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Conserved domains on  [gi|481024241|ref|WP_001295494|]
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MULTISPECIES: EAL domain-containing protein [Enterobacteriaceae]

Protein Classification

EAL domain-containing protein( domain architecture ID 11471819)

EAL domain-containing protein may act as a cyclic diguanylate phosphodiesterase, similar to Escherichia coli putative cyclic-di-GMP phosphodiesterases YjcC and YlaB

Gene Ontology:  GO:0007165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 9-522 6.74e-148

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


:

Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 434.73  E-value: 6.74e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   9 KTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHL-PLR 87
Cdd:COG4943    6 RRLLSLATLLALLAALLPLLLSLWLAQIQARRREREQLESYAQRALARAERVFDQARSALDELNALPGDPCSPAHLaALR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  88 KQAAKLQTVRSIGLVQDGTLYCSSIfGYRNVPVvdilaELPAPQPL------LRLTIDRALIKGSPVLIQwtpaagsSNA 161
Cdd:COG4943   86 RLVFSSRYVRDIGYVRDGRLLCSSL-GKLSKPV-----PLPPPDYVtadgyrLWLNVDNPLDPGRPMLIV-------GRG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 162 GVMEMINIDLLTAMLLEPqlPQISSASLTVDKRHLLYGNGLVDSLP------------QPEDNENYQVSSQRFPFTINVN 229
Cdd:COG4943  153 NYVVVIDPAAFIDVLSPQ--PGISLALLATNGGHLFASSGNPDPALlsrllrgpsswfIQGDRLYASACSPQYPICVVAA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 230 GPGATALA--WHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWN 307
Cdd:COG4943  231 APLAGLLAlwRQLLLLLLPLGLLLSLLLGLLVLRLLRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWR 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 308 NPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQ-RHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWF-SAHPIQQ 385
Cdd:COG4943  311 DPDGSVISPDIFIPLAEQSGLISPLTRQVIEQVFRDlGDLLAADPDFHISINLSASDLLSPRFLDDLERLLArTGVAPQQ 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 386 LILEITERDALLDVDYR-IARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALG 464
Cdd:COG4943  391 IVLEITERGFIDPAKARaVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMA 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481024241 465 QRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHN 522
Cdd:COG4943  471 KTLNLDVVAEGVETEEQADYLRARGVQYGQGWLFAKPLPAEEFIAWLAAQRAPASAPA 528
 
Name Accession Description Interval E-value
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 9-522 6.74e-148

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 434.73  E-value: 6.74e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   9 KTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHL-PLR 87
Cdd:COG4943    6 RRLLSLATLLALLAALLPLLLSLWLAQIQARRREREQLESYAQRALARAERVFDQARSALDELNALPGDPCSPAHLaALR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  88 KQAAKLQTVRSIGLVQDGTLYCSSIfGYRNVPVvdilaELPAPQPL------LRLTIDRALIKGSPVLIQwtpaagsSNA 161
Cdd:COG4943   86 RLVFSSRYVRDIGYVRDGRLLCSSL-GKLSKPV-----PLPPPDYVtadgyrLWLNVDNPLDPGRPMLIV-------GRG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 162 GVMEMINIDLLTAMLLEPqlPQISSASLTVDKRHLLYGNGLVDSLP------------QPEDNENYQVSSQRFPFTINVN 229
Cdd:COG4943  153 NYVVVIDPAAFIDVLSPQ--PGISLALLATNGGHLFASSGNPDPALlsrllrgpsswfIQGDRLYASACSPQYPICVVAA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 230 GPGATALA--WHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWN 307
Cdd:COG4943  231 APLAGLLAlwRQLLLLLLPLGLLLSLLLGLLVLRLLRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWR 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 308 NPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQ-RHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWF-SAHPIQQ 385
Cdd:COG4943  311 DPDGSVISPDIFIPLAEQSGLISPLTRQVIEQVFRDlGDLLAADPDFHISINLSASDLLSPRFLDDLERLLArTGVAPQQ 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 386 LILEITERDALLDVDYR-IARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALG 464
Cdd:COG4943  391 IVLEITERGFIDPAKARaVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMA 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481024241 465 QRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHN 522
Cdd:COG4943  471 KTLNLDVVAEGVETEEQADYLRARGVQYGQGWLFAKPLPAEEFIAWLAAQRAPASAPA 528
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 271-506 1.41e-92

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 282.57  E-value: 1.41e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS 350
Cdd:smart00052   2 RELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   351 S--QFHVGINVAPSHFRRGVLIKDLNQYWFSAH-PIQQLILEITErDALLDVD---YRIARELHRKNVKLAIDDFGTGNS 424
Cdd:smart00052  82 GppPLLISINLSARQLISPDLVPRVLELLEETGlPPQRLELEITE-SVLLDDDesaVATLQRLRELGVRIALDDFGTGYS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   425 SFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPL 504
Cdd:smart00052 161 SLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPL 240


                   ..
gi 481024241   505 RD 506
Cdd:smart00052 241 DD 242
PRK10551 PRK10551
cyclic di-GMP phosphodiesterase;
10-511 3.43e-90

cyclic di-GMP phosphodiesterase;


Pssm-ID: 182541 [Multi-domain]  Cd Length: 518  Bit Score: 286.12  E-value: 3.43e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  10 TYRRNRMIVCTICALVTLASTLSVRFI-----SQRNLNQQ--RVVQFANHAVEELDKVLLPLQagsevllPLIGLPCSVA 82
Cdd:PRK10551   7 SSGRKILLTSIVAGVMIALLFSCLQFLllwhkREVKYDTLitDVQKYLDTYFADLKSTTDRLQ-------PLTLDTCQQV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  83 HLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPL-LRLTIDRALIKGSPVLIQWTPAAGSSNA 161
Cdd:PRK10551  80 NPELTSRAAFSLNVRAFLLVKDKKAFCSSATGEMNTPLSELIPAIDINKPVdMAILPGTPMMPNKPAIVIWYRNPLLKNS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 162 GVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGpgaTALAWHYL 241
Cdd:PRK10551 160 GVFATLNLNLTPYLLYTSRQEDFDGIALIIGNTALSTFSSRLMNVNELPDMPLRETTIPGYPLTIRLYA---DSWTANDI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 242 PTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIP 321
Cdd:PRK10551 237 WYALLLGLLSGILVGLLCYYLLSLRMRPGKEILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFIN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 322 IAEEHHLIVPLTRYVMAETIRQ----RHVFPMSSQFhvGINVAPSHFRRGVLIKDLnQYWFSAHPIQ--QLILEITERDA 395
Cdd:PRK10551 317 YAEAQKLIVPLTQHLFELIARDaaelQKVLPVGAKL--GINISPAHLHSDSFKADV-QRLLASLPADhfQIVLEITERDM 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 396 lldVDYRIARE----LHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIEL 471
Cdd:PRK10551 394 ---VQEEEATKlfawLHSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLT 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|
gi 481024241 472 VAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWL 511
Cdd:PRK10551 471 VAEGVETPEQARWLRERGVNFLQGYWISRPLPLEDFVRWL 510
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 271-506 2.69e-88

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 271.34  E-value: 2.69e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFP-M 349
Cdd:cd01948    1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQaG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 350 SSQFHVGINVAPSHFRRGVLIKDLNQyWFSAHPI--QQLILEITERDALLDVDY--RIARELHRKNVKLAIDDFGTGNSS 425
Cdd:cd01948   81 GPDLRLSVNLSARQLRDPDFLDRLLE-LLAETGLppRRLVLEITESALIDDLEEalATLRRLRALGVRIALDDFGTGYSS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 426 FSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLR 505
Cdd:cd01948  160 LSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAE 239


                 .
gi 481024241 506 D 506
Cdd:cd01948  240 E 240
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 271-501 2.76e-64

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 209.10  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS 350
Cdd:pfam00563   2 RALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  351 SQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPI-QQLILEITERDAL--LDVDYRIARELHRKNVKLAIDDFGTGNSSFS 427
Cdd:pfam00563  82 PDIKLSINLSPASLADPGFLELLRALLKQAGPPpSRLVLEITESDLLarLEALREVLKRLRALGIRIALDDFGTGYSSLS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481024241  428 WLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQP 501
Cdd:pfam00563 162 YLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
 
Name Accession Description Interval E-value
YjcC COG4943
Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal ...
 9-522 6.74e-148

Redox-sensing c-di-GMP phosphodiesterase, contains CSS-motif and EAL domains [Signal transduction mechanisms];


Pssm-ID: 443970 [Multi-domain]  Cd Length: 528  Bit Score: 434.73  E-value: 6.74e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   9 KTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHL-PLR 87
Cdd:COG4943    6 RRLLSLATLLALLAALLPLLLSLWLAQIQARRREREQLESYAQRALARAERVFDQARSALDELNALPGDPCSPAHLaALR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  88 KQAAKLQTVRSIGLVQDGTLYCSSIfGYRNVPVvdilaELPAPQPL------LRLTIDRALIKGSPVLIQwtpaagsSNA 161
Cdd:COG4943   86 RLVFSSRYVRDIGYVRDGRLLCSSL-GKLSKPV-----PLPPPDYVtadgyrLWLNVDNPLDPGRPMLIV-------GRG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 162 GVMEMINIDLLTAMLLEPqlPQISSASLTVDKRHLLYGNGLVDSLP------------QPEDNENYQVSSQRFPFTINVN 229
Cdd:COG4943  153 NYVVVIDPAAFIDVLSPQ--PGISLALLATNGGHLFASSGNPDPALlsrllrgpsswfIQGDRLYASACSPQYPICVVAA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 230 GPGATALA--WHYLPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWN 307
Cdd:COG4943  231 APLAGLLAlwRQLLLLLLPLGLLLSLLLGLLVLRLLRRRLSPRRRLRRAIKRREFYVHYQPIVDLKTGRCVGAEALVRWR 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 308 NPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQ-RHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWF-SAHPIQQ 385
Cdd:COG4943  311 DPDGSVISPDIFIPLAEQSGLISPLTRQVIEQVFRDlGDLLAADPDFHISINLSASDLLSPRFLDDLERLLArTGVAPQQ 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 386 LILEITERDALLDVDYR-IARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALG 464
Cdd:COG4943  391 IVLEITERGFIDPAKARaVIAALREAGHRIAIDDFGTGYSSLSYLQTLPVDILKIDKSFVDAIGTDSANSAVVPHIIEMA 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 481024241 465 QRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHN 522
Cdd:COG4943  471 KTLNLDVVAEGVETEEQADYLRARGVQYGQGWLFAKPLPAEEFIAWLAAQRAPASAPA 528
EAL smart00052
Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a ...
 271-506 1.41e-92

Putative diguanylate phosphodiesterase; Putative diguanylate phosphodiesterase, present in a variety of bacteria.


Pssm-ID: 214491 [Multi-domain]  Cd Length: 242  Bit Score: 282.57  E-value: 1.41e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS 350
Cdd:smart00052   2 RELRQALENGQFLLYYQPIVSLRTGRLVGVEALIRWQHPEGGIISPDEFIPLAEETGLIVPLGRWVLEQACQQLAEWQAQ 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   351 S--QFHVGINVAPSHFRRGVLIKDLNQYWFSAH-PIQQLILEITErDALLDVD---YRIARELHRKNVKLAIDDFGTGNS 424
Cdd:smart00052  82 GppPLLISINLSARQLISPDLVPRVLELLEETGlPPQRLELEITE-SVLLDDDesaVATLQRLRELGVRIALDDFGTGYS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   425 SFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPL 504
Cdd:smart00052 161 SLSYLKRLPVDLLKIDKSFVRDLQTDPEDEAIVQSIIELAQKLGLQVVAEGVETPEQLDLLRSLGCDYGQGYLFSRPLPL 240


                   ..
gi 481024241   505 RD 506
Cdd:smart00052 241 DD 242
PRK10551 PRK10551
cyclic di-GMP phosphodiesterase;
10-511 3.43e-90

cyclic di-GMP phosphodiesterase;


Pssm-ID: 182541 [Multi-domain]  Cd Length: 518  Bit Score: 286.12  E-value: 3.43e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  10 TYRRNRMIVCTICALVTLASTLSVRFI-----SQRNLNQQ--RVVQFANHAVEELDKVLLPLQagsevllPLIGLPCSVA 82
Cdd:PRK10551   7 SSGRKILLTSIVAGVMIALLFSCLQFLllwhkREVKYDTLitDVQKYLDTYFADLKSTTDRLQ-------PLTLDTCQQV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  83 HLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPL-LRLTIDRALIKGSPVLIQWTPAAGSSNA 161
Cdd:PRK10551  80 NPELTSRAAFSLNVRAFLLVKDKKAFCSSATGEMNTPLSELIPAIDINKPVdMAILPGTPMMPNKPAIVIWYRNPLLKNS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 162 GVMEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGpgaTALAWHYL 241
Cdd:PRK10551 160 GVFATLNLNLTPYLLYTSRQEDFDGIALIIGNTALSTFSSRLMNVNELPDMPLRETTIPGYPLTIRLYA---DSWTANDI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 242 PTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIP 321
Cdd:PRK10551 237 WYALLLGLLSGILVGLLCYYLLSLRMRPGKEILTGIKRGQFYVEYQPVVDTQTLRVTGLEALLRWRHPTAGEIPPDAFIN 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 322 IAEEHHLIVPLTRYVMAETIRQ----RHVFPMSSQFhvGINVAPSHFRRGVLIKDLnQYWFSAHPIQ--QLILEITERDA 395
Cdd:PRK10551 317 YAEAQKLIVPLTQHLFELIARDaaelQKVLPVGAKL--GINISPAHLHSDSFKADV-QRLLASLPADhfQIVLEITERDM 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 396 lldVDYRIARE----LHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIEL 471
Cdd:PRK10551 394 ---VQEEEATKlfawLHSQGIEIAIDDFGTGHSALIYLERFTLDYLKIDRGFIQAIGTETVTSPVLDAVLTLAKRLNMLT 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|
gi 481024241 472 VAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWL 511
Cdd:PRK10551 471 VAEGVETPEQARWLRERGVNFLQGYWISRPLPLEDFVRWL 510
EAL cd01948
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 271-506 2.69e-88

EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.


Pssm-ID: 238923 [Multi-domain]  Cd Length: 240  Bit Score: 271.34  E-value: 2.69e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFP-M 349
Cdd:cd01948    1 ADLRRALERGEFELYYQPIVDLRTGRIVGYEALLRWRHPEGGLISPAEFIPLAEETGLIVELGRWVLEEACRQLARWQaG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 350 SSQFHVGINVAPSHFRRGVLIKDLNQyWFSAHPI--QQLILEITERDALLDVDY--RIARELHRKNVKLAIDDFGTGNSS 425
Cdd:cd01948   81 GPDLRLSVNLSARQLRDPDFLDRLLE-LLAETGLppRRLVLEITESALIDDLEEalATLRRLRALGVRIALDDFGTGYSS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 426 FSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLR 505
Cdd:cd01948  160 LSYLKRLPVDYLKIDRSFVRDIETDPEDRAIVRAIIALAHSLGLKVVAEGVETEEQLELLRELGCDYVQGYLFSRPLPAE 239


                 .
gi 481024241 506 D 506
Cdd:cd01948  240 E 240
EAL COG2200
EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) ...
 4-512 2.04e-81

EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) [Signal transduction mechanisms];


Pssm-ID: 441802 [Multi-domain]  Cd Length: 576  Bit Score: 264.72  E-value: 2.04e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   4 AQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAH 83
Cdd:COG2200   59 LLALALLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLLLLLLLALLLAALLALLLLLLLLLLLLLLSLLLLLVLVLLR 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  84 LPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGV 163
Cdd:COG2200  139 LALELLLALLLLALLALLDLLLLLLLRRLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLDNDGLGGAGLLLLLLLALL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 164 MEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQRFPFTINVNGPGATALAWHYLPT 243
Cdd:COG2200  219 LLLLLARLLLALLGGGGGGFLLLLLLLAAAAAAAAALRLLLLLLLEPLLLGGGLVVVASSGGGAAAPDDGADAALLLAAA 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 244 QLPLAVLLSLLVGYIAWLATAY-----RMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDV 318
Cdd:COG2200  299 AAAAAAAAGGGRGRVVFFAAAEararrRLALESELREALEEGELRLYYQPIVDLRTGRVVGYEALLRWRHPDGGLISPAE 378

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 319 FIPIAEEHHLIVPLTRYVMAETIRQ-RHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQyWFSAHPI--QQLILEITERDA 395
Cdd:COG2200  379 FIPAAERSGLIVELDRWVLERALRQlARWPERGLDLRLSVNLSARSLLDPDFLERLLE-LLAEYGLppERLVLEITESAL 457

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 396 LLDVD--YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVA 473
Cdd:COG2200  458 LEDLEaaIELLARLRALGVRIALDDFGTGYSSLSYLKRLPPDYLKIDRSFVRDIARDPRDQAIVRAIVALAHRLGLKVVA 537

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 481024241 474 EGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPKWLA 512
Cdd:COG2200  538 EGVETEEQLEALRELGCDYAQGYLFGRPLPLEELEALLR 576
COG5001 COG5001
Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain ...
 262-516 1.32e-80

Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain [Signal transduction mechanisms];


Pssm-ID: 444025 [Multi-domain]  Cd Length: 678  Bit Score: 265.10  E-value: 1.32e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 262 ATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETI 341
Cdd:COG5001  419 RARERLELEADLRRALERGELELHYQPQVDLATGRIVGAEALLRWQHPERGLVSPAEFIPLAEETGLIVPLGEWVLREAC 498

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 342 RQRHVFPMS--SQFHVGINVAPSHFRRGVLIKDLNQYwFSAHPI--QQLILEITERDALLDVDY--RIARELHRKNVKLA 415
Cdd:COG5001  499 RQLAAWQDAglPDLRVAVNLSARQLRDPDLVDRVRRA-LAETGLppSRLELEITESALLEDPEEalETLRALRALGVRIA 577

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 416 IDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQG 495
Cdd:COG5001  578 LDDFGTGYSSLSYLKRLPVDTLKIDRSFVRDLAEDPDDAAIVRAIIALAHSLGLEVVAEGVETEEQLEFLRELGCDYAQG 657

                        250       260
                 ....*....|....*....|.
gi 481024241 496 YLYAQPMPLRDFPKWLAGSQP 516
Cdd:COG5001  658 YLFSRPLPAEELEALLRARAA 678
EAL pfam00563
EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL ...
 271-501 2.76e-64

EAL domain; This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


Pssm-ID: 425752 [Multi-domain]  Cd Length: 235  Bit Score: 209.10  E-value: 2.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  271 REINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVFPMS 350
Cdd:pfam00563   2 RALRRALENGEFVLYYQPIVDLRTGRVVGYEALLRWQHPDGGLISPARFLPLAEELGLIAELDRWVLEQALADLAQLQLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  351 SQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPI-QQLILEITERDAL--LDVDYRIARELHRKNVKLAIDDFGTGNSSFS 427
Cdd:pfam00563  82 PDIKLSINLSPASLADPGFLELLRALLKQAGPPpSRLVLEITESDLLarLEALREVLKRLRALGIRIALDDFGTGYSSLS 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 481024241  428 WLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQP 501
Cdd:pfam00563 162 YLLRLPPDFVKIDRSLIADIDKDGEARAIVRALIALAHSLGIKVVAEGVETEEQLEALRELGCDLVQGYYFSKP 235
PRK13561 PRK13561
putative diguanylate cyclase; Provisional
 262-512 1.60e-44

putative diguanylate cyclase; Provisional


Pssm-ID: 184143 [Multi-domain]  Cd Length: 651  Bit Score: 166.81  E-value: 1.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 262 ATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETI 341
Cdd:PRK13561 394 AAQKRLTEESDILNALENHQFAIWLQPQVEMRSGKLVSAEALLRMQQPDGSWDLPEGLIDRIESCGLMVTVGHWVLEESC 473

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 342 R-----QRH--VFPMSsqfhvgINVAPSHFRRGVLIKDLNQYwFSAHPIQ--QLILEITERDALLDVDYRIA--RELHRK 410
Cdd:PRK13561 474 RllaawQERgiMLPLS------VNLSALQLMHPNMVADMLEL-LTRYRIQpgTLILEVTESRRIDDPHAAVAilRPLRNA 546

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 411 NVKLAIDDFGTGNSSFSWLE---TLRPDVLKIDKSFTAAIGSDavnSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRR 487
Cdd:PRK13561 547 GVRVALDDFGMGYAGLRQLQhmkSLPIDVLKIDKMFVDGLPED---DSMVAAIIMLAQSLNLQVIAEGVETEAQRDWLLK 623

                        250       260
                 ....*....|....*....|....*.
gi 481024241 488 HGVHILQGYLYAQPMPLRDF-PKWLA 512
Cdd:PRK13561 624 AGVGIAQGFLFARALPIEIFeERYLE 649
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 277-516 4.19e-43

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 163.79  E-value: 4.19e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 277 LAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQRHVF-PMSSQFH- 354
Cdd:PRK11359 552 ISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEWrSQNIHIPa 631

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 355 VGINVAPSHFRRGVL---IKDLNQYWfsAHPIQQLILEITERDALLDVDYRIAR--ELHRKNVKLAIDDFGTGNSSFSWL 429
Cdd:PRK11359 632 LSVNLSALHFRSNQLpnqVSDAMQAW--GIDGHQLTVEITESMMMEHDTEIFKRiqILRDMGVGLSVDDFGTGFSGLSRL 709

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 430 ETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLRDFPK 509
Cdd:PRK11359 710 VSLPVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIPG 789


                 ....*..
gi 481024241 510 WLAGSQP 516
Cdd:PRK11359 790 WMSSVLP 796
PRK10060 PRK10060
cyclic di-GMP phosphodiesterase;
260-520 2.05e-42

cyclic di-GMP phosphodiesterase;


Pssm-ID: 236645 [Multi-domain]  Cd Length: 663  Bit Score: 161.00  E-value: 2.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 260 WLATAYRMsfsreinlGLAQHEFELFCQPLLNARSQQCiGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAE 339
Cdd:PRK10060 408 WLDTNLRK--------ALENDQLVIHYQPKITWRGEVR-SLEALVRWQSPERGLIPPLEFISYAEESGLIVPLGRWVMLD 478

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 340 TIRQRHVFPMSS-QFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLI-LEITERdALLDvDYRIARELHRKNVKLA-- 415
Cdd:PRK10060 479 VVRQVAKWRDKGiNLRVAVNVSARQLADQTIFTALKQALQELNFEYCPIdVELTES-CLIE-NEELALSVIQQFSQLGaq 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 416 --IDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHIL 493
Cdd:PRK10060 557 vhLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVETAKEDAFLTKNGVNER 636

                        250       260
                 ....*....|....*....|....*..
gi 481024241 494 QGYLYAQPMPLRDFPKWLAGSQPPPAR 520
Cdd:PRK10060 637 QGFLFAKPMPAVAFERWYKRYLKRKLI 663
PRK11829 PRK11829
biofilm formation regulator HmsP; Provisional
 266-507 5.29e-42

biofilm formation regulator HmsP; Provisional


Pssm-ID: 183329 [Multi-domain]  Cd Length: 660  Bit Score: 159.72  E-value: 5.29e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 266 RMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIR--- 342
Cdd:PRK11829 403 RLTQENDLLQAIENHDFTLFLQPQWDMKRQQVIGAEALLRWCQPDGSYVLPSGFVHFAEEEGMMVPLGNWVLEEACRila 482

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 343 --QRH--VFPMSSQFHvGINVAPSHFrrGVLIKDL-NQYWFSAhpiQQLILEITERDALLDVD--YRIARELHRKNVKLA 415
Cdd:PRK11829 483 dwKARgvSLPLSVNIS-GLQVQNKQF--LPHLKTLiSHYHIDP---QQLLLEITETAQIQDLDeaLRLLRELQGLGLLIA 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 416 IDDFGTGNSSFSWLETLRP---DVLKIDKSFTAAIGSDavnSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHI 492
Cdd:PRK11829 557 LDDFGIGYSSLRYLNHLKSlpiHMIKLDKSFVKNLPED---DAIARIISCVSDVLKVRVMAEGVETEEQRQWLLEHGIQC 633

                        250
                 ....*....|....*
gi 481024241 493 LQGYLYAQPMPLRDF 507
Cdd:PRK11829 634 GQGFLFSPPLPRAEF 648
CSS-motif pfam12792
CSS motif domain associated with EAL; This family with its characteriztic highly conserved CSS ...
 42-240 1.09e-34

CSS motif domain associated with EAL; This family with its characteriztic highly conserved CSS sequence motif is found N-terminal to the EAL, pfam00563, domain in many cyclic diguanylate phosphodiesterases.


Pssm-ID: 463709  Cd Length: 209  Bit Score: 129.57  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241   42 NQQRVVQFANHAVEELDKVLLPLQAGSEVLLPLIGLPCSVAHL-PLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV 120
Cdd:pfam12792   1 EQEQLDAFAERALRRLESVLDQADQALDRLLPLTGQPCSPAHLaELRRIVAFSPYVRDVGLVKNGRLYCSSLWGELDTPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  121 VDILAELPAPQPL-LRLTIDRALIKGSPVLIQWTPAAGSSNAGVMeMINIDLLTAMLLEPQLPQISSASLTVDKRHLLyG 199
Cdd:pfam12792  81 PLLPPDLTTPPGVrLWLLRGTPLVPGRPALVLRRGGYGVVIDPGV-FIDVQYLPGLLAAVSQPDGRLLALVVGDDALL-F 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 481024241  200 NGLVDSLPQP-------EDNENYQVSSQRFPFTINVNGPGATALAWHY 240
Cdd:pfam12792 159 DGRLHSLAEPapgtarsGGALYARARSTRYPLTVVVYAPRASLLANWR 206
PRK09776 PRK09776
putative diguanylate cyclase; Provisional
 267-504 5.31e-21

putative diguanylate cyclase; Provisional


Pssm-ID: 182070 [Multi-domain]  Cd Length: 1092  Bit Score: 97.44  E-value: 5.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  267 MSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMAETIRQrHV 346
Cdd:PRK09776  840 LSLAEQWRMIKENQLMMLAHGVASPRIPEARNHWLISLRLWDPEGEIIDEGAFRPAAEDPALMHALDRRVIHEFFRQ-AA 918

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  347 FPMSSQ-FHVGINVAPSHFRRGVLIKDL-NQYWFSAHPIQQLILEITErDALL---DVDYRIARELHRKNVKLAIDDFGT 421
Cdd:PRK09776  919 KAVASKgLSIALPLSVAGLSSPTLLPFLlEQLENSPLPPRLLHLEITE-TALLnhaESASRLVQKLRLAGCRVVLSDFGR 997

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241  422 GNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQP 501
Cdd:PRK09776  998 GLSSFNYLKAFMADYLKLDGELVANLHGNLMDEMLISIIQGHAQRLGMKTIAGPVELPLVLDTLSGIGVDLAYGYAIARP 1077


                  ...
gi 481024241  502 MPL 504
Cdd:PRK09776 1078 QPL 1080
YuxH COG3434
c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction ...
 287-505 1.14e-10

c-di-GMP phosphodiesterase YuxH/PdeH, contains EAL and HDOD domains [Signal transduction mechanisms];


Pssm-ID: 442660 [Multi-domain]  Cd Length: 407  Bit Score: 63.67  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 287 QPLLNaRSQQCIGVEILLRwnnprqgwISPDVFIPIAEEHHLivplTRYVMAET---------IRQRHVFpmssqfhvgI 357
Cdd:COG3434    9 QPILD-RDQRVVGYELLFR--------SGLENSAPDVDGDQA----TARVLLNAfleigldrlLGGKLAF---------I 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 358 NvapshFRRGVLIKDLnqywFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLrpDVL 437
Cdd:COG3434   67 N-----FTEELLLSDL----PELLPPERVVLEILEDVEPDEELLEALKELKEKGYRIALDDFVLDPEWDPLLPLA--DII 135

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 481024241 438 KIDksFTAAIGSDAVNstvtdiIIALGQRLNIELVAEGVETQEQAKYLRRHGVHILQGYLYAQPMPLR 505
Cdd:COG3434  136 KID--VLALDLEELAE------LVARLKRYGIKLLAEKVETREEFELCKELGFDLFQGYFFSKPEILK 195
PRK11596 PRK11596
cyclic-di-GMP phosphodiesterase; Provisional
 406-504 3.66e-06

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183222 [Multi-domain]  Cd Length: 255  Bit Score: 48.46  E-value: 3.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 481024241 406 ELHRknvkLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQEQAKYL 485
Cdd:PRK11596 151 EFGP----LWLDDFGTGMANFSALSEVRYDYIKVARELFIMLRQSEEGRNLFSQLLHLMNRYCRGVIVEGVETPEEWRDV 226

                         90
                 ....*....|....*....
gi 481024241 486 RRHGVHILQGYLYAQPMPL 504
Cdd:PRK11596 227 QRSPAFAAQGYFLSRPAPF 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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