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Conserved domains on  [gi|58219056|ref|NP_997719|]
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EEF1A lysine methyltransferase 2 isoform 1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11227116)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-219 2.87e-18

Methyltransferase domain; This family appears to have methyltransferase activity.


:

Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 79.38  E-value: 2.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    80 DASVLDIGTGNGVFLVELAKFGFSN--ITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGT 155
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58219056   156 FDAISlNPDNAIEKrkqyvksLSRVLKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 219
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-219 2.87e-18

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 79.38  E-value: 2.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    80 DASVLDIGTGNGVFLVELAKFGFSN--ITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGT 155
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58219056   156 FDAISlNPDNAIEKrkqyvksLSRVLKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 219
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-191 2.41e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.72  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  57 EIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVED 136
Cdd:COG0500   4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056 137 FLNLSTqlsgfhicIDKGTFDAISLNpdNAI-----EKRKQYVKSLSRVLKVKGFFLITS 191
Cdd:COG0500  84 LAELDP--------LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 83-190 2.47e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 2.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  83 VLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLN 162
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISD 73

                        90       100       110
                ....*....|....*....|....*....|
gi 58219056 163 P--DNAIEKRKQYVKSLSRVLKVKGFFLIT 190
Cdd:cd02440  74 PplHHLVEDLARFLEEARRLLKPGGVLVLT 103
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 65-152 2.30e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.52  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   65 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFsNITGIDYSPSAIQLSGSIIEKEGLS-NIKLKVEDflnLSTQ 143
Cdd:PRK07580  49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD---LESL 124

                         90
                 ....*....|.
gi 58219056  144 LSGFH--ICID 152
Cdd:PRK07580 125 LGRFDtvVCLD 135
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 80-219 2.87e-18

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 79.38  E-value: 2.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    80 DASVLDIGTGNGVFLVELAKFGFSN--ITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGT 155
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58219056   156 FDAISlNPDNAIEKrkqyvksLSRVLKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 219
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 57-191 2.41e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.72  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  57 EIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVED 136
Cdd:COG0500   4 SYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056 137 FLNLSTqlsgfhicIDKGTFDAISLNpdNAI-----EKRKQYVKSLSRVLKVKGFFLITS 191
Cdd:COG0500  84 LAELDP--------LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 67-193 5.32e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 67.35  E-value: 5.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  67 RLIRWMQKHkIPLDASVLDIGTGNGVFLVELAKFGFsNITGIDYSPSAIQLSgsiIEKEGLSNIKLKVEDFLNLStqlsg 146
Cdd:COG2227  13 RLAALLARL-LPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIA---RERAAELNVDFVQGDLEDLP----- 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 58219056 147 fhicIDKGTFDAISLNpdNAIE---KRKQYVKSLSRVLKVKGFFLITSCN 193
Cdd:COG2227  83 ----LEDGSFDLVICS--EVLEhlpDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 83-182 7.04e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.05  E-value: 7.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    83 VLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLsNIKLKVEDFLNLStqlsgfhicIDKGTFDAISLN 162
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLP---------FPDGSFDLVVSS 70

                          90       100
                  ....*....|....*....|....*
gi 58219056   163 pdNAI-----EKRKQYVKSLSRVLK 182
Cdd:pfam13649  71 --GVLhhlpdPDLEAALREIARVLK 93
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 36-191 6.98e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 64.95  E-value: 6.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  36 EHWD---AVYERELQTFREY----GDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAK-FGFsNITG 107
Cdd:COG2230   1 HHYDlgnDFYRLFLDPTMTYscayFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARrYGV-RVTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056 108 IDYSPSAIQLSGSIIEKEGLSN-IKLKVEDFLNLSTQlsgfhicidkGTFDAISLNpdNAIE-----KRKQYVKSLSRVL 181
Cdd:COG2230  80 VTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPAD----------GQFDAIVSI--GMFEhvgpeNYPAYFAKVARLL 147

                       170
                ....*....|
gi 58219056 182 KVKGFFLITS 191
Cdd:COG2230 148 KPGGRLLLHT 157
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 67-213 1.45e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 63.86  E-value: 1.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  67 RLIRWMQKHKiplDASVLDIGTGNGVFLVELAKFGFSnITGIDYSPSAIQLSGSIIEKEGLsNIKLKVEDFLNLStqlsg 146
Cdd:COG2226  13 ALLAALGLRP---GARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP----- 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58219056 147 fhicIDKGTFDAI-SLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNW-TKEELLNEFSEgwstvAGF 213
Cdd:COG2226  83 ----FPDGSFDLViSSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPpDLAELEELLAE-----AGF 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 83-190 2.47e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.06  E-value: 2.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  83 VLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLN 162
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISD 73

                        90       100       110
                ....*....|....*....|....*....|
gi 58219056 163 P--DNAIEKRKQYVKSLSRVLKVKGFFLIT 190
Cdd:cd02440  74 PplHHLVEDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-189 1.77e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 53.82  E-value: 1.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    84 LDIGTGNGVFLVELAKFGfSNITGIDYSPSAIQLSGSIIEKEGLSNIklkVEDFLNLStqlsgfhicIDKGTFDAISLNp 163
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGLTFV---VGDAEDLP---------FPDNSFDLVLSS- 66

                          90       100
                  ....*....|....*....|....*....
gi 58219056   164 dNAIE---KRKQYVKSLSRVLKVKGFFLI 189
Cdd:pfam08241  67 -EVLHhveDPERALREIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
36-190 9.19e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.15  E-value: 9.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  36 EHWDAVYERELQTFREYgdtgeiwfgEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSnITGIDYSPSAI 115
Cdd:COG4976  12 DQYADSYDAALVEDLGY---------EAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYR-LTGVDLSEEML 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58219056 116 QLSgsiieKEGLSNIKLKVEDFLNLSTqlsgfhiciDKGTFDAI----SLNPDNAIEkrkQYVKSLSRVLKVKGFFLIT 190
Cdd:COG4976  82 AKA-----REKGVYDRLLVADLADLAE---------PDGRFDLIvaadVLTYLGDLA---AVFAGVARALKPGGLFIFS 143
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
80-190 3.64e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.51  E-value: 3.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  80 DASVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSgsiieKEGLSNIKLKVEDFLNLSTQlsgfhicidkGTFDA 158
Cdd:COG4106   2 PRRVLDLGCGTGRLTALLAErFPGARVTGVDLSPEMLARA-----RARLPNVRFVVADLRDLDPP----------EPFDL 66

                        90       100       110
                ....*....|....*....|....*....|....*
gi 58219056 159 ISLNpdNA---IEKRKQYVKSLSRVLKVKGFFLIT 190
Cdd:COG4106  67 VVSN--AAlhwLPDHAALLARLAAALAPGGVLAVQ 99
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 84-187 6.16e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.98  E-value: 6.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    84 LDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQlsgsiIEKEGLSNIKLKVEDFLNLSTQLSGFHiciDKGTFDAISLN 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEaLPGLEYTGLDISPAALE-----AARERLAALGLLNAVRVELFQLDLGEL---DPGSFDVVVAS 72

                          90       100
                  ....*....|....*....|....*...
gi 58219056   163 pdNAIE---KRKQYVKSLSRVLKVKGFF 187
Cdd:pfam08242  73 --NVLHhlaDPRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 76-182 1.36e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 47.42  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    76 KIPLDASVLDIGTGNGVFLVELAKFGFSnITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDflnlstqlsgfhicidkGT 155
Cdd:pfam13489  19 KLPSPGRVLDFGCGTGIFLRLLRAQGFS-VTGVDPSPIAIERALLNVRFDQFDEQEAAVPA-----------------GK 80

                          90       100
                  ....*....|....*....|....*..
gi 58219056   156 FDAISLNpdNAIEkrkqYVKSLSRVLK 182
Cdd:pfam13489  81 FDVIVAR--EVLE----HVPDPPALLR 101
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 65-152 2.30e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.52  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   65 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFsNITGIDYSPSAIQLSGSIIEKEGLS-NIKLKVEDflnLSTQ 143
Cdd:PRK07580  49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD---LESL 124

                         90
                 ....*....|.
gi 58219056  144 LSGFH--ICID 152
Cdd:PRK07580 125 LGRFDtvVCLD 135
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
81-141 3.41e-06

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 46.65  E-value: 3.41e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58219056   81 ASVLDIGTGNGVFLVELAKFGFsNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLS 141
Cdd:PRK11207  32 GKTLDLGCGNGRNSLYLAANGF-DVTAWDKNPMSIANLERIKAAENLDNLHTAVVDLNNLT 91
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 83-187 1.32e-05

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 44.59  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    83 VLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKvedFLNLSTQLSGFhicIDKGTFDAISL 161
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAKaNPDKNFIGIEIRVPGVAKALKKIDALGLQNLRIL---CGNALDVLPNY---FPPGSLQKIFI 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 58219056   162 N-PDNAIEKRKQ--------YVKSLSRVLKVKGFF 187
Cdd:pfam02390  79 NfPDPWPKKRHHkrrllqpeFLKEYARVLKPGGVL 113
PRK14968 PRK14968
putative methyltransferase; Provisional
 82-163 3.85e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.35  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   82 SVLDIGTGNGVFLVELAKFGfSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVE--DFLNlstqlsgfhiCIDKGTFDAI 159
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIrsDLFE----------PFRGDKFDVI 94


                 ....
gi 58219056  160 SLNP 163
Cdd:PRK14968  95 LFNP 98
TrmB COG0220
tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 ...
 83-187 6.73e-05

tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 N7-methylase TrmB is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439990  Cd Length: 204  Bit Score: 42.82  E-value: 6.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  83 VLDIGTGNGVFLVELAK----FGFsnItGIDYSPSAIQLSGSIIEKEGLSNIKL---KVEDFLNlstqlsgfhiCIDKGT 155
Cdd:COG0220  36 VLEIGFGKGEFLVELAAanpdINF--I-GIEVHEPGVAKALKKAEEEGLTNVRLlrgDAVELLE----------LFPDGS 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 58219056 156 FDAISLN-PD----NAIEKR----KQYVKSLSRVLKVKGFF 187
Cdd:COG0220 103 LDRIYLNfPDpwpkKRHHKRrlvqPEFLALLARVLKPGGEL 143
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
80-163 7.26e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.97  E-value: 7.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  80 DASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGlSNIKLKVEDFLNLStqlsgfhiciDKGTFDAI 159
Cdd:COG2263  46 GKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIP----------LGGSVDTV 114


                ....
gi 58219056 160 SLNP 163
Cdd:COG2263 115 VMNP 118
trmB PRK00121
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
 83-202 9.82e-05

tRNA (guanine-N(7)-)-methyltransferase; Reviewed


Pssm-ID: 234649  Cd Length: 202  Bit Score: 42.46  E-value: 9.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   83 VLDIGTGNGVFLVELAKfGFSNIT--GID-YSPSAIQLSGSIIEkEGLSNIKL----KVEDFLNlstqlsgfhiCIDKGT 155
Cdd:PRK00121  44 HLEIGFGKGEFLVEMAK-ANPDINfiGIEvHEPGVGKALKKIEE-EGLTNLRLlcgdAVEVLLD----------MFPDGS 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58219056  156 FDAISLN-PDNAIEKR--------KQYVKSLSRVLKVKGFFLITS-----CNWTKEELLNE 202
Cdd:PRK00121 112 LDRIYLNfPDPWPKKRhhkrrlvqPEFLALYARKLKPGGEIHFATdwegyAEYMLEVLSAE 172
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 83-136 1.48e-04

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 42.62  E-value: 1.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 58219056   83 VLDIGTGNGVFLVELAKFGFsNITGIDYSPSAIQLSGSIIEKEGLsNIKLKVED 136
Cdd:PRK12335 124 ALDLGCGQGRNSLYLALLGF-DVTAVDINQQSLENLQEIAEKENL-NIRTGLYD 175
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 81-163 2.89e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 41.69  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   81 ASVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNlstqlsgfhiCIDKGTFDAI 159
Cdd:PRK09328 110 LRVLDLGTGSGAIALALAKeRPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFE----------PLPGGRFDLI 179


                 ....
gi 58219056  160 SLNP 163
Cdd:PRK09328 180 VSNP 183
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 82-189 3.87e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.90  E-value: 3.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  82 SVLDIGTGNGVFLVELA-KFGFSNITGIDYSPSAIQLSGSIIEKEGLSN-IKLKVEDFLNLSTQLSgfhicidKGTFDAI 159
Cdd:COG4123  40 RVLDLGTGTGVIALMLAqRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELP-------PGSFDLV 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58219056 160 SLNP---------DNAIEKRKQ-----------YVKSLSRVLKVKG-FFLI 189
Cdd:COG4123 113 VSNPpyfkagsgrKSPDEARAIarhedaltledLIRAAARLLKPGGrFALI 163
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 69-162 1.69e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.17  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056    69 IRWMQKHKIPlDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSgsiieKEglsNIKL-KVEDFLNLSTQLSGF 147
Cdd:pfam06325 152 LEALERLVKP-GESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAA-----KE---NAELnGVEARLEVYLPGDLP 222

                          90
                  ....*....|....*
gi 58219056   148 hicidKGTFDAISLN 162
Cdd:pfam06325 223 -----KEKADVVVAN 232
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 69-226 1.75e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 38.98  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   69 IRWMQkhkIPLDASVLDIGTGNGVFLVELAKFG--FSNITGIDYSPSaiQLS-GS--IIEKEGLSNIKLKVEDFLNLStq 143
Cdd:PRK00216  44 IKWLG---VRPGDKVLDLACGTGDLAIALAKAVgkTGEVVGLDFSEG--MLAvGRekLRDLGLSGNVEFVQGDAEALP-- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  144 lsgfhicIDKGTFDAISL-----NpdnaIEKRKQYVKSLSRVLKVKGFFLItscnwtkeellNEFSE----GWSTVAGFW 214
Cdd:PRK00216 117 -------FPDNSFDAVTIafglrN----VPDIDKALREMYRVLKPGGRLVI-----------LEFSKptnpPLKKAYDFY 174

                        170
                 ....*....|..
gi 58219056  215 LTAALTSWAQAI 226
Cdd:PRK00216 175 LFKVLPLIGKLI 186
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 77-163 4.54e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.48  E-value: 4.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  77 IPLDASVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDflnlstQLSGfhicIDKGT 155
Cdd:COG2813  47 EPLGGRVLDLGCGYGVIGLALAKrNPEARVTLVDVNARAVELARANAAANGLENVEVLWSD------GLSG----VPDGS 116


                ....*...
gi 58219056 156 FDAISLNP 163
Cdd:COG2813 117 FDLILSNP 124
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
69-116 4.57e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 37.85  E-value: 4.57e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 58219056  69 IRWMQKHkIPLDASVLDIGTGNGVflveLA----KFGFSNITGIDYSPSAIQ 116
Cdd:COG2264 139 LEALEKL-LKPGKTVLDVGCGSGI----LAiaaaKLGAKRVLAVDIDPVAVE 185
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
69-116 4.85e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 37.82  E-value: 4.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 58219056   69 IRWMQKHkIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQ 116
Cdd:PRK00517 110 LEALEKL-VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVE 156
PRK14967 PRK14967
putative methyltransferase; Provisional
 68-116 6.81e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 36.95  E-value: 6.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 58219056   68 LIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQ 116
Cdd:PRK14967  25 LADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVR 73
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 69-163 7.17e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 7.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  69 IRWMQKHKIPldaSVLDIGTGNGVFLVELAK-FGFSNITGIDYSPSAIQLSgsiieKEglsNI-KLKVEDFLNLsTQLSG 146
Cdd:COG2890 105 LALLPAGAPP---RVLDLGTGSGAIALALAKeRPDARVTAVDISPDALAVA-----RR---NAeRLGLEDRVRF-LQGDL 172

                        90
                ....*....|....*..
gi 58219056 147 FHICIDKGTFDAISLNP 163
Cdd:COG2890 173 FEPLPGDGRFDLIVSNP 189
PLN02244 PLN02244
tocopherol O-methyltransferase
 83-192 7.51e-03

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 37.42  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056   83 VLDIGTGNGVFLVELA-KFGfSNITGIDYSPSAIQLSGSIIEKEGLSN-IKLKVEDFLNLStqlsgfhicIDKGTFDAI- 159
Cdd:PLN02244 122 IVDVGCGIGGSSRYLArKYG-ANVKGITLSPVQAARANALAAAQGLSDkVSFQVADALNQP---------FEDGQFDLVw 191

                         90       100       110
                 ....*....|....*....|....*....|...
gi 58219056  160 SLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSC 192
Cdd:PLN02244 192 SMESGEHMPDKRKFVQELARVAAPGGRIIIVTW 224
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
74-132 7.80e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 36.94  E-value: 7.80e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58219056  74 KHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLS-NIKL 132
Cdd:COG4076  30 ERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITV 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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