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Conserved domains on  [gi|46275835|ref|NP_996892|]
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DENN domain-containing protein 10 isoform 1 [Homo sapiens]

Protein Classification

DENND11 family protein( domain architecture ID 1750197)

DENND11 family protein similar to Homo sapiens DENN domain-containing protein 10, a guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B

Gene Ontology:  GO:0031267|GO:0015031|GO:0005085

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPA super family cl40631
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 158-264 1.63e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


The actual alignment was detected with superfamily member pfam08616:

Pssm-ID: 454797  Cd Length: 113  Bit Score: 51.91  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275835   158 SIKDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCT 231
Cdd:pfam08616   3 SLLKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVP 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 46275835   232 GYVAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 264
Cdd:pfam08616  81 GYIAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 158-264 1.63e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 51.91  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275835   158 SIKDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCT 231
Cdd:pfam08616   3 SLLKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVP 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 46275835   232 GYVAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 264
Cdd:pfam08616  81 GYIAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 158-264 1.63e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 51.91  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275835   158 SIKDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCT 231
Cdd:pfam08616   3 SLLKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVP 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 46275835   232 GYVAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 264
Cdd:pfam08616  81 GYIAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
Avl9 pfam09794
Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It ...
 154-262 2.55e-04

Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo.


Pssm-ID: 430832 [Multi-domain]  Cd Length: 379  Bit Score: 42.65  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46275835   154 YLAGSIKDIVSQFGMETVILHTALMLKKRIVVYHPKIEAVQEFTRTL----PALVWHRQDW--TILHSYVH--LNADELE 225
Cdd:pfam09794 161 YVGLSLRELVLKFRHNTLVLFKALLLEKKVLFYGSPVERLCNLQFSLisliPNLISNLQDSgsPSLDSYESdlTKPTSLK 240

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46275835   226 ----------------------------ALQM--------CTGYVAGFVD-LEVSNRPDLYDVFVNLAESEITI 262
Cdd:pfam09794 241 tsdrrsllrflglplqifgkgglfspytPLQQldllsdptTKSFLVGTSNsLFLQQKDLLADILVNLDNATIEI 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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