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Conserved domains on  [gi|614458217|ref|NP_997244|]
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FRAS1-related extracellular matrix protein 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 72-284 4.36e-126

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


:

Pssm-ID: 466034  Cd Length: 202  Bit Score: 395.16  E-value: 4.36e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217    72 IVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRV 151
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   152 RLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYG 231
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 614458217   232 ELLHYPQVPggareggapetLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVV 284
Cdd:pfam19309  161 RLVNATGAP-----------LMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1286-1401 9.54e-35

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 129.64  E-value: 9.54e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1286 HSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGafENIT 1365
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 614458217  1366 lgmNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDG 1401
Cdd:pfam16184   79 ---NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1406-1514 6.91e-34

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 127.33  E-value: 6.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1406 IDRYFYVSIGSIDIVFPDV-ISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQ 1484
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 614458217  1485 LQLAGNKIYYIHTaDDEVKMDSFEFQVTDG 1514
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1516-1623 7.99e-34

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.95  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1516 NPVFRTFRISISDVDNKKPVVTIHK-LVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNT--RPVMVF 1592
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217  1593 TKQDLNENLISYKHDGTESSEDSFSFTVTDG 1623
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
422-539 2.40e-30

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 117.32  E-value: 2.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   422 SDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTgpagsgPQNLVISDEDDL-EAVRLEVVAGLRHGHLVILGASSG 500
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT------PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217   501 SsaPKSFTVAELAAGQVVYQHDDRDgSLSDNLVLRMVDG 539
Cdd:pfam16184   76 P--VTNFTQADIDSGLVVYVHDGSE-STSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1174-1284 2.08e-27

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 2.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1174 SERQFFPIVIIPTNDEQPEMFMRE-FMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLiNGTVLVESF 1252
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 614458217  1253 TLDQiIESSSIIYEHDDSETQEDSFVIKLTDG 1284
Cdd:pfam16184   81 TQAD-IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
543-676 5.54e-23

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 96.13  E-value: 5.54e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   543 HQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPfLTTGHLLLRqTHPPhekq 622
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK-GAPG---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 614458217   623 ellrglwrkegafyeRTVTEWQQQDITEGRLFYRHSGphsPGPVTDQFTFRVQD 676
Cdd:pfam16184   75 ---------------LPVTNFTQADIDSGLVVYVHDG---SESTSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
923-1038 5.92e-22

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.05  E-value: 5.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   923 HVVPITLRVNVRPVDDEVPILSHPTGtlesyLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNG---I 999
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTG-----LRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGapgL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217  1000 PAEQFTQRDILEGSVVYTHTSGEigllPKADSFNLSLSD 1038
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1641-1754 1.63e-21

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.90  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1641 PQVMKIQVLAVDNSVPQIAVNKGastLRTLATGHlgFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSIT 1720
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 614458217  1721 QFTQADIDDMKICYVlREGANATSDMFYFAVEDG 1754
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1053-1170 2.03e-21

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 2.03e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1053 VTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENispapgseKSRAGIA 1132
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLP 76

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 614458217  1133 ISAFNLKDLRQGHINYvqsVHKGVEPVEDRFVFRCSDG 1170
Cdd:pfam16184   77 VTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1771-1984 1.29e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.70  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1771 ISFEKEYYLVNEDSKFLDVVLKRRGY-LGETSFISIGTRDRTAEKDKDFKGkAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1850 SETFQVVLSEP---------------VLAALEFPTVATVEIVDpGDEPTVF-IPQSKYSVEEDVGELFIPIRRSGDVSQE 1913
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217  1914 LMVVCYTQQGTATGtvptsvlSYSDYisrpEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 super family cl28802
Cadherin-like;
683-808 1.02e-15

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   683 QSGLQRFVIRIHPVDRLPPELGSGCPLRmvVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPtdtdeNHlpaplGTLV 762
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLR--LWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH-----GHLA 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 614458217   763 LTDNPSVVVTHFTQAQINHHKIAYrppgQELGVATRVAQFQFQVED 808
Cdd:pfam16184   69 LKGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Cadherin_3 super family cl28802
Cadherin-like;
815-920 2.31e-15

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 74.56  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   815 PGTFTLYLHPVDNQPPEI-LNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGH----MRVSGQILHvggl 889
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHlalkGAPGLPVTN---- 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217   890 FHLEDIKQGRVSYAHNGDKSLTDSCSLEVSD 920
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQVTD 110
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2108-2364 2.81e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 82.92  E-value: 2.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2108 AALGEPSKATVSINDSVSDLP-KMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTdt 2185
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVaLTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGT-- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2186 siITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETL----------IRIRDDADKTVIKFGE 2255
Cdd:TIGR00845  457 --LVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVaqlaspntatVTILDDDHAGIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2256 TKFSVTEpkepgESVVIRIPVIRQGDTSKVSIVRVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMR 2334
Cdd:TIGR00845  535 DVFHVSE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKN 609

                          250       260       270
                   ....*....|....*....|....*....|
gi 614458217  2335 EAFTVHLkpDENMIAEMQLTKAIVYIEEMS 2364
Cdd:TIGR00845  610 DTFFIEL--GEPRWAKRGIKAALLLNETIT 637
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1990-2223 4.30e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.60  E-value: 4.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1990 GSEFPGAQVTIVPDKDDEPI--FYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRsrkTDPPSADAGTDYVGISRN 2067
Cdd:TIGR00845  380 ARKAVSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYR---TEDGTANAGSDYEFTEGT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2068 LDFAPGVNMQPVRVVILDD------------LGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDsvSDLPKM-QFKE 2134
Cdd:TIGR00845  457 LVFKPGETQKEFRIGIIDDdifeedehfyvrLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGIfTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2135 RIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQV-MMDFEErpnTDTSIItFLPGETEKPCILELMDDVLYEEVE 2213
Cdd:TIGR00845  535 DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGgGKDFED---TCGELE-FENDETEKTIRVKIVDDEEYEKND 610

                          250
                   ....*....|
gi 614458217  2214 ELRLVLGTPQ 2223
Cdd:TIGR00845  611 TFFIELGEPR 620
Cadherin_3 super family cl28802
Cadherin-like;
336-396 9.30e-10

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 58.38  E-value: 9.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217   336 TALTPDMLAAEDAESPSDLLIFNLTSPfqPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQ 396
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLPVTNFTQADIDSGLVVYV 93
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 72-284 4.36e-126

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 395.16  E-value: 4.36e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217    72 IVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRV 151
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   152 RLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYG 231
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 614458217   232 ELLHYPQVPggareggapetLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVV 284
Cdd:pfam19309  161 RLVNATGAP-----------LMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1286-1401 9.54e-35

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 129.64  E-value: 9.54e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1286 HSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGafENIT 1365
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 614458217  1366 lgmNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDG 1401
Cdd:pfam16184   79 ---NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1406-1514 6.91e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 127.33  E-value: 6.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1406 IDRYFYVSIGSIDIVFPDV-ISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQ 1484
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 614458217  1485 LQLAGNKIYYIHTaDDEVKMDSFEFQVTDG 1514
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1516-1623 7.99e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.95  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1516 NPVFRTFRISISDVDNKKPVVTIHK-LVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNT--RPVMVF 1592
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217  1593 TKQDLNENLISYKHDGTESSEDSFSFTVTDG 1623
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
422-539 2.40e-30

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 117.32  E-value: 2.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   422 SDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTgpagsgPQNLVISDEDDL-EAVRLEVVAGLRHGHLVILGASSG 500
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT------PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217   501 SsaPKSFTVAELAAGQVVYQHDDRDgSLSDNLVLRMVDG 539
Cdd:pfam16184   76 P--VTNFTQADIDSGLVVYVHDGSE-STSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1174-1284 2.08e-27

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 2.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1174 SERQFFPIVIIPTNDEQPEMFMRE-FMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLiNGTVLVESF 1252
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 614458217  1253 TLDQiIESSSIIYEHDDSETQEDSFVIKLTDG 1284
Cdd:pfam16184   81 TQAD-IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
543-676 5.54e-23

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 96.13  E-value: 5.54e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   543 HQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPfLTTGHLLLRqTHPPhekq 622
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK-GAPG---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 614458217   623 ellrglwrkegafyeRTVTEWQQQDITEGRLFYRHSGphsPGPVTDQFTFRVQD 676
Cdd:pfam16184   75 ---------------LPVTNFTQADIDSGLVVYVHDG---SESTSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
923-1038 5.92e-22

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.05  E-value: 5.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   923 HVVPITLRVNVRPVDDEVPILSHPTGtlesyLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNG---I 999
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTG-----LRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGapgL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217  1000 PAEQFTQRDILEGSVVYTHTSGEigllPKADSFNLSLSD 1038
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1641-1754 1.63e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.90  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1641 PQVMKIQVLAVDNSVPQIAVNKGastLRTLATGHlgFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSIT 1720
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 614458217  1721 QFTQADIDDMKICYVlREGANATSDMFYFAVEDG 1754
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1053-1170 2.03e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 2.03e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1053 VTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENispapgseKSRAGIA 1132
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLP 76

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 614458217  1133 ISAFNLKDLRQGHINYvqsVHKGVEPVEDRFVFRCSDG 1170
Cdd:pfam16184   77 VTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1771-1984 1.29e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.70  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1771 ISFEKEYYLVNEDSKFLDVVLKRRGY-LGETSFISIGTRDRTAEKDKDFKGkAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1850 SETFQVVLSEP---------------VLAALEFPTVATVEIVDpGDEPTVF-IPQSKYSVEEDVGELFIPIRRSGDVSQE 1913
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217  1914 LMVVCYTQQGTATGtvptsvlSYSDYisrpEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 pfam16184
Cadherin-like;
683-808 1.02e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   683 QSGLQRFVIRIHPVDRLPPELGSGCPLRmvVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPtdtdeNHlpaplGTLV 762
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLR--LWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH-----GHLA 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 614458217   763 LTDNPSVVVTHFTQAQINHHKIAYrppgQELGVATRVAQFQFQVED 808
Cdd:pfam16184   69 LKGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
815-920 2.31e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 74.56  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   815 PGTFTLYLHPVDNQPPEI-LNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGH----MRVSGQILHvggl 889
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHlalkGAPGLPVTN---- 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217   890 FHLEDIKQGRVSYAHNGDKSLTDSCSLEVSD 920
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2108-2364 2.81e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 82.92  E-value: 2.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2108 AALGEPSKATVSINDSVSDLP-KMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTdt 2185
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVaLTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGT-- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2186 siITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETL----------IRIRDDADKTVIKFGE 2255
Cdd:TIGR00845  457 --LVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVaqlaspntatVTILDDDHAGIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2256 TKFSVTEpkepgESVVIRIPVIRQGDTSKVSIVRVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMR 2334
Cdd:TIGR00845  535 DVFHVSE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKN 609

                          250       260       270
                   ....*....|....*....|....*....|
gi 614458217  2335 EAFTVHLkpDENMIAEMQLTKAIVYIEEMS 2364
Cdd:TIGR00845  610 DTFFIEL--GEPRWAKRGIKAALLLNETIT 637
Calx-beta pfam03160
Calx-beta domain;
2249-2341 3.22e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 67.66  E-value: 3.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2249 TVIKFGETKFSVTEpkepgESVVIRIPVIRQ-GDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTF 2327
Cdd:pfam03160    2 GVIGFEPPTYQVSE-----NDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|....
gi 614458217  2328 DGVREMREAFTVHL 2341
Cdd:pfam03160   77 DDVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1990-2223 4.30e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.60  E-value: 4.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1990 GSEFPGAQVTIVPDKDDEPI--FYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRsrkTDPPSADAGTDYVGISRN 2067
Cdd:TIGR00845  380 ARKAVSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYR---TEDGTANAGSDYEFTEGT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2068 LDFAPGVNMQPVRVVILDD------------LGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDsvSDLPKM-QFKE 2134
Cdd:TIGR00845  457 LVFKPGETQKEFRIGIIDDdifeedehfyvrLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGIfTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2135 RIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQV-MMDFEErpnTDTSIItFLPGETEKPCILELMDDVLYEEVE 2213
Cdd:TIGR00845  535 DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGgGKDFED---TCGELE-FENDETEKTIRVKIVDDEEYEKND 610

                          250
                   ....*....|
gi 614458217  2214 ELRLVLGTPQ 2223
Cdd:TIGR00845  611 TFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
1882-1982 6.61e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 66.89  E-value: 6.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1882 PTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTvptsvlsySDYISRPEDhtsvVRFDKDEREKL 1960
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVvRMSGTLRRTVVVPYRTEDGTATAG--------DDYEPVEGE----LVFGPGETEKC 69

                           90       100
                   ....*....|....*....|..
gi 614458217  1961 CRIVIIDDSLYEEEETFHVLLS 1982
Cdd:pfam03160   70 INVTIIDDDVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1883-1982 1.16e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 66.12  E-value: 1.16e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   1883 TVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTvptsvlsySDYISRPedhtSVVRFDKDEREKLCR 1962
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG--------SDYEPVP----GELTFPPGETEKEIR 70

                            90       100
                    ....*....|....*....|
gi 614458217   1963 IVIIDDSLYEEEETFHVLLS 1982
Cdd:smart00237   71 IKIIDDDIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2249-2341 1.82e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.35  E-value: 1.82e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   2249 TVIKFGETKFSVTEpkepgESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
Cdd:smart00237    2 GSVGFEQPVYTVSE-----SDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|...
gi 614458217   2329 GVREMREAFTVHL 2341
Cdd:smart00237   77 DIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
2008-2102 2.30e-12

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 65.35  E-value: 2.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2008 PIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRsrkTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDL 2087
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....*
gi 614458217  2088 gqpALEGIEKFELVL 2102
Cdd:pfam03160   79 ---VYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2009-2086 1.11e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 60.35  E-value: 1.11e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 614458217   2009 IFYFGDVEYSVDESAGYVEVQVWRTGtDLSKSSSVTVRsrkTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYS---TEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76
Cadherin_3 pfam16184
Cadherin-like;
336-396 9.30e-10

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 58.38  E-value: 9.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217   336 TALTPDMLAAEDAESPSDLLIFNLTSPfqPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQ 396
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLPVTNFTQADIDSGLVVYV 93
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 63-601 8.24e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 45.25  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   63 AAGVPAEEAIVLANRGLRV------PFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEV 136
Cdd:COG3321   842 VAGVPVDWSALYPGRGRRRvplptyPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALAL 921

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  137 RYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEEC 216
Cdd:COG3321   922 AAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAA 1001

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  217 RVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSP 296
Cdd:COG3321  1002 LALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAA 1081

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  297 ALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDR 376
Cdd:COG3321  1082 AALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAA 1161

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  377 SLPLSSftqRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRP 456
Cdd:COG3321  1162 ALAAAL---LAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLAL 1238

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  457 LTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRM 536
Cdd:COG3321  1239 AAAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAA 1318

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 614458217  537 VDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLE 601
Cdd:COG3321  1319 AALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAA 1383
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 72-284 4.36e-126

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 395.16  E-value: 4.36e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217    72 IVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRV 151
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDNDPLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   152 RLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYG 231
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPGTERCKVTVLPGAGGLPRYG 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 614458217   232 ELLHYPQVPggareggapetLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVV 284
Cdd:pfam19309  161 RLVNATGAP-----------LMVDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
1286-1401 9.54e-35

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 129.64  E-value: 9.54e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1286 HSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGafENIT 1365
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 614458217  1366 lgmNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDG 1401
Cdd:pfam16184   79 ---NFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1406-1514 6.91e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 127.33  E-value: 6.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1406 IDRYFYVSIGSIDIVFPDV-ISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQ 1484
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQ 82

                           90       100       110
                   ....*....|....*....|....*....|
gi 614458217  1485 LQLAGNKIYYIHTaDDEVKMDSFEFQVTDG 1514
Cdd:pfam16184   83 ADIDSGLVVYVHD-GSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1516-1623 7.99e-34

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 126.95  E-value: 7.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1516 NPVFRTFRISISDVDNKKPVVTIHK-LVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNT--RPVMVF 1592
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217  1593 TKQDLNENLISYKHDGTESSEDSFSFTVTDG 1623
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
422-539 2.40e-30

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 117.32  E-value: 2.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   422 SDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTgpagsgPQNLVISDEDDL-EAVRLEVVAGLRHGHLVILGASSG 500
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPIT------PDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKGAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217   501 SsaPKSFTVAELAAGQVVYQHDDRDgSLSDNLVLRMVDG 539
Cdd:pfam16184   76 P--VTNFTQADIDSGLVVYVHDGSE-STSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1174-1284 2.08e-27

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 108.84  E-value: 2.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1174 SERQFFPIVIIPTNDEQPEMFMRE-FMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLiNGTVLVESF 1252
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 614458217  1253 TLDQiIESSSIIYEHDDSETQEDSFVIKLTDG 1284
Cdd:pfam16184   81 TQAD-IDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
543-676 5.54e-23

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 96.13  E-value: 5.54e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   543 HQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPfLTTGHLLLRqTHPPhekq 622
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK-GAPG---- 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 614458217   623 ellrglwrkegafyeRTVTEWQQQDITEGRLFYRHSGphsPGPVTDQFTFRVQD 676
Cdd:pfam16184   75 ---------------LPVTNFTQADIDSGLVVYVHDG---SESTSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
923-1038 5.92e-22

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.05  E-value: 5.92e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   923 HVVPITLRVNVRPVDDEVPILSHPTGtlesyLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNG---I 999
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTG-----LRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGapgL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 614458217  1000 PAEQFTQRDILEGSVVYTHTSGEigllPKADSFNLSLSD 1038
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYVHDGSE----STSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
1641-1754 1.63e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.90  E-value: 1.63e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1641 PQVMKIQVLAVDNSVPQIAVNKGastLRTLATGHlgFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSIT 1720
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 614458217  1721 QFTQADIDDMKICYVlREGANATSDMFYFAVEDG 1754
Cdd:pfam16184   79 NFTQADIDSGLVVYV-HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1053-1170 2.03e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 2.03e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1053 VTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENispapgseKSRAGIA 1132
Cdd:pfam16184    5 FTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL--------KGAPGLP 76

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 614458217  1133 ISAFNLKDLRQGHINYvqsVHKGVEPVEDRFVFRCSDG 1170
Cdd:pfam16184   77 VTNFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1771-1984 1.29e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.70  E-value: 1.29e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1771 ISFEKEYYLVNEDSKFLDVVLKRRGY-LGETSFISIGTRDRTAEKDKDFKGkAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGdLTNTVYVDYRTEDGTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1850 SETFQVVLSEP---------------VLAALEFPTVATVEIVDpGDEPTVF-IPQSKYSVEEDVGELFIPIRRSGDVSQE 1913
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILD-DDHAGIFtFEEDVFHVSESIGIMEVKVLRTSGARGT 559

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217  1914 LMVVCYTQQGTATGtvptsvlSYSDYisrpEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Cdd:TIGR00845  560 VIVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 pfam16184
Cadherin-like;
683-808 1.02e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 1.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   683 QSGLQRFVIRIHPVDRLPPELGSGCPLRmvVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPtdtdeNHlpaplGTLV 762
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLR--LWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGP-----SH-----GHLA 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 614458217   763 LTDNPSVVVTHFTQAQINHHKIAYrppgQELGVATRVAQFQFQVED 808
Cdd:pfam16184   69 LKGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Cadherin_3 pfam16184
Cadherin-like;
815-920 2.31e-15

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 74.56  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   815 PGTFTLYLHPVDNQPPEI-LNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGH----MRVSGQILHvggl 889
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHlalkGAPGLPVTN---- 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217   890 FHLEDIKQGRVSYAHNGDKSLTDSCSLEVSD 920
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQVTD 110
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2108-2364 2.81e-15

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 82.92  E-value: 2.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2108 AALGEPSKATVSINDSVSDLP-KMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTdt 2185
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDPVsKIFFEPGHYTCLENCGTVaLTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGT-- 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2186 siITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETL----------IRIRDDADKTVIKFGE 2255
Cdd:TIGR00845  457 --LVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVaqlaspntatVTILDDDHAGIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2256 TKFSVTEpkepgESVVIRIPVIRQGDTSKVSIVRVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMR 2334
Cdd:TIGR00845  535 DVFHVSE-----SIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKN 609

                          250       260       270
                   ....*....|....*....|....*....|
gi 614458217  2335 EAFTVHLkpDENMIAEMQLTKAIVYIEEMS 2364
Cdd:TIGR00845  610 DTFFIEL--GEPRWAKRGIKAALLLNETIT 637
Calx-beta pfam03160
Calx-beta domain;
2249-2341 3.22e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 67.66  E-value: 3.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2249 TVIKFGETKFSVTEpkepgESVVIRIPVIRQ-GDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTF 2327
Cdd:pfam03160    2 GVIGFEPPTYQVSE-----NDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|....
gi 614458217  2328 DGVREMREAFTVHL 2341
Cdd:pfam03160   77 DDVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1990-2223 4.30e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.60  E-value: 4.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1990 GSEFPGAQVTIVPDKDDEPI--FYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRsrkTDPPSADAGTDYVGISRN 2067
Cdd:TIGR00845  380 ARKAVSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYR---TEDGTANAGSDYEFTEGT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2068 LDFAPGVNMQPVRVVILDD------------LGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDsvSDLPKM-QFKE 2134
Cdd:TIGR00845  457 LVFKPGETQKEFRIGIIDDdifeedehfyvrLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILD--DDHAGIfTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2135 RIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQV-MMDFEErpnTDTSIItFLPGETEKPCILELMDDVLYEEVE 2213
Cdd:TIGR00845  535 DVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGgGKDFED---TCGELE-FENDETEKTIRVKIVDDEEYEKND 610

                          250
                   ....*....|
gi 614458217  2214 ELRLVLGTPQ 2223
Cdd:TIGR00845  611 TFFIELGEPR 620
Calx-beta pfam03160
Calx-beta domain;
1882-1982 6.61e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 66.89  E-value: 6.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1882 PTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTvptsvlsySDYISRPEDhtsvVRFDKDEREKL 1960
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVvRMSGTLRRTVVVPYRTEDGTATAG--------DDYEPVEGE----LVFGPGETEKC 69

                           90       100
                   ....*....|....*....|..
gi 614458217  1961 CRIVIIDDSLYEEEETFHVLLS 1982
Cdd:pfam03160   70 INVTIIDDDVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1883-1982 1.16e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 66.12  E-value: 1.16e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   1883 TVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTvptsvlsySDYISRPedhtSVVRFDKDEREKLCR 1962
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG--------SDYEPVP----GELTFPPGETEKEIR 70

                            90       100
                    ....*....|....*....|
gi 614458217   1963 IVIIDDSLYEEEETFHVLLS 1982
Cdd:smart00237   71 IKIIDDDIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2249-2341 1.82e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 65.35  E-value: 1.82e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   2249 TVIKFGETKFSVTEpkepgESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
Cdd:smart00237    2 GSVGFEQPVYTVSE-----SDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|...
gi 614458217   2329 GVREMREAFTVHL 2341
Cdd:smart00237   77 DIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
2008-2102 2.30e-12

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 65.35  E-value: 2.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2008 PIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRsrkTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDL 2087
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|....*
gi 614458217  2088 gqpALEGIEKFELVL 2102
Cdd:pfam03160   79 ---VYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2009-2086 1.11e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 60.35  E-value: 1.11e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 614458217   2009 IFYFGDVEYSVDESAGYVEVQVWRTGtDLSKSSSVTVRsrkTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYS---TEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76
Calx-beta pfam03160
Calx-beta domain;
1771-1858 1.17e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 60.34  E-value: 1.17e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1771 ISFEKEYYLVNEDSKFLDV-VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQkQVQFNPGQTRATWRVRILSDGEHEQ 1849
Cdd:pfam03160    4 IGFEPPTYQVSENDGVAEVcVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEG-ELVFGPGETEKCINVTIIDDDVYEG 82


                   ....*....
gi 614458217  1850 SETFQVVLS 1858
Cdd:pfam03160   83 DENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1771-1858 5.78e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.42  E-value: 5.78e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   1771 ISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQkQVQFNPGQTRATWRVRILSDGEHEQS 1850
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPG-ELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 614458217   1851 ETFQVVLS 1858
Cdd:smart00237   83 ETFYVRLS 90
Cadherin_3 pfam16184
Cadherin-like;
336-396 9.30e-10

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 58.38  E-value: 9.30e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 614458217   336 TALTPDMLAAEDAESPSDLLIFNLTSPfqPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQ 396
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLPVTNFTQADIDSGLVVYV 93
Calx-beta pfam03160
Calx-beta domain;
2128-2220 2.84e-07

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 50.71  E-value: 2.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  2128 PKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTdtsiITFLPGETEKPCILELMDD 2206
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAeVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGE----LVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|....
gi 614458217  2207 VLYEEVEELRLVLG 2220
Cdd:pfam03160   78 DVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2129-2220 7.10e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 49.56  E-value: 7.10e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   2129 KMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTdtsiITFLPGETEKpCI-LELMDDV 2207
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGE----LTFPPGETEK-EIrIKIIDDD 77

                            90
                    ....*....|...
gi 614458217   2208 LYEEVEELRLVLG 2220
Cdd:smart00237   78 IYEKDETFYVRLS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1772-1863 2.15e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.09  E-value: 2.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKD-KDFKGkAQKQVQFNPGQTRATWRVRILSDGEHEQS 1850
Cdd:TIGR00845  531 TFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFED-TCGELEFENDETEKTIRVKIVDDEEYEKN 609

                           90
                   ....*....|...
gi 614458217  1851 ETFQVVLSEPVLA 1863
Cdd:TIGR00845  610 DTFFIELGEPRWA 622
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 815-920 7.89e-04

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 40.79  E-value: 7.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   815 PGTFTLYLHPVdNQPPEILNTGFTIqekghhilSETELHVNDVDTD-----VAHISFTLTQAPKHGHMRVSGQilhvggl 889
Cdd:pfam17963    1 TATVTVTVTPV-NDAPVAVDDSVTV--------TEDTVLANDSDPDgdpltITSLTVTIVTAPANGTVTVNAD------- 64

                           90       100       110
                   ....*....|....*....|....*....|.
gi 614458217   890 fhledikqGRVSYAHNGDKSLTDSCSLEVSD 920
Cdd:pfam17963   65 --------GTLTYTPNAGFSGTDSFTYTVSD 87
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 63-601 8.24e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 45.25  E-value: 8.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217   63 AAGVPAEEAIVLANRGLRV------PFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEV 136
Cdd:COG3321   842 VAGVPVDWSALYPGRGRRRvplptyPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALAL 921

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  137 RYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEEC 216
Cdd:COG3321   922 AAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAA 1001

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  217 RVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSP 296
Cdd:COG3321  1002 LALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAA 1081

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  297 ALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDR 376
Cdd:COG3321  1082 AALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAA 1161

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  377 SLPLSSftqRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRP 456
Cdd:COG3321  1162 ALAAAL---LAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLAL 1238

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 614458217  457 LTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRM 536
Cdd:COG3321  1239 AAAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAA 1318

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 614458217  537 VDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLE 601
Cdd:COG3321  1319 AALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAA 1383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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