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Conserved domains on  [gi|83745139|ref|NP_997519|]
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fibronectin type-III domain-containing protein 3A [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
274-620 6.14e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.74  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  274 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 353
Cdd:COG3401  141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  354 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 433
Cdd:COG3401  216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  434 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 501
Cdd:COG3401  293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  502 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 577
Cdd:COG3401  373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 83745139  578 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 620
Cdd:COG3401  439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
818-1096 5.74e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 5.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  818 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 894
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  895 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 967
Cdd:COG3401  264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  968 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1045
Cdd:COG3401  344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 83745139 1046 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1096
Cdd:COG3401  420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-754 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83745139  678 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 754
Cdd:cd00063   16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 756-848 7.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  756 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 832
Cdd:cd00063    1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 83745139  833 SVVGAGPFSEVVACVT 848
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
274-620 6.14e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.74  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  274 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 353
Cdd:COG3401  141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  354 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 433
Cdd:COG3401  216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  434 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 501
Cdd:COG3401  293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  502 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 577
Cdd:COG3401  373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 83745139  578 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 620
Cdd:COG3401  439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-462 8.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 8.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  371 PDPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDY 449
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 83745139  450 GVSDFSEEVLYYT 462
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
818-1096 5.74e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 5.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  818 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 894
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  895 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 967
Cdd:COG3401  264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  968 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1045
Cdd:COG3401  344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 83745139 1046 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1096
Cdd:COG3401  420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 875-947 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  875 STCLAISWKEPYDHGSEILAYSI---DLGDKQPLTV----GKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKT 947
Cdd:cd00063   14 STSVTLSWTPPEDDGGPITGYVVeyrEKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-754 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83745139  678 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 754
Cdd:cd00063   16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 756-848 7.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  756 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 832
Cdd:cd00063    1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 83745139  833 SVVGAGPFSEVVACVT 848
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-452 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     371 PDPPNAPRIANRTKNSLTLQWKAPSDNG--SKIQSFILEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSAKND 448
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 83745139     449 YGVS 452
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
272-359 2.84e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    272 PVASDIQARTVLLTWSPPSSfINGEVNetavpelfNYEVLVSSTGKEGKYRSVYI-GEETSVTLNDLKPATDYHAKVQAE 350
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 83745139    351 SNSIKGIPS 359
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
875-940 3.45e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.45e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83745139    875 STCLAISWKEPYDHGSEILAYSI------DLGDKQPLTVGKMT-SYIIDSLQPDTTYRIRIQALNSLGAGPFS 940
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 756-838 5.17e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     756 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--VTEYRLEWGGVEGSMQMCYCGPG-LSCELKGLSPATTYYCRVQAM 832
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 83745139     833 SVVGAG 838
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
763-841 1.12e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    763 RPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEW---GGVEGSMQMCYCGPGLSCELKGLSPATTYYCRVQAMSVVGAGP 839
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   ..
gi 83745139    840 FS 841
Cdd:pfam00041   84 PS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 662-744 1.44e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.44e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     662 PGPclPPRLQGRPKAKE-IQLRWGPPQVDGG-SPISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAAN 739
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 83745139     740 RIGFG 744
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 875-937 1.89e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.89e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     875 STCLAISWKEPYDHG--SEILAYSIDLGDKQPL-----TVGKMTSYIIDSLQPDTTYRIRIQALNSLGAG 937
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
678-747 3.96e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 3.96e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83745139    678 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDVYQ--GSEVECTVGSLLPGKTYSFRLRAANRIGFGPFS 747
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
274-620 6.14e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.74  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  274 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 353
Cdd:COG3401  141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  354 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 433
Cdd:COG3401  216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  434 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 501
Cdd:COG3401  293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  502 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 577
Cdd:COG3401  373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 83745139  578 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 620
Cdd:COG3401  439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
444-933 1.21e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.97  E-value: 1.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  444 SAKNDYGVSDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL 523
Cdd:COG3401   16 SAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  524 AYTVKNLRRSTKYKFKVIAYNsegksnPSEVVEFSTCPDKPGVPVKPSVKGKIHSHGFKITWDPPKDNGGAPINKYVVEM 603
Cdd:COG3401   96 TLTGSGSVGGATNTGLTSSDE------VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  604 AEGSNGNKWDMIYSGTTREH-----LCDRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AK 677
Cdd:COG3401  170 VSPDTSATAAVATTSLTVTSttlvdGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  678 EIQLRWGPPQVDGgspISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAANRIGF-GPFSEKYDITTAP 756
Cdd:COG3401  248 SVTLSWDPVTESD---ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDL 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  757 GPPDqcrPPQ-VTCRSATCAQV--NWEipLSNGTDVTEYRLE-WGGVEGSMQ-MCYCGPGLSCELKGLSPATTYYCRVQA 831
Cdd:COG3401  325 TPPA---APSgLTATAVGSSSItlSWT--ASSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  832 MSVvgAGPFSEVVACVTPPSVPAIVTCLQEISDDDIEYPHYSPSTcLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMT 911
Cdd:COG3401  400 VDA--AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGAT-AAASAASNPGVSAAVLADGGDTGNAVPFTTTSST 476

                        490       500
                 ....*....|....*....|..
gi 83745139  912 SYIIDSLQPDTTYRIRIQALNS 933
Cdd:COG3401  477 VTATTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-462 8.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 8.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  371 PDPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDY 449
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 83745139  450 GVSDFSEEVLYYT 462
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
818-1096 5.74e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 5.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  818 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 894
Cdd:COG3401  198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  895 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 967
Cdd:COG3401  264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  968 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1045
Cdd:COG3401  344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 83745139 1046 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1096
Cdd:COG3401  420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
273-620 1.67e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.67e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  273 VASDIQARTVLLTWSPPSSfingevnetavPELFNYEVLVSSTGkEGKYRSVYIGEETSVTLNDLKPATDYHAKVQAE-S 351
Cdd:COG3401  240 TATADTPGSVTLSWDPVTE-----------SDATGYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  352 NSIKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEGKGnGEFCQ-CYMGSQKQFKI 430
Cdd:COG3401  308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSGG-GTYTKiAETVTTTSYTD 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  431 TKLSPAMGCKFRLSAKNDYGV-SDFSEEVlyytSGCAPSVPASPVLTKAGVTW---LSLQWTKPSGTPSDEGISYILEME 506
Cdd:COG3401  385 TGLTPGTTYYYKVTAVDAAGNeSAPSEEV----SATTASAASGESLTASVDAVpltDVAGATAAASAASNPGVSAAVLAD 460

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  507 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFSTCPDKPGVPVKPSVKGKIHSHGFKITWD 586
Cdd:COG3401  461 GGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGA 540

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 83745139  587 PPKD------NGGAPINKYVVEMAEGSNGNKWDMIYSGTT 620
Cdd:COG3401  541 STGDvlitdlVSLTTSASSSVSGAGLGSGNLYLITTLGGS 580
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 467-559 1.76e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  467 PSVPASPVLTKAGVTWLSLQWTKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 545
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 83745139  546 EGKSNPSEVVEFST 559
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 875-947 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  875 STCLAISWKEPYDHGSEILAYSI---DLGDKQPLTV----GKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKT 947
Cdd:cd00063   14 STSVTLSWTPPEDDGGPITGYVVeyrEKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 678-754 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 83745139  678 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 754
Cdd:cd00063   16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 756-848 7.95e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  756 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 832
Cdd:cd00063    1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 83745139  833 SVVGAGPFSEVVACVT 848
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 564-657 3.24e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  564 PGVPVKPSVKGkIHSHGFKITWDPPKDNGGaPINKYVVEMAEgSNGNKWDMI--YSGTTREHLCDRLTPGCYYRLRVYCI 641
Cdd:cd00063    1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                         90
                 ....*....|....*.
gi 83745139  642 SDGGQSAVSESLLVQT 657
Cdd:cd00063   78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
872-1154 6.02e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.56  E-value: 6.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  872 YSPSTCLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLP 951
Cdd:COG3401  153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  952 PDPP-RLECVAFNHQNLKLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEA 1029
Cdd:COG3401  233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139 1030 G-EGPLSQEYVFTTPKSLPAALKAPKIEKINDHICEITWeylQPMKGDPVI-YNLQVMVGKDSEFKQIYKGPD-TSFRYS 1106
Cdd:COG3401  309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTtTSYTDT 385

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 83745139 1107 SLQLNCEYRFRVCAIrqcqDPTGhqdLVGPYSTTVFFISQRTEPPASS 1154
Cdd:COG3401  386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESL 426
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 267-366 1.55e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  267 SNIVKPVASDIQARTVLLTWSPPSSfINGEVnetavpelFNYEVLVSSTGKEGKYR-SVYIGEETSVTLNDLKPATDYHA 345
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPED-DGGPI--------TGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|.
gi 83745139  346 KVQAESNSIKGIPSEAESFTT 366
Cdd:cd00063   73 RVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-452 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     371 PDPPNAPRIANRTKNSLTLQWKAPSDNG--SKIQSFILEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSAKND 448
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 83745139     449 YGVS 452
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
272-359 2.84e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    272 PVASDIQARTVLLTWSPPSSfINGEVNetavpelfNYEVLVSSTGKEGKYRSVYI-GEETSVTLNDLKPATDYHAKVQAE 350
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 83745139    351 SNSIKGIPS 359
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
875-940 3.45e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.45e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 83745139    875 STCLAISWKEPYDHGSEILAYSI------DLGDKQPLTVGKMT-SYIIDSLQPDTTYRIRIQALNSLGAGPFS 940
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
372-455 3.99e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    372 DPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSAKNDY 449
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 83745139    450 GVSDFS 455
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 756-838 5.17e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     756 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--VTEYRLEWGGVEGSMQMCYCGPG-LSCELKGLSPATTYYCRVQAM 832
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 83745139     833 SVVGAG 838
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 467-549 8.59e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.59e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     467 PSVPASPVLTKAGVTWLSLQWTKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 543
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 83745139     544 NSEGKS 549
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
763-841 1.12e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    763 RPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEW---GGVEGSMQMCYCGPGLSCELKGLSPATTYYCRVQAMSVVGAGP 839
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   ..
gi 83745139    840 FS 841
Cdd:pfam00041   84 PS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 662-744 1.44e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.44e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     662 PGPclPPRLQGRPKAKE-IQLRWGPPQVDGG-SPISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAAN 739
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 83745139     740 RIGFG 744
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 875-937 1.89e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.89e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     875 STCLAISWKEPYDHG--SEILAYSIDLGDKQPL-----TVGKMTSYIIDSLQPDTTYRIRIQALNSLGAG 937
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
678-747 3.96e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 3.96e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 83745139    678 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDVYQ--GSEVECTVGSLLPGKTYSFRLRAANRIGFGPFS 747
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
583-742 1.59e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 55.72  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  583 ITWDPPKDNggapiNKYVVEmAEGSNGNkWDMIYSGTTREHLCDRLTPGCYYrLRVYCISDGGQS----AVSESLLVQTP 658
Cdd:COG4733  556 VSWDAPAGA-----VAYEVE-WRRDDGN-WVSVPRTSGTSFEVPGIYAGDYE-VRVRAINALGVSsawaASSETTVTGKT 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  659 AVPPGPclpPRLQGRPKAKEIQLRWGPPqVDGGSP---IScYAVEMTPADKDEPRDVYQGSEVecTVGSLLPGKTYSFRL 735
Cdd:COG4733  628 APPPAP---TGLTATGGLGGITLSWSFP-VDADTLrteIR-YSTTGDWASATVAQALYPGNTY--TLAGLKAGQTYYYRA 700


                 ....*..
gi 83745139  736 RAANRIG 742
Cdd:COG4733  701 RAVDRSG 707
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 952-1042 2.43e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 2.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139  952 PDPPR-LECVAFNHQNLKLKWGEgtPKTLSTDAVQYHLQMEDRNGRFVSLYRGPC---HTYKVQRLSESTSYKFCIQACN 1027
Cdd:cd00063    1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 83745139 1028 EAGEGPLSQEYVFTT 1042
Cdd:cd00063   79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 951-1032 1.53e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.53e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     951 PPDPPRLECVAFNHQNLKLKWGEGTPKTLSTDAVQYHLQMEDRNGRFVSLYRGPCHT-YKVQRLSESTSYKFCIQACNEA 1029
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 83745139    1030 GEG 1032
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 564-647 1.70e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.70e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     564 PGVPVKPSVKGkIHSHGFKITWDPPK-DNGGAPINKYVVEMAEGSNGNKwDMIYSGTTREHLCDRLTPGCYYRLRVYCIS 642
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 83745139     643 DGGQS 647
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
468-552 2.76e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    468 SVPASPVLTKAGVTWLSLQWTKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSE 546
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 83745139    547 GKSNPS 552
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 267-352 3.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 3.63e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139     267 SNIVKPVASDIQARTVLLTWSPPSSFINGEvnetavpELFNYEVLVSSTGKEGKYRSVyIGEETSVTLNDLKPATDYHAK 346
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITG-------YIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 83745139     347 VQAESN 352
Cdd:smart00060   74 VRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
578-650 8.96e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.40  E-value: 8.96e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 83745139    578 SHGFKITWDPPKDNGGaPINKYVVEMAEGSNGNKWDMIY-SGTTREHLCDRLTPGCYYRLRVYCISDGGQSAVS 650
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1047-1144 9.18e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139 1047 PAALKAPKIEKINDHICEITWEYLQPMKGDPVIYNLQVMVGKDSEFKQIYK--GPDTSFRYSSLQLNCEYRFRVCAIRqc 1124
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                         90       100
                 ....*....|....*....|
gi 83745139 1125 qdptghQDLVGPYSTTVFFI 1144
Cdd:cd00063   79 ------GGGESPPSESVTVT 92
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 279-366 9.96e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 36.62  E-value: 9.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83745139    279 ARTVLLTWSPPSSFINGEVNETAVPElfNYEVLVSSTGKEGKYRSVYIGEETSVTLNDLKPATDYHAKVQAESnsikGIP 358
Cdd:pfam16656   12 STSMTVSWVTPSAVTSPVVQYGTSSS--ALTSTATATSSTYTTGDGGTGYIHRATLTGLEPGTTYYYRVGDDN----GGW 85


                   ....*...
gi 83745139    359 SEAESFTT 366
Cdd:pfam16656   86 SEVYSFTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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