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Conserved domains on  [gi|489147517|ref|WP_003057255|]
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MULTISPECIES: K+/H+ antiporter subunit F [Comamonas]

Protein Classification

cation:proton antiporter subunit F( domain architecture ID 10012679)

cation:proton antiporter subunit F, part of an antiporter complex involved in monovalent cation transport; important in resistance to high concentrations of Na+, K+, Li+ and/or alkali

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06161 PRK06161
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-92 3.36e-31

putative monovalent cation/H+ antiporter subunit F; Reviewed


:

Pssm-ID: 180435  Cd Length: 89  Bit Score: 104.93  E-value: 3.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  6 YWVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFL 85
Cdd:PRK06161  3 AWAILIAQVALALAMLLALWRLLRGPRAQDRILALDTLYINAILLLLVFGIRLGSTIYFEAALLIALLGFVSTVALAKFL 82


                ....*..
gi 489147517 86 LRGEVIE 92
Cdd:PRK06161 83 LRGEVIE 89
 
Name Accession Description Interval E-value
PRK06161 PRK06161
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-92 3.36e-31

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 180435  Cd Length: 89  Bit Score: 104.93  E-value: 3.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  6 YWVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFL 85
Cdd:PRK06161  3 AWAILIAQVALALAMLLALWRLLRGPRAQDRILALDTLYINAILLLLVFGIRLGSTIYFEAALLIALLGFVSTVALAKFL 82


                ....*..
gi 489147517 86 LRGEVIE 92
Cdd:PRK06161 83 LRGEVIE 89
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
4-87 1.01e-20

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 78.22  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  4 WFYWVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAK 83
Cdd:COG2212   1 MMTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFAR 80


                ....
gi 489147517 84 FLLR 87
Cdd:COG2212  81 FLER 84
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 35-86 2.93e-10

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 50.86  E-value: 2.93e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489147517  35 DRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFLL 86
Cdd:pfam04066  1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARFLE 52
 
Name Accession Description Interval E-value
PRK06161 PRK06161
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-92 3.36e-31

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 180435  Cd Length: 89  Bit Score: 104.93  E-value: 3.36e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  6 YWVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFL 85
Cdd:PRK06161  3 AWAILIAQVALALAMLLALWRLLRGPRAQDRILALDTLYINAILLLLVFGIRLGSTIYFEAALLIALLGFVSTVALAKFL 82


                ....*..
gi 489147517 86 LRGEVIE 92
Cdd:PRK06161 83 LRGEVIE 89
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
4-87 1.01e-20

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 78.22  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  4 WFYWVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAK 83
Cdd:COG2212   1 MMTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFAR 80


                ....
gi 489147517 84 FLLR 87
Cdd:COG2212  81 FLER 84
PRK12600 PRK12600
Na(+)/H(+) antiporter subunit F1;
8-92 6.54e-14

Na(+)/H(+) antiporter subunit F1;


Pssm-ID: 183617  Cd Length: 94  Bit Score: 61.10  E-value: 6.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  8 VLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFLLR 87
Cdd:PRK12600  5 ILSIALIIVAISMLLMLIRVIKGPTLADRVVALDAIGINLIAIIALFSILLDTKAYLEVILLIGILAFIGTAAFSKFIEK 84


                ....*
gi 489147517 88 GEVIE 92
Cdd:PRK12600 85 GKVIE 89
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 35-86 2.93e-10

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 50.86  E-value: 2.93e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489147517  35 DRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFLL 86
Cdd:pfam04066  1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARFLE 52
PRK12599 PRK12599
putative monovalent cation/H+ antiporter subunit F; Reviewed
 8-92 5.09e-10

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 237148  Cd Length: 91  Bit Score: 51.06  E-value: 5.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517  8 VLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFLLR 87
Cdd:PRK12599  7 AFLIAAVLLVLALILSLYRVILGPTLPDRVVALDTLNTITVGIIAVLAAATGRPLYLDIAIVYALLSFLGTVAIAKYLVG 86


                ....*
gi 489147517 88 GEVIE 92
Cdd:PRK12599 87 RGGVL 91
PRK12657 PRK12657
putative monovalent cation/H+ antiporter subunit F; Reviewed
 7-92 5.01e-08

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 183657  Cd Length: 100  Bit Score: 46.29  E-value: 5.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489147517   7 WVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKFLL 86
Cdd:PRK12657   8 IMIISALIIFGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRFIG 87


                 ....*.
gi 489147517  87 RGEVIE 92
Cdd:PRK12657  88 GGHVFN 93
PRK07948 PRK07948
putative monovalent cation/H+ antiporter subunit F; Reviewed
 7-84 7.41e-05

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 181179  Cd Length: 86  Bit Score: 37.74  E-value: 7.41e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489147517  7 WVLMASLVMLLAAMGCSVLRLLKGPHAQDRVLALDCMYLNGMLAMLVMGILYDSTNYFEAALLVALFGCVGSTAMAKF 84
Cdd:PRK07948  3 VVLTIAAVFLSLAAILTTYRILAGPNSLDRLVALDTLVAVTMCALATWAAWTLDTTVTNAMTALALIGFIGSVSVARF 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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