFTFHDGDDWVDPDYTDFFINSF 109
Cdd:cd04192   81 AKGDWIVTTDADCVVPSNWLLTFVAFI 107
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 6-100 3.61e-05

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 43.83  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934    6 QLTVIMPVYNVEKYIGRALEaLLNQKNRNFKLLIVnDGSKDKtrqIAESYSDKFLYFKLIN-------KANEGVAAARNV 78
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLR-YYSDFGCDYRIIIA-DSSDEK---FNENNLKVFKNYSNPNitylhypDLGVPFYEKLLD 75

                          90       100
                  ....*....|....*....|..
gi 493780934   79 ALAHVDTPYFTFHDGDDWVDPD 100
Cdd:TIGR04440  76 ALEQVETPYVVICADDDFIIPS 97
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 8-133 5.44e-05

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 43.07  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493780934   8 TVIMPVYNVEK--YIGRALEALLNQKNRNFKLLIVNDGS-KDKTRQIAESYSDKfLYFKLIN-KANEGVAAARNVALAHV 83
Cdd:cd04195    1 SVLMSVYIKEKpeFLREALESILKQTLPPDEVVLVKDGPvTQSLNEVLEEFKRK-LPLKVVPlEKNRGLGKALNEGLKHC 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 493780934  84 DTPYFTFHDGDDWVDPDYTDFFINSFKRYPHVSLIscGYWIDK----EKQKKSR 133
Cdd:cd04195   80 TYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIV--GGGVLEfdsdGNDIGKR 131
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 9-71 1.15e-04

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 42.14  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQ-KNRNFKLLIVNDGSKDKTRQIAESYSDKFLYFKLINKANEG 71
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAAlKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKR 64
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 9-53 6.59e-03

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 36.59  E-value: 6.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 493780934   9 VIMPVYNVEKYIGRALEALLNQKnRNFKLLIVNDGSKDKTRQIAE 53
Cdd:cd06436    1 VLVPCLNEEAVIQRTLASLLRNK-PNFLVLVIDDASDDDTAGIVR 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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