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Conserved domains on  [gi|55741912|ref|NP_998442|]
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acidic leucine-rich nuclear phosphoprotein 32 family member E [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
57-146 9.56e-11

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.01  E-value: 9.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912    57 LAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDLFNCEITTLEDYRESIF 136
Cdd:pfam14580  57 LDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVI 136

                          90
                  ....*....|
gi 55741912   137 ELLPQVTYLD 146
Cdd:pfam14580 137 YKVPQLRLLD 146
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
57-146 9.56e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.01  E-value: 9.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912    57 LAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDLFNCEITTLEDYRESIF 136
Cdd:pfam14580  57 LDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVI 136

                          90
                  ....*....|
gi 55741912   137 ELLPQVTYLD 146
Cdd:pfam14580 137 YKVPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-129 4.43e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 4.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  47 LSMVNVGLTSLAKLPSLPKLRKLELSDNNISgTLETLaEKCANLTYLNLSGNKIKElstLEALQNLKNLKSLDLFNCEIT 126
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKIT-KIENL-EFLTNLTHLYLQNNQIEK---IENLENLVNLKKLYLGGNRIS 81


                ...
gi 55741912 127 TLE 129
Cdd:cd21340  82 VVE 84
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-128 4.46e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  42 KELEFLSMVNVGLTSLAK-LPSLPKLRKLELSDNNISGTLETLAeKCANLTYLNLSGNKIkelSTLEALQNLKNLKSLDL 120
Cdd:COG4886 182 TNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---TDLPELGNLTNLEELDL 257


                ....*...
gi 55741912 121 FNCEITTL 128
Cdd:COG4886 258 SNNQLTDL 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-122 1.40e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912    3 MKKRISLELRnrtpaevaelvvDNCRSsdGEIEGLTDDFKELEFLSMVNVGLTslAKLP----SLPKLRKLELSDNNISG 78
Cdd:PLN00113 283 LQKLISLDLS------------DNSLS--GEIPELVIQLQNLEILHLFSNNFT--GKIPvaltSLPRLQVLQLWSNKFSG 346

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 55741912   79 TLETLAEKCANLTYLNLSGNKIK-ELStlEALQNLKNLKSLDLFN 122
Cdd:PLN00113 347 EIPKNLGKHNNLTVLDLSTNNLTgEIP--EGLCSSGNLFKLILFS 389
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
57-146 9.56e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.01  E-value: 9.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912    57 LAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDLFNCEITTLEDYRESIF 136
Cdd:pfam14580  57 LDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVI 136

                          90
                  ....*....|
gi 55741912   137 ELLPQVTYLD 146
Cdd:pfam14580 137 YKVPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-129 4.43e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 4.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  47 LSMVNVGLTSLAKLPSLPKLRKLELSDNNISgTLETLaEKCANLTYLNLSGNKIKElstLEALQNLKNLKSLDLFNCEIT 126
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKIT-KIENL-EFLTNLTHLYLQNNQIEK---IENLENLVNLKKLYLGGNRIS 81


                ...
gi 55741912 127 TLE 129
Cdd:cd21340  82 VVE 84
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-128 4.46e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  42 KELEFLSMVNVGLTSLAK-LPSLPKLRKLELSDNNISGTLETLAeKCANLTYLNLSGNKIkelSTLEALQNLKNLKSLDL 120
Cdd:COG4886 182 TNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---TDLPELGNLTNLEELDL 257


                ....*...
gi 55741912 121 FNCEITTL 128
Cdd:COG4886 258 SNNQLTDL 265
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-129 3.89e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 3.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  40 DFKELEFLSMVNVGLTSL-AKLPSLPKLRKLELSDNNISgTLETLAeKCANLTYLNLSGNKIKELSTLEalqNLKNLKSL 118
Cdd:COG4886 203 NLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT-DLPELG-NLTNLEELDLSNNQLTDLPPLA---NLTNLKTL 277

                        90
                ....*....|.
gi 55741912 119 DLFNCEITTLE 129
Cdd:COG4886 278 DLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-128 4.76e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 4.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912   7 ISLELRNRTPAEVAELVVDNCRSSDGEIEGLTDDFKELEFLSMVNvgLTSLAKLPSLPKLRKLELSDNNISgTLETLAEK 86
Cdd:COG4886  58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD--LSGNEELSNLTNLESLDLSGNQLT-DLPEELAN 134

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 55741912  87 CANLTYLNLSGNKIKELStlEALQNLKNLKSLDLFNCEITTL 128
Cdd:COG4886 135 LTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDL 174
LRR_8 pfam13855
Leucine rich repeat;
64-125 5.85e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 5.85e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55741912    64 PKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELStLEALQNLKNLKSLDLFNCEI 125
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-153 1.81e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  54 LTSLAKLPSLPKLRKLELSDNNISgTLETLaEKCAN------------------------------LTYLNLSGNKIkel 103
Cdd:cd21340  58 IEKIENLENLVNLKKLYLGGNRIS-VVEGL-ENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNI--- 132

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55741912 104 STLEALQNLKNLKSLDLFNCEITTLEDyresIFELLPQVTYLDGFDAEDN 153
Cdd:cd21340 133 DSLEPLAPLRNLEQLDASNNQISDLEE----LLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-154 2.52e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 2.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  66 LRKLELSDNNISgTLETLAeKCANLTYLNLSGNKIKELSTL-EALQNLKNLKSLDLFNCEITTLEDYRESIFELLPQVTY 144
Cdd:cd21340 122 LRVLNISGNNID-SLEPLA-PLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEV 199

                        90
                ....*....|
gi 55741912 145 LDGFDAEDNE 154
Cdd:cd21340 200 LDGKEITDTE 209
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-120 1.70e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.70e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55741912  53 GLTSLAK-LPSLPKLRKLELSDNNIS-GTLETLAEKCAN---LTYLNLSGNKIKE---LSTLEALQNLKNLKSLDL 120
Cdd:COG5238 224 GAEILAEaLKGNKSLTTLDLSNNQIGdEGVIALAEALKNnttVETLYLSGNQIGAegaIALAKALQGNTTLTSLDL 299
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 89-133 5.32e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 5.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55741912    89 NLTYLNLSGNKIKElstLEALQNLKNLKSLDL-FNCEITTLEDYRE 133
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLsGNNKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 42-85 1.35e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 55741912    42 KELEFLSMVNVGLTSLAKLPSLPKLRKLELSDNNISGTLETLAE 85
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-122 1.40e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912    3 MKKRISLELRnrtpaevaelvvDNCRSsdGEIEGLTDDFKELEFLSMVNVGLTslAKLP----SLPKLRKLELSDNNISG 78
Cdd:PLN00113 283 LQKLISLDLS------------DNSLS--GEIPELVIQLQNLEILHLFSNNFT--GKIPvaltSLPRLQVLQLWSNKFSG 346

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 55741912   79 TLETLAEKCANLTYLNLSGNKIK-ELStlEALQNLKNLKSLDLFN 122
Cdd:PLN00113 347 EIPKNLGKHNNLTVLDLSTNNLTgEIP--EGLCSSGNLFKLILFS 389
FBXL18_LRR pfam19729
F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from ...
 66-126 1.43e-03

F-box/LRR-repeat protein 18, LRR; This entry represents the leucine-rich repeats (LRR) from F-box/LRR repeat protein 18 (also known as F-box and leucine-rich repeat protein 18, FBXL18), associated with F-box domains. This protein is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex through its F-box and the LRR motifs mediate the protein-protein interactions required for the binding of the specific substrates by SCFs complexes.


Pssm-ID: 466163 [Multi-domain]  Cd Length: 594  Bit Score: 39.73  E-value: 1.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55741912    66 LRKLElsDNNISGTLETLAEKCANLTYLNLSG-------NKIKELSTLeaLQNLKNLKSLDLFNCEIT 126
Cdd:pfam19729 280 LRKAE--DDIDSSIVETLVACCPNLRHLNLSAahhhsseGLGGHLCAL--LARLKHLRSLSLPVCAVA 343
LRR_8 pfam13855
Leucine rich repeat;
89-146 2.29e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 55741912    89 NLTYLNLSGNKIKELSTlEALQNLKNLKSLDLFNCEITTLEdyrESIFELLPQVTYLD 146
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLS---PGAFSGLPSLRYLD 55
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-120 4.17e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912   32 GEIEGLTDDFKELEFLSM-VNVGLTSLAKLPSLPKLRKLELSDNNISGTLETLAEKCANLTYLNLSGNKIKELSTLEaLQ 110
Cdd:PLN00113 442 GRINSRKWDMPSLQMLSLaRNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE-LS 520

                         90
                 ....*....|
gi 55741912  111 NLKNLKSLDL 120
Cdd:PLN00113 521 SCKKLVSLDL 530
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-120 5.80e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 5.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741912  40 DFKELEFLSMVNVGLTSL------AKLPSLPKLRKLELSDNNISGT-----LETLAEKCANLTYLNLSGNKIKEL---ST 105
Cdd:cd00116 191 ANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDITDDgakDL 270

                        90
                ....*....|....*
gi 55741912 106 LEALQNLKNLKSLDL 120
Cdd:cd00116 271 AEVLAEKESLLELDL 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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