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Conserved domains on  [gi|46411172|ref|NP_997179|]
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muscleblind-like protein 1 isoform 6 [Homo sapiens]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 10646956)

zinc finger CCCH domain-containing protein similar to Homo sapiens Muscleblind-like proteins

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
181-205 1.69e-04

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|....*
gi 46411172    181 RLEVCREYQRGNCNRGENdCRFAHP 205
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
181-205 1.69e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|....*
gi 46411172    181 RLEVCREYQRGNCNRGENdCRFAHP 205
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 185-204 3.96e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 34.31  E-value: 3.96e-03
                          10        20
                  ....*....|....*....|
gi 46411172   185 CREYQRGNCNRGENdCRFAH 204
Cdd:pfam18345   1 CKFFLKGRCRYGDK-CRFAH 19
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
181-205 1.69e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|....*
gi 46411172    181 RLEVCREYQRGNCNRGENdCRFAHP 205
Cdd:smart00356   3 KTELCKFFKRGYCPRGDR-CKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 185-204 3.96e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 34.31  E-value: 3.96e-03
                          10        20
                  ....*....|....*....|
gi 46411172   185 CREYQRGNCNRGENdCRFAH 204
Cdd:pfam18345   1 CKFFLKGRCRYGDK-CRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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