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Conserved domains on  [gi|148231468|ref|NP_997293|]
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GDNF family receptor alpha-like precursor [Homo sapiens]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 8.59e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 66.40  E-value: 8.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  131 CLEVAEACVGDVVCNAQLASYLKACSANGNPCD----LKQCQAAIRFFYQNIPFNIAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 148231468  204 ALHSKTC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.13e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.62  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVtRKCHedencistlskqdlTCSGSDDCKAAY------IDILGTVLQVQCTC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYrmtpnyVDNLGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 148231468  294 RTITQSEEsLCKIFQHMLHRKSC 316
Cdd:pfam02351  66 KGSGNQDE-ECEEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 8.59e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 66.40  E-value: 8.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  131 CLEVAEACVGDVVCNAQLASYLKACSANGNPCD----LKQCQAAIRFFYQNIPFNIAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 148231468  204 ALHSKTC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.13e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.62  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVtRKCHedencistlskqdlTCSGSDDCKAAY------IDILGTVLQVQCTC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYrmtpnyVDNLGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 148231468  294 RTITQSEEsLCKIFQHMLHRKSC 316
Cdd:pfam02351  66 KGSGNQDE-ECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.42e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 59.96  E-value: 1.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468   220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHED--ENCISTLSkqdltcsgSDDCKAAYIDilGTVLQVQCTCRTit 297
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAYC--------GLALRPFYDD--NSSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 148231468   298 qSEESLCKIFQHMLHRKSC 316
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 1.51e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 51.49  E-value: 1.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468   131 CLEVAEACVGDVVCNAQLASYLKACSANGNP---------CDLKQCQAAIRFFYQNIPFniaqMLAFCDCA-QSDIPCQQ 200
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenseaCLRAYCGLALRPFYDDNSS----VLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 148231468   201 SKEALHSKTC 210
Cdd:smart00907  77 FRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 8.59e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 66.40  E-value: 8.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  131 CLEVAEACVGDVVCNAQLASYLKACSANGNPCD----LKQCQAAIRFFYQNIPFNIAQMLAFCDCAQS---DIPCQQSKE 203
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSgcpnPARCLRAYRMTPNYVDNLGTSLLLWCTCKGSgnqDEECEEFRR 80


                  ....*..
gi 148231468  204 ALHSKTC 210
Cdd:pfam02351  81 NFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.13e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 60.62  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468  220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVtRKCHedencistlskqdlTCSGSDDCKAAY------IDILGTVLQVQCTC 293
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSP-ESCS--------------GCPNPARCLRAYrmtpnyVDNLGTSLLLWCTC 65

                          90       100
                  ....*....|....*....|...
gi 148231468  294 RTITQSEEsLCKIFQHMLHRKSC 316
Cdd:pfam02351  66 KGSGNQDE-ECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 220-316 1.42e-11

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 59.96  E-value: 1.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468   220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHED--ENCISTLSkqdltcsgSDDCKAAYIDilGTVLQVQCTCRTit 297
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGEnsEACLRAYC--------GLALRPFYDD--NSSVLLFCTCAG-- 68

                           90
                   ....*....|....*....
gi 148231468   298 qSEESLCKIFQHMLHRKSC 316
Cdd:smart00907  69 -NRDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-210 1.51e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 51.49  E-value: 1.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231468   131 CLEVAEACVGDVVCNAQLASYLKACSANGNP---------CDLKQCQAAIRFFYQNIPFniaqMLAFCDCA-QSDIPCQQ 200
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenseaCLRAYCGLALRPFYDDNSS----VLLFCTCAgNRDEECLE 76

                           90
                   ....*....|
gi 148231468   201 SKEALHSKTC 210
Cdd:smart00907  77 FRRLFHSNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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