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Conserved domains on  [gi|489952726|ref|WP_003856033|]
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triose-phosphate isomerase [Corynebacterium glutamicum]

Protein Classification

triose-phosphate isomerase family protein( domain architecture ID 10785057)

triose-phosphate isomerase (TIM or TPI) family protein such as TIM, a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.-
Gene Ontology:  GO:0005975|GO:0004807|GO:0006094|GO:0006096
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 3-246 7.95e-132

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 372.47  E-value: 7.95e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   3 RKPLIAGNWKMNLDHQQAIGTVQKLAFALPKeyFEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGE 82
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAGSPIAL--GAQNVHWEDSGAYTGE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  83 VSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAT 162
Cdd:COG0149   78 ISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 163 ELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGAS 242
Cdd:COG0149  158 QAANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGAS 237


                 ....
gi 489952726 243 LDGE 246
Cdd:COG0149  238 LDAE 241
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 3-246 7.95e-132

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 372.47  E-value: 7.95e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   3 RKPLIAGNWKMNLDHQQAIGTVQKLAFALPKeyFEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGE 82
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAGSPIAL--GAQNVHWEDSGAYTGE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  83 VSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAT 162
Cdd:COG0149   78 ISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 163 ELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGAS 242
Cdd:COG0149  158 QAANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGAS 237


                 ....
gi 489952726 243 LDGE 246
Cdd:COG0149  238 LDAE 241
tpiA PRK00042
triosephosphate isomerase; Provisional
 3-246 1.92e-131

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 371.37  E-value: 1.92e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   3 RKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEyfEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGE 82
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA--DGVEVAVAPPFTALASVKEALKGSNIKL--GAQNVHPEDSGAFTGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  83 VSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAT 162
Cdd:PRK00042  77 ISAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 163 ELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGAS 242
Cdd:PRK00042 157 QFANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGAS 235


                 ....
gi 489952726 243 LDGE 246
Cdd:PRK00042 236 LKAE 239
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-246 3.80e-113

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 324.85  E-value: 3.80e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726    5 PLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFekVDVAVTVPFTDIRSVQTLVEgdkLEVTFGAQDVSQHESGAYTGEVS 84
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESG--VEVVVAPPFTYLSAVAELLG---SNIKVGAQNVDPEESGAFTGEIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   85 ASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAtEL 164
Cdd:pfam00121  76 AEMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGA-EQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  165 ANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLD 244
Cdd:pfam00121 155 KNLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYK-EVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLK 233


                  ..
gi 489952726  245 GE 246
Cdd:pfam00121 234 AE 235
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-246 3.01e-108

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 312.55  E-value: 3.01e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   5 PLIAGNWKMNLDHQQAIGTVQKLAFALPKEyfEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGEVS 84
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDE--SGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGEIS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  85 ASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAteL 164
Cdd:cd00311   77 AEMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVED--L 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 165 ANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLD 244
Cdd:cd00311  155 APVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                 ..
gi 489952726 245 GE 246
Cdd:cd00311  234 AE 235
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 6-246 1.63e-38

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 133.39  E-value: 1.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726    6 LIAGNWKMnldHQQAIGTVQKLAFALPKEYFEK--VDVAVTVPFTDIRSVQtlvegDKLEVTFGAQDVSQHESGAYTGEV 83
Cdd:TIGR00419   1 LVIGNWKT---YNESRGMRALEVAKIAEEVASEagVAVAVAPPFVDLPMIK-----REVEIPVYAQHVDAVLSGAHTGEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   84 SASMLAKLNCSWVVVGHSERReyHNESDelVAAKAKAALSNGISPIVCvgepleireagthVEYVVEQTRkslagldATE 163
Cdd:TIGR00419  73 SAEMLKDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVC-------------TNNVLTTAA-------AAA 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  164 LANTVIAYEPVWAIGTGKVASAADAQEVCKAIRglivelAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASL 243
Cdd:TIGR00419 129 LEPDVVAVEPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSL 202


                  ...
gi 489952726  244 DGE 246
Cdd:TIGR00419 203 KAD 205
 
Name Accession Description Interval E-value
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 3-246 7.95e-132

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 372.47  E-value: 7.95e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   3 RKPLIAGNWKMNLDHQQAIGTVQKLAFALPKeyFEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGE 82
Cdd:COG0149    2 RKPLIAGNWKMNGTLAEAKALLAALAAALAD--LADVEVVVCPPFTYLAAVAEALAGSPIAL--GAQNVHWEDSGAYTGE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  83 VSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAT 162
Cdd:COG0149   78 ISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 163 ELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGAS 242
Cdd:COG0149  158 QAANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGAS 237


                 ....
gi 489952726 243 LDGE 246
Cdd:COG0149  238 LDAE 241
tpiA PRK00042
triosephosphate isomerase; Provisional
 3-246 1.92e-131

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 371.37  E-value: 1.92e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   3 RKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEyfEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGE 82
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAALPDA--DGVEVAVAPPFTALASVKEALKGSNIKL--GAQNVHPEDSGAFTGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  83 VSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAT 162
Cdd:PRK00042  77 ISAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 163 ELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGAS 242
Cdd:PRK00042 157 QFANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGAS 235


                 ....
gi 489952726 243 LDGE 246
Cdd:PRK00042 236 LKAE 239
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-246 3.80e-113

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 324.85  E-value: 3.80e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726    5 PLIAGNWKMNLDHQQAIGTVQKLAFALPKEYFekVDVAVTVPFTDIRSVQTLVEgdkLEVTFGAQDVSQHESGAYTGEVS 84
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESG--VEVVVAPPFTYLSAVAELLG---SNIKVGAQNVDPEESGAFTGEIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   85 ASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAtEL 164
Cdd:pfam00121  76 AEMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGA-EQ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  165 ANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLD 244
Cdd:pfam00121 155 KNLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYK-EVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLK 233


                  ..
gi 489952726  245 GE 246
Cdd:pfam00121 234 AE 235
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-246 3.01e-108

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 312.55  E-value: 3.01e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   5 PLIAGNWKMNLDHQQAIGTVQKLAFALPKEyfEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTGEVS 84
Cdd:cd00311    1 PLVAGNWKMNGTLAEALELAKALNAVLKDE--SGVEVVVAPPFTYLAAVAEALEGSKIKV--GAQNVSPEDSGAFTGEIS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  85 ASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDAteL 164
Cdd:cd00311   77 AEMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVED--L 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 165 ANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLD 244
Cdd:cd00311  155 APVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLK 233


                 ..
gi 489952726 245 GE 246
Cdd:cd00311  234 AE 235
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 2-246 8.32e-102

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 309.35  E-value: 8.32e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   2 ARKPLIAGNWKMNLDHQQAIGTVQKLAFALPKEyfeKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESGAYTG 81
Cdd:PRK13962 396 PRKPIIAGNWKMNKTPAEAKEFVNELKKYVKDA---QAEVVVCPPFTALPSVKEAVDGSNIKL--GAQNVFYEEKGAYTG 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  82 EVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDA 161
Cdd:PRK13962 471 EISGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNGLSA 550

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 162 TELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGA 241
Cdd:PRK13962 551 EQVKKVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGA 630


                 ....*
gi 489952726 242 SLDGE 246
Cdd:PRK13962 631 SLKAQ 635
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 1.31e-78

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 237.89  E-value: 1.31e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   1 MARKPLIAGNWKMNLDHQQA---IGTVQKLAFAlpkeyFEKVDVAVTVPFTDIRSVQTLVEGDKLEVtfGAQDVSQHESG 77
Cdd:PTZ00333   2 MKRKPFVGGNWKCNGTKASIkelIDSFNKLKFD-----PNNVDVVVAPPSLHIPLVQEKLKNKNFKI--SSQNVSLTGSG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  78 AYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLA 157
Cdd:PTZ00333  75 AFTGEISAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 158 GLDATELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGL 237
Cdd:PTZ00333 155 KVSDEAWDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFL 234


                 ....*....
gi 489952726 238 VGGASLDGE 246
Cdd:PTZ00333 235 VGGASLKPD 243
PLN02561 PLN02561
triosephosphate isomerase
 1-246 5.45e-65

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 203.13  E-value: 5.45e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   1 MARKPLIAGNWKMNLDHQQAIGTVQKLAFA-LPKEyfEKVDVAVTVPFTDIRSVQTLVEGDkleVTFGAQDVSQHESGAY 79
Cdd:PLN02561   1 MARKFFVGGNWKCNGTVEEVKKIVTTLNEAeVPSE--DVVEVVVSPPFVFLPLVKSLLRPD---FQVAAQNCWVKKGGAF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  80 TGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTrKSLAGl 159
Cdd:PLN02561  76 TGEISAEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQT-KAIAD- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 160 DATELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRGLIVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVG 239
Cdd:PLN02561 154 KVSDWANVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVG 233


                 ....*..
gi 489952726 240 GASLDGE 246
Cdd:PLN02561 234 GASLKPE 240
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 6-244 1.33e-49

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 163.01  E-value: 1.33e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   6 LIAGNWKMNLDHQQAIGTVQKLA--FALPKEyfeKVDVAVTVPFTdirSVQTLVEGDKlEVTFGAQDVSQHESGAYTGEV 83
Cdd:PRK14565   4 LIVANWKMNGDFSLFSSFLKELSnkLANNEI---TLKLVICPPFT---AMSSFVECNP-NIKLGAQNCFYGSSGGYTGEI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  84 SASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAgldatE 163
Cdd:PRK14565  77 SAKMLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCLP-----K 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 164 LANTVIAYEPVWAIGTGKVASAADAQEVCKAIRglivelagdEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASL 243
Cdd:PRK14565 152 HGEFIIAYEPVWAIGGSTIPSNDAIAEAFEIIR---------SYDSKSHIIYGGSVNQENIRDLKSINQLSGVLVGSASL 222


                 .
gi 489952726 244 D 244
Cdd:PRK14565 223 D 223
PLN02429 PLN02429
triosephosphate isomerase
 39-245 4.63e-47

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 158.80  E-value: 4.63e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  39 VDVAVTVPFTDIRSVQTLVEgDKLEVTfgAQDVSQHESGAYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKA 118
Cdd:PLN02429  97 VDVVVSPPFVYIDQVKSSLT-DRIDIS--GQNSWVGKGGAFTGEISVEQLKDLGCKWVILGHSERRHVIGEKDEFIGKKA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 119 KAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDATElaNTVIAYEPVWAIGTGKVASAADAQEVCKAIRGL 198
Cdd:PLN02429 174 AYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWD--NIVVAYEPVWAIGTGKVASPQQAQEVHVAVRGW 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489952726 199 IVELAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLDG 245
Cdd:PLN02429 252 LKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKG 298
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 11-246 3.98e-39

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 136.66  E-value: 3.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  11 WKMNLDHQQAIGTVQKLAFALPKEyfEKVDVAVTVPFTDIRSV--QTLVEGDKLEVTFGAQDVSQHESGAYTGEVSASML 88
Cdd:PRK15492  13 YKGIADATDFLAKLSELADDIPAD--KDIELFVIPSFTAIQDAiaATLAIPHDHPIIIGAQNMNPNDNGQFTGDISPLML 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  89 AKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKSLAGLDATELANTV 168
Cdd:PRK15492  91 KEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKIGLHGINPDQLAKLR 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489952726 169 IAYEPVWAIGTGKVASAAD-AQEVCKAIRGLIVELAGDEvAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASLDGE 246
Cdd:PRK15492 171 IAYEPVWAIGEAGIPASADyADEKHAVIKQCLIELFGDA-GDDIPVFYGGSVNAENANELFGQPHIDGLFIGRSAWDAD 248
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 6-246 1.63e-38

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 133.39  E-value: 1.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726    6 LIAGNWKMnldHQQAIGTVQKLAFALPKEYFEK--VDVAVTVPFTDIRSVQtlvegDKLEVTFGAQDVSQHESGAYTGEV 83
Cdd:TIGR00419   1 LVIGNWKT---YNESRGMRALEVAKIAEEVASEagVAVAVAPPFVDLPMIK-----REVEIPVYAQHVDAVLSGAHTGEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   84 SASMLAKLNCSWVVVGHSERReyHNESDelVAAKAKAALSNGISPIVCvgepleireagthVEYVVEQTRkslagldATE 163
Cdd:TIGR00419  73 SAEMLKDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVC-------------TNNVLTTAA-------AAA 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  164 LANTVIAYEPVWAIGTGKVASAADAQEVCKAIRglivelAGDEVAEGLRILYGGSVKAETVAEIVGQPDVDGGLVGGASL 243
Cdd:TIGR00419 129 LEPDVVAVEPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSL 202


                  ...
gi 489952726  244 DGE 246
Cdd:TIGR00419 203 KAD 205
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 1-246 1.05e-37

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 135.54  E-value: 1.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726   1 MARKPLIAGNWKM---NLDHQQAIGTVQKLAFALPKEYfeKVDVAVTVPFTDIRSVQTLV--EGDKLEVTFGAQDVSQHE 75
Cdd:PRK14905   1 MAKKIYFGTNLKMykgNAETVDYLSELLAFAEKFKSDY--DIELFVIPSYIALKDAVEAAasETGHPKIKIGAQNMNAKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  76 SGAYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKAKAALSNGISPIVCVGEPLEIREAGTHVEYVVEQTRKS 155
Cdd:PRK14905  79 KGQFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 156 LAGLDATELANTVIAYEPVWAIGTGKV-ASAADAQEVCKAIRGLIVELAGDEvAEGLRILYGGSVKAETVAEIVGQPDVD 234
Cdd:PRK14905 159 LHGVSAEQLPHLFIAYEPVWAIGEGGIpASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLENANELIMKPHID 237

                        250
                 ....*....|..
gi 489952726 235 GGLVGGASLDGE 246
Cdd:PRK14905 238 GLFIGRSAWDAQ 249
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 39-217 4.97e-09

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 54.87  E-value: 4.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726  39 VDVAVTVPFTDIRSVQTLVEgdkLEVTfgAQDVSQHESGAYTGEVSASMLAKLNCSWVVVGHSERREYHNESDELVAAKA 118
Cdd:PRK04302  37 VRIAVAPQALDIRRVAEEVD---IPVY--AQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTLADIEAVVERAK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489952726 119 kaalSNGISPIVCVGEPLEIREagthveyvveqtrkslagldATELANTVIAYEPVWAIGTGKVASAADAQEVCKAIRgl 198
Cdd:PRK04302 112 ----KLGLESVVCVNNPETSAA--------------------AAALGPDYVAVEPPELIGTGIPVSKAKPEVVEDAVE-- 165

                        170
                 ....*....|....*....
gi 489952726 199 ivelAGDEVAEGLRILYGG 217
Cdd:PRK04302 166 ----AVKKVNPDVKVLCGA 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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