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Conserved domains on  [gi|302308568|ref|NP_985517|]
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AFL031Wp [Eremothecium gossypii ATCC 10895]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 374-490 1.36e-13

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 67.06  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568  374 EYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDDnsvREYFKTFSKVAYKDFKGFEQMETC 453
Cdd:pfam00989   2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEED---DAEVAELLRQALLQGEESRGFEVS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 302308568  454 VLLSPieGRTIECSCMWTWKRDVFGMPMMIVGHFLPV 490
Cdd:pfam00989  79 FRVPD--GRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 13-56 2.95e-07

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 46.97  E-value: 2.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 302308568    13 KKTNVACVNCSRSHVTCESQRP-CTRCVKKGLEmsCVNAPRKRRK 56
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLE--CTYSDSKKRK 43
 
Name Accession Description Interval E-value
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 374-490 1.36e-13

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 67.06  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568  374 EYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDDnsvREYFKTFSKVAYKDFKGFEQMETC 453
Cdd:pfam00989   2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEED---DAEVAELLRQALLQGEESRGFEVS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 302308568  454 VLLSPieGRTIECSCMWTWKRDVFGMPMMIVGHFLPV 490
Cdd:pfam00989  79 FRVPD--GRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 13-56 2.95e-07

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 46.97  E-value: 2.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 302308568    13 KKTNVACVNCSRSHVTCESQRP-CTRCVKKGLEmsCVNAPRKRRK 56
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLE--CTYSDSKKRK 43
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 382-490 5.52e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 45.32  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568 382 IGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD-NSVREYFKtfskvayKDFKGFEQMETCVLLSPIE 460
Cdd:cd00130    1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDrEELRERLE-------NLLSGGEPVTLEVRLRRKD 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 302308568 461 GRTIECSCMWTWKRDVFGMPMMIVGHFLPV 490
Cdd:cd00130   74 GSVIWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 370-426 7.99e-05

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 40.85  E-value: 7.99e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 302308568   370 RTLLEYdrfitqIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD 426
Cdd:smart00091   4 RAILES------LPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPED 54
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 14-48 1.00e-04

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 39.57  E-value: 1.00e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 302308568  14 KTNVACVNCSRSHVTC-ESQRPCTRCVKKGLEmsCV 48
Cdd:cd00067    1 RVRRACDRCRRRKIKCdGEKPPCSNCIKLGLE--CT 34
PAS COG2202
PAS domain [Signal transduction mechanisms];
365-426 3.55e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 42.32  E-value: 3.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302308568 365 EQSYQRTLLEYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD 426
Cdd:COG2202    3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPED 64
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 391-435 4.88e-04

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 39.97  E-value: 4.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 302308568  391 RNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD-NSVREYFKT 435
Cdd:TIGR00229  21 LEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDrEEVRERIER 66
 
Name Accession Description Interval E-value
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 374-490 1.36e-13

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 67.06  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568  374 EYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDDnsvREYFKTFSKVAYKDFKGFEQMETC 453
Cdd:pfam00989   2 DLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEED---DAEVAELLRQALLQGEESRGFEVS 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 302308568  454 VLLSPieGRTIECSCMWTWKRDVFGMPMMIVGHFLPV 490
Cdd:pfam00989  79 FRVPD--GRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 13-56 2.95e-07

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 46.97  E-value: 2.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 302308568    13 KKTNVACVNCSRSHVTCESQRP-CTRCVKKGLEmsCVNAPRKRRK 56
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLE--CTYSDSKKRK 43
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 382-490 5.52e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 45.32  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568 382 IGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD-NSVREYFKtfskvayKDFKGFEQMETCVLLSPIE 460
Cdd:cd00130    1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDrEELRERLE-------NLLSGGEPVTLEVRLRRKD 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 302308568 461 GRTIECSCMWTWKRDVFGMPMMIVGHFLPV 490
Cdd:cd00130   74 GSVIWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 370-426 7.99e-05

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 40.85  E-value: 7.99e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 302308568   370 RTLLEYdrfitqIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD 426
Cdd:smart00091   4 RAILES------LPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPED 54
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 14-48 1.00e-04

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 39.57  E-value: 1.00e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 302308568  14 KTNVACVNCSRSHVTC-ESQRPCTRCVKKGLEmsCV 48
Cdd:cd00067    1 RVRRACDRCRRRKIKCdGEKPPCSNCIKLGLE--CT 34
PAS COG2202
PAS domain [Signal transduction mechanisms];
365-426 3.55e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 42.32  E-value: 3.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302308568 365 EQSYQRTLLEYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD 426
Cdd:COG2202    3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPED 64
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 391-435 4.88e-04

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 39.97  E-value: 4.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 302308568  391 RNGQISYLNDEFCLLTGWTREELLSKMTFIVELLDD-NSVREYFKT 435
Cdd:TIGR00229  21 LEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDrEEVRERIER 66
PAS COG2202
PAS domain [Signal transduction mechanisms];
349-439 8.95e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 41.16  E-value: 8.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302308568 349 FIASAVDLTEEDMifMEQSYQRTLLEYDRFITQIGTPTCVWRRNGQISYLNDEFCLLTGWTREELLSKMtfIVELLDDNS 428
Cdd:COG2202  115 FVGIARDITERKR--AEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKS--LLDLLHPED 190

                         90
                 ....*....|.
gi 302308568 429 VREYFKTFSKV 439
Cdd:COG2202  191 RERLLELLRRL 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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