|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
93-560 |
2.15e-85 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 270.49 E-value: 2.15e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 93 LSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnletlkenc 172
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 173 ktrsDPEGDSqvkmhvlpekqiltvedrpdwtdrseqrnqeevrreaeyqmKVWKGFLICIPYAASIGGTATLTGTAPNL 252
Cdd:COG0471 70 ----GSEKRS-----------------------------------------KFGSALLLPIAFAASIGGMGTLIGTPPNL 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 253 ILVGQLKSYFPEcdLVNFGSWFVFAFPLMLLFLILGWIWIAFLYGGLNTRLCISKNderaaaeakanaVIDEDYKKLGPI 332
Cdd:COG0471 105 IAAGLLEEATGI--PISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKE------------VIREELAELGPL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 333 KFAEGSIAFFFIIfaillftrdpkFVTGWsVFFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSW 412
Cdd:COG0471 171 SRREKIALAIFAL-----------TVLLW-ITGSLHGIPIAVVALLGAVLLLLTG---------------------VLTW 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 413 RKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQP-LAQVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAE 491
Cdd:COG0471 218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47086231 492 LAIRVKVNPLYFMIPATTGCSYAFMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:COG0471 298 LAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
41-560 |
8.33e-74 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 240.95 E-value: 8.33e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 41 LYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVG 120
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 121 VKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnletlkencktrsdpeGDSQVKMhvlpekqiltvedr 200
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL------------------DISPSRL-------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 201 pdwtdrseqrnqeevrreaeyqmkvwkgfLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdlvnfGSWFVFAFPL 280
Cdd:cd01115 129 -----------------------------LMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQ------GFSFFEFTPI 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 281 MLLFLILGWIWIAFLYGGLNTRLCIsknderaaaeakanavidedykklgpikfaegsiafffiifaillftrdpkfvTG 360
Cdd:cd01115 174 GLPLLIIGLLYLWFIFRLAVLIITI-----------------------------------------------------VL 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 361 WSV-FFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSWRKAQECVPWNIILLLGGGFAMAKGCEE 439
Cdd:cd01115 201 LAAlAAITGLLPVSVAIAIGAIVLVFGG---------------------VLLTKEDYKSIDWGIIFLFAGGIPLGKALES 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 440 SGLAVWIGNHLQPLAQVPPPVAVMLITA-FIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMIPATTGCSYAFMLP 518
Cdd:cd01115 260 SGAAALIAEALISLLGGLPPFAILLLLClLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLP 339
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 47086231 519 VSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:cd01115 340 VGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
36-560 |
1.72e-65 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 221.48 E-value: 1.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 36 KEGKCLYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGI-LPSKK---VCPQYFLETNFLFLSGLVMASAIEEWGLHRRI 111
Cdd:pfam00939 29 KAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGtLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 112 ALKVLKIVGVKPawLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnLETLKencktrSDPEGDSQvkmhvlpe 191
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSL---PPAFG------SDPEKGSE-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 192 kqiltvedrpdwtdrseqrnqeevRREAEYQMKvwkgfliCIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdLVNFG 271
Cdd:pfam00939 170 ------------------------RRIGAYLMW-------TVYQSTSITSAMFLTAMAPNLLLLGLMNSILGV--TITWA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 272 SWFVFAFPLMLLFLILGWIWIAFLYGGLNTRlcisKNDeraaaeakANAVIDEDYKKLGPIKFAEGSIAFFFIIFaillf 351
Cdd:pfam00939 217 SWFLAAIPPGVILLLLAPLLLYVLYPPEIKS----VPD--------AKAIAKTELKELGPMTFREKALLGLFVLL----- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 352 trdpkfVTGWsVFFPKGYVSDAVTGVIIISILFFfpsqrpslrwwfdsrasntpyVPLLSWRKA-QECVPWNIILLLGGG 430
Cdd:pfam00939 280 ------LLLW-IFGGSLNIDATTVAIIGLALMLL---------------------LRILDWKDIvKNKGAWNTLIWLGGL 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 431 FAMAKGCEESGLAVWIGNHLQPLAQ--VPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELAIRVK-VNPLYFMIPA 507
Cdd:pfam00939 332 IMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLL 411
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 47086231 508 TTGCSYA-FMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:pfam00939 412 GFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWW 465
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
43-561 |
7.97e-51 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 181.39 E-value: 7.97e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 43 VVLLMAVYWCTEALPLAVTAMLPV----CLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKI 118
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIpiiaVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 119 VGVKPAWL-ILGMMITSSFLSMWLSNTA-TTAMMLPIANAILESLfgnletlkencktRSDPEGDSQvkmhvlpekqilt 196
Cdd:TIGR00785 96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-------------GSKPEKSPR------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 197 vedrpdwtdrseqrnqeevrreaeyqmKVWKGFLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdLVNFGSWFVF 276
Cdd:TIGR00785 150 ---------------------------KIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGI--QISWGDWFLA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 277 AFPLMLLFLILGWIWIAFLYgglntRLCISKNDERAAaeakanaVIDEDYKKLGPIKFAEGSIAFFFIIFaillftrdpk 356
Cdd:TIGR00785 201 GLPLGIILLLLVPLLLYVLF-----PPELKLKDEVDL-------WAKEELEEMGPMSFREKALLGIFLLA---------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 357 fVTGWsVFFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSWRKAQE-CVPWNIILLLGGGFAMAK 435
Cdd:TIGR00785 259 -LLLW-IFGGSLGINASVVALLAVVLMLFLG---------------------IVTWKDIQKnKVAWNTLILFGGLIGLAG 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 436 GCEESGLAVWIGNHLQP-LAQVPPPVAVM-LITAFIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMIPATTGCSY 513
Cdd:TIGR00785 316 GLKKSGFIKWFSEKLVGiLDGLSPTIAVLvLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASL 395
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 47086231 514 A-FMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTWA 561
Cdd:TIGR00785 396 MgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
93-560 |
2.15e-85 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 270.49 E-value: 2.15e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 93 LSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnletlkenc 172
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 173 ktrsDPEGDSqvkmhvlpekqiltvedrpdwtdrseqrnqeevrreaeyqmKVWKGFLICIPYAASIGGTATLTGTAPNL 252
Cdd:COG0471 70 ----GSEKRS-----------------------------------------KFGSALLLPIAFAASIGGMGTLIGTPPNL 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 253 ILVGQLKSYFPEcdLVNFGSWFVFAFPLMLLFLILGWIWIAFLYGGLNTRLCISKNderaaaeakanaVIDEDYKKLGPI 332
Cdd:COG0471 105 IAAGLLEEATGI--PISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKE------------VIREELAELGPL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 333 KFAEGSIAFFFIIfaillftrdpkFVTGWsVFFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSW 412
Cdd:COG0471 171 SRREKIALAIFAL-----------TVLLW-ITGSLHGIPIAVVALLGAVLLLLTG---------------------VLTW 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 413 RKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQP-LAQVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAE 491
Cdd:COG0471 218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47086231 492 LAIRVKVNPLYFMIPATTGCSYAFMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:COG0471 298 LAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
41-560 |
8.33e-74 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 240.95 E-value: 8.33e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 41 LYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVG 120
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 121 VKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnletlkencktrsdpeGDSQVKMhvlpekqiltvedr 200
Cdd:cd01115 81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKL------------------DISPSRL-------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 201 pdwtdrseqrnqeevrreaeyqmkvwkgfLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdlvnfGSWFVFAFPL 280
Cdd:cd01115 129 -----------------------------LMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQ------GFSFFEFTPI 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 281 MLLFLILGWIWIAFLYGGLNTRLCIsknderaaaeakanavidedykklgpikfaegsiafffiifaillftrdpkfvTG 360
Cdd:cd01115 174 GLPLLIIGLLYLWFIFRLAVLIITI-----------------------------------------------------VL 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 361 WSV-FFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSWRKAQECVPWNIILLLGGGFAMAKGCEE 439
Cdd:cd01115 201 LAAlAAITGLLPVSVAIAIGAIVLVFGG---------------------VLLTKEDYKSIDWGIIFLFAGGIPLGKALES 259
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 440 SGLAVWIGNHLQPLAQVPPPVAVMLITA-FIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMIPATTGCSYAFMLP 518
Cdd:cd01115 260 SGAAALIAEALISLLGGLPPFAILLLLClLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLP 339
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 47086231 519 VSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:cd01115 340 VGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLI 381
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
36-560 |
1.72e-65 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 221.48 E-value: 1.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 36 KEGKCLYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGI-LPSKK---VCPQYFLETNFLFLSGLVMASAIEEWGLHRRI 111
Cdd:pfam00939 29 KAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGtLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 112 ALKVLKIVGVKPawLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnLETLKencktrSDPEGDSQvkmhvlpe 191
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSL---PPAFG------SDPEKGSE-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 192 kqiltvedrpdwtdrseqrnqeevRREAEYQMKvwkgfliCIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdLVNFG 271
Cdd:pfam00939 170 ------------------------RRIGAYLMW-------TVYQSTSITSAMFLTAMAPNLLLLGLMNSILGV--TITWA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 272 SWFVFAFPLMLLFLILGWIWIAFLYGGLNTRlcisKNDeraaaeakANAVIDEDYKKLGPIKFAEGSIAFFFIIFaillf 351
Cdd:pfam00939 217 SWFLAAIPPGVILLLLAPLLLYVLYPPEIKS----VPD--------AKAIAKTELKELGPMTFREKALLGLFVLL----- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 352 trdpkfVTGWsVFFPKGYVSDAVTGVIIISILFFfpsqrpslrwwfdsrasntpyVPLLSWRKA-QECVPWNIILLLGGG 430
Cdd:pfam00939 280 ------LLLW-IFGGSLNIDATTVAIIGLALMLL---------------------LRILDWKDIvKNKGAWNTLIWLGGL 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 431 FAMAKGCEESGLAVWIGNHLQPLAQ--VPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELAIRVK-VNPLYFMIPA 507
Cdd:pfam00939 332 IMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLL 411
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 47086231 508 TTGCSYA-FMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTW 560
Cdd:pfam00939 412 GFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWW 465
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
43-561 |
7.97e-51 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 181.39 E-value: 7.97e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 43 VVLLMAVYWCTEALPLAVTAMLPV----CLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKI 118
Cdd:TIGR00785 16 IFVAAIVGWILEPLPLPVTALLAIpiiaVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 119 VGVKPAWL-ILGMMITSSFLSMWLSNTA-TTAMMLPIANAILESLfgnletlkencktRSDPEGDSQvkmhvlpekqilt 196
Cdd:TIGR00785 96 MGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLL-------------GSKPEKSPR------------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 197 vedrpdwtdrseqrnqeevrreaeyqmKVWKGFLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdLVNFGSWFVF 276
Cdd:TIGR00785 150 ---------------------------KIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGI--QISWGDWFLA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 277 AFPLMLLFLILGWIWIAFLYgglntRLCISKNDERAAaeakanaVIDEDYKKLGPIKFAEGSIAFFFIIFaillftrdpk 356
Cdd:TIGR00785 201 GLPLGIILLLLVPLLLYVLF-----PPELKLKDEVDL-------WAKEELEEMGPMSFREKALLGIFLLA---------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 357 fVTGWsVFFPKGYVSDAVTGVIIISILFFFPsqrpslrwwfdsrasntpyvpLLSWRKAQE-CVPWNIILLLGGGFAMAK 435
Cdd:TIGR00785 259 -LLLW-IFGGSLGINASVVALLAVVLMLFLG---------------------IVTWKDIQKnKVAWNTLILFGGLIGLAG 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 436 GCEESGLAVWIGNHLQP-LAQVPPPVAVM-LITAFIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMIPATTGCSY 513
Cdd:TIGR00785 316 GLKKSGFIKWFSEKLVGiLDGLSPTIAVLvLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASL 395
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 47086231 514 A-FMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAMNTWA 561
Cdd:TIGR00785 396 MgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLWW 444
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
48-557 |
9.18e-45 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 163.57 E-value: 9.18e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 48 AVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIvGVKPAWLI 127
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 128 LGMMITSSFLSMWLSNTATTAMMLPIANAILeslfgnletlkencktrsdpegdsqvkmhvlpekqiltvedrpdwtdrs 207
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALL------------------------------------------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 208 eqrnqeevrreAEYQMKVWKGFLICIPYAASIGGTATLTGTAPNLILVGQLKsyfpecdlVNFGSWFVFAFPLMLLFLIL 287
Cdd:cd00625 111 -----------RKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLSG--------LGFLDFLAFMAPPALGLLLL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 288 GWIWIAFLYGGLntrlcISKNDERAAAEAKANAVIDEDYKKLGPIKFAEGSIafffiifaillftrdpkFVTGWSVFFPK 367
Cdd:cd00625 172 LLGLLYLLFRKK-----LLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLL-----------------FVLLFFFLIPL 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 368 GYVSDAVTGVIIISILFFfpsqrpslrwwfdsrasntpyvplLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIG 447
Cdd:cd00625 230 GLIALLGALLLLLLLVRG------------------------LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLA 285
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 448 NHLQPLAQVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELAIRVK-----VNPLYFMIPATTGCSYAFMLPVSTP 522
Cdd:cd00625 286 ELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPEPawlalALGSTLGGNLTLIGSLANLIPLGAA 365
|
490 500 510
....*....|....*....|....*....|....*
gi 47086231 523 PNSIAfasgHLMVKDMVKTGFVMNILGILCVSLAM 557
Cdd:cd00625 366 ENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
48-493 |
1.94e-34 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 133.59 E-value: 1.94e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 48 AVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLI 127
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 128 LGMMITSSFLSMWLSNTATTAMMLPIANAILESLfgnletlkencktrsdpegdsqvKMHVLPekqiltvedrpdwtdrs 207
Cdd:pfam03600 81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRL-----------------------GLPPSP----------------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 208 eqrnqeevrreaeyqmkvwkgFLICIPYAASIGGTATLTGTAPNLILVGQLKSYFPEcdlvnfgsWFVFAFPLMLLFLIL 287
Cdd:pfam03600 121 ---------------------LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD--------FGFFMFPPVGVALLL 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 288 GWIWIAFLYgglntrlcisknderaaaeakanavidedYKKLGPIKFAEGSIAFFFIIFAILLFTRDPKFVTgwsvffpk 367
Cdd:pfam03600 172 VGLLPLLLI-----------------------------FRKLLPVRKEEEAELEELRKRAIKDKLLLAISAL-------- 214
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 368 gyvsdavtgVIIISILFFFPSQRPSLRWwfdsrASNTPYVPLLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIG 447
Cdd:pfam03600 215 ---------VLALVILGFLLLSVLALAG-----ALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALA 280
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 47086231 448 NHLQPLaqVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELA 493
Cdd:pfam03600 281 DALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMA 324
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
405-557 |
4.22e-14 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 73.89 E-value: 4.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 405 PYVPLLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQPLAQVPP---PVAVMLITAFIACfteFASNTAT 481
Cdd:pfam03600 23 VLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPrrlLVALMLATALLSA---FLSNDGT 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47086231 482 IIIFLPVIAELAIRVKVNPLYFMIPATTGCSYAFML-PVSTPPNSIAFASGHLMVKDMVKTGFVMNILGILCVSLAM 557
Cdd:pfam03600 100 VLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
36-161 |
2.25e-10 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 62.48 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 36 KEGKCLYVVLLMAVYWCTEA---LPLAVTAMLPVCLFPTMGILPSKKVcpQYFLETNFLFL--SGLVMASAIEEWGLHRR 110
Cdd:COG0471 173 REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDA--YKSIPWGVLLLfgGGLALGAALEKTGLAAW 250
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 47086231 111 IALKVLKIVGVKPAWLIL-GMMITSSFLSMWLSNTATTAMMLPIANAILESL 161
Cdd:COG0471 251 LADALLPLLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
56-505 |
9.06e-10 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 60.91 E-value: 9.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 56 LPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSS 135
Cdd:COG1055 23 LNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 136 FLSMWLSNTATTAMMLPIANAILESLfgnletlkencktrsdpegdsqvKMHVLPekqiltvedrpdwtdrseqrnqeev 215
Cdd:COG1055 103 LLSAFLDNDTTALLLTPVVLAIARRL-----------------------GLNPVP------------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 216 rreaeyqmkvwkgFLICIPYAASIGGTATLTGTAPNLILVGQLKsyfpecdlVNFGSWFVFAFPLMLLFLILGWIWIAFL 295
Cdd:COG1055 135 -------------FLIAIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 296 YGGLNTRLCISKNDERAAAEAKANAvidedyKKLGPIkfaegsiafffiifaillftrdpkFVTGWSVFFPKGY--VSDA 373
Cdd:COG1055 194 FRKELPAAPDLEDDPKEAIKDRRLL------RISLLV------------------------LALLLVGFVLHSFlgLPPA 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 374 VTGVIIISILFFFPSQRPslrwwfdsrasntpyvpllswRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQPL 453
Cdd:COG1055 244 LIALLGAAVLLLLARVDV---------------------REVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASL 302
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 47086231 454 AQVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELAIRVKVNPLYFMI 505
Cdd:COG1055 303 TGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL 354
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
409-533 |
1.23e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 57.45 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 409 LLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQPLAQVPPPVAVMLITAFIACFTEFASNTATIIIFLPV 488
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 47086231 489 IAELAIRVKVNPLYFMIP----ATTGcsyAFMLPVSTPPNSIAFASGHL 533
Cdd:COG1055 121 VLAIARRLGLNPVPFLIAivfaANIG---GAATPIGNPTNIMIASAGGL 166
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
36-161 |
3.75e-06 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 49.23 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 36 KEGKCLYVVLLMAVYWCTEALPLAVTAMLPVCLFPTMGILPSKKVCPQYFLETNFLFLSGLVMASAIEEWGLHRRIALKV 115
Cdd:pfam03600 204 KDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADAL 283
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 47086231 116 LKIVGvkPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESL 161
Cdd:pfam03600 284 GGLSG--LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAA 327
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
235-296 |
1.34e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 47.82 E-value: 1.34e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47086231 235 YAASIGGTATLTGTAPNLILVGQLKSYFPEcdlVNFGSWFVFAFPLMLLFLILGWIWIAFLY 296
Cdd:COG1055 356 LGATLGGNLTPIGSAANVIVLGIAEKKGIK---ISFGEFLKVGLPLTLLTLLIALLYLLLLY 414
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
421-551 |
6.51e-04 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 42.25 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 421 WNIILLLGGGFAMAKGCEESGLAVWIGNHLQPLAQVPPPVAVMLITAFIACFTEFASNTATIIIFLPVIAELAIRVKVNP 500
Cdd:cd01118 52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKK 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 47086231 501 L----YFMIPATTGCSYAFMLPVSTPPNSIAFASGHLMVKDMVKTGFVMNILGIL 551
Cdd:cd01118 132 NrtlpFLYACAFIADAASLPLPISNLVNIVTAGYFGIGFTEYAALMFLPSIVSIL 186
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
83-501 |
1.14e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 41.47 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 83 QYFLETNFLFLSGLVMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLF 162
Cdd:cd01116 44 WVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 163 GNletlkencktrsdpegdsqvkmhVLPekqiltvedrpdwtdrseqrnqeevrreaeyqmkvwkgFLICIPYAASIGGT 242
Cdd:cd01116 124 LN-----------------------PVP--------------------------------------VLISEVIAANIGGA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 243 ATLTGTAPNLILVGQLKSYFPECDLVNFGSWFVFAFPLMLLFLILGWIWIaflygglntrlciskndERAAAEAKANAVI 322
Cdd:cd01116 143 ATLIGDPPNIMIGSAAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNIL-----------------KAREEDVLALAEL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 323 DEDYKKLGPIKFAEGSIAFFFIIFaillftrdpKFVTGWSVFFPKGYVsdAVTGVIIISILFFFpsqrpslrwwfdsras 402
Cdd:cd01116 206 EPKYPIKDKVLLLKSLTILTLVII---------GFVLHSPLGVSLGWI--ALLGALLLLLLADK---------------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086231 403 ntpyvplLSWRKAQECVPWNIILLLGGGFAMAKGCEESGLAVWIGNHLQPLAQVPPPVAVMLITAFIACFTEFASNTATI 482
Cdd:cd01116 259 -------LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVT 331
|
410
....*....|....*....
gi 47086231 483 IIFLPVIAELAIRVKVNPL 501
Cdd:cd01116 332 ATMIPIVKDLASQLGIPLL 350
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
91-168 |
1.46e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 41.47 E-value: 1.46e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47086231 91 LFLSGL-VMASAIEEWGLHRRIALKVLKIVGVKPAWLILGMMITSSFLSMWLSNTATTAMMLPIANAILESLFGNLETL 168
Cdd:cd01116 274 LFFAGLfVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPL 352
|
|
| |
