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Conserved domains on  [gi|45387729|ref|NP_991216|]
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zinc finger protein 410 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779705)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 2.00e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 45387729   295 SLRKHMLVHSGEKPHVCSVCGKTFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-274 4.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 155 DARATANSEHLLSCASDGQK--RESSPRVSSRSEKIHRCPYESCCRTFTYPAHLKYH-LKTHRNDRTFRCGAEGCGKSFY 231
Cdd:COG5189 314 RKLPCTNSSSNGKLAHGGERniDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFS 393

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45387729 232 VlqrlqvhmrthnGEKPFICSEnnCGKKFTTAGNLKNHrRTHT 274
Cdd:COG5189 394 A------------KDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-332 1.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.70e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387729 275 GEKPFLCEVNNCGRSFAEYSSLRKHML-------------------VHSGEKPHVCSVCGKTFSQSGSRNVHMKKRH 332
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 2.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 45387729   295 SLRKHMLVHSGEKPHVCSVCGKTFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-274 4.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 155 DARATANSEHLLSCASDGQK--RESSPRVSSRSEKIHRCPYESCCRTFTYPAHLKYH-LKTHRNDRTFRCGAEGCGKSFY 231
Cdd:COG5189 314 RKLPCTNSSSNGKLAHGGERniDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFS 393

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45387729 232 VlqrlqvhmrthnGEKPFICSEnnCGKKFTTAGNLKNHrRTHT 274
Cdd:COG5189 394 A------------KDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-332 1.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.70e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387729 275 GEKPFLCEVNNCGRSFAEYSSLRKHML-------------------VHSGEKPHVCSVCGKTFSQSGSRNVHMKKRH 332
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 191-269 2.72e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729   191 CPYESCCRTFTYPAHLKYHLKTH------RNDRTFRCGAEGCGKSFYVLQRLQVHMRTHNGEKPFICSEnNCGKKFTTAG 264
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCE-NCLLRFRTHR 80


                  ....*
gi 45387729   265 NLKNH 269
Cdd:pfam15909  81 SLFKH 85
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 2.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.00e-05
                          10        20
                  ....*....|....*....|....*.
gi 45387729   295 SLRKHMLVHSGEKPHVCSVCGKTFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-274 4.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 155 DARATANSEHLLSCASDGQK--RESSPRVSSRSEKIHRCPYESCCRTFTYPAHLKYH-LKTHRNDRTFRCGAEGCGKSFY 231
Cdd:COG5189 314 RKLPCTNSSSNGKLAHGGERniDTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFS 393

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45387729 232 VlqrlqvhmrthnGEKPFICSEnnCGKKFTTAGNLKNHrRTHT 274
Cdd:COG5189 394 A------------KDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-319 1.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 176 ESSPRVSSRSEKIHRCPY--ESCCRTFTYPAHLKYHLKTHRNDRTFRCGAEGCGKSFYVLQRLQVHMRTHNGEKPFICSE 253
Cdd:COG5048 277 ESDSSSEKGFSLPIKSKQcnISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45387729 254 NNCGKKFTTAGNLKNH-----RRTHTGEKPFLCEVNNCGRSFAEYSSLRKHMLVHSGEKPHVC--SVCGKTFS 319
Cdd:COG5048 357 LNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-282 2.01e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.01e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45387729 215 NDRTFRCgaEGCGKSFYVLQRLQVHMRTHNGEKPFICSENNCGKKFTTAGNLKNHRRTHTGEKPFLCE 282
Cdd:COG5048  30 APRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-327 1.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 166 LSCASDGQKRESSPRVSSRSEKIHRCPYESCCRTFTYPAHLKYHLKTHRNDRTFRCGAEGCGKSFYVL----QRLQVHMR 241
Cdd:COG5048 299 FSRSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnnePPQSLQQY 378

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729 242 -THNGEKPFICSENNCGKKFTTAGNLKNHRRTHTGEKPFLCEVNNCGRSFAEYSSLRKHMLVHSGEKPHVCSVCGKTFSQ 320
Cdd:COG5048 379 kDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458


                ....*..
gi 45387729 321 SGSRNVH 327
Cdd:COG5048 459 LDLSNHG 465
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 275-332 1.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 1.70e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387729 275 GEKPFLCEVNNCGRSFAEYSSLRKHML-------------------VHSGEKPHVCSVCGKTFSQSGSRNVHMKKRH 332
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 191-269 2.72e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387729   191 CPYESCCRTFTYPAHLKYHLKTH------RNDRTFRCGAEGCGKSFYVLQRLQVHMRTHNGEKPFICSEnNCGKKFTTAG 264
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCE-NCLLRFRTHR 80


                  ....*
gi 45387729   265 NLKNH 269
Cdd:pfam15909  81 SLFKH 85
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 249-273 5.74e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|....*
gi 45387729   249 FICSEnnCGKKFTTAGNLKNHRRTH 273
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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